Clinical trials: Carcinoma Cervix
HPV-Related Cervical Carcinoma
Effectiveness of Targeted Educational Interventions at Increasing HPV Vaccine Acceptability and Uptake
This study aims to assess the effectiveness of targeted educational interventions in increasing the acceptability and knowledge of the HPV vaccine among females ages 12 through 26.
- Trial name
- NCT03337269
- Testing
- Educational video, Educational handout, Control
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cervical Cancer
Para Aortic Lymphadenectomy : Always ?
Cervical cancer affects more than 3000 new cases per year in France. The treatment of stage IB3 to IVA cervical cancer is based on concomitant radio-chemotherapy.
- Trial name
- PALA (NCT04392895)
- Testing
- Para Aortic Lymphadenectomy (PAL) by laparoscopy
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Montpellier
Malignant Neoplasms of Female Genital Organs
Low-Cost Imaging for Cervical Cancer Prevention in the Texas Lower Rio Grande Valley
The purpose of this study is to evaluate a different type of medical equipment called "High-Resolution Microendoscope" (HRME) for the diagnosis of cervical pre-cancerous lesions and cervical cancer.
- Trial name
- NCT02714439
- Testing
- Proflavine, High-Resolution Microendoscopy (HRME)
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Recurrent Cervical Carcinoma, Metastatic Cervical Carcinoma
Tislelizumab and Radiotherapy for Recurrent Cervical Cancer
This study is a prospective, multicenter, phase II clinical trial to evaluate the efficacy and safety of albumin-bound paclitaxel plus bevacizumab for platinum-resistant recurrent epithelial ovarian cancer.
- Conditions
- Recurrent Cervical Carcinoma, Metastatic Cervical Carcinoma, Persistent Cervical Carcinoma, Radiotherapy
- Trial name
- NCT05310383
- Testing
- Tislelizumab plus radiotherapy
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Lei Li
Cervical Cancer, DNA Methylation
Cervical Cytology DNA Methylation for Cervical Cancer Screening
Cervical cancer represents one of the foremost causes of cancer-related morbidity and mortality among women worldwide. Given the current limitations, such as the low specificity of human papillomavirus (HPV) testing and the…
- Conditions
- Cervical Cancer, DNA Methylation, Cytology, Human Papillomavirus Infection
- Trial name
- NCT06557954
- Testing
- human PAX1 and JAM3 gene methylation assays (PAX1m/JAM3m)
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- Lei Li
Cervical Cancer, Cancer
The Association Between Cervical Cancer Screening and Cancer Occurrence
To investigate the protective effect of cervical cancer incidence and mortality by screening attending frequency or screening pattern, and to evaluate the possible risk of developing malignancies among women with cervical…
- Trial name
- NCT01015079
- Where
- Taiwan
- Volunteers
- 6,000,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
HPV Infections
Reactogenicity Study of Cervarix and Gardasil in UK Adolescent Girls
This is a phase IV study to evaluate the body's immune response of participants to the Cervarix and Gardasil vaccines against the Human Papilloma Virus (HPV) types associated with increased risk of cervical cancer.
- Trial name
- HPV CSP01 (NCT00956553)
- Testing
- Cervarix, Gardasil
- Where
- 3 sites in United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Public Health England
Sarcoma, Melanoma
A Study of PRT1419 in Patients With Advanced Solid Tumors
This is a Phase 1 dose-escalation study of PRT1419, a myeloid cell leukemia 1 (MCL1) inhibitor, in patients with advanced solid tumors.
- Conditions
- Sarcoma, Melanoma, Lung Cancer, Breast Cancer
- Trial name
- NCT04837677
- Testing
- PRT1419
- Where
- 7 sites in United States
- Volunteers
- 26 people
- Sponsor
- Prelude Therapeutics Incorporated
Cervical Intraepithelial Neoplasia, Cervical Cancer
Chinese Cancer Prevention Study(CHICAPS)
The purpose of this study is to develop and implement a community based preventive healthcare model using cervical cancer screening as the target medical intervention.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Cervical Neoplasm, Cervical Dysplasia
- Trial name
- CHICAPS (NCT01524003)
- Testing
- cryotherapy, Colposcopy
- Where
- China
- Volunteers
- 8,382 people, healthy volunteers welcome
- Sponsor
- Preventive Oncology International, Inc.
Cervical Cancer, Precancerous Condition
Vaccine Therapy in Preventing Cervical Cancer in Patients With Cervical Intraepithelial Neoplasia
RATIONALE: Vaccines made from protein and DNA may help the body build an effective immune response to kill abnormal cells in the cervix. The use of vaccine therapy may prevent cervical cancer.
