Clinical trials: Carcinomatosis, Peritoneal
BRCA Mutation, Serous Tubal Intraepithelial Carcinoma
International Registration of Isolated STIC: to Report and Investigate the Risk of Serous Peritoneal Carcinomatosis
To prospectively assess the incidence of peritoneal carcinomatosis for women with isolated STIC (serous tubal intraepithelial carcinoma).
- Conditions
- BRCA Mutation, Serous Tubal Intraepithelial Carcinoma, Ovarian Carcinoma, Peritoneal Carcinoma
- Trial name
- STICRISC (NCT06393543)
- Testing
- No intervention, only registration
- Volunteers
- 600 people
- Sponsor
- Radboud University Medical Center
Primary Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer
Interleukin-12 in Treating Patients With Ovarian Epithelial Cancer or Primary Peritoneal Cancer
Phase II trial to study the effectiveness of intraperitoneal interleukin-12 in treating patients who have ovarian epithelial cancer or primary peritoneal cancer.
- Trial name
- NCT00016289
- Testing
- recombinant interleukin-12
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Peritoneal Carcinomatosis
Treating Peritoneal Carcinomatosis With PIPAC
This is a feasibility study that aims to evaluate whether PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy) is a safe and feasible treatment in Danish patients with peritoneal cancer.
- Trial name
- NCT02320448
- Testing
- PIPAC
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Michael Bau Mortensen
Anxiety Disorder, Depression
Stress Reduction in Improving Quality of Life in Patients With Recurrent Gynecologic or Breast Cancer
This pilot clinical trial studies stress reduction in improving quality of life in patients with recurrent gynecologic or breast cancer.
- Conditions
- Anxiety Disorder, Depression, Fatigue, Leydig Cell Tumor
- Trial name
- NCT01764789
- Testing
- questionnaire administration, quality-of-life assessment, psychosocial assessment and care
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Gastric Cancer Stage IV, Peritoneal Carcinomatosis
Intraperitoneal Paclitaxel Plus Systemic mFOLFOX6
Treatment for stage 4 gastric cancer with peritoneal carcinomatosis has been unchanged for decades. The median survival for stage 4 gastric cancer is 9-14 months with systemic chemotherapy.
- Conditions
- Gastric Cancer Stage IV, Peritoneal Carcinomatosis, Intraperitoneal Paclitaxel, mFOLFOX6
- Trial name
- IPLUS (NCT03618758)
- Testing
- Paclitaxel, mFOLFOX6 regimen
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seoul National University Bundang Hospital
Fallopian Tube Cancer, Ovarian Cancer
Intraperitoneal Infusion of Autologous Monocytes With Sylatron (Peginterferon Alfa-2b) and Actimmune (Interferon Gamma-1b) in Women With Recurrent or Refractory Ovarian Cancer, Fallopian Tube Cancer or Primary Peritoneal Cancer
Ovarian cancer is a leading cause of cancer death in women. Monocytes are white blood cells that slow tumor growth. Interferons (IFNs) are molecules that help immune cells fight cancer.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cancer
- Trial name
- NCT02948426
- Testing
- Autologous Monocytes + ACTIMMUNE + SYLATRON
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Cancer Institute (NCI)
Peritoneal Neoplasms
A Phase II Study of Surgical Debulking With Peritonectomy and Biweekly Intraperitoneal 5FU With Systemic Oxaliplatin/5FU/Leucovorin in Patients With Pseudomyxoma Peritonei or Peritoneal Carcinomatosis
This study prospectively evaluates a multidisciplinary approach to patients with intraperitoneal carcinomatosis at Washington University.
- Trial name
- NCT00352755
- Testing
- Surgical debulking with peritonectomy, Intraperitoneal 5FU, FOLFOX
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Washington University School of Medicine
Gastric Cancer
Intraperitoneal Aerosol Chemotherapy in Gastric Cancer
A prospective series of patients with recurrent gastric cancer will be treated with three cycles of chemotherapy (doxorubicin and cisplatin) instilled into the abdominal cavity in the form of an aerosol under pressure via…
- Trial name
- PIPAC-GA01 (NCT01854255)
- Testing
- doxorubicin and cisplatin
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Ruhr University of Bochum
Colorectal Cancer, Peritoneal Carcinomatosis, Anastomosis Insufficiency
The Impact of Gut Microbiota in Anastomoses Insufficiency After Resection and Direct Anastomosis for Colorectal Cancer.
The role of gut microbiota in anastomosis insufficiency in patients operated for colorectal cancer and for peritoneal carcinomatosis is going to be investigated. This is a pilot study.
- Trial name
- NCT04252560
- Testing
- Colectomy, CRS+HIPEC
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- Uppsala University Hospital
Peritoneal Carcinomatosis
A Nomogram to Predict Major Postoperative Complications After Cytoreductive Surgery and HIPEC Based on Pre and Peroperative Criteria: Which Patient Require Intensive Monitoring?
In this study, the investigators tend to highlight pre and peroperative factors that predict major postoperative complication after a surgery for resection of peritoneal carcinomatosis.
- Trial name
- NCT05547568
- Testing
- Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
- Where
- France
- Volunteers
- 219 people
- Sponsor
- CHU de Reims
Pancreas Cancer, Duct Cell Adenocarcinoma, Pancreas Adenocarcinoma
Diagnostic Value of DWI-MRI for Detection of Peritoneal Metastases in High-risk Pancreatic Ductal Adenocarcinoma.
