Clinical trials: Cancer-Related Condition
Gastroesophageal Varices Hemorrhage, Gastrointestinal Cancer
Management of Oxaliplatin-related Gastroesophageal Variceal Bleeding
In this randomized controlled study, we aim to compare the efficacy and safety of these two interventions in patients with oxaliplatin-induced gastroesophageal variceal bleeding.
- Conditions
- Gastroesophageal Varices Hemorrhage, Gastrointestinal Cancer, Received Oxaliplatin-based Chemotherapy
- Trial name
- NCT05141617
- Testing
- Endoscopic treatment, TIPS
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Breast Cancer
Examining the Relationships Between Sleep, Fatigue, and Pain in Aromatase Inhibitor-treated Patients
Aromatase inhibitors are commonly prescribed for treatment of postmenopausal women with breast cancer. These medications can cause side effects in some women, and occasionally they can be quite bothersome.
- Trial name
- NCT01983995
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- University of Michigan
Cellular Diagnosis, Chronic Lymphocytic Leukemia
Association of CD49d and CD44 in CLL Patients and Their Role in Prognosis
The interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote CLL cell survival and proliferation
- Trial name
- NCT03380299
- Volunteers
- 2 people
- Sponsor
- Assiut University
Lymphedema
Acupuncture for Lymphedema Secondary to Breast Cancer Treatment
This study is being conducted to determine if electro-acupuncture can reduce swelling of the arm due to breast cancer treatment (commonly referred to as 'lymphedema').
- Trial name
- NCT02158832
- Testing
- Acupuncture + Electrical Stimulation
- Where
- Canada
- Sponsor
- McMaster University
Lung Cancer, Tobacco Use Disorder
Phenethyl Isothiocyanate in Preventing Lung Cancer in Smokers
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of phenethyl isothiocyanate may prevent lung cancer in people who smoke cigarettes.
- Trial name
- NCT00691132
- Testing
- phenethyl isothiocyanate
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- University of Minnesota
Hepatocellular Carcinoma
A Phase III Study in Post-operative HBV-related Hepatocellular Carcinoma
Research Objective and Study End Points To evaluate the anti-HBV as well as HCC recurrence reducing effects of standard (18 months) lamivudine treatment at time of HBV reactivation with hepatitis flare up (HBV DNA > 105 copies/mL…
- Trial name
- NCT00455091
- Testing
- Adefovir Dipivoxil and Lamivudine
- Where
- 8 sites in Taiwan
- Volunteers
- 117 people
- Sponsor
- National Health Research Institutes, Taiwan
Breast Cancer Lymphedema
Tacrolimus as Treatment of Breast Cancer-Related Lymphedema
BACKGROUND Breast cancer-related lymphedema is a severe and life-long side-effect to breast cancer treatment. The condition increases the risk of infections and decreases health-related quality of life (HR-QOL) in patients.
- Trial name
- NCT04541290
- Testing
- Protopic 0.1 % Topical Ointment
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Carcinoma, Squamous Cell of Head and Neck, Tobacco Use Disorder
Smoking Tobacco Cessation Integrated Program of Patients Treated for the Head and the Neck Cancer
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosa of the upper aero-digestive tract. They are the 6th most prevalent type of cancer worldwide.
- Trial name
- INTENT (NCT03788785)
- Testing
- Experimental arm, Control arm
- Where
- 3 sites in France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer
Assessment of Cardiotoxicity After Chemotherapy for Breast Cancer by Cardio-vascular Magnetic Resonance (MR)
Consecutive patients with a first diagnosis of breast cancer will be identified at the Tom Baker Cancer Centre (TBCC) and included into the study, if they are going to receive chemotherapy with anthracyclines and / or Trastuzumab…
- Trial name
- Cardiotox (NCT00679874)
- Testing
- Cardio-vascular MRI
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Calgary
Breast Cancer, Traumatic Brain Injury
Purpose in Life Survey
At present, there is no empirical data that specifies the likely prevalence of purpose in life disruption among various clinical populations.
- Trial name
- PIL (NCT05790278)
- Testing
- Survey
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mary Radomski
Colorectal Cancer, Liver Metastases
SAMe in Prevention of Oxaliplatin-associated Liver Injury
This is an open-label, phase II study that may provide evidence that taking S-adenosylmethionine (SAMe) supplementation prevents oxaliplatin, a type of chemotherapy drug, associated liver toxicity in patients with resectable…
- Conditions
- Colorectal Cancer, Liver Metastases, Liver Metastasis Colon Cancer, Liver Injury
- Trial name
- NCT06258525
- Testing
- Standard of care oxaliplatin-based chemotherapy, S-adenosylmethionine (SAMe) supplement, Surgery
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Cedars-Sinai Medical Center
Depression, Thyroid Cancer
Study on the Mechanism of Ganoderma Lucidum Spore Powder in the Treatment of Depression
To clarify the clinical effect of Ganoderma lucidum spore powder intervention on postoperative depressive symptoms of papillary thyroid carcinoma ; to elucidate the antidepressant mechanism of Ganoderma lucidum spore powder.
