Clinical trials: Capsule Opacification
Cataract Surgery
A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery
The primary objective was to demonstrate that two days of treatment with 0.5% prednisolone acetate eye-drops after cataract surgery are superior to vehicle in reducing the flare in the anterior chamber of the operated eye.
- Trial name
- NCT00170729
- Testing
- Prednisolone acetate
- Volunteers
- 62 people
- Sponsor
- Novartis
Postoperative Complications, Cataract
Safety and Efficacy Study of Topical Bromfenac Versus Placebo to Treat Ocular Inflammation After Cataract Surgery
The primary objective of this study was to investigate the efficacy of bromfenac sodium ophthalmic solution 0.09% for treatment of post-operative ocular inflammation in subjects who undergo cataract extraction and intraocular…
- Trial name
- NCT00198445
- Testing
- Bromfenac
- Where
- 39 sites in United States
- Volunteers
- 527 people
- Sponsor
- Bausch & Lomb Incorporated
Inflammation
Study of Difluprednate Ophthalmic Emulsion in the Treatment of Postoperative Inflammation
The purpose of this phase 2 study is to determine if difluprednate ophthalmic emulsion is effective in the treatment of postoperative inflammation.
- Trial name
- NCT00407225
- Testing
- Difluprednate Ophthalmic Emulsion
- Volunteers
- 24 people
- Sponsor
- Sirion Therapeutics, Inc.
Macular Edema
A Clinical Safety and Efficacy Comparison of NEVANAC 0.1% to Vehicle After Cataract Surgery in Diabetic Retinopathy Patients
The purpose of this study is to determine whether nepafenac is safe and effective for reducing the incidence of macular edema following cataract surgery in diabetic retinopathy patients.
- Trial name
- NCT00782717
- Testing
- Nepafenac ophthalmic suspension, 0.1% (NEVANAC), Nepafenac ophthalmic suspension vehicle, Prednisolone acetate ophthalmic suspension (OMNIPRED)
- Volunteers
- 263 people
- Sponsor
- Alcon Research
Low Vision, Age Related Macular Degeneration
Early Feasibility Study Using IOPCL MAG to Improve Near Vision in ARMD Subjects
This early feasibility study aims to improve near vision in subjects 55 years or older who have a clinical diagnosis of Age-Related Macular Degeneration.
- Trial name
- NCT04984590
- Testing
- IOPCL AMD MAG
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- OnPoint Vision Inc
Cataract
Clinical Results of Asqelio™ EDOF Toric Soft Hydrophobic Intraocular Lens After Cataract Surgery
The goal of this observational study is to assess the clinical outcomes of binocular implantation of Asqelio EDOF Toric IOLs in healthy cataract patients.
- Trial name
- NCT06229756
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AST Products, Inc.
Cataract After
Patient Acceptability of Autonomous Telemedicine
Patients will have an automated call supervised by a human clinician to check how they are after uncomplicated cataract surgery as part of their standard of care.
- Trial name
- NCT04885868
- Testing
- This study assess acceptability of autonomous conversation as part of cataract surgery follow up.
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ufonia
IOL, Cataract
Post-Market Clinical Follow-Up Study on the Rotational Stability of an Intraocular Lens After Cataract Surgery
The goal of this post-market, prospective study at multiple clinics is to evaluate the rotational stability of the RayOne Model RAO800S non-toric monofocal intraocular lens with orientation marks in adult patients undergoing…
- Trial name
- NCT07099079
- Volunteers
- 92 people
- Sponsor
- Rayner Intraocular Lenses Limited
Refractive Errors
Early Feasibility Study to Evaluate the AccuraSee in Correcting Residual Refractive Errors After Cataract Surgery
To determine if the intraocular pseudophakic contact lens (IOPCL), referred to as the AccuraSee, corrects residual refractive errors after cataract surgery using a plus powered lens in subjects with ocular pathology previously…
- Trial name
- NCT05113979
- Testing
- AccuraSee IOPCL with +3.0D add
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- OnPoint Vision Inc
Endothelial Cell Density Loss
Study of Endothelial Cell Condition After Cataract Surgery Performed Using Capsulorhexis or ZEPTO
This study will use images of the subjects' corneal endothelium obtained using non-invasive specular microscopy to obtain corneal endothelial cell density, the coefficient of variation in endothelial cell size, and the percentage…
- Trial name
- ZEPTO (NCT04882189)
- Testing
- Imaging
- Where
- 4 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centricity Vision, Inc.
Post Ocular Surgical Inflammation and Pain
Phase 3 Study Evaluating Safety and Efficacy of OTX-DP for Treatment of Ocular Inflammation and Pain After Cataract Surgery
To evaluate the safety and efficacy of OTX-DP as a sustained release drug (dexamethasone) depot when placed in the canaliculus of the eyelid for the treatment of post-surgical inflammation and pain in subjects who have undergone…
- Trial name
- NCT02034019
- Testing
- Dexamethasone, Punctum Plug
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- Ocular Therapeutix, Inc.
