Clinical trials: Cancer of the Esophagus
Barrett's Esophagus
Evaluation of a Miniaturized Microscope Device for the Detection of Barrett's Neoplasia: A Pilot Study
The overall objective of this study is to obtain data to evaluate whether high-resolution imaging of barrett's esophagus in vivo can assist clinicians in detecting dysplastic (precancerous) areas.
- Trial name
- NCT01384227
- Testing
- Proflavine Hemisulfate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Anandasabapathy, Sharmila, M.D.
Suspected or Known Squamous Cell Neoplasia, Prior History of Squamous Cell Dysplasia and /or Neoplasia
Effectiveness and Performance of an Optical Biopsy Technology for Esophageal Cancer in Brazil and the United States
In a previous clinical trial in China and the United States (US), the investigators developed and validated a mobile, high-resolution microendoscope (mHRME) for screening and surveillance of esophageal squamous cell neoplasia…
- Trial name
- NCT06435286
- Testing
- Proflavine Hemisulfate, Artificial Intelligence Mobile High-Resolution Microendoscope
- Where
- 4 sites in United States, Brazil
- Volunteers
- 200 people
- Sponsor
- Baylor College of Medicine
Barrett Esophagus
Non-magnified NBI in Barrett's Oesophagus Neoplasia Detection and Delineation
Endoscopy plays a pivotal role in the management (diagnosis and treatment) of Barrett's related neoplasia. The standard endoscopy is generally done under white light, which is known to be imperfect in detecting early neoplastic…
- Trial name
- NCT04621474
- Testing
- Narrow band imaging (NBI)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Cambridge
Esophageal Cancer TNM Staging, Magnetic Resonance Imaging
The Application of 3T MRI in Esophageal Cancer
It is very significant that assessing TN staging in esophageal cancer patients before surgery, furthermore, determining the optimize surgical strategy, predict the the efficacy of radiotherapy for patients who were not chosen to…
- Conditions
- Esophageal Cancer TNM Staging, Magnetic Resonance Imaging, Prognosis
- Trial name
- NCT03635619
- Testing
- No intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Henan Cancer Hospital
Esophageal Cancer
A Study of Irinotecan, Cisplatin and Celebrex in Patients With Metastatic or Unresectable Esophageal Cancer
This study is for patients with cancer of the esophagus. This study uses the drugs irinotecan, cisplatin and celecoxib. Irinotecan (also known as CPT-11) was recently approved by the U.S.
- Trial name
- NCT00183807
- Testing
- irinotecan, cisplatin, celecoxib
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Southern California
Esophageal Cancer, Thoracic Diseases
Generation of a Surgical Field in the Left Lateral Decubitus Position
The generation of a good surgical field at the mid-lower mediastinum during thoracoscopic esophagectomy in the left lateral decubitus position is often complicated.
- Trial name
- NCT04683601
- Testing
- Thoracoscopic esophagectomy in left decubitus
- Volunteers
- 154 people
- Sponsor
- Shizuoka Cancer Center
Esophageal Cancer, Esophageal Neoplasms
Rehabilitation and Recovery for Persons With Esophageal or Gastric Cancer
This study aims to develop and evaluate a model for systematic and evidence-based cancer rehabilitation for people with esophageal and gastric cancer to provide conditions for a better quality of life and fewer cancer-related…
- Conditions
- Esophageal Cancer, Esophageal Neoplasms, Gastric Cancer, Stomach Neoplasm
- Trial name
- NCT05698992
- Testing
- evidence-based individualized rehabilitation
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Esophageal Carcinoma
Liposomal Paclitaxel Combined Nedaplatin in Treatment of Advanced or Recurrent Esophageal Carcinoma
The purpose of this study is to evaluate the safety, tolerance and efficacy of Liposomal Paclitaxel With Nedaplatin as First-line in patients with Advanced or Recurrent Esophageal Carcinoma
- Trial name
- NCT02861690
- Testing
- Liposomal Paclitaxel, Nedaplatin
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Sun Yat-sen University
Esophageal Cancer, Stomach Cancer
KD019 and Trastuzumab in Patients With Esophagus, Gastroesophageal Junction and Stomach Cancer
This dose-escalation study is to determine the safety, maximum tolerated dose (MTD) and efficacy of KD019 in combination with trastuzumab and mFOLFOX-6.
- Trial name
- NCT02205463
- Testing
- KD019
- Where
- United States
- Sponsor
- NYU Langone Health
Esophageal Cancer, Lung Cancer
Optimizing (Breathing) Techniques for Radiotherapy of Esophageal and Lung Carcinomas
Neo-adjuvant chemoradiotherapy (neo-CRT) is increasingly applied in the curative treatment of esophageal cancer, with the aim to downstage the tumor, to increase the rate of radical resections, and consequently to improve the…
- Trial name
- ABC (NCT02497664)
- Testing
- Active Breathing Control
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- University Medical Center Groningen
Esophageal Squamous Cell Carcinoma (ESCC)
A Study of Trifluridine/Tipiracil Combined With Anlotinib as Second-line Treatment for Recurrent and Metastatic Esophageal Squamous Cell Carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the malignant tumors with a high incidence worldwide, especially remaining persistently high in Asian regions.
