Clinical trials: Cannabis Abuse
Schizophrenia, Cannabis Abuse
Niacin Flushing as Marker of Cannabis Effects on Arachidonic Acid Pathways in Schizophrenia
Increasing evidence suggests modulating effects of cannabinoids on time of onset, severity, and outcome of schizophrenia. Efforts to discover the underlying pathomechanism have led to the assumption of gene x environment…
- Trial name
- NCT00376233
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Jena
HIV, Drug Addiction
Treating South African Pregnant Women for Methamphetamine
The purpose of this study was to develop and initially evaluate an efficacious, comprehensive, culturally sensitive, women-centered model of care for pregnant South African women by adapting and refining PI Jones'…
- Trial name
- NCT01386138
- Testing
- Psycho-education, Experimental
- Where
- South Africa
- Volunteers
- 60 people
- Sponsor
- RTI International
Multiple Sclerosis
Short-Term Effects of Medicinal Cannabis Therapy on Spasticity in Multiple Sclerosis
The purpose of this study is to determine whether or not smoked marijuana improves spasticity in patients with multiple sclerosis.
- Trial name
- NCT00248378
- Testing
- Smoked Cannabis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Center for Medicinal Cannabis Research
Tobacco Use Disorder, Nicotine Dependence
Young Adult Tobacco/Nicotine and Cannabis Co-use
The goal of this project is to better understand the relationship between tobacco/nicotine and cannabis using behavioral economics during a tobacco/nicotine quit attempt.
- Trial name
- YouthCAT (NCT06239350)
- Testing
- Counseling, Contingency management, Text-based support
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Back Pain, Depressive Symptoms
Cannabidiol for Reduction of Brain Neuroinflammation
This study will investigate whether cannabidiol (CBD), the primary centrally and peripherally active non-intoxicating compound in the cannabis plant, exerts anti-neuroinflammatory effects in patients with chronic low back pain…
- Trial name
- CBD (NCT05066308)
- Testing
- CBD
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Massachusetts General Hospital
Cannabis Use Disorder
UH3 Varenicline for Cannabis Use Disorder
Marijuana is the most commonly used illicit drug. There is high demand for effective interventions for cannabis use disorder, yet few specific treatments for have been developed.
- Trial name
- NCT03980561
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 174 people
- Sponsor
- Medical University of South Carolina
Childhood Cancer, Cancer
CANnabinoids in Pediatric ONCology
CANnabinoids in Pediatric ONCology is a randomized, double blind, adaptive clinical trial looking at the tolerability of cannabinoids in children with cancer across 3 Canadian children's hospitals.
- Trial name
- CAN-PONC (NCT05754840)
- Testing
- MPL-001, MPL-005, MPL-009
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Manitoba
Cannabis Dependence, Tobacco Use
Characterization of the Pattern of Consumption and Withdrawal Syndrome From Dual Cannabis and Tobacco Use
Aims: To characterize the pattern of cannabis and tobacco use and withdrawal symptoms in people who start treatment for cannabis use disorders (exclusive cannabis, concurrent and/or simultaneous with various tobacco products)…
- Conditions
- Cannabis Dependence, Tobacco Use, Withdrawal Syndrome, Substance Abuse
- Trial name
- DuCATA_GAMCaT (NCT05512091)
- Volunteers
- 282 people
- Sponsor
- Cristina Martínez Martínez
Cannabis Use
Feasibility and Acceptability of the Cannabis Awareness and Prevention Toolkit
The Stanford Smart Talk Cannabis Awareness and Prevention Curriculum includes 5 lessons, each providing activities, online quiz games, and worksheets in addition to presentations, resources, and other materials aimed at…
- Trial name
- NCT05521321
- Testing
- Stanford Smart Talk Cannabis Awareness and Prevention curriculum
- Where
- United States
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Stanford University
Tobacco Use
A Laboratory Model of Increasing Delta-9-tetrahydrocannabinol (THC) Potency on Cigarette Smoking
The objective of the proposed research is to investigate how smoking increasing potency of THC (i.e., the psychoactive ingredient in marijuana) changes tobacco cigarette smoking behavior, urges, subjective effects, and abuse…
- Trial name
- MJCIG (NCT02961309)
- Testing
- THC
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Battelle Memorial Institute
Marijuana Abuse
Effectiveness of Nefazodone and Bupropion in Treating Marijuana Dependent Individuals
Recent research has identified the following withdrawal symptoms to be associated with abruptly stopping marijuana use: anxiety, irritability, bodily aches and pains, and difficulty sleeping.
- Trial name
- NCT00249509
- Testing
- Nefazodone, Bupropion
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy
Cannabis and Polysubstance Use: Response Inhibition and Stress Exposure
The purpose of this Phase I non-therapeutic trial is to examine the neurological effects of cannabis on stress reactivity and inhibition in healthy cannabis users.
- Trial name
- CAPU RISE (NCT05261321)
- Testing
- Cannabis oil with a high ratio of THC to CBD, Cannabis oil with a high ratio of CBD to THC
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Marijuana Smoking
Nabilone & Marijuana Addiction
Safety of Nabilone in reducing marijuana craving
- Trial name
- NCT01025700
- Testing
- Cesemat
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of British Columbia
Pain, Pain Syndrome
Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Central Neuropathy of Any Genesis
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071949
- Testing
- Adezunap
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Cannabis
Detection of Cannabis Impairment With ISBRG's SpotLight-THC
Subjects will participate in a 2-visit study protocol in which they will be administered cannabis of pre-determined concentrations and asked to complete a simulated drive in a driving simulator.
- Trial name
- NCT05276232
- Testing
- Cannabis(THC) inhaled
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- ISBRG Corp
Cannabis Use Disorder
Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder
There has been a considerable rise in cannabis consumption in recent years, with estimates of 200 million individual users globally.
- Trial name
- NCT05859347
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Centre for Addiction and Mental Health
Postoperative Pain
Cannabis in Postoperative Pain Management
Postoperative pain management is critical for surgical recovery, affecting patient outcomes, hospitalization duration, and quality of life.
- Trial name
- Cannabis (NCT06903624)
- Volunteers
- 70,000 people
- Sponsor
- Assuta Medical Center
Attention Deficit Disorder With Hyperactivity, Marijuana Abuse
Atomoxetine for Treating Marijuana-Abusing Adolescents Who Have Attention Deficit Hyperactivity Disorder
Attention Deficit Hyperactivity Disorder (ADHD) is common among adolescents seeking treatment for marijuana dependence. The purpose of this study is to determine the use of atomoxetine in treating adolescents who abuse marijuana…
- Trial name
- NCT00142961
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Dependence
Safety and Efficacy of a FAAH-Inhibitor to Treat Cannabis Withdrawal
Cannabis dependence is associated with changes in the brain's cannabinoid system. When cannabis dependent individuals try to quit using cannabis, some of them experience problems that make it difficult for them to achieve and…
- Trial name
- NCT01618656
- Testing
- PF-04457845
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Yale University
Cannabis, Cannabis Use
Marijuana Effects on Simulated Driving Performance
This study will examine the effects of various strains of marijuana on simulated driving performance; the effects of alcohol administration will also be examined to further understand how marijuana-induced driving changes compare…
- Conditions
- Cannabis, Cannabis Use, Marijuana, Marijuana Usage
- Trial name
- NCT03699540
- Testing
- Marijuana, Alcohol, Inactive marijuana
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shanna Babalonis, PhD