Clinical trials: Cannabis Abuse
Healthy Volunteers
Cannabis Effects on Electroencephalography
Background: Tetrahydrocannabinol (THC) is a partial CB1/CB2 agonist and causes its pharmacological effects by binding to cannabinoid receptors.
- Trial name
- CEG (NCT04316598)
- Testing
- Cannabis Sativa
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Cannabis Use Disorder
Understanding Effects of Cannabis Use and Abstinence on Neural Glutamate Homeostasis
This study will be the first in vivo human multimodal neuroimaging study exploring the relationship between mGluR5 availability (PET), neural oscillations (EEG), and cognitive function in people with CUD.
- Trial name
- NCT05664763
- Testing
- [18F]FPEB with PET, Cannabis abstinence
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Yale University
Anxiety, Anxiety Disorders
Anxiety, Inflammation, Stress, and Cannabinoids
This study investigates whether the anxiolytic effects and anti-inflammatory properties of cannabis vary as a function of the ratio of CBD to THC, with the goal that these effects may shed light on the mixed data linking cannabis…
- Conditions
- Anxiety, Anxiety Disorders, Anxiety Generalized, Anxiety Chronic
- Trial name
- NCT03491384
- Testing
- Cannabis (smoked flower, ingested edible)
- Where
- United States
- Volunteers
- 361 people
- Sponsor
- University of Colorado, Boulder
Cannabis Use Disorder
Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder
There has been a considerable rise in cannabis consumption in recent years, with estimates of 200 million individual users globally.
- Trial name
- NCT05859347
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- Centre for Addiction and Mental Health
Cannabis Dependence, Cannabis Withdrawal
Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using…
- Trial name
- SCCAN (NCT00656487)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Scripps Research Institute
Cannabis, Memory
Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 1
This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users.
- Conditions
- Cannabis, Memory, Electroencephalography
- Trial name
- COBRA (NCT05868213)
- Testing
- Cannabis (smoked flower)
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Chronic Obstructive Pulmonary Disease (COPD), Breathlessness
CAN BREATHE in COPD Trial
A growing body of physiological evidence now exists to support a potential role for inhaled cannabis in the medical management of adults with chronic obstructive pulmonary disease (COPD), particularly as it may related to…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Breathlessness, Exercise Intolerance
- Trial name
- NCT03060993
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- McGill University
Intra Ocular Pressure
Effects of Marihuana Use on Optic Nerve Parameters and Ocular Blood Flow
Purpose of study: to check the effect of medical cannabis given for approved medical indications on ocular parameters including intra ocular pressure, optic nerve fibers thickness and choroidal thickness.
- Trial name
- NCT02080676
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Carmel Medical Center
Cannabis Dependence
Atomoxetine for the Treatment of Cannabis Dependence
The purpose of this small open-label trial is to evaluate the feasibility of recruiting cannabis dependent patients for treatment with Atomoxetine and MIT.
- Trial name
- NCT00167297
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
HIV, Cannabis
Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV
This study has the potential to contribute to a more complete understanding of the independent and combined effects of cannabis use and HIV on the brain and on inflammation.
- Conditions
- HIV, Cannabis, THC, Neuroinflammatory Disease
- Trial name
- CAMI (NCT05514899)
- Testing
- THC, CBD
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Chronic Post-Traumatic Stress Disorder, Marijuana Abuse
Short-Term Exposure for PTSD
This study examines how marijuana use affects processes related to recovery from chronic posttraumatic stress disorder (PTSD). Half the participants will be individuals with chronic PTSD and heavy marijuana use and half will be…
- Trial name
- STEP (NCT02874898)
- Testing
- Brief Imaginal Exposure
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Washington
Cannabis Dependence
Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream
This clinical trial assesses differences in the delivery of THC to the bloodstream depending on whether nicotine vapes are used before or after THC.
- Trial name
- NCT06334016
- Testing
- Biospecimen Collection, Cannabis sativa Extract, Nicotine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Opioid Use, Marijuana
Does Medical Cannabis Reduce Opioid Use in Adults With Pain
The study will examine how medical cannabis use affects opioid analgesic use. This landmark study will be among the first to examine the effect of medical cannabis with different THC/CBD (Tetrahydrocannibinol/Cannabidiol) content…
- Conditions
- Opioid Use, Marijuana, Chronic Pain
- Trial name
- ReLeaf-E (NCT04308148)
- Where
- United States
- Volunteers
- 217 people
- Sponsor
- Albert Einstein College of Medicine
Cannabis, Addictive Behavior
Validation of the Cannabis Abuse Screening Test in General Practice(GP-CAST)
In France, consumption levels of alcohol, tobacco and cannabis remain high despite changes in regulations aimed at limiting access to these products and repeated prevention campaigns.
- Conditions
- Cannabis, Addictive Behavior, General Practice, Primary Care
- Trial name
- GP-CAST (NCT05633043)
- Where
- 5 sites in France
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Mild Cognitive Impairment
CBD for Individuals at Risk for Alzheimer's Disease
This is a double-blind, randomized controlled trial designed to test the effects of cannabidiol (CBD) on validated biomarkers of Alzheimer's disease (AD) progression, and behavioral, neurocognitive, and clinical measures, with…
- Trial name
- NCT05822362
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- University of Colorado, Denver
Cannabis Dependence
Interactions Between Physical Activity and Cannabis Use in Adults
In this study the investigators will explore the relationship between physical activity and cannabis use. The investigators will compare regional brain activation detected by imaging technique(fRMI) before and after exercise in…
- Trial name
- NCT00838448
- Testing
- Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Marijuana Impairment
Neuroscience of Marijuana Impaired Driving
Marijuana is one of the most widely used substances. However, marijuana intoxication is not fully understood in relation to driving.
- Trial name
- MJDriving (NCT02757313)
- Testing
- Low dose THC marijuana, High dose THC marijuana
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Yale University
Cannabis Use
Effects of Cannabis Administration Routes on Human Performance and Pharmacokinetics
Background: Marijuana (cannabis) is an illegal drug. Researchers want to study people s reactions, attention, and behavior after they take marijuana in different ways.
- Trial name
- NCT02177513
- Testing
- 6.9% cannabis oral
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Epilepsy, Unspecified, Refractory (Medically)
The Use of Medicinal Cannabinoids as Adjunctive Treatment for Medically Refractory Epilepsy
Many families of children with medically refractory epilepsy are choosing to use medicinal cannabinoids (MCBD) as an adjunctive alternative treatment option. The safety, tolerability and efficacy of these products are not known.
- Trial name
- NCT02523183
- Testing
- Medical Cannabis
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Cannabis
Laboratory Smoking of Marijuana "Blunts"
This is a double-blind within-subjects clinical laboratory study comparing the product appeal and abuse liability-related subjective effects of different flavored cigar wrappers for marijuana blunts.
- Trial name
- NCT03546790
- Testing
- Marijuana
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Battelle Memorial Institute