Clinical trials: Carcinoma of Prostate (Disorder)
Hypercalcemia of Malignancy, Lung Cancer
Zoledronate in Treating Patients With Solid Tumors That Have Spread to the Bone
RATIONALE: Zoledronate may help to relieve some of the symptoms caused by bone metastases. It is not yet known if zoledronate is more effective than no further therapy in relieving symptoms of bone metastases or preventing…
- Conditions
- Hypercalcemia of Malignancy, Lung Cancer, Metastatic Cancer, Pain
- Trial name
- NCT00003884
- Testing
- zoledronic acid, quality-of-life assessment
- Where
- 55 sites in United States
- Volunteers
- 600 people
- Sponsor
- Novartis
Breast Cancer, Lung Cancer
Pillars4Life Trial
This study aims to explore whether cancer patients can benefit from completing the Pillars4Life online coping program. This randomized control trial will have half its subject completing the program and the other half receiving…
- Conditions
- Breast Cancer, Lung Cancer, Esophageal Cancer, Colon Cancer
- Trial name
- Pillars4Life (NCT02465892)
- Testing
- Pillars4Life
- Where
- United States
- Volunteers
- 284 people
- Sponsor
- Duke University
Prostate Cancer
Study of Focal Cryoablation in Low-Risk Prostate Cancer
The purpose of this study is to find out if men, with low-risk prostate, can have the small amount of cancer within their prostate removed by freezing, called Focal Cryoablation or Cryotherapy.
- Trial name
- NCT00774436
- Testing
- focal cryotherapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prostate Cancer
Microwave Needle Thermoablation for Treatment of Localized Prostate Cancer
Conventional treatment options for localized prostate cancer include prostatectomy, radiotherapy and active surveillance. However, prostatectomy and radiotherapy carry certain degree of morbidity, including the risks of urinary…
- Trial name
- NCT04113811
- Testing
- Biomedical TATO3® Microwave needle thermoablation device (Koelis, Grenoble, France)
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Adenocarcinoma of the Prostate, Recurrent Prostate Cancer
Ixabepilone Compared With Mitoxantrone and Prednisone in Treating Patients With Refractory Metastatic Prostate Cancer
This randomized phase II trial is studying ixabepilone to see how well it works compared to mitoxantrone and prednisone in treating patients with metastatic prostate cancer that has not responded to paclitaxel, docetaxel, or…
- Conditions
- Adenocarcinoma of the Prostate, Recurrent Prostate Cancer, Stage IV Prostate Cancer
- Trial name
- NCT00058084
- Testing
- ixabepilone, mitoxantrone hydrochloride, prednisone
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Cancer, Prostate Cancer
Artificial Intelligence (AI)-Enhanced Pretreatment Peer-review Process to Improve Patient Safety in Radiation Oncology
This prospective study will test artificial intelligence (AI) and machine learning (ML) decision support tools. This tool is designed to help doctors, physicists and other staff during pre-treatment peer review, a step where…
- Trial name
- NCT07463833
- Testing
- The Artificial Intelligence (AI)/ Machine Learning (ML) contribution to treatment planning
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Bladder Neoplasm, Prostate Neoplasm
Pre-Operative Single Shot Rectus Sheath Block
Objectives The primary objective is to demonstrate that in patients undergoing major urologic surgery, Patient Controlled Analgesia (PCA) opioid consumption in the first 24 hours after surgery will be significantly less in…
- Conditions
- Bladder Neoplasm, Prostate Neoplasm, Pelvic Neoplasm, Urologic Neoplasms
- Trial name
- NCT03458598
- Testing
- Rectus sheath block, Bilateral rectus sheath catheter, Patient controlled opioid analgesia (PCA)
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- University of Alberta
Prostate Cancer, Prostate Adenocarcinoma
Study of 18F-DCFPyL PET/CT Imaging in Patients With Suspected Recurrence of Prostate Cancer
This study evaluates the diagnostic performance and safety of 18F-DCFPyL (PyL) PET/CT imaging in patients with suspected recurrence of prostate cancer who have negative or equivocal findings on conventional imaging.
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Prostate Cancer Recurrent, Prostate Cancer Metastatic
- Trial name
- CONDOR (NCT03739684)
- Testing
- 18F-DCFPyL, PET/CT Imaging
- Where
- 14 sites in United States, Canada
- Volunteers
- 208 people
- Sponsor
- Progenics Pharmaceuticals, Inc.
Urinary Incontinence, Prostate Cancer
Return of Continence Following Robot-Assisted Radical Prostatectomy With or Without a Urethrovesical Sling
The purpose of this study is to determine the impact of an absorbable urethrovesical sling on the post-operative return of urinary continence after robot-assisted radical prostatectomy.
- Trial name
- NCT00937833
- Testing
- Prostatectomy, Surgisis Male Sling
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Cook Group Incorporated
Prostate Cancer
S0437 Long-Term Follow-Up of Patients Who Were Diagnosed With Prostate Cancer on PCPT
RATIONALE: Learning about the long-term effects of chemoprevention drugs, such as finasteride, in patients with prostate cancer may help doctors plan better treatment and follow-up care.
