Clinical trials: Cancers of the Head and Neck
Molecular Classification of HNSCC
HNSCC Immuno-genomics Project
For locally advanced and recurrent / metastatic head \& neck squamous cell carcinoma (HNSCC), the is an unmet need for the development of efficient treatment combinations, particularly with immune checkpoint inhibitors.
- Trial name
- NCT06725342
- Testing
- Combined DNA/RNA sequencing on clinical FFPE material (technically challenging; innovative); immuno-genomics test.
- Volunteers
- 401 people
- Sponsor
- Hellenic Cooperative Oncology Group
Esophageal Cancer
Radiotherapy,Chemotherapy,Before and After Surgery in Advanced Esophageal or Gastroesophageal Junction Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by…
- Trial name
- NCT00258323
- Testing
- cisplatin, fluorouracil, Iressa
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Case Comprehensive Cancer Center
Solid Tumors, Head and Neck Neoplasms
Trial to Determine Optimal Phase II Dose of the Oral Dual CAIX Inhibitor/ Radiosensitizer
This is a Phase I multicenter, open-label, dose-escalation study of DTP348. DTP 348 is an oral dual drug with two mechanisms of action: 1.
- Trial name
- NCT02216669
- Testing
- DTP348
- Where
- Netherlands
- Sponsor
- Maastricht Radiation Oncology
Mucositis
Effect of Lactobacillus Brevis CD2 in Prevention of Radio-chemotherapy Induced Oral Mucositis in Head and Neck Cancer
Oral mucositis is a debilitating side effect for oncology patients and there is a clear need for new therapeutic options. The lozenges containing Lactobacillus brevis CD2 proved a potential new alternative for the prevention of…
- Trial name
- NCT01707641
- Testing
- CD#2, bicarbonate sodium mouthwash
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- S. Andrea Hospital
Head and Neck Cancer
PATH Trial: Personalized Approaches in the Treatment of Head and Neck Cancer
1. To determine genomic markers of radioresistance by comparing patients with H\&N cancer who develop recurrence within twelve months of curative intent radiation and/or chemoradiotherapy to those without recurrence 2.
- Trial name
- PATH (NCT05373251)
- Testing
- Whole genomic DNA/RNA tumour sequencing
- Volunteers
- 500 people
- Sponsor
- British Columbia Cancer Agency
Thyroid Neoplasms
Efficacy and Safety of Vandetanib (ZD6474) in Patients With Metastatic Papillary or Follicular Thyroid Cancer
This was a parallel group, randomized, double blind, placebo controlled, multicentre study designed to assess whether vandetanib (ZD6474) conferred an improvement in PFS as compared to placebo in participants with locally…
- Trial name
- NCT00537095
- Testing
- Vandetanib
- Where
- 15 sites in Belgium, Denmark and 5 more
- Volunteers
- 164 people
- Sponsor
- Genzyme, a Sanofi Company
Head and Neck Cancer
Neuropathic Pain in Head and Neck Cancer
The goal of this research study is to learn more about chronic pain associated with cancer treatment.
- Trial name
- NCT01846286
- Testing
- Questionnaires, Quantitative Sensory Testing
- Where
- 2 sites in United States
- Volunteers
- 838 people
- Sponsor
- M.D. Anderson Cancer Center
HNSCC
A Phase II Study to Evaluate the Efficacy and Safety of SKB571 in Recurrent or Metastatic HNSCC Participants
This is a multicenter, open-label, Phase II clinical study to assess the efficacy, safety, tolerability, PK characteristics, and immunogenicity of SKB571 in participants with recurrent or metastatic HNSCC.
- Trial name
- NCT07668154
- Testing
- SKB571, Pembrolizumab, carboplatin
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.
Thyroid Cancer
Assessment of Repeat Fine Needle Aspiration (FNA) to Detect Thyroid Cancer
Thyroid nodules are common (prevalence of 12.7% in women), but are malignant in only 5% of cases. International experts agree that a preliminary cytological examination by fine needle aspiration (FNA) is required.
- Trial name
- CYT2THYR (NCT00954837)
- Testing
- Fine needle aspiration
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer of the Cervix, Vulvar Cancer
Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers
This study expands on protocol (NCT01908504"PET adaptive RT") designed to evaluate the utility of adaptive PET-CT planning for radiation therapy (RT).
