Clinical trials: Cancer of the Thyroid
Thyroid Cancer, Treatment Related Cancer
A Multicenter Trial of PLA vs. Surgery for Treating PTMC
This is a multicenter prospective controlled trial of percutaneous laser ablation(PLA) versus conventional surgery for the treatment of papillary thyroid microcarcinoma (PTMC).
- Trial name
- NCT03377829
- Testing
- PLA, Thyroid Surgery
- Where
- 13 sites in China, Italy
- Volunteers
- 200 people
- Sponsor
- WeiWei Zhan
Thyroid Neoplasm, Lymphatic Metastasis
Prophylactic Selective Lateral Neck Dissection in Patients With Papillary Thyroid Carcinoma
The purpose of this study is to prospectively analyze the incidence of occult lateral neck metastasis (LNM) and to elucidate the factors that predict LNM in papillary thyroid carcinoma (PTC) with central neck metastasis (CNM) by…
- Trial name
- NCT01103557
- Testing
- prophylactic selective lateral neck dissection
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Thyroid Carcinoma
Feasibility of Endoscopic Thyroidectomy for Thyroid Carcinoma
Endoscopic thyroidectomy has been used to treat thyroid diseases in China. However, whether this technique is rational to treat thyroid carcinoma is still in controversy.
- Trial name
- NCT00993837
- Testing
- thyroidectomy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Military Medical University
Advanced Solid Tumor, BRAF V600 Mutation
Safety and Tolerability of ABM-1310 in Patients With Advanced Solid Tumors
This is a Phase I, First-In-Human, open label, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-cancer activity of ABM-1310 in adult patients with locally…
- Trial name
- NCT04190628
- Testing
- ABM-1310, Cobimetinib
- Where
- 8 sites in United States
- Volunteers
- 53 people
- Sponsor
- ABM Therapeutics Corporation
Neuroendocrine Tumors
Capecitabine and Temozolomide for Neuroendocrine Cancers
This phase II study is designed to assess whether treatment with capecitabine/temozolomide (CAP/TEM) is safe and effective in treating subjects with progressive, differentiated, metastatic neuroendocrine tumors (NET).
- Trial name
- NCT00869050
- Testing
- Capecitabine, Temozolomide
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Columbia University
Thyroid Nodule, Thyroid Cancer
Clinical Validation of a Molecular Signature to Detect Cancer in Thyroid Nodules With Indeterminate Cytology
1. Principal objective: The primary objective of this study is to validate the diagnostic performance of a Dx15 molecular test based on molecular transcriptomic signatures previously identified in distincts cohorts of samples to…
- Trial name
- CITHY (NCT02225509)
- Testing
- FNA biopsy for thyroid nodule(s)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Diaxonhit
Thyroid Cancer
Salivary dysfuncTion After Radioiodine Treatment
Aim/Introduction: The treatment of differentiated thyroid cancer includes generally a total thyroidectomy, followed by a radioiodine (131I)-therapy.
- Trial name
- START (NCT04876287)
- Testing
- Radioiodine
- Where
- France
- Volunteers
- 138 people
- Sponsor
- French Nuclear Safety and Radiation Protection Authority (ASNR)
Hypocalcemia
Prevention of Hypocalcemia in Patients Undergoing Total Thyroidectomy Plus Central Neck Dissection
the increased risk of hypocalcemia following total thyroidectomy plus central neck dissection can be minimized by routine administration of oral calcium and vitamin D supplements during the early postoperative period.
- Trial name
- NCT00630214
- Testing
- Oral calcium plus vitamin D, Oral calcium alone
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center
Diabetes Mellitus, Hypothyroidism
Evaluation of the Effects of Teleconsultations on a Endocrinology Referral List
The aim of this study is evaluate the effects of telephone teleconsultations to primary care physicians (compared to the state's referral protocol) in the referrals waiting list for endocrinological appointments.
- Conditions
- Diabetes Mellitus, Hypothyroidism, Hyperthyroidism, Goiter
- Trial name
- NCT02710799
- Testing
- Teleconsultation, Protocol
- Where
- Brazil
- Volunteers
- 3,470 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Thyroid Nodule
Comparison Between Combined Scoring of Bethesda Cytology and TIRADS Ultrasound With Histopathology in Thyroid Nodule
A thyroid nodule is a discrete lesion within the thyroid gland that is radiologically distinct from the surrounding thyroid parenchyma. Most thyroid nodules are benign, with only 10% to 15% harboring cancer.
