Clinical trials: Carbon Dioxide
Peritoneal Inflammation, Peritoneum; Injury
Effect of Warmed Humidified CO2 on Peritoneum During Laparotomy
The operating theatre is deliberately made to be cold and dry to prevent bacteria from growing. The problem with this is that during open abdominal surgery, the intestine and the overlying peritoneum is exposed to cold dry air.
- Trial name
- NCT02975947
- Testing
- Humidified, warmed CO2 insufflation of open peritoneum using Fisher & Paykel's HUMIGARD (Fisher & Paykel Healthcare Ltd, Auckland, New Zealand), Standard heating
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Concord Repatriation General Hospital
Hyperventilation Syndrome, Hypocapnia
Comparison of Transcutaneous Vs End-tidal CO2 Pressure Measurements in Hyperventilation Syndrome Diagnosis
Hyper Ventilation Syndrome is a frequent disease affecting adults whose diagnosis is often belated or even unrecognized due to the lack of "gold standard" criteria.
- Conditions
- Hyperventilation Syndrome, Hypocapnia, Alkalosis, Respiratory, Hyperventilation
- Trial name
- TCvsPETCO2 (NCT03614806)
- Testing
- Simultaneous Transcutaneous and End-tidal CO2 measurements
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Rouen
Abdominal Aortic Aneurysm
An Innovative Approach to Automated Carbon Dioxide Angiography During Endovascular Abdominal Aortic Aneurysm Repair
The study aims to perform Endovascular Aortic Repair procedures with CO2-Angiography using a standardized an operative Protocol
- Trial name
- CO2-EVAR (NCT04721951)
- Testing
- Endovascular Aortic Repair using Carbon Dioxide Angiography
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- University of Bologna
Melasma
Evaluation of Laser and Tranexamic Acid in Treatment of Melasma
Melasma Is an acquired, chronic, recurrent, symmetrical hypermelanosis, which is characterized by brown patches of variable darkness on sun exposed areas of the body. It is more common in women.
- Trial name
- NCT04599205
- Testing
- Tranexamic acid
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Trauma
Tissue Perfusion Indices as Predictor of Outcome in Poly Trauma Patients
Early intervention and resuscitation based upon a lot of clinical, laboratory findings make a big difference regarding outcome in poly trauma patients, the study uses the dynamic lactate change and the difference between arterial…
- Trial name
- NCT02727946
- Testing
- optimal resuscitation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Scar Prevention
Scar Prevention Using Fractional Carbon Dioxide Laser Treatment
In this study the investigators intend to determine the impact of fractional CO2 laser treatment on the edges of a fresh wound during surgical area closure on thin skin (e.g.
- Trial name
- NCT01826942
- Testing
- Lumenis UltraPulse single fractional CO2 laser treatment thin skin, Single fractional CO2 treatment at surgical area closure procedure on thick skin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lumenis Be Ltd.
Anesthesia
The Influence of Two Different CO2 Absorbers on Sevoflurane Consumption During Anaesthesia
Traditional sodalime CO2 absorbers are known to not only react with CO2 but also with sevoflurane. Therewith, a potentially harmful compound (compound A) is formed that can be nephrotoxic.
- Trial name
- NCT04271462
- Testing
- Comparing two CO2 absorbers in the ventilator circuit
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Postoperative Respiratory Complications
The Clinical Value of Applying TOF and TcPO2 to Guide Elderly Patients Extubation
Three hundred aged(age>65y) patients were randomized to Commom group(C group). Qualitative TOF monitoring (TOF group). Qualitative TOF and transcutaneous partial pressure of carbon dioxide monitoring(Unite group).
- Trial name
- NCT02327910
- Testing
- TOF unit TcPCO2 group, TOF group
- Volunteers
- 300 people
- Sponsor
- Beijing Municipal Science & Technology Commission
Post Anesthesia Care Optimaization
Agreements Between Transcutaneous and Arterial Monitoring of Oxygen and Carbon Dioxide After Non-cardiac Surgery
The primary aim of the study is to describe the association between changes in TcO2 and TcCO2 and interventions such as blood transfusion, fluid therapy, respiratory support, use of vasopressors, analgesics, and adverse events…
- Trial name
- NCT04735380
- Testing
- TCM-5 Flex monitor connected to a Sensor 84 (Radiometer Medical Aps, Brønshøj, Denmark)
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Aortic Aneurysm
CO2 Automated Angiographies With Fusion Imaging for Zero- or Near Zero- Contrast FEVAR.
Fenestrated endovascular aneurysm repair (FEVAR) is an established technique used to treat complex aortic aneurysms (TAAAs), with satisfactory early and midterm results.
