Clinical trials: Carbapenems
Severe Sepsis, Carbapenem Resistant Bacterial Infection
Clinical Study on Monitoring the Plasma Concentration of Ceftazidime-Avibactam in Critically Ill Patients
This prospective observational study is conducted at the First Affiliated Hospital of Zhejiang University School of Medicine from June 1, 2021 to January 1, 2024.
- Trial name
- NCT05413343
- Testing
- Ceftazidime-avibactam
- Where
- China
- Volunteers
- 33 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Infection, Bacterial
Clinical Outcomes of Hypervirulent Carbapenem-resistant Klebsiella Pneumoniae Infection
The goal of this observational study is to learn about the risk factors of mortality for CRKP infected patients, and to compare the clinical outcomes between hvCRKP infection and cCRKP infection.
- Trial name
- HVCRKP (NCT06190548)
- Where
- China
- Volunteers
- 556 people
- Sponsor
- West China Hospital
Blood Stream Infections, Ventilator Associated Pneumonia
EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics
RAPID is an investigator initiated Phase 4, multinational, multicentre, open-label, randomised controlled superiority trial evaluating the clinical impact of rapid microbiological diagnostics combined with antimicrobial…
- Conditions
- Blood Stream Infections, Ventilator Associated Pneumonia, Healthcare Associated Infection, Carbapenem-Resistant Enterobacteriaceae Infection
- Trial name
- RAPID (NCT05979545)
- Testing
- Rapid Diagnostics
- Where
- 21 sites in India, Malaysia and 5 more
- Volunteers
- 1,526 people
- Sponsor
- National University of Singapore
Pneumonia, Pneumonia, Ventilator-Associated
PROUD Study: A Prospective Study on the Usage Patterns of Doripenem in the Asia Pacific Region
The purpose of this study is to understand the utilization patterns of doripenem in Asia Pacific, including the profile of the patients treated with carbapenems.
- Conditions
- Pneumonia, Pneumonia, Ventilator-Associated, Urinary Tract Infections
- Trial name
- NCT00986102
- Testing
- doripenem
- Where
- 16 sites in Hong Kong, Indonesia and 3 more
- Volunteers
- 216 people
- Sponsor
- Janssen Research & Development, LLC
Carbapenem-Resistant Enterobacteriaceae Infection
Fecal Microbiota Transplantation for Carbapenem Resistant Enterobacteriaceae
Open-label, single center, prospective interventional non-comparative study for CRE carriers.
- Trial name
- NCT04790565
- Testing
- FMT
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Rambam Health Care Campus
Klebsiella Pneumoniae Carbapenemase Resistant Associated Bacteremia or Pneumonia
A Study Evaluating the Role of Oral Antibiotics in an Aim to Eradicate Carrier State of Carbapenem- Resistant Klebsiella Pneumonia (KPC).
Klebsiella pneumonia, inhabitant of the digestive tract, is a frequent nosocomial pathogen. It is currently the fourth most common cause of pneumonia and fifth most common cause of bacteremia in intensive care patients (1-3).
- Trial name
- NCT01266499
- Testing
- Colistin (Polymyxin E) 100mg x 4/d, both medications, will not receive PO treatment
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Rambam Health Care Campus
Carbapenem-Resistant Enterobacteriaceae Infection
Ceftazidime-Avibactam Use in Critically Ill Patients With Carbapenem-Resistant Enterobacteriaceae Infections
Carbapenem-Resistant Enterobacteriaceae (CRE) infections are a growing national and international challenge in healthcare settings.
- Trial name
- AVI-ICU (NCT05258851)
- Testing
- Ceftazidime-avibactam, Colistin
- Where
- Saudi Arabia
- Volunteers
- 29 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Enterobacteriaceae Infections, Carrier State
Study of Probiotic Adjunctive Therapy for Decolonization of Carbapenem-Resistant Enterobacterales
To evaluate the efficacy of probiotic preparations as adjunctive therapy for the decolonization of intestinal carbapenem-resistant organisms (CRO), in comparison with conventional antibiotic therapy alone, with the primary…
- Trial name
- NCT07707869
- Testing
- Probiotic Preparation, Conventional Antibiotic
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Carbapenem-resistant Hypervirulent Klebsiella Pneumoniae Infection
Impact of Siderophore Genes on Cefiderocol Susceptibility in Carbapenem Resistant Hypervirulent Klebsiella Pneumoniae
1. Sample: Clinical specimens (blood, urine, sputum, wound swabs) will be collected aseptically and transported to the microbiology laboratory for analysis. 2.
