Clinical trials: Cannabis Use
Cannabis Use, Adolescent Behavior
Pilot Trial of Contingency Management for Long-Term Cannabis Abstinence
This study is a critically important first-of-its-kind investigation of the potential research utility of using contingency management to examine long-term changes in cannabis use with six months of abstinence.
- Trial name
- NCT03786224
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cannabis Use
Stress-Reactivity and Cannabis Use in Cannabis-Using Older Adults
The goal of the study is to evaluate how cannabis use affects memory and thinking skills and response to stress in older adults.
- Trial name
- PUMA (NCT05072795)
- Testing
- Trier Social Stress Task (TSST)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Medical University of South Carolina
Cannabis, Cannabis Use
Marijuana Effects on Simulated Driving Performance
This study will examine the effects of various strains of marijuana on simulated driving performance; the effects of alcohol administration will also be examined to further understand how marijuana-induced driving changes compare…
- Conditions
- Cannabis, Cannabis Use, Marijuana, Marijuana Usage
- Trial name
- NCT03699540
- Testing
- Marijuana, Alcohol, Inactive marijuana
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shanna Babalonis, PhD
Cannabis Use Disorder
Fatty Acid Amide Hydrolase (FAAH) Inhibitor Treatment of Cannabis Use Disorder (CUD)
A Phase 2B, 8-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy, Safety and Tolerability of the Fatty Acid Amide Hydrolase (FAAH) Inhibitor PF-04457845 in Adults with DSM-5 Current…
- Trial name
- FAAH-I MULTI (NCT03386487)
- Testing
- PF 04457845
- Where
- 4 sites in United States
- Volunteers
- 228 people
- Sponsor
- Yale University
Cannabis Use, Cognitive Change
Cognitive Recovery With Cannabis Abstinence Among High School-Aged Adolescents
This study will use a randomized controlled design to test whether 30 days of cannabis abstinence, compared to 30 days of monitoring, is associated with improvements in cognitive functioning.
- Conditions
- Cannabis Use, Cognitive Change, Adolescent Behavior
- Trial name
- NCT03276221
- Testing
- Abstinence
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cannabis Use Disorder
UH3 Varenicline for Cannabis Use Disorder
Marijuana is the most commonly used illicit drug. There is high demand for effective interventions for cannabis use disorder, yet few specific treatments for have been developed.
- Trial name
- NCT03980561
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 174 people
- Sponsor
- Medical University of South Carolina
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans- STUDY 2
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid cannabidiol (CBD; Epidiolex) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use
- Trial name
- NCT04036968
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid dronabinol (Marinol) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use, Unspecified
- Trial name
- NCT02901275
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use
Impact of Progesterone on Stress Reactivity and Cannabis Use
This is a research study to find out if a hormone called progesterone affects marijuana users' stress response and marijuana use.
- Trial name
- NCT03729869
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Medical University of South Carolina
Cannabis Use Disorder
A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
This investigation will preliminarily determine if a course of high-frequency rTMS applied to the left dorsolateral prefrontal cortex, will reduce behavioral craving, and fMRI cue-reactivity in treatment-seeking cannabis use…
- Trial name
- NCT03144232
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Stanford University
Cannabis Use Disorder, Cannabis Dependence, Continuous
Brain Imaging of Cannabinoid Receptors
All participants will be healthy volunteers and all procedures will be completed for research purposes only. Two groups will be recruited, females who use cannabis (marijuana, MJ), and female who do not use cannabis (controls).
- Trial name
- NCT03204305
- Testing
- 11C-OMAR, Cannabis
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use
Brief Intervention Combined With Health Coaching Via Social Media for Cannabis Use
The purpose of the study is to develop and test social media interventions to help young people increase well-being and reduce risky behaviors.
- Trial name
- NCT04316741
- Testing
- Snapcoach
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Michigan
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Insomnia Chronic, Cannabis Use
Reducing Cannabis Use for Sleep Among Adults Using Medical Cannabis
As medical cannabis use becomes more common in the United States, it is essential to understand the ways in which adults who use medical cannabis perceive the benefits of cannabis use and to identify effective strategies to help…
- Trial name
- CannSleep (NCT03964974)
- Testing
- Cognitive Behavioral Therapy for Insomnia in Cannabis Users (CBTi-CB), Sleep Hygiene Education (SHE)
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- University of Michigan
Cannabis Use
Effect of Lorcaserin on Cannabis Withdrawal and Self-administration
In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.
- Trial name
- NCT03253926
- Testing
- Lorcaserin, Marijuana
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cannabis Use, Pain, Acute
Eye Tracking as a Biomarker of Cannabis Effects
Biomarkers of recent drug use and intoxication have societal relevance, in that they are used by law enforcement and other agencies to detect drug impairment.
- Trial name
- NCT04100590
- Testing
- Cannabis
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Cannabis Use
Social Media Intervention for Cannabis Use in Emerging Adults
The purpose of the study is to develop and test social media interventions to help young people increase well-being and reduce risky behaviors.
- Trial name
- NCT04187989
- Testing
- Social Media Intervention
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- University of Michigan
Cannabis-use Disorders
Behavioral Effects of Pregabalin and Cannabis
Cannabis is the most commonly used illicit drug in the United States, and its use is associated with rates of development of abuse and dependence, treatment admission and relapse that are comparable to other illicit drugs.
- Trial name
- NCT01511640
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Joshua A. Lile, Ph.D.
Cannabis Use Disorder
Effect of Clonazepam on Cannabis Withdrawal and Relapse in Treatment-seeking Patients
The proposed protocol is a double-blind, placebo-controlled inpatient and outpatient study,looking at the clinical treatment of cannabis use disorder. The treatment study is a total of 12 weeks.
- Trial name
- NCT02913924
- Testing
- Clonazepam
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- New York State Psychiatric Institute
Schizophrenia, Dual Diagnosis
Cannabis and Schizophrenia: Self-Medication and Agonist Treatment
The first aim of this study is to determine whether a brain reward center (BRC) deficiency in patients with schizophrenia (SCZ) and cannabis use disorder (CUD) will be normalized when patients are given cannabis or dronabinol.
- Conditions
- Schizophrenia, Dual Diagnosis, Schizoaffective Disorder, Psychotic Disorder
- Trial name
- NCT00946348
- Testing
- Dronabinol, Cannabis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center