Clinical trials: Cancer-related Cognitive Dysfunction
Breast Cancer
Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast Cancer Survivors
The purpose of this study is to assess the feasibility of a 4-week intervention combining exercise and transcranial alternating current stimulation (Ex+tACS) in breast cancer survivors who report experiencing cancer-related…
- Trial name
- NCT07587957
- Testing
- Exercise + transcranial alternating current stimulation (Ex+tACS), Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Florida Atlantic University
Cognitive Impairment, Cognitive Change
Early Cognitive Interventions in Digital Format for Cancer Survivors
The aim of this study is to evaluate the usability and effectiveness of two professionally supervised home-based cognitive training interventions as part of an early rehabilitation protocol for cancer-related cognitive…
- Conditions
- Cognitive Impairment, Cognitive Change, Cancer
- Trial name
- INCOTEM (NCT07729969)
- Testing
- Computerized cognitive treatment, Virtual reality cognitive training
- Where
- 3 sites in Spain
- Volunteers
- 110 people
- Sponsor
- Biogipuzkoa Health Research Institute
Survivorship, Cognitive Dysfunction
Biobehavioral Correlates of Cancer-related Cognitive Dysfunction and Its Co-occurring Symptoms
This descriptive, cross-sectional study will evaulate and fully characterize factors associated with cognitive dysfunction in Breast Cancer (BCS) and Colorectal Cancer (CRC) survivors that have cognitive concerns, and factors…
- Conditions
- Survivorship, Cognitive Dysfunction, Pain, Depression
- Trial name
- NCT04611620
- Testing
- Cognitive Dysfunction
- Where
- United States
- Volunteers
- 682 people
- Sponsor
- Indiana University
Breast Cancer, Neurotoxicity
EGb761 in Maintaining Mental Clarity in Women Receiving Chemotherapy for Newly Diagnosed Breast Cancer
RATIONALE: Chemotherapy may cause memory loss, attention loss, and other problems that make it difficult for patients to think clearly. EGb761 may help maintain mental clarity in patients undergoing chemotherapy.
- Trial name
- NCT00046891
- Testing
- Ginkgo Biloba
- Where
- 175 sites in United States
- Volunteers
- 226 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Cancer, Cognitive Dysfunction
Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation
This study will test the preliminary efficacy of transcranial direct current stimulation (tDCS) to improve fatigue and cognition in women with a history of breast cancer and persistent fatigue.
- Conditions
- Breast Cancer, Cognitive Dysfunction, Fatigue
- Trial name
- NCT03143894
- Testing
- tDCS
- Where
- 3 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cancer, Fatigue
Health-related Quality of Life-intervention in Survivors of Breast and Other Cancers Experiencing Cancer-related Fatigue Using Traditional Chinese Medicine: The HERBAL Trial
This study is a phase 2, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy and safety of a Traditional Chinese Medicine decoction, the modified Xiang Bei Yang Rong Tang, in alleviating cancer related…
- Conditions
- Cancer, Fatigue, Cognitive Impairment
- Trial name
- HERBAL (NCT04104113)
- Testing
- Modified Xiang Bei Yang Rong Tang
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- National University of Singapore
Cognitive Dysfunction
Feasibility of the Memory and Attention Adaptation-Training Geriatrics Intervention in Older Cancer Survivors With Mild Cognitive Impairment
Cancer-related cognitive dysfunction (CRCD) affects up to 75% of patients receiving chemotherapy and older adults are at greater risk of developing CRCD, which can negatively affect their functional independence and quality of…
- Trial name
- urochester (NCT05258058)
- Testing
- Memory and Adaptation Training-Geriatrics
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Allison Magnuson
Breast Cancer
Chemotherapy Effect on Brain Structure, Neurophysiology and Psychomotor Behavior in Breast Cancer Patients
Some cancer patients report experiencing mild problems with thinking during or following chemotherapy. Symptoms include problems concentrating, slow thinking, some gaps in memory and difficulty performing complex or multi-tasks.
- Trial name
- NCT02896504
- Testing
- Exposure: Adjuvant chemotherapy treatment, Exposure: Adjuvant hormonal therapy treatment
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Breast Cancer, Chemotherapy-related Cognitive Impairment
Evaluation of Cognitive Education Activities in Breast Cancer Patients Receiving Chemotherapy
Breast cancer is one of the most common cancer types worldwide and accounts for approximately 31% of all cancers in women. The global incidence of breast cancer is increasing, making it a significant public health problem.
- Trial name
- NCT07570251
- Testing
- Cognitive Function Training Activities
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Saglik Bilimleri Universitesi
Cancer-related Cognitive Impairment
Photobiomodulation for Cancer-Related Cognitive Impairment
This is a single site, pilot randomized, double blinded control trial designed to assess changes in cognitive symptoms in cancer survivors with cancer-related cognitive impairment.
