Clinical trials: Cancer of Rectum
Rectal Neoplasms
Preoperative Chemoradiation With VMAT-SIB in Rectal Cancer
This was a prospective phase II study on patients with locally advanced rectal cancer or local recurrence, to evaluate the pathological response and resectability of a neoadjuvant treatment based on the use of a combined…
- Trial name
- GRACE (NCT02745639)
- Testing
- VMAT-SIB, XELOX
- Volunteers
- 18 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Rectal Cancer T3-4N0-2M0
Procedure RACHEL in Complex Treatment of Rectal Cancer
AIM OF RESEARCH. The aim of our research is to improve the results of the combined treatment of patients with locally advanced rectal cancer using endovascular methods and reservoir and plastic surgery. TASKS OF RESEARCH. 1.
- Trial name
- RACHEL (NCT02022553)
- Testing
- usual rectal cancer surgery, RACHEL
- Where
- Russia
- Volunteers
- 52 people
- Sponsor
- Voronezh N.N. Burdenko State Medical Academy
Rectal Neoplasms
A Prospective Clinical Study for Transanal Double Purse-string Rectal Anastomosis Preformed With KOL Stapler
The most challenge for the surgery of low rectal carcinoma was whether to perform low anterior resection (LAR) and preserve anal function improving the quality of life for patients, for which anastomotic leak is a great obstacle…
- Trial name
- NCT02565667
- Testing
- KOL, traditional staple
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Colon Cancer, Diverticulitis
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
A database has been established to track the outcomes of all cases performed in the University Hospitals Department of Surgery in an effort to improve quality of surgical performance and case management.
- Conditions
- Colon Cancer, Diverticulitis, Colorectal Polyps, Crohn's Disease
- Trial name
- SOCRATES (NCT00622557)
- Where
- United States
- Volunteers
- 200,000 people
- Sponsor
- University Hospitals Cleveland Medical Center
Colon Carcinoma, Rectum Carcinoma
Trial for Retractor Sponge Evaluation in Laparoscopic Colorectal Surgery
Laparoscopic surgery of the distal colon and rectum requires surgery with an appropriate field of view. A commonly used technique to create a clear exposure is the steep Trendelenburg position in which the patient is positioned…
- Trial name
- SPONGE (NCT03334383)
- Testing
- Sponge
- Where
- Netherlands
- Volunteers
- 188 people
- Sponsor
- St. Antonius Hospital
Colorectal Cancer
Oxaliplatin, Capecitabine, and Radiation Therapy in Treating Patients With Locally Advanced Cancer of the Rectum
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin and capecitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00086931
- Testing
- capecitabine, oxaliplatin, conventional surgery
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Roswell Park Cancer Institute
Rectal Cancer, Chemoradiation
Translational Research in Identifying Molecular Mechanisms for Rectal Cancer Metastasis
Rectal cancer, comprised of 30% of overall colorectal cancer cohort, is one of the leading cancers of Taiwan. In patients with advanced disease, the standard of care is concurrent chemoradiotherapy (CCRT) before surgery.
- Trial name
- NCT02979795
- Testing
- Preoperative chemoradiotherapy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- China Medical University Hospital
Rectal Cancer
Curative Chemoradiation of Low Rectal Cancer
The aim of the present study is to investigate whether curative chemoradiation of low rectal cancer is feasible, safe and effective in a multicenter study with results comparable to those of single center studies.
- Trial name
- WW2 (NCT02438839)
- Where
- 5 sites in Denmark
- Volunteers
- 108 people
- Sponsor
- Vejle Hospital
Rectal Cancer
Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer
This is a phase III randomized controlled trial comparing the efficacy and safety of FOLFOXIRI versus CapeOX as neoadjuvant regimen in treating patients with middle and upper locally advanced (MRI T3-4 or N+) rectal cancer.
- Trial name
- RCNAC (NCT05201430)
- Testing
- FOLFOXIRI, CapeOX
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fudan University
Rectal Adenocarcinoma, Stage II Rectal Cancer AJCC v7
Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer
This randomized phase II trial studies how well veliparib or pembrolizumab work with combination chemotherapy and radiation therapy in treating patients with rectal cancer that has spread from where it started to nearby tissue or…
- Conditions
- Rectal Adenocarcinoma, Stage II Rectal Cancer AJCC v7, Stage III Rectal Cancer AJCC v7
- Trial name
- NCT02921256
- Testing
- Capecitabine, Fluorouracil, Intensity-Modulated Radiation Therapy
- Where
- 650 sites in United States, Puerto Rico
- Volunteers
- 363 people
- Sponsor
- National Cancer Institute (NCI)
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable)
Colorectal cancer is the 2nd and 3rd most common cancer in respectively women and men, of which about 40% is located in the rectum.