- Trial name
- NCT00121173
- Testing
- pNGVL4a-Sig/E7(detox)/HSP70 DNA vaccine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Uterine Cervical Neoplasm, Endometrial Neoplasms
Optimal Margin Evaluation of Online Adaptive Radiotherapy for Postoperative Treatment of Endometrial and Cervical Cancer
Online adaptive radiotherapy has demonstrated to be feasible to reduce inter-fractional radiotherapy errors as it re-optimizes treatment plan every fraction.
- Trial name
- NCT05682950
- Testing
- online adaptive radiotherapy
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Peking Union Medical College Hospital
Cervical Cancer
Localization of Point A in Cervical Cancer
Point A, the major critical point for dose specification of intracavitary brachytherapy, is defined as the crossing of uterine artery and ureter in treatment of cervical cancer.
- Trial name
- NCT00319462
- Testing
- hemoclip
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Mackay Memorial Hospital
Cervical Cancer, HIV/AIDS
Cervical Cancer Screening in Cameroon
Human immunodeficiency virus-infected (HIV[+]) women have a several-fold increased risk of invasive cervical cancer (ICC) as well as increased risk of cervical pre-cancer.
- Trial name
- NCT04401670
- Testing
- HPV screening and triage tests, HPV self-sampling
- Where
- Cameroon
- Volunteers
- 873 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Atezolizumab and Bevacizumab in Treating Patients With Recurrent, Persistent, or Metastatic Cervical Cancer
This phase II trial studies how well atezolizumab and bevacizumab work in treating patients with cervical cancer that has come back, remains despite treatment, or has spread to other places in the body.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Recurrent Cervical Carcinoma
- Trial name
- NCT02921269
- Testing
- Atezolizumab, Bevacizumab, Laboratory Biomarker Analysis
- Where
- 22 sites in United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Abnormal Uterine Bleeding, Endometriosis
Performance of SYMMCORA® vs. V-Loc® Suture Material in Patients Undergoing Laparoscopic Total Hysterectomy
The aim of this study is to show the superiority of the new unidirectional barbed suture (SYMMCORA® mid-term, unidirectional) to conventional suture material in terms of time to perform the vaginal cuff closure during gynecologic…
- Conditions
- Abnormal Uterine Bleeding, Endometriosis, Uterine Prolapse, Uterine Cancer
- Trial name
- BARHYSTER (NCT06024109)
- Testing
- Closure of the Vaginal Cuff after Total Hysterectomy
- Where
- 2 sites in Germany, Spain
- Volunteers
- 132 people
- Sponsor
- Aesculap AG
Cervix Cancer
Dosimetric Planning Study Comparing Intensity Modulated Radiotherapy (IMRT) and 4-field Radiotherapy for Definitive Treatment of Cancer of the Cervix
A theoretical planning study to compare the normal tissue irradiation when using intensity modulated radiotherapy (IMRT) as opposed to standard radiotherapy for the definitive treatment of cervical cancer.
- Trial name
- NCT00981552
- Testing
- IMRT planning, 4-Field Radiation Planning
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cervical Cancer by FIGO Stage 2018
Reduction of Hematologic Toxicity in Locally Advanced Cervical Cancers
Cervical cancer is the fourth most common cancer among women and is mainly linked to infection with high-risk human papillomaviruses (HPV).
- Trial name
- RETHEMCOL (NCT07461142)
- Testing
- radiotherapy with bone marrow contouring
- Volunteers
- 72 people
- Sponsor
- Institut Paoli-Calmettes
Cervical Cancer
DX-8951f in Treating Women Who Have Advanced or Recurrent Cancer of the Cervix
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of DX-8951f in treating women who have advanced or…
- Trial name
- NCT00004866
- Testing
- exatecan mesylate
- Where
- 6 sites in United States
- Sponsor
- Daiichi Sankyo
Uterine Cervical Neoplasms, Chemoradiotherapy
Concurrent Chemoradiotherapy Combined With Adjuvant Chemotherapy Treated Advanced Cervical Cancer
This study carried out a prospective, randomized, controlled clinical study under the background of intensity-modulated radiation therapy and three-dimensional afterloading therapy.
- Conditions
- Uterine Cervical Neoplasms, Chemoradiotherapy, Adjuvant Chemotherapy
- Trial name
- NCT05735145
- Testing
- paclitaxel combined with platinum
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Fourth Affiliated Hospital of Guangxi Medical University
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Social Health, Activity Behaviors, and Quality of Life Among Young Adult Cancer Survivors
This longitudinal observational study examines how social health, including social support, social roles, loneliness, social anxiety, and social network characteristics, relates to physical activity, sedentary time, and quality…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT07259304
- Testing
- Medical Device Usage and Evaluation, Quality-of-Life Assessment, Survey Administration
- Where
- 3 sites in United States
- Volunteers
- 173 people
- Sponsor
- University of Southern California