- Trial name
- NCT07142421
- Testing
- Combination therapy (COMB)
- Where
- China
- Volunteers
- 35 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Head and Neck Squamous Cell Carcinoma HNSCC, Non-Small Cell Lung Cancer NSCLC
A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer
This is a study to evaluate the safety and preliminary anti-tumor activity of STRO-004 in adults with metastatic cancer. This study includes 3 parts: Part 1A is a dose escalation study of STRO-004 monotherapy in selected tumor…
- Conditions
- Head and Neck Squamous Cell Carcinoma HNSCC, Non-Small Cell Lung Cancer NSCLC, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT07227168
- Testing
- STRO-004, Pembrolizumab
- Where
- 9 sites in United States
- Volunteers
- 200 people
- Sponsor
- Sutro Biopharma, Inc.
Esophageal Squamous Cell Carcinoma
A Phase II Clinical Study of Fruquintinib Combined With S-1 for Advanced Esophageal Squamous Cell Carcinoma
Investigators conduct the clinical trial to further explore the efficacy and safety of Fruquintinib combined with S-1 in treating recurrent or metastatic esophageal squamous cell carcinoma after the failure of conventional…
- Trial name
- NCT05636150
- Testing
- Fruquintinib in Combination with S-1
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Peking Union Medical College Hospital
Stomach Neoplasms, Esophageal Neoplasms
Safety and Efficacy of G17DT Immunogen in the Treatment of Gastric and Gastroesophageal Cancer
This study will test whether the G17DT Immunogen, when administered in combination with chemotherapy, is an effective and safe treatment for gastric cancer.
- Trial name
- NCT00042510
- Testing
- Treatment group
- Volunteers
- 103 people
- Sponsor
- Cancer Advances Inc.
Gastroesophageal Reflux Disease (GERD)
Experimental Study to Determine the Effects of Human Refluxate on Macrophage Phenotype and Its Correlation With GERD
This study is proposed to evaluate the role of motoric dysfunctions and type of refluxate in GERD patients, analyzed the blood monocyte/macrophage phenotypes of gastroesophageal reflux diseases (GERD) patients.
- Trial name
- NCT02699060
- Testing
- Upper gastrointestinal endoscopy with biopsy and collection of refluxate, Esophageal high-resolution manometry and 24-h esophageal pH-impedance monitoring
- Where
- 2 sites in Russia
- Volunteers
- 68 people
- Sponsor
- Ivashkin Vladimir Trofimovich
Esophagus Cancer
Impact of Dose to Cardiac Substructures on Survival in Patients With Esophageal Cancer Treated With Radiotherapy or Chemoradiotherapy (SATIATION)
Treatment of non-operable esophageal cancers is based on radiochemotherapy, or exclusive radiotherapy. The cardiac toxicity of radiotherapy in the treatment of thoracic tumor localizations is well documented, however, more and…
- Trial name
- SATIATION (NCT05996276)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
Eosinophilic Esophagitis, Barrett Esophagus
Imaging of the Esophagus Using a SECM Capsule
The goal of this validation study is to compare Spectrally Encoded Confocal Microscopy (SECM) Tethered Capsule Endoscopy (TCE) diagnosis of Eosinophilic Esophagitis to that of standard of care endoscopic biopsy.
- Trial name
- NCT03546660
- Testing
- SECM capsule
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colorectal Neoplasm, Head and Neck Neoplasm
Phase 2 Study of Temozolomide in Pre-Selected Advanced Aerodigestive Tract Cancers (Study P04273AM2)(TERMINATED)
This study is proposed to evaluate the efficacy and safety of temozolomide, an oral anti-cancer agent, in a participant population selected for a biomarker.
- Conditions
- Colorectal Neoplasm, Head and Neck Neoplasm, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasm
- Trial name
- NCT00423150
- Testing
- Temozolomide
- Volunteers
- 86 people
- Sponsor
- Merck Sharp & Dohme LLC
Head and Neck Cancer, Non-Small Cell Lung Cancer
Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV)
This is a Phase II clinical study for people with stage IV cancer. The study will evaluate the use of stereotactic body radiation therapy (SBRT), a type of focused radiation treatment, together with immunotherapy-based treatment.
- Conditions
- Head and Neck Cancer, Non-Small Cell Lung Cancer, Cervical Cancer, Esophageal Cancer
- Trial name
- NCT07770100
- Testing
- Stereotactic Body Radiation Therapy (SBRT), Pembrolizumab, Nivolumab
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mark Bernard
Esophageal Cancer
Cologne Esophageal Response Prediction Study (CERP-Study)
RATIONALE: The prognosis of patients with advanced esophageal cancer may be improved by preoperative chemoradiation. But only those patients have a benefit from this additional therapy, whose tumor shows a response after…
- Trial name
- CERP (NCT00953511)
- Testing
- ERCC1 pathways analysis
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Elfriede Bollschweiler
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