- Conditions
- Rectal Cancer, LARS - Low Anterior Resection Syndrome, Active Surveillance
- Trial name
- Treatable (NCT06914245)
- Testing
- Electronic bowel diary, Faecal Incontinence Quality of Life questionnaire (FIQL), EuroQoL 5 dimensions, 5 levels (EQ-5D-5L)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- KU Leuven
Colorectal Cancer
Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of aspirin and/or folic acid may be effective in preventing recurrent polyps in patients who have…
- Trial name
- NCT00033319
- Testing
- folic acid, acetylsalicylic acid
- Where
- 32 sites in United Kingdom
- Sponsor
- Queen's Medical Center
Colon Cancer, Rectal Cancer
Validation of Colon Biomarkers for the Early Detection of Colorectal Adenocarcinoma
The investigators are undertaking a multi-center, 13000 subject validation study of several biomarkers for early detection of colon cancer.
- Trial name
- GLNE010 (NCT01511653)
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Rectal Cancer
Capecitabine, Irinotecan Hydrochloride, Cetuximab, and Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EXCITE (NCT00972881)
- Testing
- cetuximab, capecitabine, irinotecan hydrochloride
- Where
- 5 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- University College, London
Colo-rectal Cancer, Colon Adenoma
Outcomes of Colonoscopy With Non-anesthesiologist Administered Propofol
The Efficacy and safety of Non-anesthesiologist administered propofol (NAAP) for gastrointestinal endoscopy have been widely documented although there is not information which has evaluated the outcomes of colonoscopy it self…
- Conditions
- Colo-rectal Cancer, Colon Adenoma, ADR
- Trial name
- ADR_NAAP (NCT03922074)
- Testing
- Sedation directed by an endoscopist, Sedation directed by an anesthesiologist
- Volunteers
- 630 people
- Sponsor
- Serveis de Salut Integrats Baix Empordà
Rectal Cancer, Cancer of Rectum
Biomarkers for Predicting Neoadjuvant Chemoradio-resistance for Middle-low Advanced Rectal Cancer
Neoadjuvant therapy has been widely applied to locally advanced rectal cancer. However, about 50% of patients receiving this therapy do not respond well as evidenced by the fact that their T or N stages are not effectively…
- Conditions
- Rectal Cancer, Cancer of Rectum, Cancer of the Rectum, Neoplasms, Rectal
- Trial name
- NCT03573791
- Where
- 2 sites in China
- Volunteers
- 152 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Rectal Cancer, Feasibility
Feasibility of the Maastro Applicator in Rectal Cancer
The goal of this interventional pilot trial is to confirm that Maastro endoluminal HDR ( High Dose Radiation) contact brachytherapy boosting is feasible and may increase the chance of functional organ sparing of the rectum in…
- Conditions
- Rectal Cancer, Feasibility, Toxicity, Quality of Life
- Trial name
- NCT06087718
- Testing
- Maastro applicator
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht Radiation Oncology
Rectal Cancer Stage I
Preoperative Chemoradiotherapy and Transanal Endoscopic Microsurgery Versus Ttransanal Endoscopic Microsurgery in T1 N0, M0 Rectal Cancer (TAUTEM-T1 Study)
Introduction: The standard treatment for rectal adenocarcinoma is total mesorectal excision (TME), a technique involving resection of the rectum, with or without a temporary or permanent stoma.
- Trial name
- TAUTEM-T1 (NCT06450574)
- Testing
- Capecitabine (Xeloda), 50.4 Gy, Transanal Endoscopic Microsurgery (TEM)
- Volunteers
- 106 people
- Sponsor
- Corporacion Parc Tauli
Rectum Cancer
Removal Time of Urinary Catheter After Laparoscopic Anterior Resection of the Rectum
Traditionally these catheters are retained for 7 days, because a higher incidence of urinary retention is related to early removal of the urinary catheter.
- Trial name
- NCT03065855
- Testing
- Early removal group, Normal removal group
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer
Gemcitabine in Treating Patients With Advanced Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of gemcitabine in treating patients who have advanced…
- Trial name
- NCT00007943
- Testing
- gemcitabine hydrochloride
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Wake Forest University Health Sciences