- Trial name
- NCT06337890
- Testing
- Zero contrast FEVAR
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Bologna
Patient Monitoring
Non-invasive Carbon Dioxide Monitoring and Endoscopic Retrograde Cholangiopancreatography Patients
CO2 monitoring through non-invasive methods to provide an early warning of hypoventilation during procedural sedation.
- Trial name
- NCT04481308
- Testing
- propofol (2 mg/kg) and fentanyl (1ug/kg) and 4 liters O2 flow through nasal cannula
- Where
- 2 sites in Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Conscious Sedation During Procedure, Ablation of Arrhythmias
Transcutaneous Carbon-dioxide Monitoring in Electrophysiological Procedures in Deep Sedation
Complex procedures for treatment of cardiac arrhythmias are usually performed under deep sedation, since a quiet position of the patient is usually required over several hours and a significant risk of injury is caused by…
- Trial name
- TRACES (NCT04038476)
- Testing
- Standard monitoring + transcutaneous CO2 monitoring, Standard monitoring
- Where
- Germany
- Volunteers
- 726 people
- Sponsor
- University of Ulm
Coronary Artery Disease
CO2 as a Stress Agent for Perfusion Imaging
Myocardial perfusion imaging (MPI) is a nuclear scan using a radioisotope to see blood flow to the muscles of the heart when the heart is at rest and when it is under stress.
- Trial name
- CO2 STRESS (NCT02043535)
- Testing
- Delivery of precise levels of carbon dioxide with the RA-MR™ Virtual Sequential Gas Delivery System., Delivery of rubidium radioisotope (Rb-82) using the automated pump/elution system
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Post-Acne Atrophic Scars, Carbon Dioxide Lasers
PRP Plus Fractional CO₂ Laser for Acne Scars
This randomized controlled trial aims to evaluate whether adding platelet-rich plasma (PRP) to fractional CO₂ laser resurfacing improves the treatment of moderate-to-severe acne scars compared with laser alone.
- Conditions
- Post-Acne Atrophic Scars, Carbon Dioxide Lasers, Platelet-Rich Plasma
- Trial name
- PRPLT (NCT07352215)
- Testing
- Fractional CO₂ Laser + Platelet-Rich Plasma (PRP), Fractional CO₂ Laser Only
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Gujranwala medical college District Headquarters Hospital, Gujranwala
Hypothermia
Effects of Warmed, Humidified CO2 Insufflation on Body Core Temperature and Cytokine Response
The aim of this study is to assess if the conditioning of the insufflation carbon dioxide (CO2) allows for an additional benefit in terms of prevention of the heat loss, when compared with the usual prevention with a forced warm…
- Trial name
- NCT02586974
- Testing
- Humigard
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Lung Cancer (Diagnosis), Lobectomy
Simplified Exercise-based Risk Assessment in Lung Cancer
Physiological evaluation is part of the preoperative risk estimation in patients with lung cancer, and it aids in the choice of treatment.
- Conditions
- Lung Cancer (Diagnosis), Lobectomy, Surgery Complications, Neoadjuvant Chemoimmunotherapy
- Trial name
- EXHALE-CO2 (NCT07506889)
- Where
- 5 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Linkoeping University
Exposure Laser
Evaluation of the Safety and Efficacy of Carbon Dioxide (CO2) Acupulse Laser Treatment on Urinary Stress Incontinence.
The study is intended to assess the safety and efficacy of CO2 AcuPulse laser treatment in patients with stress urinary incontinence (SUI).
- Trial name
- NCT02861391
- Testing
- CO2 AcuPulse Laser
- Where
- Israel
- Volunteers
- 125 people
- Sponsor
- Rambam Health Care Campus
Scars
Burn Scar Appearance After Treatment With Fractional Carbon Dioxide (CO2) Laser
The purpose of this study is to determine if fractional carbon dioxide laser treatment of a burn scar is a more effective method for improving the appearance of scars than the current available treatments.
- Trial name
- NCT00969215
- Testing
- Lumenis fractional carbon dioxide laser
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Moy-Fincher Medical Group
Infant, Very Low Birth Weight, Infant, Premature, Diseases
Regulation of Cerebral Blood Flow in Very Low Birth Weight Infants
Advances in newborn intensive care have lead to dramatic improvements in survival for the most premature infants-often weighing 1 pound at birth.
- Conditions
- Infant, Very Low Birth Weight, Infant, Premature, Diseases, Cerebral Hemorrhage
- Trial name
- NCT00579943
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Arkansas
Overweight
Study of the Carbon Dioxide Treatment for Fat Reduction
The primary objective of this study is to demonstrate the efficacy and safety of the carbon dioxide for subcutaneous fat reduction.
- Trial name
- NCT00974415
- Testing
- CO2
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northwestern University