Clinical trials: Carcinoma, Basal Cell
Basal Cell Carcinoma of the Skin, Pain
Photodynamic Therapy Using Methyl-5-Aminolevulinate Hydrochloride Cream in Determining Pain Threshold in Patients With Skin Cancer
RATIONALE: Photodynamic therapy uses a drug that becomes active when it is exposed to a certain kind of light. When the drug is active, cancer cells are killed.
- Conditions
- Basal Cell Carcinoma of the Skin, Pain, Recurrent Skin Cancer
- Trial name
- NCT01292668
- Testing
- methyl-5-aminolevulinate hydrochloride cream, photodynamic therapy, laser therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Roswell Park Cancer Institute
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer
Bevacizumab may reduce CNS side effects caused by radiation therapy. This randomized phase II trial is studying how well bevacizumab works in reducing CNS side effects in patients who have undergone radiation therapy to the brain…
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Meningioma, Adult Anaplastic Oligodendroglioma
- Trial name
- NCT00492089
- Testing
- bevacizumab, magnetic resonance imaging, quality-of-life assessment
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Basal Cell Carcinoma
Pilot Study of Line-Field Confocal Optical Coherence Tomography for Detection of Mohs Micrographic Surgery Margins of Basal Cell Carcinomas
To assess the feasibility and provide information on the utility of noninvasive line field confocal optical coherence tomography (LC-OCT) for the presurgical assessment of Mohs micrographic surgery sites in patients undergoing…
- Trial name
- NCT07182240
- Testing
- LC-OCT Imaging
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Roswell Park Cancer Institute
Basal Cell Carcinoma
PDT With Metvix 160 mg/g Cream Versus PDT With Placebo Cream in Participants With Primary Nodular Basal Call Carcinoma
Photodynamic therapy (PDT) was the selective destruction of abnormal cells through light activation of a photosensitiser in the presence of oxygen. These cells accumulated more photosensitiser than normal cells.
- Trial name
- NCT00472043
- Testing
- PDT with Metvix 160 mg/g cream
- Where
- 7 sites in Australia
- Volunteers
- 66 people
- Sponsor
- Galderma R&D
Basal Cell Carcinoma
Reflectance Confocal Microscopy to Diagnose BCC
It is proposed to undertake a study to determine the diagnostic utility of using RCM for the diagnosis of Basal Cell Carcinoma (BCC) in a tertiary referral centre as outlined by the recent NICE report (Nov 2015).
- Trial name
- NCT03509415
- Testing
- In-vivo imaging
- Where
- United Kingdom
- Volunteers
- 324 people
- Sponsor
- Skin Care Network Ltd.
Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma
Intralesional Cemiplimab for Adult Patients With Cutaneous Squamous Cell Carcinoma or Basal Cell Carcinoma
This study is researching an experimental drug called cemiplimab. The study is focused on Cutaneous Squamous Cell Carcinoma (CSCC) and Basal Cell Carcinoma (BCC).
- Trial name
- NCT03889912
- Testing
- Cemiplimab
- Where
- 18 sites in United States, Australia and 1 more
- Volunteers
- 97 people
- Sponsor
- Regeneron Pharmaceuticals
Basal Cell Carcinoma
Topical Itraconazole in the Treatment of Basal Cell Carcinoma
This research is being done to study the molecular effects of topically applied itraconazole ointment on the growth of basal cell carcinomas.
- Trial name
- NCT02120677
- Testing
- Itraconazole
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
BCC - Basal Cell Carcinoma, BCC
CellFX Treat & Resect Low-Risk BCC Feasibility Study
This prospective, multicenter, study is designed to evaluate the safety and effectiveness of the CellFX System in adults subjects with low-risk basal cell carcinoma (superficial and nodular) for complete histological clearance of…
- Conditions
- BCC - Basal Cell Carcinoma, BCC, Excision Margin
- Trial name
- NCT04918381
- Testing
- CellFX System
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pulse Biosciences, Inc.
