Clinical trials: Cannabis Use Disorder
Opioid Use, Alcohol Drinking
TACUNA (Traditions and Connections for Urban Native Americans)
This study responds to Request For Application-DA-19-035, HEAL (Helping End Addiction Long Term) initiative: Preventing OUD in Older Adolescents and Young Adults (ages 16-30) by developing and implementing a culturally centered…
- Conditions
- Opioid Use, Alcohol Drinking, Marijuana Use
- Trial name
- TACUNA (NCT04617938)
- Testing
- TACUNA plus Wellness Circle, Opioid Education Workshop
- Where
- 3 sites in United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- RAND
Cannabis Use Disorder
Buspirone, Stress, and Attentional Bias to Marijuana Cues
This project has two primary goals. The first goal is to further scientific understanding about marijuana abuse by examining two recognized factors in marijuana use and relapse: (1) stress/anxiety and (2) atypical reactivity to…
- Trial name
- NCT02132832
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- The University of Texas Health Science Center, Houston
Marijuana Abuse
The Effect of Prescription Medications in Marijuana Users
A subset of heavy marijuana users have trouble quitting marijuana use and the number of those seeking treatment for problems related to marijuana is increasing.
- Trial name
- NCT00893074
- Testing
- Dronabinol 30mg/day, Dronabinol 60mg/day, Dronabinol 120mg/day
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use, Tobacco Use Disorder
N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use
Tobacco and cannabis co-use is a common and growing public health problem, especially in states that have legalized cannabis. There are no pharmacologic treatments for co-occurring tobacco and cannabis use.
- Conditions
- Cannabis Use, Tobacco Use Disorder, Drug Use Disorder
- Trial name
- NAC_CUD-TUD (NCT04627922)
- Testing
- N-Acetyl cysteine, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Ellen Herbst
Marijuana Abuse
The Effect of Food on the Oral Bioavailability of AEF0117 in Healthy Volunteers
Cannabis use is increasing and will only further escalate with legalization of recreational and medical cannabis use in western countries , with a prevalence greater than 30 % in the US and most European countries for individuals…
- Trial name
- NCT05451017
- Testing
- 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fed condition, 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one in fasting condition
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aelis Farma
Cannabis Dependence
Facilitating the Behavioral Treatment of Cannabis Use Disorder
Cannabis use disorders remain a significant public health problem. The pharmacological facilitation of behavioral treatment represents a promising strategy for addressing disordered cannabis use.
- Trial name
- NCT02946489
- Testing
- CI-581a
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Use Disorder
N-Acetylcysteine for Youth Cannabis Use Disorder
This is a 12-week randomized, placebo-controlled trial of N-acetylcysteine for cannabis use disorder (CUD) in youth (N=192). Participants will be randomized to double-blind NAC or PBO, yielding two equally-allocated treatment…
- Trial name
- NCT03055377
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Medical University of South Carolina
Substance Use Disorders
Behavioral Treatment of Adolescent Substance Use
This study will continue research designed to improve treatment outcomes for adolescent substance use disorders by integrating neuroscience- and behaviorally-based treatments.
- Trial name
- SMART (NCT02063984)
- Testing
- Intensive Outpatient Treatment (IOP) + Contingency Management (CM), Working Memory Training
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cannabis Use Disorder
Fatty Acid Amide Hydrolase (FAAH) Inhibitor Treatment of Cannabis Use Disorder (CUD)
A Phase 2B, 8-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy, Safety and Tolerability of the Fatty Acid Amide Hydrolase (FAAH) Inhibitor PF-04457845 in Adults with DSM-5 Current…
- Trial name
- FAAH-I MULTI (NCT03386487)
- Testing
- PF 04457845
- Where
- 4 sites in United States
- Volunteers
- 228 people
- Sponsor
- Yale University
Cannabis Use
Feasibility and Acceptability of the Cannabis Awareness and Prevention Toolkit
The Stanford Smart Talk Cannabis Awareness and Prevention Curriculum includes 5 lessons, each providing activities, online quiz games, and worksheets in addition to presentations, resources, and other materials aimed at…
- Trial name
- NCT05521321
- Testing
- Stanford Smart Talk Cannabis Awareness and Prevention curriculum
- Where
- United States
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Stanford University
Cannabis Dependence, Tobacco Dependence
Varenicline for Co-occurring Cannabis and Tobacco Use