- Trial name
- NCT00288106
- Testing
- Follow-up
- Where
- 52 sites in United States
- Volunteers
- 961 people
- Sponsor
- SWOG Cancer Research Network
Anemia, Fatigue
Epoetin Alfa With or Without Dexamethasone in Treating Fatigue and Anemia in Patients With Hormone-Refractory Prostate Cancer
RATIONALE: Epoetin alfa may stimulate red blood cell production and may help improve cancer-related anemia and fatigue. Steroid therapy with dexamethasone may increase the effectiveness of epoetin alfa.
- Conditions
- Anemia, Fatigue, Prostate Cancer
- Trial name
- NCT00060398
- Testing
- epoetin alfa, dexamethasone
- Where
- 140 sites in United States
- Volunteers
- 282 people
- Sponsor
- Eastern Cooperative Oncology Group
Prostate Cancer, Metastatic Castration-resistant Prostate Cancer
PET Imaging Study of 89Zr-DFO-YS5 in Men With Prostate Cancer
CD46 is an exciting new therapeutic target in prostate cancer, with the antibody drug conjugate FOR46 under investigation in phase I clinical trials.
- Trial name
- NCT05245006
- Testing
- 89Zr-DFO-YS5, YS5 antibody, Positron Emission Tomography (PET)/Computerized tomography (CT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Robert Flavell, MD, PhD
Prostate Cancer
Assessing DNA Changes in High Risk Prostate Cancer to Determine Prognosis
One of the biggest problems facing prostate cancer patients and their treating physicians is who needs to be treated and when. Common clinical and pathological parameters are useful (PSA, Gleason score, etc.) but do not clearly…
- Trial name
- NCT01350180
- Where
- 8 sites in Canada
- Sponsor
- Dr. Tamim Niazi
Prostate Cancer, Prostate Cancer Diagnosis
Cognitive Fusion Prostate Biopsy With Biparametric Magnetic Resonance in the Detection of Prostate Cancer
The goal of this prospective observational study is to evaluate the diagnostic precision of the Biparametric Magnetic Resonance Imaging (bpMRI) in the detection of clinically significant prostate cancer (PCa) in patients with…
- Trial name
- NCT05818631
- Testing
- fusion cognitive prostate biopsy
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- José Joaquín Mira
Prostatic Neoplasms
Evaluation of Atherosclerotic Plaques in Abdominal CT Studies
Background: Fat and calcium can build up as plaque in artery walls. The Agatston score measures plaque using computed tomography (CT) that does not use an injected contrast agent.
- Trial name
- NCT04652973
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Prostate Neoplasm
F-18 Sodium Fluoride in Prostate Cancer
Background: Sodium fluoride (NaF) is a common compound that is found in various foods and can be used to increase bone strength.
- Trial name
- NCT01240551
- Testing
- F-18 NaF
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute (NCI)
Solid Cancers, BRCA Mutation
A PARG Inhibitor DAT-2645 Monotherapy in Patients with Advanced/Metastatic Solid Tumors Harboring BRCA1/2 Loss of Function Alterations And/or Other Defects in the DDR Pathway
The primary objective of the study is to evaluate the safety, tolerability, PK, PD, and prilimary efficacy of a PARG inhibitor DAT-2645 in patients with advanced/metastatic solid tumors harboring BRCA1/2 loss of function…
- Conditions
- Solid Cancers, BRCA Mutation, HRD Cancer, Breast Cancer
- Trial name
- NCT06614751
- Testing
- DAT-2645 tablet
- Where
- 2 sites in China
- Volunteers
- 112 people
- Sponsor
- Danatlas Pharmaceuticals Co., Ltd
Prostate Cancer
A Phase III Intensity Radiotherapy Dose Escalation for Prostate Cancer Using Hypofractionation
The goal of this clinical research study is to compare using external beam radiotherapy with intensity modulated beams for fewer days at a higher dose per day to the same type of therapy for more days at a lower dose per day in…
- Trial name
- NCT00667888
- Testing
- Conventional Fractionated Intensity Modulated Radiotherapy, Hypofractionated Intensity Modulated Radiotherapy
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- M.D. Anderson Cancer Center
Prostatic Neoplasm
Detection Rate of Prostate Cancer in Men Undergoing MRI
To assess prostate cancer (PCa) detection rate in men undergoing magnetic resonance imaging (MRI) before planning prostate biopsy. Results will be stratified considering men with/without previous negative prostate biopsy.
- Trial name
- NCT04398173
- Testing
- multiparametric MRI
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Prostate Cancer
Prostate Cancer Screening: a Pilot Study
Prostate Cancer (PCa) is the second most frequently diagnosed tumour and the third most lethal among men in Europe. The lack of precise tools and examinations to precisely diagnose PCa has caused overtreatment of indolent and…
- Trial name
- ProScreenMRI (NCT06238661)
- Testing
- Urology visit with Risk Calculator and MRI
- Where
- Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
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