Clinical trials: Cancer of the Thyroid
Recurrent Malignant Solid Neoplasm, Recurrent Melanoma
Cabozantinib S-Malate in Treating Younger Patients With Recurrent or Refractory Solid Tumors
This phase I trial studies the side effects and best dose of cabozantinib S-malate in treating younger patients with solid tumors that have come back or no longer respond to treatment.
- Conditions
- Recurrent Malignant Solid Neoplasm, Recurrent Melanoma, Recurrent Primary Central Nervous System Neoplasm, Recurrent Thyroid Gland Carcinoma
- Trial name
- NCT01709435
- Testing
- Cabozantinib S-malate, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 23 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- National Cancer Institute (NCI)
Non-Small Cell Lung Cancer, Medullary Thyroid Cancer
Phase I/II Study of SY-5007, a RET Inhibitor, in Patients With RET-altered Advanced Solid Tumor
This is a phase I/II, open-label, multi-center, first-in-human study designed to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity of SY-5007 administered orally to participants with…
- Conditions
- Non-Small Cell Lung Cancer, Medullary Thyroid Cancer, Solid Tumor
- Trial name
- NCT05278364
- Testing
- SY-5007
- Where
- 2 sites in China
- Volunteers
- 184 people
- Sponsor
- Shouyao Holdings (Beijing) Co. LTD
Peritoneal Mesothelioma, Gestational Trophoblastic Tumor
IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers
Immune checkpoint inhibitors (ICI) have revolutionized the management of advanced cancers. However, most rare cancers have been excluded from this progress due to the lack of clinical trials involving these diseases.
- Conditions
- Peritoneal Mesothelioma, Gestational Trophoblastic Tumor, Anaplastic Thyroid Carcinomas, Gastroenteropancreatic Neuroendocrine Tumor
- Trial name
- IMMUNORARE5 (NCT06790706)
- Testing
- DOMVANALIMAB + ZIMBERELIMAB, DOMVANALIMAB + ZIMBERELIMAB + FOLFOX-4
- Where
- 15 sites in France
- Volunteers
- 27 people
- Sponsor
- Hospices Civils de Lyon
Differentiated Thyroid Cancer
Nomogram for Predicting Difficult Transoral and Submental Thyroidectomy
No prior studies have stratified the difficulty of transoral and submental thyroidectomy (TOaST). The investigators aimed to investigate preoperative factors as indicators of difficult TOaSTs and to develop a predictive model…
- Trial name
- NCT06671184
- Testing
- Observations on clinicopathological factors influencing the difficulty of surgery
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai 6th People's Hospital
Benign Tumor of Thyroid, Hyperparathyroidism
Bilateral Superficial Cervical Plexus Block in Thyroid/Parathyroid Surgery
To compare efficacy and safety between bilateral superficial cervical plexus block combined with intravenous sedation (RA group) and general anesthesia (GA group) for thyroid and parathyroid operations.
- Trial name
- NCT04051099
- Testing
- Bilateral superficial cervical plexus block with 0.25% bupivacaine 8 ml each (total 16 ml), Dexmedetomidine plus propofol infusion, Local infiltraion analgesia
- Where
- Thailand
- Volunteers
- 52 people
- Sponsor
- Mahidol University
Lymph Node Metastases
Central Cervical Dissection for Clinical Node Negative Papillary Thyroid Carcinoma
This study is divided into three stages. In the first stage, the investigators try to explore the objective clinical imaging standard of cN0PTC on the basis of previous studies, formulate the "clinical imaging standard of…
- Trial name
- NCT03813173
- Testing
- lymph node dissection
- Volunteers
- 6,000 people
- Sponsor
- Zhejiang University
Differentiated Thyroid Carcinoma
OnT4-Thyroglobulin Assay Before rhTSH-Aided Radioiodine Ablation
Thyroidectomy followed by administration of large activities of 131-iodine (131I) is the treatment of choice for differentiated thyroid carcinoma (DTC).
- Trial name
- NCT00439127
- Volunteers
- 28 people
- Sponsor
- Oncology Institute of Southern Switzerland
Virtual Reality Therapy, Ultrasound
The Effect of Virtual Reality Applications
Thyroid nodules are a common health problem in the adult population. Ultrasound-guided fine-needle aspiration biopsy (FNAB) is the standard diagnostic procedure for evaluating suspected thyroid nodules.
- Conditions
- Virtual Reality Therapy, Ultrasound, Fine Needle Aspiration Biopsy, Thyroid Nodule (Diagnosis)
- Trial name
- NCT06792929
- Testing
- Virtual reality headset
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Dicle University
Thyroid Cancer, Neck Pain
The Effect of Transcutaneous Electrical Nerve Stimulation on Posterior Neck Pain After Thyroidectomy
The purpose of tihs study is to determine whether transcutaneous electric nerve stimulation (TENS) during thyroidectomy is effective in the reduction of posterior neck pain after thyroidectomy.
