Clinical trials: Cancer of the Head and Neck
Cancer, Solid Tumor
Study of CRLX101 (NLG207) in the Treatment of Advanced Solid Tumors
CRLX101 is a nanopharmaceutical comprised of the chemotherapeutic camptothecin (CPT) conjugated to a linear, cyclodextrin-based polymer.
- Trial name
- NCT00333502
- Testing
- Camptothecin (CPT) conjugated to a linear, cyclodextrin-based polymer
- Where
- 3 sites in United States
- Volunteers
- 62 people
- Sponsor
- NewLink Genetics Corporation
Malignant Neoplasm of Other Specified Site of Nasopharynx
Retrospective Investigation of the Impacts of Prognosis for Nasopharyngeal Carcinoma Patients
To investigate whether the additional induction chemotherapy (IC) to concurrent chemoradiotherapy (CCRT) was able to improve overall survival (OS) and disease-free survival (DFS), and to clarify if stage-specified…
- Trial name
- NCT02604472
- Testing
- CCRT, IC+CCRT
- Volunteers
- 12,206 people
- Sponsor
- Sun Yat-sen University
Squamous Cell Carcinoma of the Head and Neck
Functional ImaGing of Heterogeneity in Head and Neck Tumors - Validation From Surgical Specimens
The purpose of this study is to investigate if heterogeneity in head and neck squamous cell carcinoma as seen in functional imaging with PET/MR can be correlated to biologic heterogeneity in surgical specimens.
- Trial name
- FIGHHT (NCT03160495)
- Testing
- All patients
- Where
- Denmark
- Volunteers
- 33 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypopharyngeal Carcinoma
Neoadjuvant Chemotherapy Combined With Finotonlimab in the Treatment of Locally Advanced Hypopharyngeal Carcinoma
This is a multi-center, randomized controlled, prospective clinical study.
- Trial name
- NCT07248956
- Testing
- Finolizumab, Albumin-Bound Paclitaxel /nab-Paclitaxel, Cisplatin
- Where
- 7 sites in China
- Volunteers
- 116 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Oral Leukoplakia
Comparison of Topical Photodynamic Therapy With Topical Calcipotriol in Management of Oral Leukoplakia
(i)Rationale/ gaps in existing knowledge,: Oral cancer, one of the top three common cancers in India is usually preceded by Oral potentially malignant disorders in nearly two thirds of the cases like Oral leukoplakia.
- Trial name
- PDT CALCI HOL (NCT07453472)
- Testing
- Non-invasive Photo Dynamic Therapy using LED of wavelength ranging from 630-660nm( Fluence 15 J/cm2) as light source and 2.5% TB as photosensitizer, Topical application of Calcipotriol ointment 0.005% twice a day for 4 weeks along with preventive and conventional therapy, Conventional non-invasive management : All subjects in the two groups will receive the same standard conventional non- invasive management advised for OL as per current scientific evidence
- Where
- India
- Volunteers
- 166 people
- Sponsor
- Dr. Shalini Gupta
Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma
Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)
A Phase 2 Study of evorpacept (ALX148) in Combination With pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma.
- Trial name
- NCT04675294
- Testing
- evorpacept, pembrolizumab
- Where
- 53 sites in United States, Australia and 7 more
- Volunteers
- 189 people
- Sponsor
- ALX Oncology Inc.
Head and Neck Cancer
Real-Time kV Imaging vs. Real-Time 3D Patient Surface Tracking for Head & Neck Cancer
To determine if a new optical system that can track a patient's movement during treatment can be used to measure motion and allow for motion adjustments in order to decrease the amount of healthy tissue that receives radiation…
- Trial name
- NCT01011842
- Testing
- Radiotherapy, Align RT
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Stanford University
Lymphoma, Head and Neck Cancer
DOLPHIN-VIVO: Diagnosis Of LymPHoma IN Vivo (Ex Vivo Phase)
Lymphoma diagnosis often involves removal and biopsy of one or more lymph nodes. Many (around half) of these diagnostic procedures show that no cancer is present, hence unnecessary removal results in numerous side effects and…
- Trial name
- DOLPHIN-VIVO (NCT04162431)
- Testing
- spectroscopic measurement, FNA biopsy, histopathology and cytology
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Carcinoma, Renal Cell, Kidney Diseases
A Study of Varlilumab and Atezolizumab in Patients With Advanced Cancer
This is a study to determine the clinical benefit (how well the drug works), safety and tolerability of combining varlilumab and atezolizumab.
- Conditions
- Carcinoma, Renal Cell, Kidney Diseases, Kidney Neoplasms, Urogenital Neoplasms
- Trial name
- NCT02543645
- Testing
- Combination of Varlilumab and Atezolizumab
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Celldex Therapeutics
Head and Neck Cancer, Radiotherapy; Adverse Effect
Monitoring Skeletal Muscle Mass Using CBCT in Patients With H&N Cancer Undergoing Chemoradiotherapy
Chemoradiotherapy is the standard treatment for unresectable locally advanced head and neck cancer (HNC). However, malnutrition is present in 44-88% HNC patients during chemoradiotherapy, which leads to loss of skeletal muscle…
- Trial name
- MELINOE (NCT05126095)
- Testing
- Radical radiotherapy
- Where
- China
- Volunteers
- 135 people
- Sponsor
- Guangdong Provincial People's Hospital
Human Papilloma Virus Infection, Stage III Squamous Cell Carcinoma of the Oropharynx
Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer
This randomized phase II trial studies how well transoral surgery followed by low-dose or standard-dose radiation therapy works in treating patients with human papilloma virus (HPV) positive stage III-IVA oropharyngeal cancer.