Treatment for Basal Cell Carcinomas (BCCs) in Gorlin Syndrome Patients
A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients
Part I was a double-blind, randomized, vehicle-controlled Proof of Concept (PoC) study to evaluate the safety, local tolerability, pharmacokinetics and pharmacodynamics of multiple topical administrations of LDE225 (a specific…
- Trial name
- NCT00961896
- Testing
- Vehicle, LDE225 0.25%, LDE225 0.75%
- Where
- 3 sites in Austria, Switzerland
- Volunteers
- 18 people
- Sponsor
- Novartis Pharmaceuticals
Basal Cell Carcinoma, Optical Coherence Tomography
D-OCT for Detection and Subtyping of BCC: a Diagnostic Cohort Study
The current gold standard for diagnosing basal cell carcinoma (BCC) is the histopathological examination of biopsy specimen. However, non-invasive imaging modalities such as optical coherence tomography (OCT) may replace biopsy…
- Trial name
- NCT06273722
- Testing
- Vivosight Multi-beam Swept-Source Frequency Domain OCT scanner
- Volunteers
- 424 people
- Sponsor
- Maastricht University Medical Center
Basal Cell Carcinoma, Chondrosarcoma
IPI-926 Extension Protocol for Continuation of Treatment With IPI-926
A treatment protocol that enables patients to have continued access to IPI-926.
- Trial name
- NCT01609179
- Testing
- IPI-926
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Infinity Pharmaceuticals, Inc.
Basal Cell Carcinoma
Clinical Diagnosis of Basal Cell Carcinoma Subtype
Skin cancer is the most common cancer in Caucasians. Basal cell carcinoma (BCC) is the most frequent skin cancer with around 44.000 new tumours per year in the Netherlands, and its incidence is still rising.
- Trial name
- NCT01370824
- Testing
- Punch biopsy, Surgical excision
- Where
- 2 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Acute Leukemia, Adenomatous Polyposis
Familial Investigations of Childhood Cancer Predisposition
NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll.
- Conditions
- Acute Leukemia, Adenomatous Polyposis, Adrenocortical Carcinoma, AML
- Trial name
- SJFAMILY (NCT03050268)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- St. Jude Children's Research Hospital
Basal Cell Carcinoma
Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors
This is a prospective single-center, open label, pilot study to investigate the safety and efficacy of LDE225 in patients with locally advanced or metastatic basal cell carcinoma.
- Trial name
- NCT01529450
- Testing
- LDE225
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Anne Chang
Basal Cell Carcinoma
Assessment of the Clinic-pathological Correlation of Basal Cell Carcinoma
Assessment of the concordance of the initial clinical and histological diagnosis and to explore its prognostic impact in terms of risk of recurrence.
- Trial name
- CAC-CBC (NCT02825511)
- Where
- 17 sites in France
- Volunteers
- 2,738 people
- Sponsor
- University Hospital, Bordeaux
Head and Neck Cancer, Pain
Acupuncture or Standard Therapy in Treating Pain and Dysfunction in Patients Who Have Undergone Neck Surgery for Head and Neck Cancer
RATIONALE: Acupuncture may help relieve pain and dysfunction caused by cancer surgery. It is not yet known whether acupuncture is more effective than standard therapy in treating pain and dysfunction in patients who have…
- Trial name
- NCT00090337
- Testing
- acupuncture therapy, standard follow-up care
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Non-melanoma Skin Cancer
Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma
Vitamin D has a crucial role in cancer control and prevention.vitamin D receptor (VDR) and its heterodimer Retinoid X receptor (RXR) are equally important in the cell.
- Trial name
- NCT05550766
- Volunteers
- 50 people
- Sponsor
- Sohag University
Skin Cancers - Basal Cell Carcinoma, Skin Cancers - Squamous Cell Carcinoma
An Observational Study Using The LumAssure Device In Participants Undergoing Assessment Of Skin Conditions.
This is an observational study in adult males and females utilising skin condition measurements using the LumAssure Raman device.
- Conditions
- Skin Cancers - Basal Cell Carcinoma, Skin Cancers - Squamous Cell Carcinoma, Melanoma of Skin, Inflammatory Dermatoses
- Trial name
- NCT06661577
- Where
- 2 sites in New Zealand
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Basal Cell Carcinoma
Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Nodular Basal Cell Carcinoma
The purpose of this study is to determine whether topical application of PEP005 is safe for the treatment of nodular basal cell carcinoma.
- Trial name
- NCT00108121
- Testing
- PEP005
- Where
- 10 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Peplin
Locally Advanced Basal Cell Carcinoma, Basal Cell Carcinoma
Cemiplimab Plus Fianlimab for the Treatment of Locally Advanced Head and Neck Basal Cell Carcinoma Before Surgery
A non-randomized two-cohort study of neoadjuvant Cemiplimab or neoadjuvant Cemiplimab plus Fianlimab (CF) in patients with basal cell carcinoma of the head and neck.
- Trial name
- NCT05929664
- Testing
- Cemiplimab, Computed Tomography, Biospecimen Collection
- Where
- 3 sites in United States
- Volunteers
- 70 people
- Sponsor
- Thomas Jefferson University