Clinical trials: Cancer of the Thyroid
Cancer Harboring BRAF Alterations, HGG
A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations
The objective of this Master Protocol is to evaluate the efficacy and safety of plixorafenib in participants with BRAF altered (BRAF V600E or BRAF fusions) locally advanced or metastatic solid tumors, or recurrent or progressive…
- Conditions
- Cancer Harboring BRAF Alterations, HGG, LGG, Solid Tumors
- Trial name
- NCT05503797
- Testing
- Plixorafenib
- Where
- 70 sites in United States, Australia and 10 more
- Volunteers
- 254 people
- Sponsor
- Fore Biotherapeutics
Carcinoma of Head/Neck
Observational Study on Thyroid Tumors and EvaLuation of the roLe of New pOntential Predictive/Prognostic Factors
The OTELLO Study is a monocentric, ambispective observational study that systematically analyzes the clinical, laboratory, anatomopathological, and molecular characteristics of patients with thyroid neoplasms treated at the…
- Trial name
- OTELLO (NCT07064369)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Drainage, Thyroid Cancer
No Drainage During Transoral Endoscopic Thyroidectomy Vestibular Approach(TOETVA)
This study evaluates the viability and safety of no drainage tube placement during transoral endoscopic thyroidectomy vestibular approach in treatment of patients with papillary thyroid carcinoma.
- Trial name
- NCT04931576
- Testing
- no drainage tube applied
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Thyroid Nodule
Elastography and FNAC in Thyroid Nodule
Evaluate the accuracy of USE in comparison with FNAC in characterization of solitary thyroid nodule and assessment the risk of malignancy
- Trial name
- NCT05734326
- Testing
- Ultrasound elastography
- Volunteers
- 50 people
- Sponsor
- Assiut University
Suspicious for Papillary Thyroid Carcinoma
Role of Cytomorphometry and BRAFV600E Immunocytochemistry With a Cytologic Diagnosis "Suspicious for Papillary Thyroid Carcinoma"
Thyroid nodules (TNs) are a common finding, detected by ultrasound in about 70% of healthy individuals, with women being four times more affected.
- Trial name
- NCT06901908
- Volunteers
- 45 people
- Sponsor
- Assiut University
Thyroid, Thyroid Cancer
Parathyroid Vascularization During Total Thyroidectomy Using Indocyanine Green Angiography
Prospective, observational, single-center study about the use of indocyanine green angiography during total thyroidectomy. The main objective of the study is to identify a quantitative score of parathyroid vascularization as an…
- Conditions
- Thyroid, Thyroid Cancer, Hypoparathyroidism, Vascularization
- Trial name
- ANGIO_PARA (NCT05328076)
- Testing
- Indocyanine green, SPY Portable Handheld Imaging (SPY-PHI)
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- IRCCS San Raffaele
Thyroid Cancer
Comparison of Quality of Life in Patients with Differentiated Thyroid Carcinoma Undergoing Different Surgery
The incidence of thyroid cancer has increased rapidly in recent years, especially in women. Early differentiated thyroid cancer has a good prognosis, and surgery is the main treatment.
- Trial name
- NCT06037174
- Testing
- minimally invasive procedure, Conventional Open Surgery
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Malignant Neoplasm of Thyroid Stage I, Malignant Neoplasm of Thyroid Stage II
Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer
Differentiated thyroid cancer is the most common neoplasm of endocrine system. After surgery and radioiodine treatment, thyroid stimulating hormone (TSH) suppression is the main goal which is achieved with levothyroxine…
- Trial name
- NCT01341886
- Testing
- Metformin
- Where
- Iran
- Volunteers
- 51 people
- Sponsor
- Mashhad University of Medical Sciences
Differentiated Thyroid Cancer (DTC)
The EMIRATES Study
This pilot study will take place in thyroid outpatient clinics. It will have two study arms running in consecutive order: first, a Control arm where standard care will take place without PDA-TC, then a Patient Decision Aid (PDA)…
- Trial name
- NCT06855680
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Hurthle Cell Thyroid Cancer, Tall Cell Variant Thyroid Cancer
Studies on Tumors of the Thyroid
Participants in this study will be patients diagnosed with or suspected to have a thyroid nodule or thyroid cancer. The main purpose of this study is to further understand the methods for the diagnosis and treatment of thyroid…
- Conditions
- Hurthle Cell Thyroid Cancer, Tall Cell Variant Thyroid Cancer, Follicular Thyroid Cancer, Thyroid Cancer
- Trial name
- NCT00001160
- Testing
- 68-Gallium Dotatate
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Malignant Neoplasm of Thyroid, Heart Diseases
Thyrotropin Over-suppression and Heart
The investigators evaluated the cardiac effects of Thyroid-stimulating hormone (TSH) over-suppression in women with differentiated thyroid cancer (DTC) frequently encountered during suppression therapy.
