Clinical trials: Cancer of the Head and Neck
Glottis Tumor, Larynx Cancer
VoiceS: Voice Quality After Transoral CO2-Laser Surgery Versus Single Vocal Cord Irradiation for Larynx Cancer
Laser surgery and radiotherapy are well-established standards of care for unilateral stage 0 \& I carcinoma in situ (Cais) and squamous cell carcinoma of glottic larynx (SCCGL).
- Trial name
- VoiceS (NCT04057209)
- Testing
- Single Vocal Cord Irradiation (SVCI), Arm A: Transoral CO2-Laser Microsurgical Cordectomy (TLM)
- Where
- 4 sites in France, India and 1 more
- Volunteers
- 34 people
- Sponsor
- Olgun Elicin
Papillary Thyroid Cancer, Follicular Thyroid Cancer
A Drug-Drug Interaction Study of the Effects of XL184 (Cabozantinib) on Rosiglitazone in Subjects With Solid Tumors
The primary objective of this clinical study is to determine whether the inhibition of cytochrome P450 (CYP) isozyme CYP2C8 by XL184 observed in in vitro preclinical studies translates into the potential for clinically…
- Conditions
- Papillary Thyroid Cancer, Follicular Thyroid Cancer, Huerthle Cell Thyroid Cancer, Renal Cell Carcinoma
- Trial name
- NCT01100619
- Testing
- rosiglitazone, XL184
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Exelixis
Triple-negative Breast Cancer, Head and Neck Squamous Cell Carcinoma
Study to Evaluate Safety and Efficacy of TJ107 Combine With PD-1 in Patients With Solid Tumors
Study Purpose and Design:A Multicenter, Open-label, Exploratory Phase II Clinical Study to Evaluate the Safety and Tolerability and Preliminary Efficacy of TJ107 in Combination with Pembrolizumab Injection in Patients with…
- Trial name
- NCT05145907
- Testing
- TJ107 +Pembrolizumab
- Where
- 20 sites in China
- Volunteers
- 133 people
- Sponsor
- TJ Biopharma Co., Ltd.
Esophageal Carcinoma
Feasibility Study of Chemoradiation, TRAstuzumab and Pertuzumab in Resectable HER2+ Esophageal Carcinoma
Despite neoadjuvant chemoradiation regimens esophageal cancer remains a disease with poor outcome. The clinical benefit of HER2 targeting with trastuzumab has been shown in the setting of advanced disease and disease and safety…
- Trial name
- TRAP (NCT02120911)
- Testing
- Pertuzumab, trastuzumab
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Oesophageal Cancer, Rectal Cancer
Placing Trust in Endoscopic Ultrasonography: Impact on Planning Conformal Radiotherapy of Cancer of the Esophagus and Rectum
The purpose of this study is to estimate the rate of patients in whom a significant change in the area to be irradiated will be observed between the assessment before and after laying the evaluation of Trustees.
- Trial name
- FIDUCOR (NCT02526134)
- Testing
- radio opaque markers (Echo Tip Ultra Fiducial Needle - ETUF)
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Institut Paoli-Calmettes
HEAD AND NECK CANCER, CARCINOMA OROPHARYNX
Evaluation of 3DCRT Versus IGRT and Analysis of Early Response in Head and Neck Cancer.
This study aims to study the impact image guided radiotherapy with Cone beam CT will have on the outcomes(toxicities and response) of head and neck cancer when compared to 3D conformal radiotherapy without CBCT based setup error…
- Conditions
- HEAD AND NECK CANCER, CARCINOMA OROPHARYNX, CARCINOMA PYRIFORM SINUS, CARCINOMA LARYNX
- Trial name
- NCT01124409
- Testing
- EPID Verification, CBCT verification
- Where
- India
- Volunteers
- 41 people
- Sponsor
- All India Institute of Medical Sciences
Esophageal Squamous Cell Carcinoma, Chemoradiotherapy
To Compare the Effect of Different Nutritional Pathways on Improving Nutritional Status of Esophageal Cancer Patients Undergoing Chemoradiotherapy
This study prospectively recruited esophageal squamous-cell carcinoma patients who received nasogastric tube (NG), gastrostomy feeding and oral intake to compare the changes in nutritional status and quality of life during…
- Conditions
- Esophageal Squamous Cell Carcinoma, Chemoradiotherapy, Enteral Nutrition
- Trial name
- NCT04199832
- Testing
- Dietary guidance
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Malignant Neoplasm in the Head and Neck, Metastatic Malignant Neoplasm in the Head and Neck
Preoperative Embolization of Hypervascular Head and Neck Tumors to Improve Surgical Outcomes
This phase I trial tests whether embolization done prior to surgery (preoperative) will improve surgical outcomes in head and neck tumors with large amounts of blood vessels (hypervascular).
