Clinical trials: Cannabidiol
Phobia, Social
Investigating the Effects of Cannabidiol on Social Anxiety Disorder
The purpose of this study is to test whether a single-dose of Epidiolex (cannabidiol) is associated with reduced psychological, physiological, and neuroimaging measures of anxiety in people diagnosed with social anxiety disorder…
- Trial name
- CAN-SAD (NCT05649059)
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts Institute of Technology
Insomnia
Evaluation of an Oral Cannabidiol (CBD)-Terpene Formulation on Sleep Physiology in Participants With Insomnia
Insomnia is a disorder in which people have inadequate or poor-quality sleep due to a number of factors, such as difficulty falling asleep, waking up frequently during the night with difficulty returning to sleep, waking up too…
- Trial name
- NCT05233761
- Testing
- Defined CBD
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Defined Research
Autism, Autism Spectrum Disorder
Placebo-Controlled Study of Terpenes-Enriched Cannabis Oil T1/C28 for Children With Autism
The goal of this clinical trial is to determine whether cannabidiol (CBD, 28%) combined with terpenes and a small amount of THC (1%) can help reduce symptoms of autism, and to evaluate the safety of this treatment.
- Trial name
- TECA (NCT07199218)
- Testing
- Terpenes-Enriched CBD-Predominant Oil, Terpenes-Enriched CBD Oil (THC-Free)
- Where
- Israel
- Volunteers
- 78 people
- Sponsor
- Bazelet Nehushtan LtD.
Pain
Bioequivalence Assessment of Oral Administration Vs. Oral Spray of a Cannabinoids (Tetrahydrocannabinol and Cannabidiol)
This project is intended to evaluate self-emulsifying drug delivery system termed Piperine-Pro-Nano-Lipospheres (P-PNL) for enhancing the oral bioavailability of tetrahydrocannabinol (THC) and cannabidiol (CBD).The oral…
- Trial name
- NCT01893424
- Testing
- Sativex buccal spray, CBD-THC-Piperine-PNL capsule
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Chronic Pain, Opioid Use Disorder
Combined THC and CBD for OUD and Chronic Pain
The primary objective of this phase 2 study is to investigate the therapeutic potential of orally administered combined delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in relieving both pain and cue-induced opioid…
- Trial name
- NCT06544291
- Testing
- CBD 300mg, CBD 600mg
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Yale University
Irritable Bowel Syndrome
The Effect of CanChew® Cannabidiol (CBD) Containing Chewing Gum on Irritable Bowel Syndrome
Rationale: IBS is the most common functional gastrointestinal disorder with a prevalence worldwide ranging from 9-23%. Complaints include abdominal discomfort or pain and altered bowel habits.
- Trial name
- NCT03003260
- Testing
- CBD chewing gum
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Wageningen University
Cannabidiol Pharmacokinetics
The Pharmacokinetics and Pharmacodynamics of Oral and Vaporized Cannabidiol
This study will evaluate the pharmacokinetics and pharmacodynamics of cannabidiol administered via inhalation and oral ingestion.
- Trial name
- NCT03164512
- Testing
- Oral or vaporized cannabidiol
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dravet Syndrome, Lennox Gastaut Syndrome
The Pharmacokinetics of Cannabidiol (CBD) and Its Effects in Children With Severe Epilepsy
The purpose of this study is to determine if cannabidiol (CBD) obtained via the state of Minnesota reduces seizures in patients with severe intractable epilepsy (Dravet Syndrome or Lennox Gastaut Syndrome), and to measure blood…
- Trial name
- NCT02910297
- Sponsor
- Gillette Children's Specialty Healthcare
Sickle Cell Disease
Cannabidiol in Sickle Cell Disease
Randomized, placebo-controlled, double masked, dose finding study of twice daily cannabidiol given at 3 dose levels, 200mg, 400mg, and 600mg, compared to placebo for 4 weeks.
- Trial name
- SPICE (NCT06930703)
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Treatment Resistant Depression
Cannabidiol for Treatment Resistant Depression
With this study, the investigators will address the following scientific aims: 1. Demonstrate the antidepressant effects of CBD in human adults with treatment refractory MDD as measured by standard rating scales. 2.
