Clinical trials: Cancer-related Cognitive Dysfunction
Breast Cancer, Cognitive Impairments
Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors
This Phase III trial will examine the efficacy of computerized cognitive training methods on perceived cognitive impairment in breast cancer survivors.
- Trial name
- NCT05896189
- Testing
- Arm 1: Computerized Cognitive Training-Global Stimulation Games, Arm 2: Computerized Cognitive Training-Neuroplasticity Games
- Where
- 680 sites in United States, Puerto Rico
- Volunteers
- 386 people
- Sponsor
- NRG Oncology
Cancer-related Cognitive Impairment, Oncology
Effects of a Cognitive Training Program on Chemotherapy-induced Cognitive Impairment (Chemobrain) in Breast Cancer Patients Undergoing Active Treatment
Introduction: Given the increase in breast cancer survival rates, resulting from technological and biomedical advancements, it is essential to conduct an exhaustive study of the secondary symptoms associated with the oncological…
- Conditions
- Cancer-related Cognitive Impairment, Oncology, Breast Cancer, Cognitive Training
- Trial name
- NCT06686823
- Testing
- Health Education Program, Cognitive Training Program
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Alzheimer Disease, Dementia, Mild
Event-Related Potential (ERP) Components in Clinical Diagnosis
In this study, the investigators will use a novel electroencephalogram (EEG) system that participants will wear during a single in-person research session to investigate whether ERPs are now ready for validation as a tool…
- Conditions
- Alzheimer Disease, Dementia, Mild, Mild Cognitive Impairment
- Trial name
- NCT05673759
- Testing
- Electroencephalogram (EEG) system, Standard Neuropsychological Testing, Additional neuropsychological tests
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Boston University
Cancer-related Cognitive Impairment
Electroacupuncture for Cognitive Toxicity in Cancer Survivors: Assessing Implementation, Cost, and Effectiveness for Integration
The goal of this clinical trial is to evaluate the clinical effectiveness and understand the biological mechanisms of electroacupuncture (EA) in reducing cognitive toxicity among cancer survivors.
- Trial name
- EAST-ALIGN (NCT07583979)
- Testing
- True electroacupuncture
- Where
- Singapore
- Volunteers
- 168 people
- Sponsor
- National Cancer Centre, Singapore
Breast Cancer Female, Cancer-Related Condition
Effect of Methylphenidate on Cancer-related Cognitive Impairment
Cancer-related cognitive Impairment (CRCI), commonly referred to as "chemo brain" or "brain fog"-impact severely on the Quality of Life (QoL) of cancer survivors. However, it still remains underdiagnosed and challenging to treat.
- Trial name
- CogMet (NCT02970500)
- Testing
- Methylphenidate HCl 10Mg SR
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- CHU de Quebec-Universite Laval
Postoperative Cognitive Dysfunction, Postoperative Delirium
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature…
- Conditions
- Postoperative Cognitive Dysfunction, Postoperative Delirium, Frailty
- Trial name
- POCD (NCT04837391)
- Testing
- Near Infrared Spectroscopy (NIRS), Blood sample, Addenbrooke Cognitive Examination III (ACE-III)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul University
Chemotherapy-related Cognitive Dysfunction
Telehealth and Memory Study
The overall purpose of this trial is to confirm the efficacy of Memory and Attention Adaptation Training (MAAT), a cognitive-behavioral therapy (CBT) for treatment of chemotherapy-related cognitive dysfunction among (female or…
- Trial name
- TAMS (NCT04586530)
- Testing
- Memory and Attention Adaptation Training (MAAT), Supportive Therapy (ST)
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- University of Pittsburgh
Breast Cancer, Gynecologic Cancer
Clinical Investigation of the Effects of Semiconductor Embedded Therapeutic Garments on Cancer-related Cognitive Impairment in Breast and Gynecological Cancer Patients
The purpose of this study is to assess the feasibility of a wearing semiconductor embedded headband for cancer-related cognitive impairment in patients with breast or gynecological cancers.
- Conditions
- Breast Cancer, Gynecologic Cancer, Cancer-related Cognitive Difficulties
- Trial name
- HEADBAND (NCT07173101)
- Testing
- Semiconductor embedded headband
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Utah
Ovarian Cancer, Cognitive Impairment
Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT
This is a phase I, dose-escalation and phase II dose-expansion clinical trial determining the maximum tolerated dose (MTD) and safety and tolerability of adding N-Acetyl-Cysteine (NAC) to ovarian cancer patients who are receiving…
- Trial name
- NCT04520139
- Testing
- N-Acetyl-Cysteine
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of California, Irvine
Breast Cancer
Study of the Effects of Chemotherapy on Memory and Other Mental Functions in Women With Breast Cancer
Many breast cancer patients treated with chemotherapy complain of problems with concentration and memory. This has been referred to as chemo fog.
