Clinical trials: Carcinoma of Prostate (Disorder)
Prostate Cancer
PRostate Evaluation for Clinically Important Disease: MRI vs Standard Evaluation Procedures
The aim of this study is to assess the efficacy of MRI-targeted biopsy compared to standard of care systematic TRUS guided biopsy in the detection of clinically significant and clinically insignificant prostate cancer in men…
- Trial name
- PRECISE (NCT02936258)
- Testing
- Standard of Care, MRI, MRI Targeted Biopsy
- Where
- 5 sites in Canada
- Volunteers
- 450 people
- Sponsor
- Canadian Urology Research Consortium
Prostate Cancer
Mental Wellbeing and Quality of Life in Prostate Cancer
The complex relationship that exists between physical and mental health in prostate cancer is increasingly being understood. Psychiatric symptoms are common in this group and have important consequences for the quality of life…
- Trial name
- MIND-P (NCT04647474)
- Where
- 7 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- King's College London
Prostatic Neoplasms
Study of Trovax® Plus Docetaxel Versus Docetaxel Alone in Patients With Progressive Hormone Refractory Prostate Cancer
The purpose of this study is to evaluate the role of combination therapy with Trovax plus Docetaxel or Docetaxel alone in patients with prostate cancer with a rising prostate specific antigen (PSA).
- Trial name
- NCT00521274
- Testing
- MVA 5T4, Docetaxel
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The Methodist Hospital Research Institute
Prostate Cancer, Metastases
A Research Study for Patients With Prostate Cancer
The purpose of this study is to evaluate the activity of romidepsin (depsipeptide,FK228) in patients with metastatic prostate cancer who have developed a rising prostate specific antigen (PSA) while undergoing hormonal therapy.
- Trial name
- NCT00106418
- Testing
- Romidepsin
- Volunteers
- 35 people
- Sponsor
- Celgene
Breast Cancer, Prostate Cancer
Patient Recall of Cancer Screening and Diagnosis
The purpose of this research is to try to better understand how much information relating to cancer screening and diagnoses that people can recall on their own and to better understand how to help people get better information.
- Trial name
- NCT05014295
- Testing
- Accessing personal medical records online via online portals
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer
Paclitaxel and Carboplatin in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00049257
- Testing
- carboplatin, paclitaxel
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Prostate Cancer, Robotic Prostatectomy
Dorsal Penile Block for Post-Robotic Prostatectomy Foley Discomfort
The indwelling urethral foley is a major source of discomfort following radical prostatectomy. Our hypothesis is that intra-operative dorsal penile nerve block with bupivacaine may decrease immediate post-operative foley…
- Conditions
- Prostate Cancer, Robotic Prostatectomy, Foley Catheter Discomfort
- Trial name
- NCT01565512
- Testing
- Bupivacaine, Saline
- Where
- United States
- Sponsor
- Columbia University
Prostate Cancer
Evaluation of PSMA-PET and mpMRI in High-risk Prostate Cancer - Using Histopathologic Validation
In this trial the connection between image properties (mpMRI and PSMA-PET) and tissue properties (molecular and histopathology) will be investigated in order to improve diagnostics and image-based treatment guidance of prostate…
- Trial name
- NCT06565247
- Testing
- [18F]PSMA-PET, MRI sequences optimized for prostate cancer examinations
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Region Västerbotten
Prostate Cancer
Gene-Environment Interaction in Prostate Cancer
The purpose of this study is to determine whether certain environmental factors, namely occupational exposures and diet, have a greater effect on prostate cancer risk in the presence of selected inherited genetic factors.
- Trial name
- NCT00041847
- Where
- United States
- Volunteers
- 881 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Metastatic Castration-resistant Prostate Cancer, Advanced Prostate Adenocarcinoma
Dual-target PSMA/PSCA CAR-NK Cells in Advanced Prostate Cancer
This example Phase 1 study is designed to evaluate the safety, tolerability, feasibility, and preliminary anti-tumor activity of ETB-DualNK-01, an allogeneic dual-target PSMA/PSCA CAR-NK cell therapy, in adults with metastatic…
- Conditions
- Metastatic Castration-resistant Prostate Cancer, Advanced Prostate Adenocarcinoma, PSCA-positive Prostate Cancer, PSMA-Positive Progressive Metastatic Castration-Resistant Prostate Cancer
- Trial name
- DUAL-NK-PC (NCT07641049)
- Testing
- ETB-DualNK-01, Fludarabine, Cyclophosphamide
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Beijing Biotech
Prostate Cancer
Quantitative mpMRI to Predict Metastatic Potential of Prostate Cancer
The primary aim of this study is to assess the potential of quantitative MRI measurements to predict localized prostate cancer T-stage and disease spread to nodes (N-stage) by correlating quantitative MRI measurements of the…
- Trial name
- QmpMRI (NCT05252806)
- Testing
- MRI examination of the prostate
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Prostate Cancer
Monitoring and Mapping of Erectile Nerve During RALP (MMEN Study)
To evaluate the safety and efficacy of pelvic autonomic nerve monitoring and mapping during robot assisted laparoscopic radical prostatectomy for preservation of erectile function.