Pilot, eight week, open-label, within-subject cross over trial of four weeks of standard clinical care (SCC) in an outpatient substance use disorder treatment program and four weeks of SCC and varenicline among current and former…
- Trial name
- NCT04595318
- Testing
- Standard clinical care first, followed by standard clinical care and varenicline, Standard clinical care and varenicline first, followed by standard clinical care
- Volunteers
- 7 people
- Sponsor
- Albert Einstein College of Medicine
Alcohol Abuse, Tobacco Use Disorder
Screening to Augment Referral to Treatment- Project START
The investigators propose to use obstetric-gynecological clinics to conduct a randomized clinical trial that would compare two SBIRTS (Screening, Brief Intervention, Referral and Treatment), delivered either by a trained nurse or…
- Conditions
- Alcohol Abuse, Tobacco Use Disorder, Marijuana Abuse, Substance-Related Disorders
- Trial name
- ProjectSTART (NCT01539525)
- Testing
- Motivational Interview, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 439 people
- Sponsor
- Yale University
Pain, Cannabis
Enhancing Medication-based Analgesia in Humans- STUDY 2
This is a single-group, within-subject, double-blind, double-dummy, placebo and active-controlled study evaluated whether the FDA-approved cannabinoid cannabidiol (CBD; Epidiolex) would enhance analgesia, subjective reports, and…
- Conditions
- Pain, Cannabis, Opioid Use
- Trial name
- NCT04036968
- Testing
- Within-subject test of blinded study medications
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use Disorder, Attention-deficit/Hyperactivity Disorder
Treatment of Cannabis Use Disorder Among Adults With Comorbid Attention-Deficit/Hyperactivity Disorder
The proposed protocol is a double-blind, placebo-controlled outpatient study of the safety and benefit of Extended-release mixed amphetamine salt (Adderall-XR, MAS-XR) in the treatment of individuals with Cannabis Use Disorder…
- Trial name
- MJ-ADHD (NCT02803229)
- Testing
- Adderall-XR
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Use Disorder
Effect of Clonazepam on Cannabis Withdrawal and Relapse in Treatment-seeking Patients
The proposed protocol is a double-blind, placebo-controlled inpatient and outpatient study,looking at the clinical treatment of cannabis use disorder. The treatment study is a total of 12 weeks.
- Trial name
- NCT02913924
- Testing
- Clonazepam
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- New York State Psychiatric Institute
Smoking Cessation, Marijuana Use
Project CheckUP: A Brief Behavioral Intervention for Quitline Callers Who Use Marijuana (MJ) and Tobacco
Smoking cigarettes remains the number one preventable cause of death and disease in the US. Smokers who call tobacco quitlines and use marijuana struggle to quit tobacco due to the interactive effects of nicotine and marijuana.
- Trial name
- NCT04737772
- Testing
- Behavioral: Quitline treatment as usual, QL Marijuana Check-Up intervention (QL-MJCU)
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Consumer Wellness Solutions
Alcohol Drinking, Marijuana Smoking
Motivation and Skills for Delta-9-tetrahydrocannabinol/Ethanol (THC/ETOH+) Teens in Jail
This study will focus on treating substance abusing incarcerated teens using individually administered Motivational Interviewing (MI) followed by group Cognitive Behavior Therapy (CBT).
- Trial name
- SMART (NCT00506753)
- Testing
- MI/CBT, RT/SU
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Pregnancy, Cannabis
Development of a Lifestyle Physical Activity Intervention to Reduce Risk for Perinatal Cannabis Use
This study will recruit 20 women who are high risk for prenatal cannabis use for a 12-week program of using the tracker and receiving a Lifestyle Physical Activity program.
- Trial name
- NCT05528380
- Testing
- LPA + Fitbit Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Butler Hospital
Cannabis Dependence, Cannabis Withdrawal
Gabapentin Treatment of Cannabis Dependence
This is a clinical study to evaluate the efficacy of the medication gabapentin in treating persons with cannabis dependence.
- Conditions
- Cannabis Dependence, Cannabis Withdrawal, Cognitive Deficits
- Trial name
- NCT00974376
- Testing
- gabapentin 1200mg/day, Manual-guided behavioral counseling
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The Scripps Research Institute
Marijuana Smoking
Effects of Dronabinol (Oral THC) on Cannabis Use
Study participants received dronabinol (0, 120mg/day and 240mg/day) for 12 consecutive days in a randomized order. During each dronabinol maintenance period they were able to self-administer active or placebo cannabis using…
- Trial name
- NCT01394185
- Testing
- Dronabinol 120mg/day, Dronabinol 240mg/day
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University