Clinical trials: Carcinoma of Prostate (Disorder)
Prostate Cancer
Neoadjuvant Dupilumab in Men With Localized High-Risk Prostate Cancer
This is a single-center, single arm, open-label phase II study evaluating the safety, anti-tumor effect, and immunogenicity of neoadjuvant Dupixent given prior to radical prostatectomy.
- Trial name
- NCT03886493
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Prostate Cancer
Health Status, Quality of Life and Function in Survivors After Radical Treatment for Prostate Cancer. Part I and IIA
In this study, addressing prostate cancer survivors, i.e. men who received potentially curative (radical) treatment two to six years ago, we will investigate if older age at time of treatment is a detrimental factor with respect…
- Trial name
- OPS (NCT04863352)
- Where
- Norway
- Volunteers
- 657 people
- Sponsor
- Sykehuset Innlandet HF
Prostate Cancer
Advanced Prostate Imaging of Recurrent Cancer After Radiotherapy
The investigators are attempting to determine if a new form of imaging called 18F-DCFPyL PET/CT is helpful to physicians in deciding how to manage suspected prostate cancer recurrence.
- Trial name
- PICs (NCT02793284)
- Testing
- 18F-DCFPyL PET/CT scan
- Where
- 4 sites in Canada
- Volunteers
- 80 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Solid Tumors
Avelumab in Metastatic or Locally Advanced Solid Tumors (JAVELIN Solid Tumor)
This is a Phase 1, open-label, dose-escalation trial of avelumab [antibody targeting programmed death ligand 1 (anti PD-L1)] with consecutive parallel group expansion in participants with selected tumor indications.
- Trial name
- NCT01772004
- Testing
- Avelumab
- Where
- 74 sites in United States, Belgium and 7 more
- Volunteers
- 1,756 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Prostate Cancer
Vaccine Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy
Rationale: Vaccines may make the body build an immune response to kill tumor cells. It is not yet known if vaccine therapy is effective for prostate cancer.
- Trial name
- NCT00005947
- Testing
- sipuleucel-T
- Where
- 34 sites in United States
- Volunteers
- 127 people
- Sponsor
- Dendreon
Prostate Neoplasms
A Study of Abiraterone Acetate Plus Low-Dose Prednisone Plus Androgen Deprivation Therapy (ADT) Versus ADT Alone in Newly Diagnosed Participants With High-Risk, Metastatic Hormone-Naive Prostate Cancer (mHNPC)
The purpose of this study is to determine if newly diagnosed (within previous 3 months) participants with metastatic (spread of cancer cells from one part of the body to another ) hormone-naive prostate cancer (mHNPC) who have…
- Trial name
- NCT01715285
- Testing
- Abiraterone acetate, Prednisone, Androgen deprivation therapy (ADT)
- Where
- 208 sites in Argentina, Australia and 31 more
- Volunteers
- 1,209 people
- Sponsor
- Janssen Research & Development, LLC
Castration-Resistant Prostatic Cancer, Metastatic Disease
Safety and Targeting of Anti-hk2 Antibody in mCRPC
This is an imaging trial, to develop h11B6 as a therapeutic radiopharmaceutical for men with mCRPC. This imaging study will be conducted to confirm the safety and estimate the mass amount of antibody h11B6, and confirm in vivo…
- Trial name
- NCT04116164
- Testing
- 111In-DOTA-h11B6
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- SpectronRX
Prostate Cancer
Utility of Hyperpolarized 13C-pyruvate Metabolic Magnetic Resonance Imaging
This is a two-tiered pilot study in which there will be no randomization and no placebo treatment. This study will be to perform metabolic magnetic resonance imaging on men suspected to have a prostate cancer to understand if…
- Trial name
- NCT04698564
- Testing
- Hyperpolarized 13C-Pyruvate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Maryland, Baltimore
Prostate Cancer
Trial Comparing Irradiation Plus Long Term Adjuvant Androgen Deprivation With GnRH Antagonist Versus GnRH Agonist Plus Flare Protection in Patients With Very High Risk Localized or Locally Advanced Prostate Cancer
The primary objective of the trial is to assess if GnRH antagonists in combination with external beam radiation therapy improve progression free survival (progression that can be biological, clinical, or death) compared to GnRH…
- Trial name
- PEGASUS (NCT02799706)
- Testing
- Degarelix, approved GnRH agonist, Radiotherapy
- Where
- 39 sites in Belgium, Denmark and 6 more
- Volunteers
- 885 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Prostatic Neoplasms
External Beam Radiation Therapy - Target Volume
Delivery of conformal radiation therapy following radical prostatectomy is limited by the inability to define the clinical target volume (CTV).