- Trial name
- NCT05490381
- Testing
- Iodixanol, Angiogram, Arterial Embolization
- Where
- United States
- Sponsor
- University of Washington
Cancer of the Head and Neck
PET With [18F]HX4 in Head and Neck Cancer
The aim of this study is to (i) Determine if tumor hypoxia can be accurately visualised with [18F] HX4 PET imaging in head and neck tumors (ii) correlate the [18F] HX4 PET images with blood and tissue markers and (iii)…
- Trial name
- NCT01347281
- Testing
- Injection of [18F]HX4
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- Maastricht Radiation Oncology
Cancer of Head and Neck, Narcotic Use
Perioperative Analgesia Using Gabapentin in Head and Neck Cancer Surgery
Patients undergoing head and neck cancer surgery often have a lot of pain after surgery, which can lead to a need for a lot of narcotic pain medication.
- Trial name
- NCT03682367
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of California, Davis
Thyroid Nodular Disease
Microvascular Profiling of Nodules in the Thyroid Gland
The purpose of this study is to examine tiny blood vessels in different thyroid nodules using advanced ultrasound. In the long term, we hope this can help doctors better tell the difference between types of nodules and more…
- Trial name
- NCT07041307
- Where
- 2 sites in Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Head and Neck Cancer, Prostate Cancer
Application of High Resolution Diffusion-weighted MR Imaging Pulse Sequence in Head and Neck, and Prostate Cancers
Magnetic resonance imaging (MRI) is a diagnostic study that makes pictures of organs of the body using magnetic field and radio frequency pulses that can not be felt.
- Trial name
- NCT01535898
- Testing
- MRI scanner with sequence
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Nasopharyngeal Neoplasms
Combination of Docetaxel, Cisplatin, and Capecitabine (DCX) in the Treatment of Nasopharyngeal Carcinoma
The standard treatment strategy for locally advanced (stage IVA) and metastatic (stage IVB) nasopharyngeal carcinoma has not been defined yet.
- Trial name
- NCT02360501
- Testing
- Docetaxel, Cisplatin, Capecitabine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sun Yat-sen University
Head and Neck Cancer, Free Tissue Transfer
Local Infusion of Ropivacaine for Post-Op Pain Control After Osseocutaneous Free Flaps
Head and neck oncologic surgery often requires the use of free tissue transfer, or microvascular reconstruction, to reconstruct defects created by tumor resections.
- Trial name
- NCT03349034
- Testing
- Ropivicaine, Local Saline Infusion
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Thyroid Neoplasms
Study of Anlotinib Hydrochloride Capsules in the Treatment of Locally Advanced or Metastatic Radioiodine-Refractory Differentiated Thyroid Carcinoma
The study aims to observe and investigate the efficacy and safety of Anlotinib capsules in patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid carcinoma in the real world, and to summarize…
- Trial name
- NCT05994365
- Testing
- Anlotinib Hydrochloride Capsule
- Where
- 3 sites in China
- Volunteers
- 380 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Squamous Cell Carcinoma of Head and Neck
sEphB4-HSA With RT+Chemo or Cetux in Patients With Intermediate to High Risk LAHNSCC
This is a Phase I dose-escalation study of sEphB4-HSA in combination with chemotherapy, cetuximab and radiotherapy (RT). The purpose is to estimate the maximum tolerated dose (MTD) that can be administered concurrently with…
- Trial name
- NCT04091867
- Testing
- sEphB4-HSA with chemotherapy, Cetuximab, Radiation Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Colorado, Denver
Malnutrition, Esophageal Cancer
INEC Study: Immuno-modulating Enteral Nutrition in Cancer
The aim of this study is to investigate if enteral immunonutrition of head and neck or esophageal cancer patients, using an arginine, omega 3 fatty acid, nucleotides-enhanced diet [Impact (R), Novartis] versus a standard enteral…
- Conditions
- Malnutrition, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT00333099
- Testing
- Impact (R) Enteral Nutrition, impact
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Clermont-Ferrand
Colorectal Cancer, Pancreatic Cancer
Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
The overall goal of this feasibility study is to assess the initial safety and efficacy of LUM015 in ex vivo far-red imaging of colorectal, pancreatic, and esophageal cancers (adenocarcinoma) using the LUM Imaging System.
- Conditions
- Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT02584244
- Testing
- LUM015, LUM 2.6 Imaging Device
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Lumicell, Inc.
Papillary Thyroid Carcinoma
Diagnostic Accuracy of Fluorodeoxyglucose-18 PET in the Evaluation of RPTC With Patient's Raised Thyroglobulin Level
This research will employ cross-sectional analytical to determine diagnostic accuracy of Flourodeoxyglucose-18 Positron Emission Computed Tomography in the evaluation of Recurrent Papillary Thyroid Carcinoma with patient's raised…
- Trial name
- NCT07062211
- Where
- Pakistan
- Volunteers
- 39 people
- Sponsor
- Superior University
Esophageal Cancer, Lymph Node Metastases
99m Tc-3PRGD2 SPECT/CT Imaging in the Diagnosis of Lymph Node Metastasis of Esophageal Carcinoma
The esophageal squamous cell carcinoma (ESCC) has high prevalence and mortality in China, which become a severe challenge for public health.
- Conditions
- Esophageal Cancer, Lymph Node Metastases, Diagnoses Disease
- Trial name
- NCT04504565
- Testing
- 99mTc-3PRGD2
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fifth Affiliated Hospital, Sun Yat-Sen University
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