- Trial name
- NCT02012686
- Testing
- TENS
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Cancer, Tumor, Solid
Study of JK08 in Patients with Unresectable Locally Advanced or Metastatic Cancer
This is a Phase 1/2, open-label, multi-center, first-in-human, dose escalation and cohort expansion study evaluating multiple doses and schedules of subcutaneously administered JK08 in patients with unresectable locally, advanced…
- Conditions
- Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer
- Trial name
- NCT05620134
- Testing
- JK08, Pembrolizumab, Lenvatinib Pill
- Where
- 11 sites in Belgium, Spain
- Volunteers
- 263 people
- Sponsor
- Salubris Biotherapeutics Inc
Thyroid Cancer, Papillary Thyroid Carcinoma
Shared Decision-Making for Determining Treatment Strategies in Low-Risk Thyroid Cancer
This study is a multicenter cluster-randomized controlled trial conducted in Korea. A parallel, two-group cluster-randomized design will be used to test whether the Shared decision-making Group (SDM; intervention) is different…
- Trial name
- MAeSTro-SDM (NCT06730893)
- Testing
- SDM protocol
- Volunteers
- 310 people
- Sponsor
- National Cancer Center, Korea
Differentiated Thyroid Cancer, Anaplastic Thyroid Cancer
Sacituzumab govitEcan in THYroid Cancers
SETHY is a prospective, multicohort, phase II, single-arm, non-randomized, non-blinded, investigator-initiated study of sacituzumab govitecan in patients with advanced or metastatic radioactive-iodine refractory differentiated…
- Trial name
- SETHY (NCT06235216)
- Testing
- Sacituzumab govitecan
- Where
- 11 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Grupo Espanol de Tumores Neuroendocrinos
Thyroid Gland Medullary Carcinoma
Patient Decision Aid in Supporting Decision-Making About When to Start or Stop New Drugs, Join Clinical Trials, or Continue Active Surveillance in Patients With Medullary Thyroid Cancer and Their Caregivers
This trial develops and studies how well a patient decision aid works in supporting decision-making about when to start or stop new drugs, join clinical trials, or continue active cancer monitoring for patients with medullary…
- Trial name
- NCT03892993
- Testing
- Decision Aid, Questionnaire Administration
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Nodule (Diagnosis), Thyroid Cancer
Thyroid Nodule Gene Sequencing in a Danish Population
This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population.
- Trial name
- NCT05377736
- Testing
- Molecular analyses
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Aarhus University Hospital
Cancer, Thyroid
Thyroid Ultrasound Elasticity (TrUE) Imaging
In this study the researchers will scan the thyroid nodules of patients scheduled for surgical removal of these nodules. During their preadmission testing, but prior to their surgery, the researchers will perform standard…
- Trial name
- NCT03307694
- Testing
- Ultrasound, Shear wave elasticity imaging, Multi-angle compound shear wave elasticity imaging
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Emory University
Differentiated Thyroid Cancer
Comparing Complete Remission After Treatment With Selumetinib/Placebo in Patient With Differentiated Thyroid Cancer
The study is designed to evaluate the clinical efficacy, safety and tolerability of selumetinib with radioactive iodine therapy in patients with differentiated thyroid cancer.
- Trial name
- ASTRA (NCT01843062)
- Testing
- Selumetinib, Radioactive Iodine Therapy
- Where
- 45 sites in United States, Brazil and 6 more
- Volunteers
- 233 people
- Sponsor
- AstraZeneca
Malignancy of Thyroid Nodules
Value of the Combination Ultrasonography With Ti-RADS Score / Dual Tracer Scintigraphy MIBI-Tc99m/Iodine-123 in the Detection of Malignancy of Thyroid Nodules (≥15 mm) Classified Bethesda III or IV on Cytology
The main objective of the study is to show that the addition of ultrasonography to the dual tracer scintigraphy MIBI-Tc99m/Iodine-123 will increase (at least +5%) the negative predictive value compared to the dual tracer…
- Trial name
- MIBI-THYR (NCT03498183)
- Testing
- MIBI-Tc99m/Iodine-123
- Where
- 7 sites in France
- Volunteers
- 372 people
- Sponsor
- Nantes University Hospital
Thyroid Cancer
Influencing Factors and Prediction Model of False-negative Central Lymph Nodes in Thyroid Cancer Patients
The problem of false-negative lymph nodes in the central region (CLN) refers to the inability to detect lymph nodes (LN) metastasis during preoperative ultrasound examination but is confirmed by surgical and postoperative…
- Trial name
- NCT06423105
- Volunteers
- 6,369 people
- Sponsor
- Ningning Ren
Head and Neck Cancers
Collection Of Tissue, Blood, and Other Specimens From Patients With Head and Neck Tumors To Study the Causes, Diagnosis, Prevention and Treatment of Cancers
This is a protocol to collect tissues, blood, and other specimens from patients with malignant or nonmalignant diseases of the head and neck.
- Trial name
- NCT00580203
- Where
- United States
- Volunteers
- 1,468 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Thyroid Cancer, Colon Cancer
QUILT-3.040: ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D)) Vaccine in Combination With ALT-803 (Super-agonist IL-15) in Subjects Having CEA-Expressing Cancer
This is a phase 1b/2 study to evaluate the safety, tolerability, and efficacy of ETBX-011 vaccine used in combination with ALT-803 in subjects with locally advanced or metastatic CEA-expressing cancers whose tumor has recurred…
- Conditions
- Thyroid Cancer, Colon Cancer, Ovarian Cancer, Breast Cancer
- Trial name
- NCT03127098
- Testing
- ETBX-011, ALT-803
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- NantCell, Inc.
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