Clinical trials: Carcinoma Breast
Heart Failure, Anthracycline-induced Cardiac Toxicity
Use of Dapagliflozin in Primary Prevention of Cardiotoxicity of Anthracycline Chemotherapy in Breast Cancer Patients
The goal of this randomized, double-blind, placebo-controlled clinical trial is to determine whether dapagliflozin, a sodium-glucose cotransporter-2 (SGLT-2) inhibitor, can help prevent anthracycline-induced cardiotoxicity caused…
- Conditions
- Heart Failure, Anthracycline-induced Cardiac Toxicity, Endothelial Function (FMD), Arterial Stiffness
- Trial name
- Alpaca (NCT07245069)
- Testing
- Dapagliflozin 10 mg
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Breast Cancer
A Non-interventional Study for Women With HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer to Evaluate the Real-world Effectiveness of Treatment Algorithms Beginning With Ribociclib + AI/FUL, or With Endocrine Therapy or Chemotherapy as First Line Treatment
This is a non-interventional observational study conducted in Germany to evaluate the real-world effectiveness, tolerability, safety, and quality of life in patients with locally advanced/metastatic HR+/HER2- breast cancer…
- Trial name
- RIBANNA (NCT06311383)
- Testing
- First-line Ribociclib + endocrine therapy, First-line endocrine therapy, First-line chemtherapy
- Where
- 265 sites in Germany
- Volunteers
- 2,610 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer Prevention
MELIORA Data Collection Campaigns
To support the development of the MELIORA digital app for the MELIORA main intervention, an initial pilot study (Data Collection Campaign, DCC) is being conducted with the three target participant groups: healthy women at…
- Trial name
- DCC (NCT07190066)
- Testing
- Data Collection campaign
- Where
- 7 sites in Greece, Lithuania and 2 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Early Stage Breast Cancer
Anti-proliferative Effects of Vitamin D and Melatonin in Breast Cancer
Investigators plan to carry out a study to investigate two different pills, Vitamin D and melatonin, and whether they can reduce the spread of cancer cells in the tumors of women with breast cancer.
- Trial name
- MELO-D (NCT01965522)
- Testing
- Melatonin, Vitamin D
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Juravinski Cancer Center
Breast Neoplasms
Biomarkers Investigation of Neoadjuvant Chemotherapy for Breast Cancer
The BINC-B trial is a diagnostic and interventional study in which various function imaging methods as Magnetic Resonance Imaging (PWI, DWI and DCE-MRI) and will be compared with common imaging methods (mammography and/or…
- Trial name
- BINC-B (NCT03242551)
- Testing
- Chemotherapy
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Shenzhen People's Hospital
Breast Cancer
Predicting Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Using Machine Learning Models.
This retrospective observational study aims to develop and validate a clinicopathology-based machine learning model to predict pathological complete response (pCR) following neoadjuvant chemotherapy in patients with breast…
- Trial name
- NCT07426653
- Volunteers
- 298 people
- Sponsor
- Florence Nightingale Hospital, Istanbul
CIPN - Chemotherapy-Induced Peripheral Neuropathy
The CONTRoL Trial: Cryotherapy vs. cOmpression Neuropathy TRiaL
The primary objective of this study is to select the best intervention from cold therapy, compression therapy and placebo at reducing neuropathic pain as measured by the change in the Neurotoxicity (NTX) component of the…
- Trial name
- CONTRoL (NCT03873272)
- Testing
- Cryotherapy, Compression Therapy, Loose glove/sock
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Columbia University
Breast Cancer
Study of Blood Samples From High-Risk Postmenopausal Women Who Received Treatment on Breast Cancer Prevention Clinical Trials NSABP-P-1 or NSABP-P-2
RATIONALE: Studying the genes expressed in samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00967239
- Testing
- DNA analysis, polymorphism analysis, laboratory biomarker analysis
- Volunteers
- 1,881 people, healthy volunteers welcome
- Sponsor
- NSABP Foundation Inc
Non-Metastatic Breast Cancer
Study of Chemotherapy-Induced Hair Changes and Alopecia, Skin Aging and Nail Changes in Women With Non-Metastatic Breast Cancer
The purpose of this study is to see how many patients develop hair, skin and nail changes due to cancer treatments. The investigators would like to study the clinical factors, genetic markers, and impact on patients'…
- Trial name
- NCT02530177
- Testing
- Clinical Assessments, Questionnaires, Saliva sample
- Where
- United States
- Volunteers
- 546 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Healthy
A Comparing Study Between ALT02(Trastuzumab Biosimilar) and Herceptin® in Healthy Subjects
The purpose of this study is to compare ALT02 (Trastuzumab biosimilar) and Herceptin® (US-licensed Trastuzumab and EU-licensed Trastuzumab) in healthy male subjects about the pharmacokinetics, safety, tolerability and…
- Trial name
- NCT03242239
- Testing
- ALT02, EU-licensed Herceptin, US-licensed Herceptin
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Alteogen, Inc.