- Trial name
- TIRADS (NCT06391021)
- Where
- Nepal
- Volunteers
- 42 people
- Sponsor
- Tribhuvan University, Nepal
Thyroid Cancer, Intermediate Risk
Systematic Radioiodine Administration Versus Decision of Radioiodine Treatment Guided by a Post-operative Work-up
This trial is comparing two strategies in intermediate-risk differentiated thyroid cancer patients: Systematic radioiodine administration versus decision of radioiodine treatment guided by a post-operative work-up based on serum…
- Trial name
- INTERMEDIATE (NCT04290663)
- Testing
- Systematic RAI-treatment, Decision of RAI-treatment guided by a post-operative assessment
- Where
- 29 sites in France
- Volunteers
- 368 people
- Sponsor
- Centre Francois Baclesse
Anaplastic Thyroid Cancer
Evaluating Trends in Anaplastic Thyroid Cancer Patients' Clinical Study Experiences
Clinical trials can sometimes favor certain demographic groups. Additionally, there is limited research that delves into the factors that influence participation in clinical study, both positive and negative.
- Trial name
- NCT05819593
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Thyroid Neoplasms
Study of Clinical Outcomes of Thyroid Cancer
The Italian Thyroid Cancer Observatory (ITCO) repository was established to collect data on thyroid cancer management in a prospective and consecutive series of newly-diagnosed patients, enrolled in centers uniformly distributed…
- Trial name
- ITCO (NCT04031339)
- Testing
- Standard treatment
- Where
- 35 sites in Italy
- Volunteers
- 15,000 people
- Sponsor
- University of Roma La Sapienza
Thyroid Cancer
A Study Using Regorafenib as Second or Third Line Therapy in Metastatic Medullary Thyroid Cancer
This research study is studying a targeted therapy as a possible treatment for thyroid cancer. A targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific types of cancer cells…
- Trial name
- NCT02657551
- Testing
- Regorafenib
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Dana-Farber Cancer Institute
Advanced Solid Tumor, Lung Cancer
Carbon Nanoparticle-Loaded Iron [CNSI-Fe(II)] in the Treatment of Advanced Solid Tumor
This Phase I clinical trial aims to evaluate the safety, tolerability, pharmacokinetics (PK) profile and preliminary efficacy of intratumoral injection of Carbon Nanoparticle-Loaded Iron [CNSI-Fe(II)] in patients with advanced…
- Conditions
- Advanced Solid Tumor, Lung Cancer, Pancreas Cancer, Breast Cancer
- Trial name
- CNSI-Fe(II) (NCT06048367)
- Testing
- CNSI-Fe(II) 30 mg, CNSI-Fe(II) 60 mg, CNSI-Fe(II) 90 mg
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Sichuan Enray Pharmaceutical Sciences Company
Thyroid Cancer
An Open-label, Multicenter, Phase II Study of Dovitinib in Advanced Thyroid Cancer
There has been no effective treatment for advanced thyroid cancer that is not amenable to surgery and that does not concentrate iodine.
- Trial name
- NCT01964144
- Testing
- Dovitinib
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Neuroendocrine Tumors, Hyperthyroidism
Optimising Molecular Radionuclide Therapy
This project will examine the role of the whole body, PET and SPECT imaging before, during and after radionuclide treatment for 177Lu-Dotatate therapy, whole body and SPECT imaging for 131-I for thyroid cancer therapy, and…
- Conditions
- Neuroendocrine Tumors, Hyperthyroidism, Thyroid Cancer, Thyroid Carcinoma
- Trial name
- SELFIE (NCT04922801)
- Testing
- Nuclear Medicine whole-body, SPECT/CT imaging., PET/CT imaging.
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College London
Sperm Preservation, Irradiated Semen
Impact of Ionizing Treatment on the Nuclear Structure of Human Spermatozoa.
Differentiated thyroid cancer is the third cause of cancer in young men of childbearing age. Its treatment by irradiation with Radioactive Iodine 131 therapy (RAT) could alter spermatogenesis and result in azoospermia and…
- Trial name
- NCT04715828
- Testing
- Cryopreserved semen, Acute and low irradiation, Long and low irradiation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Clermont-Ferrand
Thyroid Surgery
The Effect of the Application of Head Mounted Magnifying Glasses on Postoperative PTH Changes in Thyroid Surgery: Stage II
This study is a prospective research. This study aims to investigate and follow up patients who undergo open thyroidectomy in the Department of Breast and Thyroid Surgery at Shandong Provincial Hospital from January 2020 to…
- Trial name
- NCT06838728
- Testing
- Head Mounted Magnifying Glasses
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shandong Provincial Hospital
Papillary Thyroid Cancer
Definition of Mutational Profile of Papillary Thyroid Tumors by Mass-ARRAY
Somatic mutations in the MAP (mitogen-activated protein) kinase pathway have been found in about 80% of papillary thyroid tumors (PTCs).
- Trial name
- PTC-ARRAY (NCT05766098)
- Testing
- Genotyping
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Istituto Auxologico Italiano
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