Clinical trials: Cancer-related Pain
Neoplasms
Educational Intervention Targeting Nurses Attitudes and Knowledge About Cancer-related Pain Management
The purpose of this study is to investigate whether an intervention consisting of the implementation of guidelines about daily systematic pain assessment following a theory based education, targeting cancer-related pain and pain…
- Trial name
- NCT01313234
- Testing
- Education
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Blekinge Institute of Technology
Prostate Cancer, Pain Cancer
Determining the Effect of Abiraterone on the Metabolism of Oxycodone in Men With Prostate Cancer (the ENABLE Study)
Prostate cancer often leads to bone metastases, which require adequate pain management with opioids such as oxycodone. This study investigates whether abiraterone - a drug used in the treatment of prostate cancer - affects the…
- Trial name
- ENABLE (NCT07001709)
- Testing
- Oxycodone oral capsule 15 mg, Abiraterone Acetate Tablets 500 mg
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- Deventer Ziekenhuis
Opioid-Refractory Chronic Cancer-Related Pain
The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.
This is a randomized, double-blinded, placebo-controlled, cross-over trial examining the effect of a series of two weekly intravenous infusions of lidocaine 4 mg/kg and ketamine 0.2 mg/kg in patients with moderate to severe…
- Trial name
- NCT07408193
- Testing
- Lidocaine and Ketamine Infusion
- Where
- Greece
- Volunteers
- 24 people
- Sponsor
- National and Kapodistrian University of Athens
Cancer, Opioid Use
Opioid Misuse in Patients With Cancer
The success of opioid treatment in terminally ill cancer patients set the stage for extending the same treatment principles to the treatment of all chronic pain conditions including chronic non-cancer pain and chronic pain in…
- Conditions
- Cancer, Opioid Use, Opioid Misuse, Pain
- Trial name
- NCT06489769
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Breast Cancer
Mindfulness Based Couples Therapy
The goal of this study is to explore the effects of a Mindfulness Based Couples Intervention on relationship satisfaction with quality of life and immune system function among breast cancer survivors and their partners.
- Trial name
- NCT02349217
- Testing
- Mindfulness-Based Relationship Enhancement (MBRE), Self-Help Materials, Pain Assessment
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Cancer, Pain
Sublingual Methadone for the Management of Cancer-related Breakthrough Pain in Outpatients
The purpose of this Phase II study is to determine the feasibility of the dose titration and assessment protocol in the outpatient population before conducting an appropriately powered phase III study.
- Trial name
- NCT00351715
- Testing
- Sublingual Methadone
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- AHS Cancer Control Alberta
Intractable Pain, Neoplasms
NP2 Enkephalin For Treatment of Intractable Cancer Pain
The purpose of this study is to examine the impact of intradermal delivery of NP2 on pain scores and pain medication usage in subjects with intractable pain due to malignant disease.
- Trial name
- NCT01291901
- Testing
- NP2
- Where
- 18 sites in United States
- Volunteers
- 33 people
- Sponsor
- Diamyd Inc
Cancer-related Problem/Condition, Head and Neck Cancer
S9908: Glutamine in Treating Mucositis Caused by Radiation Therapy in Patients With Newly Diagnosed Cancer of the Mouth or Throat
RATIONALE: Glutamine may be effective in decreasing side effects, such as inflammation of the mouth and throat, caused by radiation therapy. The effectiveness of glutamine for mucositis is not yet known.
- Conditions
- Cancer-related Problem/Condition, Head and Neck Cancer, Pain
- Trial name
- NCT00006994
- Testing
- glutamine, radiation therapy
- Where
- 107 sites in United States, Canada
- Volunteers
- 23 people
- Sponsor
- SWOG Cancer Research Network
Cancer Pain
A Study to Compare Safety and Efficacy of Osmotic Release Oral Syytem (OROS) Hydromorphone Hydrochloride (HCl) With Morphine Sustain Release (SR) in Participants With Cancer Pain
The purpose of this study is to evaluate the effectiveness and safety of Osmotic Release Oral System (OROS) hydromorohone Hydrochloride (HCl) compared with morphine sustain release (SR) in participants with chronic (lasting a…
- Trial name
- NCT00803283
- Testing
- Hydromprphone Hydrochloride (HCl) OROS, Morphine Sustain Release (SR)
- Volunteers
- 2 people
- Sponsor
- Johnson & Johnson Taiwan Ltd
Pain
Clinical Usefulness and Quality of Life of OROS Hydromorphone in Patients Who Have Not Been Treated With a Strong Opioid
The primary purpose of this study is to evaluate the usefulness of hydromorphone to treat cancer pain in patients who have not been treated with a strong opioid.
- Trial name
- NCT01532895
- Testing
- Hydromorphone HCI OROS
- Where
- 11 sites in South Korea
- Volunteers
- 400 people
- Sponsor
- Janssen Korea, Ltd., Korea
Intractable Pain, Palliative Care
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer
This study will examine the safety of giving the experimental drug, resiniferatoxin (RTX), to treat severe pain in patients with advanced cancer. RTX is a chemical extracted from a cactus-like plant.