- Conditions
- Malignant Neoplasm of Thyroid, Heart Diseases, Thyrotoxicosis on Thyroxine Therapy
- Trial name
- NCT02645786
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Recombinant Human Thyroid Stimulating Hormone
Safety and Efficacy of Recombinant Human Thyroid Stimulating Hormone for Adjuvant Diagnosis in Patients With Locally Advanced/Metastatic Differentiated Thyroid Cancer
Exogenous injection of recombinant human thyroid stimulating hormone (rhTSH) can elevate TSH in the short term (2 days) to meet the requirements of diagnostic 131I SPECT/CT whole-body scans.
- Trial name
- NCT06431620
- Testing
- Recombinant Human Thyroid Stimulating Hormone
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Anaplastic Thyroid Cancer
Phase II Study Assessing the Efficacy and Safety of Lenvatinib for Anaplastic Thyroid Cancer
The purpose of this phase Ⅱ study is to assess the efficacy and safety of lenvatinib for anaplastic thyroid cancer patients who are diagnosed as unresectable. The total duration of the study will be 30 months.
- Trial name
- HOPE (NCT02726503)
- Testing
- Lenvatinib
- Where
- 23 sites in Japan
- Volunteers
- 39 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Hyperthyreosis and Goiter, Thyroid Cancer
The Incidence of Thyroid Cancer in 4474 Patients Treated for Hyperthyroidism or Goiter
Patients with hyperthyroidism and/or goiter are evaluated with blood samples and scintiscan before they are treated with radioiodine for their thyroid disease.
- Trial name
- NCT01384786
- Where
- Denmark
- Volunteers
- 4,474 people
- Sponsor
- Copenhagen University Hospital at Herlev
Melanoma, Non-small Sell Lung Cancer (NSCLC)
Phase I/II Study of PDR001 in Patients With Advanced Malignancies
The purpose of this "first-in-human" study of PDR001 was to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of PDR001 administered i.v.
- Conditions
- Melanoma, Non-small Sell Lung Cancer (NSCLC), Triple Negative Breast Cancer, Anaplastic Thyroid Cancer
- Trial name
- NCT02404441
- Testing
- PDR001
- Where
- 41 sites in United States, Canada and 12 more
- Volunteers
- 319 people
- Sponsor
- Novartis Pharmaceuticals
Thyroid Cancer
Focus on Values to Stimulate Shared Decisions
Most patients with non-medullary thyroid carcinoma (TC) achieve remission after primary treatment. Nonetheless, 30% develop recurrent disease and/or distant metastases resulting in worse survival.
- Trial name
- NCT03905369
- Testing
- Decision aid and SDM booster, Deliberation training
- Where
- 11 sites in Netherlands
- Volunteers
- 128 people
- Sponsor
- Radboud University Medical Center
Head and Neck Cancer
Combretastatin A4 Phosphate in Treating Patients With Advanced Anaplastic Thyroid Cancer
RATIONALE: Combretastatin A4 phosphate may stop the growth of anaplastic thyroid cancer by stopping blood flow to the tumor. PURPOSE: This phase II trial is studying how well combretastatin A4 phosphate works in treating patients…
- Trial name
- NCT00060242
- Testing
- fosbretabulin disodium
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- Case Comprehensive Cancer Center
Thyroid Goiter, Thyroid Carcinoma
Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: a Simple Way to Avoid Ipoparathyroidism and Evaluate Graft Function
The purpose of this study is to evaluate safety and effectiveness of normal parathyroid tissue reimplantation in forearm subcutaneous tissue in case of accidental removal of parathyroid gland during thyroid surgery.
- Conditions
- Thyroid Goiter, Thyroid Carcinoma, Multinodular Goiter, Graves Diseases
- Trial name
- NCT02194920
- Testing
- Thyroidectomy and parathyroid reimplantation in forearm subcutaneous tissue
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Thyroid Carcinoma, Thyroid Papillary Carcinoma
Malignancy Predictors, Bethesda and TI-RADS Scores Correlated With Final Histopathology in Thyroid Diseases
In the last decades, thyroid cancer incidence has continuously increased all over the world, almost exclusively due to a sharp rise in the incidence of the papillary histologic subtype, which has the highest incidence of…
- Conditions
- Thyroid Carcinoma, Thyroid Papillary Carcinoma, Multinodular Goiter, Adolescent, Solitary Thyroid Nodule
- Trial name
- NCT04411290
- Testing
- Total thyroidectomy (TT)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Umraniye Education and Research Hospital
Differentiated Thyroid Cancer (DTC), Poorly Differentiated Thyroid Cancer
A Phase II Trial of Cabozantinib for the Treatment of Radioiodine (RAI)-Refractory Differentiated Thyroid Carcinoma (DTC) in the First-line Setting
Phase II, non-randomized, open-label study to determine the efficacy of cabozantinib as a firstline treatment for patients with differentiated thyroid cancer (DTC). Subjects will receive drug at a starting dose of 60mg PO QD.
- Trial name
- NCT02041260
- Testing
- Cabozantinib
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Thomas Jefferson University
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