- Trial name
- NCT00260975
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity
Investigating Cognitive Impairment in Young Patients With Cancer Prospectively
The MyBrain study investigates the brain function of children, adolescents and young adults during and after chemo treatment for cancer.
- Conditions
- Chemotherapy-Related Cognitive Impairment, Chemotherapeutic Toxicity, Chemo-brain, Cancer
- Trial name
- MyBrain (NCT05840575)
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chemo Fog
Ashwagandha for Cognitive Dysfunction
This is a 1:1 randomized double blinded placebo controlled trial. • To determine if ashwagandha can improve cognitive dysfunction when compared with placebo in patients undergoing chemotherapy for cancer.
- Trial name
- NCT04092647
- Testing
- Ashwagandha
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Sutter Health
Breast Cancer, Cancer of the Breast
Prehabilitation to Revolutionize Oncology: Telehealth Exercise for Cognitive Triumphs (The PROTECT Trial)
The investigators propose to deliver a pilot randomized controlled trial to 40 women newly diagnosed with breast cancer and scheduled to undergo chemotherapy.
- Trial name
- NCT05716542
- Testing
- Physical Activity Intervention
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Washington University School of Medicine
Cognition Disorders, Polyneuropathies
Chemotherapy-induced Cognitive Alterations in Recruits With Ovarian and Breast Cancer
Neurotoxic phenomena are among the most common and difficult to treat side effects of chemotherapy. The development of chemotherapy induced peripheral neuropathy (CIPN) is a well-recognized adverse reaction in the peripheral…
- Trial name
- CICARO (NCT02753036)
- Testing
- Chemotherapy
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Charite University, Berlin, Germany
Breast Cancer, Fatigue
The Role of Circadian Rhythms in Cancer-Related Symptoms
Emerging evidence indicates that circadian rhythms may be disrupted following cancer and its treatment, and that circadian rhythm disruption may be an underlying pathophysiological mechanism of cancer- and cancer…
- Conditions
- Breast Cancer, Fatigue, Cognitive Impairment, Sleep
- Trial name
- CHRONO (NCT04401189)
- Where
- Denmark
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Breast Neoplasms, Exercise Therapy
Aerobic Dance During Chemotherapy in Breast Cancer Patients With Cognitive Impairment
The goal of this clinical trial is to learn about breast cancer patients. The main questions it aims to answer are: Does Aerobic Dance During Chemotherapy Improve Cognitive Function in Breast Cancer Patients？ Does the efficacy of…
- Conditions
- Breast Neoplasms, Exercise Therapy, Chemotherapy-Related Cognitive Impairment, Cognitive Dysfunction
- Trial name
- ADANC (NCT06234150)
- Testing
- Aerobic dance, Fast-walking
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Neoplasm, Colorectal, Cognitive Impairment
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
The purpose of this research study is to see how the brain changes in patients receiving chemotherapy (cytotoxic drug) treatment for colon or rectal cancer at Parkview Cancer Institute.
- Conditions
- Neoplasm, Colorectal, Cognitive Impairment, Cognitive Dysfunction, Cognitive Change
- Trial name
- Chemo Brain (NCT05014399)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Joseph McCollom
Cancer-related Cognitive Difficulties
The Effects of Physical Activity and Low-Dose Ibuprofen on Cognitive Function in Cancer Patients
This research seeks to determine if a combination of low-dose ibuprofen along with a structured home-based walking and progressive resistance exercise program, EXCAP, will be effective in reducing cognitive difficulties among…
- Trial name
- NCT01238120
- Testing
- Ibuprofen, Home-Based Exercise
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Rochester
Effects of Chemotherapy, Cognitive Impairment
Cognitive Changes in Adult Cancer Survivors
This study will document the cognitive (mental) and functional abilities of newly diagnosed cancer patients. The study will also examine the changes in cognitive and functional abilities during and after chemotherapy (your cancer…
- Trial name
- CFCC (NCT01569932)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Washington University School of Medicine
Breast Cancer
Exercise, Cancer and Cognition: The ECCO-Study
The "ECCO"-study evaluates the efficacy of simultaneous controlled exercise during neo/-adjuvant chemotherapy in breast cancer patients and its effects on neurocognition.
- Trial name
- ECCO (NCT04789187)
- Testing
- High-Intensity-Interval-Training, General Physical Activity Recommendations
- Where
- Austria
- Volunteers
- 126 people
- Sponsor
- Johannes Kepler University of Linz