- Trial name
- NCT02507427
- Testing
- NIM-Eclipse
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Esophageal Diseases, Gastrointestinal Diseases
Evaluation of Arterial Pressure Based Cardiac Output for Goal-Directed Perioperative Therapy
The purpose of this study is to determine whether the early identification and more precise intervention of operating room (OR) patient fluid administration optimization using arterial pressure-based cardiac output (APCO) yields…
- Conditions
- Esophageal Diseases, Gastrointestinal Diseases, Disorder of the Genitourinary System, Gynecologic Diseases
- Trial name
- NCT00526331
- Testing
- Vigileo Monitor, FloTrac Sensor
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- M.D. Anderson Cancer Center
Cancer of Lung, Lung Metastasis
Real-time Motion Management During Prostate and Lung Radiotherapy
The goal of this interventional non-inferiority trial is to assess the accuracy of different real-time motion management radiotherapy techniques.
- Conditions
- Cancer of Lung, Lung Metastasis, Cancer of Prostate
- Trial name
- REMIND (NCT05844761)
- Testing
- Triggered imaging on TrueBeam with margin reduction, Synchrony MLC tracking on fiducials with margin reduction, Synchrony MLC tracking and lung adaptive model with margin reduction
- Where
- Sweden
- Volunteers
- 132 people
- Sponsor
- Region Skane
Depression, Pancreatic Cancer
A Pilot Trial of Interpersonal Psychotherapy for the Treatment of Depression in Patients With Prostate, Colorectal, Lung and Pancreatic Cancer
There is now overwhelming evidence documenting the efficacy of psychotherapy in the treatment of depression in the general population.
- Conditions
- Depression, Pancreatic Cancer, Lung Cancer, Colon Cancer
- Trial name
- NCT01940237
- Testing
- Psychotherapy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- New York State Psychiatric Institute
Small Cell Lung Cancer, Melanoma
A Study of DXC014 in Patients With Advanced Solid Tumors.
This is a phase I, open-label, first-in-human clinical study designed to evaluate the safety, tolerability, MTD, DLT, RP2D, the PK characteristics, preliminary anti-tumor activity, the immunogenicity of DXC014 in patients with…
- Conditions
- Small Cell Lung Cancer, Melanoma, Prostate Cancer, Other Advanced Solid Tumors
- Trial name
- NCT07177937
- Testing
- DXC014
- Where
- 5 sites in China
- Volunteers
- 150 people
- Sponsor
- Hangzhou DAC Biotechnology Co., Ltd.
Prostate Cancer
GTx-758 on Serum Prostate-specific Antigen (PSA) in Men With Castrate Resistant Prostate Cancer
The purpose of this study is to assess the effect of GTx-758 on Serum Prostate-specific antigen (PSA) levels in men with castrate resistant prostate cancer who are maintained on androgen deprivation therapy (Serum PSA response…
- Trial name
- NCT01420861
- Testing
- GTx-758
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- GTx
Prostate Cancer Detection, Fusion Prostate Biopsy
Comparison of Prostate Fusion Biopsies With Software and Cognitive
This study evaluates the efficacy to diagnose significant prostate cancer in patients with suspicious lesions in mpMRI (multiparametric magnetic resonance imaging) by comparing prostate biopsies performed by cognitive fusion with…
- Trial name
- NCT04291742
- Testing
- cognitive vs software
- Where
- Spain
- Volunteers
- 804 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Prostate Cancer
Shorter Duration Radiotherapy to Treat Prostate Cancer After Removal of the Prostate
Radiation therapy is one of the standard treatments for men with prostate cancer who have detectable levels of prostate specific antigen (PSA, a prostate cancer specific marker) after surgery.
- Trial name
- HypoFX (NCT01868386)
- Testing
- Hypofractionated therapy
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- Timothy Showalter, MD
Advanced Cancer, Angiosarcoma
Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer
This study is an open-label, Phase 1, multicenter study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamic (PD) profiles of a novel fragment crystallizable (Fc)-engineered immunoglobulin G1…
- Conditions
- Advanced Cancer, Angiosarcoma, Colorectal Cancer Without Liver Metastases, Endometrial Cancer
- Trial name
- NCT03860272
- Testing
- Botensilimab, Balstilimab
- Where
- 18 sites in United States, United Kingdom
- Volunteers
- 499 people
- Sponsor
- Agenus Inc.
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