- Trial name
- NCT07475429
- Testing
- Cefiderocol susceptibility testing
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Infections, Bacterial
Gram-negative Bacilli and MRSA Screening in ICU in China
Carbapenem-resistant Gram-negative bacilli [Carbapenem-resistant Acinetobacter baumannii (CRAB), Carbapenem-resistant Klebsiella pneumoniae (CRKP), and Carbapenem-resistant Pseudomonas aeruginosa (CRPsA) ] and…
- Trial name
- NCT04310722
- Testing
- None intervention. This is an observational study.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sir Run Run Shaw Hospital
Klebsiella Pneumoniae Infection
WGS-guided Tracking and Infection Control Measures of CRKP
The objective of this study is to investigate the effect of the infection control measures based on the active screening of carbapenem-resistant Klebsiella pneumoniae and whole-genome based tracking and surveillance though the…
- Trial name
- NCT04413305
- Testing
- screen of CRKP and infection control measure
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Huashan Hospital
Carbapenem-Resistant Enterobacteriaceae
Clinical Validation of the Molecular-Based GenePOC Carba Assay for the Detection and Differentiation of Carbapenemase Genes in Rectal Swab Samples.
The primary purpose of this clinical investigation is to establish the performance of the GenePOC Carba assay on the revogene. This will be achieved by comparing the test to a conventional method for detection of Carbapenemase…
- Trial name
- NCT03680898
- Testing
- Rectal swab collection
- Where
- 3 sites in United States, Canada
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Meridian Bioscience, Inc.
Hospital Acquired Pneumonia, Ventilator Acquired Pneumonia
Real-World Study of Ceftazidime Avibactam in China
This observational study will enroll approximately 450 in patients. Patients treated with CAZ AVI for at least 1 dose at around 20 research centers in China will be enroll.
- Conditions
- Hospital Acquired Pneumonia, Ventilator Acquired Pneumonia, Complicated Intra Abdominal Infections
- Trial name
- REACT (NCT05487586)
- Testing
- ceftazidime avibactam group
- Where
- 17 sites in China
- Volunteers
- 220 people
- Sponsor
- Pfizer
Bacterial Infections
A Retrospective Study on Personalized Dosing Strategy of Patients Treated by Carbapenems: 2018-2021
Patients may benefit from the personalized carbapenem dosing strategy based on pharmacokinetics. The objective of this study is to retrospectively review and analyze the clinical outcomes of patients with different dosing…
- Trial name
- NCT05762094
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Antibiotic Therapy
Evaluating a Novel Individualised Treatment Strategy for Carbapenem-Resistant Gram-Negative Bacteria Infections
Carbapenem-resistant (CR) Gram negative bacteria (GNB) - which are resistant to carbapenems (a last-line potent antibiotic with a high therapeutic index) - are also resistant to all other beta-lactam antibiotics.
- Trial name
- NCT04202861
- Testing
- In vitro antibiotic combination testing (iACT)
- Where
- Singapore
- Volunteers
- 594 people
- Sponsor
- Singapore General Hospital
Enterobacteriaceae Infections, Multi-antibiotic Resistance
FMT for the Decolonization of Carbapenem-resistant Enterobacteriaceae
Rates of antimicrobial resistance are increasing worldwide. There is increasing evidence that physiological gut microbiota is a large reservoir of antibiotic-resistance genes.
- Trial name
- FMT-CRE (NCT04759001)
- Testing
- Donor FMT
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Carbapenem Resistant Bacterial Infection
Machine Learning in the ICU: Predicting Mortality in Bloodstream Infections (ICU:Intensive Care Unit)
Using our own patient data, our study aimed to predict mortality that can develop in Carbapenem-resistant Gram-negative bacilli bloodstream infections with a machine learning-based model.
- Trial name
- ICU (NCT06167083)
- Testing
- Machine Learning to Estimate Mortality
- Where
- Turkey (Türkiye)
- Volunteers
- 197 people
- Sponsor
- Kocaeli University
Antibiotic Resistant Strain, Microbial Colonization
Fecal Microbiota Transplantation for Eradication of Carbapenem-resistant Enterobacteriaceae Colonization
Antibiotic resistance has emerged world wide and is of major concern. Multidrug resistant (MDR) bacteria is widely spread and is now a major factor in morbidity and mortality in health-care settings.
- Trial name
- NCT03391674
- Testing
- Fecal Microbiota Transplantation
- Where
- Israel
- Sponsor
- Rambam Health Care Campus
Infection Due to Carbapenem Resistant Acinetobacter
Colistin Monotherapy vs Colsitin-fosfomycine in CRAB Infection
The goal of this clinical trial is to evaluate the efficacy of colistin compared with colistin plus fosfomycin against carbapenem-resistant Acinetobacter baumanii infection in Thailand.
- Trial name
- NCT06570850
- Testing
- Colistin Sodium Methanesulfonate, Colistin Sodium Methanesulfonate plus Fosfomycin
- Where
- Thailand
- Volunteers
- 188 people
- Sponsor
- Chiang Mai University
Sepsis
Comparison Between Carbapenems and Noncarbapenem Beta-lactam Antibiotics in Septic Burn Patients
The aim of this work is to evaluate the efficacy associated with Meropenem(example of carbapenems) as initial therapy for sepsis in burn patients compared with Pipracillin/Tazobactam (example of non carbapenem beta lactam…
- Trial name
- NCT07096310
- Testing
- Meropenem I.V. 2g as a 3 hour infusion every 8 hours, Tazocin (pipercillin/tazobactam)
- Where
- Egypt
- Volunteers
- 400 people
- Sponsor
- Ain Shams University