- Trial name
- NCT00804154
- Testing
- Intrathecal Resiniferatoxin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Pain Cancer, Joint Pain
Evaluation of the Effect of Laser Acupuncture on Taxane Acute Pain Syndrome Patients
This is a prospectively randomized and double-blinded clinical study. Cancer patients were suffered from the taxanes-induced joint pain, and would be advised to receive laser acupuncture in specific points to relieve pain.
- Trial name
- NCT04872556
- Testing
- Laser acupuncture device, Pseudo-laser acupuncture
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Chang Gung Memorial Hospital
Efficacy of Adding Lidocaine 10% to Phenol in Superior Hypogastric Plexus Neurolysis
Efficacy of Adding Lidocaine 10% to Phenol in Ultrasound Guided Superior Hypogastric Plexus Neurolysis in The Management of Pelvic Cancer Pain
The superior hypogastric plexus (SHP) is a complex nervous collection located at the lumbosacral region below the level of the aortic bifurcation at the level of the lower third of the fifth lumbar vertebral body and upper third…
- Trial name
- NCT05145972
- Testing
- Ultrasound Guided Superior Hypogastric Plexus
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Cancer Pain
Optimizing Subcutaneous FEntanyl titRation: RApid Achievement of Adequate Exposure When Treating Cancer-Related paIn.
The primary objective is to evaluate the effect of loading boluses when dose incresaing treatment with SC fentanyl in patients with cancer.
- Trial name
- FERRARI (NCT06498037)
- Testing
- Fentanyl
- Where
- Netherlands
- Volunteers
- 45 people
- Sponsor
- Erasmus Medical Center
Breast Cancer, Hypercalcemia of Malignancy
S0308 Zoledronate or Ibandronate in Preventing Bone Problems in Women With Stage IV Breast Cancer That Has Spread to the Bone
RATIONALE: Zoledronate and ibandronate may prevent or help relieve bone pain and other symptoms caused by bone metastases. It is not yet known whether zoledronate is more effective than ibandronate in preventing bone problems…
- Conditions
- Breast Cancer, Hypercalcemia of Malignancy, Metastatic Cancer, Pain
- Trial name
- NCT00301886
- Testing
- ibandronate, zoledronate, quality-of-life assessment
- Sponsor
- SWOG Cancer Research Network
Non-Cancer Pain,Musculoskeletal Pain,Chronic Pain,Acute Pain
Real-World Study of Acupuncture for Pain Control
The goal of this observational study is to evaluate the real-world effectiveness of an acupuncture-first stepped care pathway for pain management in adults aged 18 years and older receiving routine outpatient clinical care for…
- Trial name
- NCT07454083
- Testing
- Acupuncture-First Stepped Care Pathway (Routine Clinical Care)
- Volunteers
- 300 people
- Sponsor
- Qi's Clinic
Cancer
A Study to Evaluate Efficacy and Safety of Oxycodone/Naloxone Compared to OxyContin in Korean Cancer Patients
Objectives: To prove non-inferiority of Targin compared to Oxycontin in terms of change of pain intensity 1. Primary objective: Change of pain intensity (NRS 0-10) score (average pain over 24 hours obtained each evening) within 4…
- Trial name
- TOP (NCT01313780)
- Testing
- Oxycodone/Naloxone, Oxycodone(single compound)
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Mundipharma Korea Ltd
Chronic Non Cancer Pain
Pharmacist for Detecting Opioid Misuse
Opioid use is increasing in Western countries and is associated with harms as hospitalization, addiction and deaths(1). Community pharmacists interact frequently with patients, giving them the opportunity to identify and prevent…
- Trial name
- NCT04544696
- Where
- France
- Volunteers
- 414 people
- Sponsor
- University Hospital, Montpellier
Chronic Pain
Efficacy and Safety Study of Fentanyl Transdermal Patch for Treatment of Chronic Pain
The purpose of this study is to confirm effectiveness and safety of fentanyl transdermal patch Durogesic® D-Trans for treatment of chronic pain in participants with chronic non-cancer pain.
- Trial name
- NCT01902524
- Testing
- Fentanyl-TTS
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Janssen Korea, Ltd., Korea
Lumbar Disc Herniation
Effect of Pulsed Mode Radiofrequency as a Treatment of Lumbar Disc Related Radicular Pain on Tumor Necrotic Factor α Level
Lumbar radiculopathy is a term that describes symptoms of pain, numbness, and/or weakness that radiate along the sciatic nerve from the lower back to the buttocks and leg (1).
- Trial name
- NCT05288920
- Testing
- Radiofrequency pulsed mode on dorsal root ganglion combined with transforaminal steroids injection, Transforaminal injection of Steroids alone
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Beni-Suef University