Breast Cancer
Axillary Radiotherapy for Early Stage Breast Cancer With Limited Positive Sentinel Lymph Nodes
This study is designed to evaluate the feasibility and safety of axillary radiotherapy for early stage breast cancer with limited positive sentinel lymph nodes.
- Trial name
- NCT02612012
- Testing
- axillary radiotherapy
- Where
- China
- Volunteers
- 475 people
- Sponsor
- Fudan University
Breast Cancer
Cognitive Training and Exercise for Women With Breast Cancer and Cognitive Impairment
Chemotherapy-related cognitive impairment is a prevalent and distressing condition among breast cancer survivors, adversely affecting memory, attention, and overall cognitive function, thereby diminishing quality of life.
- Trial name
- CHEMO-CogEx (NCT07017530)
- Testing
- Cognitive training, Psychoeducational therapy
- Where
- Spain
- Volunteers
- 220 people
- Sponsor
- Universidad de Extremadura
Breast Cancer
Intensified IAA With PBPC Support in Breast Tumors With Evidence of a HRD
This phase II/III trial will investigate the ability of chemotherapy with 'Intensified Aklylating Agents (IAA) to achieve a high pathological complete response (pCR) rate when employed in the preoperative chemotherapy of breast…
- Trial name
- NCT00448266
- Testing
- Intensified Cyclophophamide, Carboplatin and Thiotepa, dose dense adriamycine and cyclophosphamide
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer
Endocrine Therapy Base on 21-gene RS
Among patients aged ≤50 years with hormone receptor-positive, HER2-negative breast cancer and pathologic nodal stage pN0-1-limited to those with an Oncotype DX® Recurrence Score (RS) of 11-25 for pN0 and ≤25 for pN1-, we will…
- Trial name
- CUSTOM (NCT07311122)
- Testing
- Oncotype DX
- Volunteers
- 4,000 people
- Sponsor
- Gangnam Severance Hospital
Arm Lymphedema, Breast Cancer
Lymphedema Evaluation After Adjuvant Hypofractionated Radiotherapy for 1-2 Macrometastatic Sentinel Lymph Nodes
In this observational prospective studi patients with invasive breast cancer no more than 5 cm and clinically node negative, scheduled for conservative surgery and Sentinel Node Biopsy (SNB), are enrolled in the protocol if they…
- Conditions
- Arm Lymphedema, Breast Cancer, Radiotherapy Side Effect
- Trial name
- AXILL-ART (NCT06321653)
- Testing
- Hypofractionated radiotherapy scheme
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- European Institute of Oncology
Breast Neoplasm Female
A Prospective, Open, Multicenter Single-arm Clinical Studie of Docetaxel, Carboplatin Combined With Inetetamab and Pyrotinib in the Treatment of Local-advanced HER2-positive Breast Cancer
This study is a prospective, open, multi-center, single arm trial. The treatment group will receive six cycles of docetaxel, carboplatin combined with Inetetamab and Pyrotinib before surgery.
- Trial name
- neoPICD (NCT06234137)
- Testing
- Docetaxel, Carboplatin, Inetetamab
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Wang Ouchen
Breast Cancer
Bioprosthetic Mesh to Expand the Lower Pole in Tissue Expander Reconstruction
The goal of this clinical research study is to learn if the complication rate and post-surgical appearance differ based on what type of mesh is used for breast reconstruction surgery.
- Trial name
- NCT01310075
- Testing
- Alloderm, Surgimend
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Mastectomy
Kinesio Tex Tape in Reducing Edema and Seroma After Complex Reconstructive Breast Surgery
Over the last two decades in the field of oncology, the prevention, diagnosis, treatment and rehabilitation have reached a remarkable development, improving healing rates and reducing the number of deaths from cancer.
- Conditions
- Breast Cancer, Mastectomy, Breast Implantation, Edema
- Trial name
- BREASTAPE (NCT03477565)
- Testing
- Kinesio tape lymphatic drainage technique application
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Advanced Breast Cancer, Metastatic Breast Cancer
"Curcumin" in Combination With Chemotherapy in Advanced Breast Cancer
The aim of this study is to assess benefits of treatment with intravenous Curcumin® (CUC-01) vs placebo, in combination with paclitaxel chemotherapy, and to estimate the risk of adverse events in patients with locally advanced…
- Trial name
- NCT03072992
- Testing
- Curcumin, Paclitaxel
- Where
- Armenia
- Volunteers
- 150 people
- Sponsor
- National Center of Oncology, Armenia
Breast Cancer
Screening CEDM in Intermediate and High-Risk Patient Populations
This research study is being done to determine if Contrast Enhanced Digital Mammography (CEDM) can improve breast cancer detection and can be used as an additional screening method to the standard mammographic screening.
- Trial name
- NCT03859492
- Testing
- Contrast Enhanced Digital Mammography
- Where
- United States
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.