- Conditions
- Cancer of the Cervix, Vulvar Cancer, Esophageal Cancer, Anal Canal Cancer
- Trial name
- NCT03403465
- Testing
- FDG PET scan
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Duke University
Esophageal Cancer
Radiation Therapy, Pemetrexed Disodium, and Carboplatin in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed By Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as pemetrexed disodium and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the…
- Trial name
- NCT00268437
- Testing
- carboplatin, Pemetrexed, conventional surgery
- Where
- 90 sites in United States
- Volunteers
- 27 people
- Sponsor
- Alliance for Clinical Trials in Oncology
HNSCC
Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC
Evaluate the safety and efficacy of eftilagimod alpha in combination with pembrolizumab against pembrolizumab alone in 1st line metastatic or recurrent HNSCC with programmed death-ligand 1 (PD-L1) positive (combined positive…
- Trial name
- TACTI-003 (NCT04811027)
- Testing
- eftilagimod alpha, pembrolizumab (KEYTRUDA®)
- Where
- 28 sites in United States, Australia and 7 more
- Volunteers
- 171 people
- Sponsor
- Immutep S.A.S.
Head and Neck Squamous Cell Carcinoma, Stage IVA Oropharyngeal Carcinoma AJCC v7
Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer
This partially randomized phase I/II trial studies the side effects and best dose of veliparib when given together with combination chemotherapy and to see how well they work in treating patients with stage IV head and neck…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Stage IVA Oropharyngeal Carcinoma AJCC v7, Stage IVB Oropharyngeal Carcinoma AJCC v7
- Trial name
- NCT01711541
- Testing
- Carboplatin, Cisplatin, Fluorouracil
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Lung Cancer
Patient Reported Outcomes Study Using Electronic Monitoring System for Advanced or Metastatic Solid Cancer
This is a multicenter, open-label, randomized, controlled study to test the hypothesis that ePRO monitoring added to usual care helps prolong OS or maintain and improve HRQoL in patients with unresectable advanced cancers or…
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Liver Cancer
- Trial name
- NCT05931445
- Testing
- e-PRO monitoring
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Comprehensive Support Project for Oncology Research
Eosinophilic Esophagitis (EoE)
BURDEN OF ESOPHAGEAL CANCER IN EOSINOPHILIC ESOPHAGITIS (ESCAPE STUDY)
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disorder of the esophagus that can lead to symptoms such as dysphagia and food impaction.
- Trial name
- ESCAPE (NCT07102329)
- Where
- Italy
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Head and Neck Cancer
Amifostine With IMRT for Submandibular and Sublingual Salivary Sparing During Head and Neck Cancer Treatment
Primary Objective: To determine if amifostine in combination with IMRT can mitigate the decrease in production of saliva by the submandibular and sublingual salivary glands in patients with HNSCC. Secondary Objectives: 1.
- Trial name
- NCT00409331
- Testing
- Amifostine, Intensity- Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Esophageal Cancer, Gastric Cancer
Sarcopenia and Visceral Obesity in Esophageal and Gastric Cancer
In line with improvements in oncologic outcome for patients with esophageal cancer, the attritional impact of curative treatment with respect to functional status and health-related quality of life (HR-QL) in survivorship is…
- Conditions
- Esophageal Cancer, Gastric Cancer, Sarcopenia, Sarcopenic Obesity
- Trial name
- NCT03061370
- Testing
- Esophagectomy or Gastrectomy
- Where
- 2 sites in Ireland
- Volunteers
- 317 people
- Sponsor
- St. James's Hospital, Ireland
Gastrointestinal Disease, Esophageal Cancer
FDG-PET-CT and Biomarkers in Esophageal Cancer
The goal of this clinical research study is to learn if the results of a positron emission tomography/computed tomography (PET/CT) scan done 10-14 days after beginning chemotherapy and radiation (chemoradiation) can predict how a…
- Trial name
- NCT00833625
- Testing
- PET/CT (FDG PET/CT), Biomarker Testings
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center
Head and Neck Neoplasms, Radiodermatitis
Determinants of Radiation Dermatitis in Head and Neck Cancer Patients Receiving Preventive Photobiomodulation
The goal of this observational study is to identify factors associated with the occurrence of grade 2 or higher radiation dermatitis in adults with head and neck cancer treated with radiotherapy who receive preventive…
- Trial name
- COH-PBM-3J (NCT07899866)
- Testing
- Preventive photobiomodulation, External beam radiotherapy, Functional, quality-of-life and photographic assessments
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Hopital Forcilles
Oesophageal Cancer
Determination of the Role of Microarray for Prognosis and Prediction to Chemotherapy Sensitivity in Patients With Operable, Locally Advanced and Metastatic Oesophageal Cancer
Knowledge of the impact of gene expression profiling could allow optimisation of chemotherapy regimens for individual patients. It could ensure that patients do not receive a particular form of chemotherapy if it is unlikely to…
- Trial name
- NCT00220077
- Testing
- Endoscopy
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- Royal Marsden NHS Foundation Trust
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