- Trial name
- NCT06429514
- Testing
- Ganoderma lucidum spore powder
- Where
- China
- Volunteers
- 298 people
- Sponsor
- Ling Zhiqiang
Diffuse Large B-cell Lymphoma (DLBCL), Cardiotoxicity
The CARDIOPROTECT Trial
This trial is to evaluate if dexrazoxane is safer and more effective than liposomal doxorubicin in preventing heart failure events in participants with diffuse large B-cell lymphoma (DLBCL) undergoing either standard of care…
- Conditions
- Diffuse Large B-cell Lymphoma (DLBCL), Cardiotoxicity, Lymphoma
- Trial name
- NCT07654426
- Testing
- Dexrazoxane, Doxorubicin, Liposomal Doxorubicin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cancer, Cachexia
TuLip : Role of the Tumor Environment in Cancer-related Fat Loss
Cancer cachexia is defined as a weight loss of more than 5% over the last 6 months, a loss of body fat and muscle atrophy. It is found in 80% of patients with advanced cancer.
- Conditions
- Cancer, Cachexia, Adipose Tissue
- Trial name
- TuLip (NCT05128318)
- Testing
- Nissen Fundoplication, cholecystectomy
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Université Catholique de Louvain
Colorectal Cancer, Fatigue
UNTIRE: Cancer-related Fatigue With Digital Treatment
This research is being done to find out if using a smartphone app as digital treatment to reduce Cancer Related Fatigue is feasible and easy to use.
- Trial name
- NCT05584540
- Testing
- UNTIRE App
- Where
- United States
- Sponsor
- Dana-Farber Cancer Institute
Clear Cell Renal Cell Carcinoma, VHL Syndrome
Overtaking Intra and Inter Tumoral Heterogeneity In Von Hippel-Lindau Related Renal Cancer
The goal of this study is to comprehensively map intra and inter tumor heterogeneity of ccRCC in VHL patients through the use of imaging, molecular biology and genomics techniques.
- Trial name
- ITHORinVHL (NCT06195150)
- Testing
- Blood collection
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- IRCCS San Raffaele
Glioblastoma, Radionecrosis of Brain
FET-PET-Guided Management of Pseudoprogression in Glioblastoma
The goal of this diagnostic randomised clinical trial is to determine, in glioblastoma patients with diagnostic uncertainty between pseudoprogression and tumor progression on follow-up MRI after chemoradiation, the added value of…
- Trial name
- FET-POPPING (NCT06480721)
- Testing
- Clinical management based on the index MRI and an additional [¹⁸F] FET PET scan
- Where
- 8 sites in Netherlands
- Volunteers
- 144 people
- Sponsor
- Veerle Ruijters
Chronic Fatigue, Breast Cancer
Acupressure for Persistent Cancer Related Fatigue
There are over 2 million breast cancer survivors today. Persistent Cancer-Related fatigue (PCRF), a state of being tired or weary, is one of the most common and distressing symptoms experienced by breast cancer (BC) survivors.
- Conditions
- Chronic Fatigue, Breast Cancer, Sleepiness
- Trial name
- AcuCrft (NCT01281904)
- Testing
- Relaxation Acupressure, Stimulating Acupressure
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- University of Michigan
Non-Small Cell Lung Cancer, Lung Cancer
A Study Investigating BG-60366 in Adults With Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer
This is an open-label, multicenter, Phase 1a/1b clinical study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of BG-60366, a highly potent, selective EGFR-mutation…
- Conditions
- Non-Small Cell Lung Cancer, Lung Cancer, NSCLC, NSCLC (Non-small Cell Lung Carcinoma)
- Trial name
- NCT06685718
- Testing
- BG-60366
- Where
- 29 sites in United States, Australia and 5 more
- Volunteers
- 33 people
- Sponsor
- BeOne Medicines
Graft Versus Host Disease
T&B Depletion Non Malignant
The primary aim of the present trial is to assess in a randomized fashion the benefit on standard graft-versus-host disease (GVHD) prophylaxis of the addition of ATG-Fresenius S ® in transplants from matched related donors (MRD)…
- Trial name
- NCT01810926
- Testing
- polyclonal antibody, Rituximab, Treosulfan
- Where
- 4 sites in Italy
- Volunteers
- 130 people
- Sponsor
- Franco Locatelli
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