Clinical trials: Cannabis Abuse
Study Focuses on Brain Morphology and Cognition in Older Subjects
Cannabis Effects on Brain Morphology in Aging
Marijuana (Cannabis sativa) is the most widely used illicit drug worldwide, with 17.4 million Americans reporting past month use in 2010 and 4.6 million meeting criteria for dependence, underscoring the public health importance…
- Trial name
- CAN (NCT01874886)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Schizophrenia, Dual Diagnosis
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment
The first aim of this study is to determine whether a brain reward center (BRC) deficiency in patients with schizophrenia (SCZ) and cannabis use disorder (CUD) will be normalized when patients are given cannabis or dronabinol.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00946348
- Testing
- Dronabinol, Cannabis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Fibromyalgia, Pain Management
Use of Cannabis Oil in Fibromyalgia
Recently, medical cannabis has been shown to be effective in chronic pain conditions such as osteoarthritis, neuropathic pain, and other chronic non-cancer pain.
- Conditions
- Fibromyalgia, Pain Management, Cannabis, Retrospective Studies
- Trial name
- FIBRO-CB (NCT07194018)
- Testing
- Use of cannabis oil
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Substance Abuse
Computer-Assisted Brief Intervention
Due to the "unmet needs" of substance abuse treatment among court involved but non-incarcerated (CINI) adolescents and their parents, reaching and engaging CINI adolescents in intervention programs addressing marijuana use is…
- Trial name
- JJMISCOPE (NCT03107117)
- Testing
- Computer Counseling, Standard Care
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Brown University
Multiple Sclerosis, Diabetes
An Observational Post-Marketing Safety Registry of Sativex®
The purpose of this registry is to monitor safety outcomes of patients who are receiving Sativex® for Multiple Sclerosis (MS) spasticity and for off-label indications in the United Kingdom (UK), Germany and Sweden.
- Conditions
- Multiple Sclerosis, Diabetes, Cancer, Neuropathic Pain
- Trial name
- NCT02073474
- Testing
- Sativex®
- Volunteers
- 978 people
- Sponsor
- Jazz Pharmaceuticals
Cannabis Use
Perceptions of Proposed Warnings for Cannabis Edibles Packaging
The purpose of this study is to compare a delayed-effects warning to an expanded warning developed in previous experiments on knowledge, harm perceptions, and willingness to try cannabis edibles.
- Trial name
- NCT07496489
- Testing
- No Warning Control, Delayed Effects Text Only, Delayed Effects Plus Icon
- Where
- United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia, Cannabis Abuse
Niacin Flushing as Marker of Cannabis Effects on Arachidonic Acid Pathways in Schizophrenia
Increasing evidence suggests modulating effects of cannabinoids on time of onset, severity, and outcome of schizophrenia. Efforts to discover the underlying pathomechanism have led to the assumption of gene x environment…
- Trial name
- NCT00376233
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Jena
Pain, Abuse, Drug
Age-dependent Effects of Smoked and Oral Delta-9-THC
This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.
- Conditions
- Pain, Abuse, Drug, Intoxication; Cannabinoids
- Trial name
- SAGE (NCT05865470)
- Testing
- Cannabis, Dronabinol
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Spinal Cord Injuries, Spinal Cord Diseases
Vaporized Cannabis and Spinal Cord Injury Pain
This study will demonstrate that vaporized marijuana results in antinociception when compared to placebo in subjects with spinal cord injury.