Diffusion-weighted magnetic resonance imaging (DWI/MRI) has been described in recent literature as a highly sensitive and specific modality for the detection of peritoneal metastases (PM).
- Conditions
- Pancreas Cancer, Duct Cell Adenocarcinoma, Pancreas Adenocarcinoma, Peritoneal Metastases, Peritoneal Carcinomatosis
- Trial name
- DWI-PDAC (NCT05340569)
- Testing
- Whole-body diffusion-weighted magnetic resonance imaging
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Colorectal Neoplasms, Peritoneal Neoplasms
Adjuvant HIPEC in High Risk Colon Cancer
This study aims to determine the oncological effectiveness of adjuvant HIPEC, using intraperitoneal oxaliplatin with concomitant i.v.
- Trial name
- COLOPEC (NCT02231086)
- Testing
- Adjuvant HIPEC (open/laparoscopic), Standard adjuvant systemic chemotherapy, Diagnostic laparoscopy
- Where
- 9 sites in Netherlands
- Volunteers
- 204 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colorectal Neoplasms
Clinical Analysis of HIPEC for T4 Colorectal Cancer After Surgery
This multicentric study aims to determine if hyperthermic intraperitoneal chemotherapy (HIPEC) will help to prevent the development of peritoneal carcinomatosis in addition to the standard adjuvant systemic treatment after…
- Trial name
- NCT03221608
- Testing
- Surgery and HIPEC with Lobaplatin, Surgery without HIPEC
- Volunteers
- 300 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Peritoneal Carcinomatosis
Safety and Efficacy of PIPAC Using Single Agent Mitomycin in Solid Tumors
This single-center, Phase 1 dose-escalation study will evaluate the safety, tolerability, and recommended Phase 2 dose (RP2D) of pressurized intraperitoneal aerosol chemotherapy with mitomycin C (PIPAC-MMC) for patients with…
- Trial name
- NCT07487168
- Testing
- Mitomycin C (MMC), Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Ovarian Cancer, Fallopian Tube Cancer
Feasibility of Interval Debulking Surgery by Laparoscopy for Peritoneal Carcinosis in Chemosensitive Patients
This prospective nonrandomized multicenter phase II study, will evaluate the possibility of performing a laparoscopic interval debulking after a minimum of 3 cycles of chemotherapy in highly chemo-sensitive patients with advanced…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cavity Cancer
- Trial name
- CILOVE (NCT01905163)
- Testing
- Tumor Debulking Surgery by laparoscopy
- Where
- 10 sites in France
- Volunteers
- 47 people
- Sponsor
- Centre Jean Perrin
Peritoneal Carcinomatosis
PIPAC With Nab-paclitaxel and Cisplatin in Peritoneal Carcinomatosis
Phase Ib trial including investigating the combination of nab-paclitaxel and cisplatin in patients diagnosed with peritoneal carcinomatosis related to pancreatic, oeso-gastric, ovarian cancer or primitive peritoneal mesothelioma.
- Trial name
- Nab-PIPAC (NCT04000906)
- Testing
- Nab paclitaxel, Cisplatin
- Where
- 2 sites in Switzerland
- Volunteers
- 18 people
- Sponsor
- University Hospital, Geneva
Colon Cancer
Feasibility of Intraperitoneal Chemotherapy in the Surgical Treatment of Colon Cancer cT4
This is a randomised controlled study aims to determine the oncological effectiveness of adjuvant HIPEC, using intraperitoneal Mytomicin C following a curative resection of a cT4 Colon cancer in preventing the development of…
- Trial name
- NCT03561948
- Testing
- Experimental group, Control group
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Carcinomatosis, Peritoneal, Pancreas Cancer
Characterization of Biophysical Stromal Properties in Human Cancer: Towards Personalized Computational Oncology
Drug delivery in solid tumors, whether administered systemically or locoregionally, is hindered by an elevated interstitial fluid pressure (IFP).
- Conditions
- Carcinomatosis, Peritoneal, Pancreas Cancer, Ovarian Cancer, Colon Cancer
- Trial name
- DCE-MRI (NCT04512209)
- Testing
- MRI
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- University Hospital, Ghent
Carcinoma
Biweekly Intraperitoneal Oxaliplatin With Systemic Capecitabine and Bevacizumab for Patients With Peritoneal Carcinomatosis From Appendiceal or Colorectal Cancer
This study is to test escalating doses of intraperitoneal (IP) oxaliplatin in conjunction with systemic bevacizumab and capecitabine in patients with Peritoneal Carcinomatosis (PC) from either appendiceal or colorectal…
- Trial name
- NCT01061515
- Testing
- Intraperitoneal Oxaliplatin, Bevacizumab, Capecitabine
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Washington University School of Medicine
Colorectal Cancer, Appendiceal Cancer
Intraperitoneal Oxaliplatin in Combo w IV mFOLFIRI for Peritoneal Carcinomatosis From Colorectal & Appendiceal Cancer
This study is a prospective, multi-center, open-label phase I trial designed to determine the maximun tolerated dose of IP oxaliplatin when given in combination with mFOLFIRI.
- Conditions
- Colorectal Cancer, Appendiceal Cancer, Peritoneal Carcinoma
- Trial name
- IPOX-FOLFIRI (NCT04158349)
- Testing
- Oxaliplatin, mFOLFIRI
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Utah