Clinical trials: Cannabis Abuse
Cannabis
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
- Trial name
- THC-Gender (NCT02781519)
- Testing
- THC
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Yale University
Cannabis Dependence
Treatment for Cannabis Withdrawal and Dependence
Cannabis is the most widely used illicit drug in the United States, and worldwide, with 1 in 10 users estimated to meet diagnostic criteria for cannabis dependence.
- Trial name
- NCT01611948
- Testing
- Aprepitant, Manual-guided behavioral counseling
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Scripps Research Institute
Cannabis Abuse
Varenicline as a Treatment for Cannabis Use Disorder
Marijuana is the most commonly used illicit drug, and there is a high demand for effective treatments for cannabis use disorder, yet few specific pharmacological treatments have been developed.
- Trial name
- NCT07783555
- Testing
- Varenicline (Chantix)
- Volunteers
- 224 people
- Sponsor
- Medical University of South Carolina
Malnutrition, Anorexia
Sativex® and Gentamicin for Optimized Pharmagological Treatment in Older Patients (CanPan)
Malnutrition and inappropriate prescribing of renally excreted drugs are common among older persons and are associated with severe consequences such as complicated courses of treatment, mortality, and reduced quality of life.
- Conditions
- Malnutrition, Anorexia, Cannabis, Aging
- Trial name
- CanPan (NCT05503147)
- Testing
- Sativex
- Where
- Denmark
- Volunteers
- 17 people
- Sponsor
- Ove Andersen
Cannabis, Driving Under the Influence
Cannabis Edibles and Simulated Driving
The goal of this human laboratory experiment is to determine the acute and residual effects of a range of doses of orally administered cannabis edibles on driving simulator performance in people who use cannabis recreationally.
- Trial name
- NCT06595576
- Testing
- Cannabis - Low Dose (2 mg), Cannabis - Medium Dose (10 mg), Cannabis - High Dose (20 mg)
- Where
- Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cannabis Dependence
Sativex and Behavioral-relapse Prevention Strategy in Cannabis Dependence
The purpose of this study is assess Sativex as a treatment for Cannabis dependence. Initially a pilot study will be conducted in five subjects seeking treatment for cannabis dependence to ensure that our planned self-titration…
- Trial name
- NCT01747850
- Testing
- Motivational Enhancement/Cognitive Behavioral Therapy, Sativex
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Centre for Addiction and Mental Health
Cannabis Use, Cancer
Cannabis Use Registry to Improve Overall Understanding of Symptoms (CURIOUS)
Through partnership with Ontracka, the HealthPartners Institute Cancer Research Center created a secure and compliant app-based technology with the ability to seamlessly collect patient-level data on symptoms, cannabis use…
- Trial name
- CURIOUS (NCT07227324)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Abuse Cannabis, Pain
High Potency Cannabis: Acute and Protracted Effects
The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.
- Conditions
- Abuse Cannabis, Pain, Pharmacokinetics
- Trial name
- HIGH-CAP (NCT06859723)
- Testing
- Low dose THC, High dose THC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans- STUDY 2
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid cannabidiol (CBD; Epidiolex) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use
- Trial name
- NCT04036968
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use, Tobacco
Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis
This outpatient study examines how inhaled cannabis, combustible or vaporized, alters lung health and breath biomarkers compared to a tobacco cigarette.
- Conditions
- Cannabis Use, Tobacco, Biomarkers
- Trial name
- NCT07694466
- Testing
- Cannabis (THC), Tobacco Cigarette
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hannah Harris
Cannabis Use Disorder, Severe
Cannabis and Processing Emotions Study
The goal of this study is to test a causal neural mechanism of cannabis use-related problem recognition in individuals with severe cannabis use disorder using a non-invasive form of neuromodulation called transcranial magnetic…
- Trial name
- CAPE (NCT06907979)
- Testing
- TMS - Active iTBS, TMS - Active cTBS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Auburn University
Microbiome Analysis, Drug Abuse in Pregnancy
Alcohol and Cannabis Use Among Pregnant Slovenian Women
The aim of the study is to determine the prevalence of alcohol and drug use among Slovenian pregnant women. Alcohol and drug use during pregnancy has significant effects on the foetus and has short- and long-term health…
- Conditions
- Microbiome Analysis, Drug Abuse in Pregnancy, Alcohol Abuse in Pregnancy, Health Behavior, Risky
- Trial name
- NCT07456579
- Where
- Slovenia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Cannabis
Intervening to Prevent Youth Access to Marijuana Phase II
The legalization of recreational marijuana use and sales in Alaska, Colorado, Oregon, and Washington State is a dramatic change in U.S.
- Trial name
- NCT03073291
- Testing
- Responsible Marijuana Vendor Training
- Where
- 2 sites in United States
- Volunteers
- 448 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Cannabis Use Disorder, Cannabis Use Disorders
Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder
The HASHTAG Study is investigating whether the medicine semaglutide can help adults with cannabis use disorder (CUD) reduce their cannabis use. Participants will be randomly assigned to receive either semaglutide or a placebo.
- Conditions
- Cannabis Use Disorder, Cannabis Use Disorders, Cannabis Abuse, Cannabis Dependence
- Trial name
- HASHTAG (NCT07523633)
- Testing
- semaglutide
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Cannabis Use, Alcohol Use
Alcohol and Cannabis Co-Use and the Gut-Brain Axis
This observational study aims to improve our understanding of how legal market cannabis use impacts acute and long-term alcohol use, the microbiota-gut-brain-axis (MGBA), and neurobehavioral alcohol use phenotypes such as…
- Conditions
- Cannabis Use, Alcohol Use, Inflammation
- Trial name
- FRACTAL (NCT04998006)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cannabis Use Disorder
Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder
There has been a considerable rise in cannabis consumption in recent years, with estimates of 200 million individual users globally.
- Trial name
- NCT05859347
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Centre for Addiction and Mental Health
Cannabis Intoxication
Effects of Various Cannabis Strains on Perceptual, Subjective and Objective Use Outcomes
This study will evaluate the subjective and behavioral effects of cannabis products labeled as indica, sativa, or generic.
- Trial name
- NCT07214155
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis, Alcohol Effect
Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study I
The overarching goal of this study is to characterize the effects of ethanol and cannabinoids on simulated driving and related cognition.
- Conditions
- Cannabis, Alcohol Effect, Driving Under the Influence of Alcohol and Other Drugs
- Trial name
- THC-ETOH-I (NCT02709954)
- Testing
- Active inhaled delta-9-THC, Active Oral Ethanol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
THC, Cannabis
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco.
- Conditions
- THC, Cannabis, Cannabis Use, Cannabis Smoking
- Trial name
- CANNIC (NCT05999383)
- Testing
- Cannabis, Nicotine, Pax Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Gastric Ultrasound, Point of Care Ultrasound
Gastric Ultrasound Assessment for Patients Taking Cannabis
The aim of this study is to perform bedside gastric point of care ultrasound (POCUS) exams to assess the gastric volume and content (clear liquids vs solid food) perioperatively in patients who report cannabis use.
- Conditions
- Gastric Ultrasound, Point of Care Ultrasound, Cannabis Use
- Trial name
- NCT06567873
- Testing
- Gastric Ultrasound Exam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Hospital for Special Surgery, New York