- Trial name
- NCT00230438
- Testing
- External Beam Radiotherapy
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University Health Network, Toronto
Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
This phase III trial tests two questions by two separate comparisons of therapies. The first question is whether enhanced therapy (apalutamide in combination with abiraterone + prednisone) added to standard of care (prostate…
- Conditions
- Biochemically Recurrent Prostate Carcinoma, Metastatic Prostate Carcinoma, Prostate Adenocarcinoma, Stage IVB Prostate Cancer AJCC v8
- Trial name
- NCT04423211
- Testing
- 3-Dimensional Conformal Radiation Therapy, Apalutamide, Computed Tomography
- Where
- 341 sites in United States
- Volunteers
- 804 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Primary Prevention of Prostate Cancer
Prostate Cancer Prevention Trial With Quercetin and Genistein
The aim of the randomized controlled double-blind crossover trial is to evaluate the effectiveness of two dietary supplements containing polyphenolic phytochemicals (isoflavonoid genistein and flavonoid quercetin) in comparison…
- Trial name
- QUERGEN (NCT01538316)
- Testing
- Quercetin supplement, Genistein supplement
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- University of Hohenheim
Prostate Cancer, Breast Cancer
A Trial for a Preliminary Estimate of the Effectiveness of a Novel Theoretical Framework
Aim 1: To determine the preliminary effect sizes of al ActiveHeal EST (Engage-Sustain-Triumph) Program on occupational resilience.
- Trial name
- NCT06461416
- Testing
- ActiveHeal
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Arkansas
Aromatherapy, Prostate Cancer
Aromatherapy on Pain and Anxiety of the Patients Undergoing Prostate Biopsy
The study included 120 male patients who would undergo a prostate biopsy. Patients were divided into 3 groups as placebo group (n = 40), Levander group (N = 40), and Frankincense group (n = 40).
- Conditions
- Aromatherapy, Prostate Cancer, Anxiety
- Trial name
- NCT06119438
- Testing
- Aromatherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mersin Training and Research Hospital
Prostate Cancer
Understanding of Genetics by Men at Risk for Prostate Cancer
With this greater certainty regarding prognosis, men with localized prostate cancer are now equipped with make better treatment planning decisions.
- Trial name
- NCT04550845
- Testing
- Focus group analyses
- Where
- 3 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Prostate Cancer
Pain Comparison: Transrectal vs. Transperineal Prostate Biopsy
Prostate biopsy remains the gold standard for the diagnosis of prostate cancer and is most commonly performed using either the transrectal or transperineal approach.
- Trial name
- TRAP-PAIN (NCT07577895)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Kayseri Education and Research Hospital
Prostate Cancer
Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo Radical Prostatectomy
RATIONALE: Genistein may stop the growth of cancer cells by blocking the enzymes necessary for cancer cell growth. PURPOSE: Phase II trial to study the effectiveness of genistein in treating patients with localized prostate…
- Trial name
- NCT00058266
- Testing
- genistein, conventional surgery
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Northwestern University
68Ga-PSMA HBED-PET/CT, Prostate Cancer
68Ga-PSMA HBED-PET/CT in the Evaluation of the Biochemical Relapse in Patients With a History of Prostate Cancer Radically Treated
Single-center, prospective, diagnostic trial in radically treated patients with biochemical recurrence of prostate cancer. Patients with radically treated prostate cancer with biochemical relapse and negativity of all traditional…
- Trial name
- GaPSMA (NCT02920229)
- Testing
- 68Ga- PSMA
- Where
- Italy
- Volunteers
- 1,230 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Localized Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8
Computed Tomography-Guided Stereotactic Body Radiation Therapy With Intrafraction Motion Monitoring for the Treatment of Localized Prostate Cancer, ILLUSION Trial
This clinical trial studies the side effects of computed tomography (CT)-guided stereotactic body radiation therapy (SBRT) with intrafraction motion monitoring and to see how well it works in treating patients with prostate…
- Conditions
- Localized Prostate Adenocarcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8
- Trial name
- ILLUSION (NCT06995053)
- Testing
- Biospecimen Collection, Computed Tomography, CT-guided Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Prostate Cancer
Study of the Clinical Utility of PSMA Imaging in the Evaluation of Men With Prostate Cancer
In this study we aim to more precisely define the clinical utility of PSMA imaging across a range of clinical indications in men with prostate cancer.
- Trial name
- NCT02825875
- Testing
- 18F DCFPyL- Radiopharmaceutica
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.