- Conditions
- Human Papilloma Virus Infection, Stage III Squamous Cell Carcinoma of the Oropharynx, Stage IVA Squamous Cell Carcinoma of the Oropharynx, Stage IVB Squamous Cell Carcinoma of the Oropharynx
- Trial name
- NCT01898494
- Testing
- Transoral surgery, intensity-modulated radiation therapy, cisplatin
- Where
- 58 sites in United States
- Volunteers
- 519 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Head and Neck Cancer
Efficacy of EPA-enriched Supplement in Malnourished Head and Neck Cancer Patients Undergone Surgery
The purpose of this study is to study the effects of EPA-enriched supplement compared with conventional supplement in malnourished head and neck cancer patients undergone surgery. Primary outcome is perioperative weight changing.
- Trial name
- NCT02321631
- Testing
- EPA-enriched supplement, standard formula supplement
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Prince of Songkla University
Head and Neck Cancer
Non-randomized, Open-label Study of Intralesional Nivolumab for High Risk Oral Premalignant Lesions
To characterize the safety and tolerability of nivolumab injected intralesionally in patients with high-risk oral premalignant lesions.
- Trial name
- NCT05327270
- Testing
- Nivolumab
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Gastrointestinal Cancer, Colorectal Cancer
Assessment of a Serious Illness Conversation Guide (SICG) in Advanced Gastro-Intestinal Cancers
The purpose of the study is to determine whether standardized implementation of a scripted template for discussing important issues that arise near the end of life improves the care of those who have advanced cancer.
- Conditions
- Gastrointestinal Cancer, Colorectal Cancer, Pancreatic Adenocarcinoma, Gastric Cancer
- Trial name
- NCT04077372
- Testing
- Serious Illness Conversation Guide (SICG), Quality of Life (QOL) survey
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Cancer of Head and Neck
Forecasts Impact of the Pre-therapeutic TEP-TDM in the 18-FDG Restaging of Upper Aero-digestive Tract Cancers
Head and neck (HN) cancer is the sixth most common malignancy worldwide, with around 800 000 new cases and 320 000 deaths in 2015.
- Trial name
- RENOVATE (NCT03841175)
- Where
- France
- Volunteers
- 477 people
- Sponsor
- University Hospital, Brest
Head-and-neck Cancer
DAHANCA 35: Proton Versus Photon Therapy for Head-neck Cancer
Patients with squamous cell carcinoma of the pharynx or larynx and an anticipated benefit of proton radiotherapy in reducing the risk of late dysphagia or xerostomia are randomized to proton or photon radiotherapy (2:1)
- Trial name
- DAHANCA 35 (NCT04607694)
- Testing
- Proton radiotherapy, Photon radiotherapy
- Where
- 7 sites in Denmark
- Volunteers
- 600 people
- Sponsor
- Danish Head and Neck Cancer Group
Nasopharyngeal Carcinoma, Leucogen
A Multi-center, Randomized, Double-blind, Phase III Clinical Trial of Leucogen Versus Placebo on Leukocyte and Platelet Whole-course Management Assisted by PFLL Chemotherapy in the Treatment of Stage IV, Recurrent or Metastatic NPC
Toxic and side effects during and after chemoradiotherapy for nasopharyngeal carcinoma seriously affect patients' treatment compliance and long-term quality of life.
- Conditions
- Nasopharyngeal Carcinoma, Leucogen, Chemotherapy, Myelosuppression
- Trial name
- NCT05780294
- Testing
- 5-fu, Lobaplatin, leucogen
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Sun Yat-sen University
Advanced Solid Tumors
A Study of ASP1948, Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors
The purpose of this study is to evaluate the tolerability and safety profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab in participants with locally advanced (unresectable)…
- Trial name
- NCT03565445
- Testing
- ASP1948, nivolumab, pembrolizumab
- Where
- 42 sites in United States, Canada and 7 more
- Volunteers
- 190 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Head and Neck Cancer, Thoracic Cancer
Evaluation of On-Couch CBCT Image Quality
This is a prospective, single-arm, single-site study designed to generate data describing the image quality and applicability/useability of a high-performance, on-couch CBCT imaging technology (HyperSight) in patients receiving…
- Conditions
- Head and Neck Cancer, Thoracic Cancer, Abdominal Cancer, Pelvic Cancer
- Trial name
- NCT06576908
- Testing
- HyperSight Imaging
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Varian, a Siemens Healthineers Company
Head and Neck Tumors
Tislelizumab Combined APF Chemotherapy in the Treatment of Locally Advanced Head and Neck Tumors
The goal of this clinical trial is to test in describe participant population. The main questions it aims to answer are: 1. evaluate the efficacy and safety of tislelizumab combined with APF sequential surgery or radical…
- Trial name
- NCT05758389
- Testing
- Tislelizumab, Paclitaxel (albumin-bound type), Cisplatin, 5-FU
- Where
- China
- Volunteers
- 29 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.