- Trial name
- CBD (NCT04732169)
- Testing
- Active study drug ( oral CBD)
- Where
- United States
- Sponsor
- University of Alabama at Birmingham
Prader-Willi Syndrome
A Study to Assess the Long-Term Safety of Pharmaceutical Grade Synthetic Cannabidiol Oral Solution in Participants With Prader-Willi Syndrome
The objective of this study is to assess the long-term safety and tolerability of Cannabidiol Oral Solution (CBD) in participants with Prader-Willi Syndrome.
- Trial name
- NCT03458416
- Testing
- Cannabidiol Oral Solution
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Radius Pharmaceuticals, Inc.
Severe Alcohol Use Disorder (DSM 5)
Cannabidiol as an add-on Treatment During Inpatient Alcohol Cessation : CBD-OH
Randomized clinical trial of 11 days Cannabidiol versus placebo as an adjunctive treatment during inpatient alcohol detoxification to improve abstinence in patients with severe alcohol use disorder.
- Trial name
- CBD-OH (NCT05860699)
- Testing
- Half dose CBD, Full dose CBD
- Where
- 12 sites in France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Psychosis, First Episode Psychosis
Stratification and Treatment in Early Psychosis Study - ENHANCE
The purpose of this study is: To investigate whether the response to antipsychotic treatment can be enhanced by adding cannabidiol (CBD) to the existing treatment, compared to placebo, in participants with a first episode of…
- Conditions
- Psychosis, First Episode Psychosis, Psychotic Disorders, Psychotic Episode
- Trial name
- STEP-ENHANCE (NCT06778564)
- Testing
- CBD 100 mg/mL Oral Solution
- Where
- 17 sites in Austria, Germany and 7 more
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Breast Cancer
CBD for Breast Cancer Primary Tumors
This is a randomized placebo controlled partially blinded window of opportunity trial. A maximum of 84 patients with invasive breast cancer will be enrolled.
- Trial name
- NCT06148038
- Testing
- CBD Oral, Control
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder
Cannabidiol Effects on Blood Alcohol Level and Intoxication
The main objectives of this study were to test if 2 different doses of Cannabidiol (compared to placebo) alter 1) breath alcohol concentration, 2) craving and subjective responses to alcohol or 3) cognitive performance following…
- Trial name
- NCT06105138
- Testing
- 200mg Cannabidiol oral solution, 30mg Cannabidiol oral solution
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Cannabis Use Disorder
Cannabidiol and Cannabis Concentrate Users
This study is a randomized, placebo-controlled, dose-ranging trial of plant-derived cannabidiol (CBD) among people who regularly use cannabis concentrates but are not trying to stop or cut down on their use.
- Trial name
- NCT06575751
- Testing
- Broad Spectrum Cannabidiol (bsCBD) 400 mg, Broad Spectrum Cannabidiol (bsCBD) 200 mg
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Colorado, Denver
Epilepsy
Cannabidiol (CBD) to 27 Patients (Aged 2 Years - 19 Years) With Drug Resistant Epilepsy
Part A: To evaluate the safety and tolerability of multiple ascending doses of GWP42003-P compared with placebo with respect to: Incidence, type and severity of adverse events (AEs) Effect on vital signs, including weight Effect…
- Trial name
- NCT02286986
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Utah
Lennox-Gastaut Syndrome, Dravet Syndrome
The Effects of Cannabidiol (CBD) on Electrical and Autonomic Cardiac Function in Children With Severe Epilepsy
The investigators propose to study the effects of cannabidiol (CBD) on cardiac electrical function and the autonomic nervous system in children with Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS), when the CBD is…
- Trial name
- CBD1 (NCT02815540)
- Testing
- 12-Lead ECG, Cannabidiol
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gillette Children's Specialty Healthcare
Opioid Use Disorder (OUD)
Adjunctive Cannabidiol for Recovery From Opioid Study
The long-term goal of the project is to determine whether cannabidiol (CBD) can reduce craving and relapse in individuals with opioid use disorder (OUD).
- Trial name
- ACROS (NCT06940674)
- Testing
- Cannabidiol
- Where
- 2 sites in United States
- Volunteers
- 450 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Schizophrenia Spectrum Disorders, Cannabis Use
Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis
A large proportion of people with a schizophrenia-spectrum disorder, especially in the early stages of the disease, regularly consume cannabis.
- Trial name
- NCT03883360
- Testing
- Cannabidiol (CBD)
- Where
- 3 sites in United States
- Sponsor
- University of Maryland, Baltimore