- Trial name
- NCT05855694
- Testing
- THOR LED Photobiomodulation Helmet - Therapeutic, THOR LED Photobiomodulation Helmet - Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Arash Asher, MD
Cognitive Decline, Cancer
Combined Model of Online Remote Interventions for Cancer-Related Cognitive Impairment
Cancer survival rates have increased dramatically in recent years. However, many survivors report cognitive decline following treatment, which significantly impairs their quality of life.
- Trial name
- CRCI (NCT04210778)
- Testing
- Cognitive orientation to daily occupational performance (CO-OP), Computerized Cognitive Training (BrainHQ, posit science)
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Prostate Cancer, Sexual Dysfunctions, Psychological
Innovations in the Treatment of Sexual Health Post Prostate Cancer Treatment: Comparing Mindfulness vs. CBT
Up to 90% of men experience sexual difficulties after receiving treatment for prostate cancer (PC), which can negatively affect their intimate relationships and overall quality of life.
- Conditions
- Prostate Cancer, Sexual Dysfunctions, Psychological, Sexual Dysfunction, Physiological, Sexual Dysfunction Male
- Trial name
- INTROSPPECT (NCT03365518)
- Testing
- Cognitive Behavioural Therapy (CBT), Mindfulness-Based Therapy
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chemotherapy-Related Cognitive Impairment, Breast Cancer
GM1 Prophylaxis for Post-chemotherapy Cognitive Impairment in Patients With Early Operable Breast Cancer
The purpose of this study is to evaluate the prophylactic effects of Ganglioside-Monosialic Acid in post-chemotherapy cognitive impairment in patients with early operable breast cancer.
- Trial name
- NCT05239663
- Testing
- Ganglioside-Monosialic Acid, 250ml normal saline (NS)
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Sun Yat-sen University
Breast Cancer, Cognitive Dysfunction
eHealth Interventions for Breast Cancer Cognitive Impairment
This study investigates the effectiveness of integrating a cognitive rehabilitation module into a digital psychosocial intervention for recently diagnosed breast cancer patients.
- Trial name
- ICOgnition (NCT06103318)
- Testing
- ICOgnition
- Volunteers
- 176 people
- Sponsor
- Institut Català d'Oncologia
Cancer Related Cognitive Decline, Non-metastatic Breast Cancer
RAGE Inhibition to Decrease Cardiotoxicity in Women With Early Breast Cancer
This is a pilot study to evaluate the effects of azeliragon to decrease cardiac toxicity from chemotherapy and the safety of azelirgaon when given with chemotherapy.
- Trial name
- RAGE (NCT05256745)
- Testing
- TTP488, ddAC/ddT, TC
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Georgetown University
Gastrointestinal Neoplasms, Cognitive Impairment
Effects of Different Doses of Vitamin D on Cancer-related Cognitive Impairment in Patients With Gastrointestinal Tumors
To explore the effect of different doses of vitamin D drugs on gastrointestinal cancer cancer-related cognitive impairment, so as to provide reference and basis for the clinical use of our cognitive function surgery nursing plan…
- Trial name
- NCT05552729
- Testing
- Vitamin D
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Yangzhou University
Cancer-related Cognitive Dysfunction, Primary Brain Neoplasm
Virtual Home-based Exercise Intervention (RISE) to Improve Cancer-Related Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors
This clinical trial evaluates the impact of a research intervention of virtually supervised exercise program (RISE) on cancer-related cognitive impairment (CRCI), physical activity in adolescent and young adult (AYA) brain tumor…
- Trial name
- NCT06799481
- Testing
- Aerobic Exercise, Behavioral Intervention, Follow-Up
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Emory University
Breast Neoplasms
Telehealth Program to Prevent Cancer and Chemotherapy-related Cognitive Impairment.
The present randomized controlled trial has the main objective to study the effects of a videoconferenced occupational therapy program in preventing cancer and chemotherapy-related cognitive impairment and other health outcomes…
- Trial name
- NCT04783402
- Testing
- e-OTCAT program, Educational handbook and standard care
- Where
- Spain
- Volunteers
- 98 people
- Sponsor
- Universidad de Granada
Breast Cancer, Cognitive Symptoms
Computer-Based Training in Patients With Post-Chemotherapy Cognitive Impairment
The investigators hypothesize that continuous active interaction with environments that are demanding to sensory, cognitive, and motor systems, together with imbedded rewards for successful performance, will help improve memory…
- Conditions
- Breast Cancer, Cognitive Symptoms, Memory Disorders
- Trial name
- NCT00387062
- Testing
- Computer-based Cognitive Training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Posit Science Corporation
Arthritis, Pain
Non-cancer Pain and Cognitive Impairment: A Disabling Relationship
To compare the efficacy of long-acting oxycodone to extended-release acetaminophen in older persons with no and mild to moderate cognitive impairment and persistent moderate or higher intensity non-cancer lower extremity…
- Conditions
- Arthritis, Pain, Cognitive Impairment
- Trial name
- NCT01264965
- Testing
- long acting oxycodone, extra strength acetaminophen
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Chicago