Ocular Inflammation
Safety and Efficacy Study of rEV131 in the Treatment of Ocular Inflammation After Cataract Surgery
The purpose of this study is to evaluate the safety and effectiveness of three concentrations of rEV131, a new investigational anti-inflammatory agent, compared to placebo (an inactive substance) and an FDA approved…
- Trial name
- NCT00353964
- Testing
- rEV131, Prenisolone sodium phosphate 1.0%, rEV131 vehicle
- Where
- United States
- Sponsor
- Evolutec Group
Inflammation, Cataract
A Real-world Study of DEXYCU in the Treatment of Inflammation After Cataract Surgery
This is a prospective, real-world study aimed to evaluate the efficacy and safety of Dexycu in treating postoperative inflammation of cataracts.
- Trial name
- NCT06497699
- Testing
- Dexycu
- Where
- 2 sites in China
- Volunteers
- 263 people
- Sponsor
- Ocumension Therapeutics (Shanghai) Co., Ltd
Cataracts Infantile
Clobetasol Propionate Ophthalmic Nanoemulsion, 0.05% in the Treatment of Inflammation After Cataract Surgery in Pediatric Population
Multicenter, randomized, evaluator-blinded clinical trial compared to Prednisolone acetate, 1% in the treatment of inflammation and pain after cataract surgery in pediatric population.
- Trial name
- CLOSE-3 (NCT05724446)
- Testing
- Clobetasol Propionate, Prednisolone acetate ophthalmic suspension, 1%
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Salvat
Posterior Capsule Opacification
Posterior Capsule Opacification Following Cataract Surgery With Implantation of the MICS IOL L313
This study collects intra- and postoperative data from the patients´charts retrospectively and evaluates retro- and prospectively the rate of posterior capsule opacification (PCO) following implantation of the intraocular lens L…
- Trial name
- NCT03184428
- Testing
- Postoperative observation and survey
- Where
- Germany
- Volunteers
- 3,785 people
- Sponsor
- Dietrich-Bonhoeffer-Klinikum
Post-Surgical Ocular Pain, Post-Surgical Ocular Inflammation
OTX-15:003: A Phase 3 Study Evaluating the Safety and Efficacy of OTX-DP for the Treatment of Ocular Inflammation and Pain After Cataract Surgery
The objective of the study was to evaluate the safety and efficacy of OTX-DP (dexamethasone insert) 0.4 mg for intracanalicular use when placed in the canaliculus of the eyelid for the treatment of post-surgical inflammation and…
- Trial name
- NCT02736175
- Testing
- Dexamethasone
- Volunteers
- 438 people
- Sponsor
- Ocular Therapeutix, Inc.
Cataract
Confirmatory Study Nepafenac 0.3%
The purpose of this study was to assess the safety and efficacy of an investigational eye drop intended for the prevention and treatment of inflammation (swelling and redness) and pain in the eye after cataract extraction.
- Trial name
- NCT01109173
- Testing
- Nepafenac Ophthalmic Suspension, 0.3%, Nepafenac Ophthalmic Suspension, 0.1%, Nepafenac Ophthalmic Suspension 0.3% Vehicle
- Where
- United States
- Volunteers
- 2,120 people
- Sponsor
- Alcon Research
Cataracts
Show Improved Vision With the HOYA AF-1 Aspheric Intraocular Lens After Cataract Surgery
The doctors participating in this study are looking to show improved vision with the HOYA AF-1 aspheric intraocular lens after cataract surgery.
- Trial name
- NCT01382641
- Testing
- Hoya AF-1 IOL, Revital vision
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Innovative Medical
Cataract
Evaluation of Safety and Performance of the EyenableTM Intraocular Lens for Cataract Treatment
Cataract is characterized by the loss of the normal transparency of the crystalline lens. It is a progressive, chronic disease that affect individuals over the age of 50. It is the leading cause of blindness around the world.
- Trial name
- NCT06223113
- Testing
- EyenableTM PA60AS1 IOL
- Volunteers
- 200 people
- Sponsor
- Xi'an Eyedeal Medical Technology Co., Ltd
Inflammation
Phase 2: VVN461 Ophthalmic Solution for Post -Operative Ocular Inflammation After Cataract Surgery
This is a multicenter, double-masked, randomized, vehicle-controlled, parallel-comparison study conducted at sites in the United States (US) in subjects undergoing routine unilateral cataract extraction and lens replacement…
- Trial name
- NCT06164743
- Testing
- VVN461 Ophthalmic Solution 1.0%, VVN461 Ophthalmic Solution 0.5%, Vehicle
- Where
- 10 sites in United States
- Volunteers
- 91 people
- Sponsor
- VivaVision Biotech, Inc