- Trial name
- NCT01555983
- Testing
- Vaporization of Cannabis
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Barth Wilsey
Cannabinoid Hyperemesis Syndrome
Comparing Haloperidol to Olanzapine in the Treatment of Suspected Cannabinoid Hyperemesis in the Emergency Department
The aim of the study is to identify which medication (haloperidol or olanzapine) is most effective in treating nausea and abdominal pain associated with cannabinoid hyperemesis using a 10-point visual analog scale with intervals…
- Trial name
- CH2O (NCT07246187)
- Testing
- Olanzapine 10 milligram, Haloperidol
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Mercy Bon Secours Saint Vincent Medical Center
Multiple Sclerosis
Cannabis for Spasticity in Multiple Sclerosis
The purpose of this study is to learn if the use of inhaled cannabis (marijuana) and oral cannabinoid (dronabinol, Marinol or THC, which is an active ingredient of marijuana) is safe and effective in reducing the symptoms of…
- Trial name
- NCT00682929
- Testing
- Inhaled Cannabis, Oral THC
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of California, Davis
Cannabis Dependence
Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence
This is an 8 week, outpatient research study testing the use of long-acting naltrexone (Vivitrol) as a treatment for marijuana dependence.
- Trial name
- NCT02088177
- Testing
- Long-acting injectable naltrexone
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Use
Feasibility and Acceptability of the Cannabis Awareness and Prevention Toolkit
The Stanford Smart Talk Cannabis Awareness and Prevention Curriculum includes 5 lessons, each providing activities, online quiz games, and worksheets in addition to presentations, resources, and other materials aimed at…
- Trial name
- NCT05521321
- Testing
- Stanford Smart Talk Cannabis Awareness and Prevention curriculum
- Where
- United States
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cannabis Use Disorder, Pregnancy Related
Maternal Marijuana Use and Fetal and Infant Outcome
Marijuana and cannabis-containing products are growing in popularity and availability in the United States, and use during pregnancy has increased dramatically.
- Trial name
- NCT04266314
- Testing
- Maternal-fetal monitoring, NICU Network Neurobehavioral Scale
- Where
- United States
- Sponsor
- Johns Hopkins University
Chronic Post-Traumatic Stress Disorder, Marijuana Abuse
Short-Term Exposure for PTSD
This study examines how marijuana use affects processes related to recovery from chronic posttraumatic stress disorder (PTSD). Half the participants will be individuals with chronic PTSD and heavy marijuana use and half will be…
- Trial name
- STEP (NCT02874898)
- Testing
- Brief Imaginal Exposure
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Washington
HIV Infections, Neuropathic Pain
Pain, Inflammation, and Cannabis in HIV
This study will examine how medical cannabis use affects neuropathic pain, inflammation and adverse events in people living with HIV (PLWH) with neuropathic pain.
- Conditions
- HIV Infections, Neuropathic Pain, Cannabis
- Trial name
- PITCH-E (NCT04860089)
- Sponsor
- Montefiore Medical Center
Intra Ocular Pressure
Effects of Marihuana Use on Optic Nerve Parameters and Ocular Blood Flow
Purpose of study: to check the effect of medical cannabis given for approved medical indications on ocular parameters including intra ocular pressure, optic nerve fibers thickness and choroidal thickness.
- Trial name
- NCT02080676
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Carmel Medical Center
Depressive Disorder, Major, Cannabis Abuse
Effectiveness of Fluoxetine in Young People for the Treatment of Major Depression and Marijuana Dependence
Adolescents who are diagnosed with major depressive disorder are often also diagnosed with marijuana dependence. Fluoxetine is an antidepressant medication currently used to treat young people who are diagnosed with major…
- Trial name
- CADY (NCT00149643)
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pittsburgh
Cannabis Use
Electrophysiological Study of the Functioning of Magnocellular Visual Pathway in Regular Cannabis Users
This study will evaluate the impact of regular use of cannabis on the spatial sensitivity of magnocellular system (visual event-related potential, visual ERP).
- Trial name
- CAUSA MAP (NCT02864680)
- Testing
- Electroretinography, Contrast sensitivity test during Electroencephalography, Visual simultaneity test during Electroencephalography
- Where
- France
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Obsessive-Compulsive Disorder
Effects of Marijuana on Symptoms of OCD
The purpose of this pilot research study is to test whether certain components of the marijuana plant, known as "cannabinoids", may help to reduce symptoms in patients with OCD.
- Trial name
- ECOS (NCT03274440)
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- New York State Psychiatric Institute