Clinical trials: Cardiac Anaesthesia
Heart Failure, Excessive Amount of Blood / Fluid Transfusion
Anesthesia for Catheter Aortic Valve ImplantATIOn Registry
In modern cardiac surgery and cardiology Transcatheter Aortic Valve Implantation (TAVI) is an emerging procedure for high-risk patients that are assumed to be otherwise inoperable.
- Conditions
- Heart Failure, Excessive Amount of Blood / Fluid Transfusion, Intraoperative Cardiac Arrest During Cardiac Surgery, Critical Incident
- Trial name
- AVIATOR (NCT01390675)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Deutsches Herzzentrum Muenchen
General Anesthesia
Comparison of the Effects of Dexmedetomidine and Lidocaine on Blood Pressure and Heart Rate Response
Endotracheal intubation is considered a definitive therapy and the gold standard for airway management. However, this procedure carries several risks, including sudden increases in blood pressure and heart rate.
- Trial name
- NCT06573957
- Testing
- Dexmedetomidine, Lidocain
- Where
- Indonesia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Heart Surgery Via Sternotomy, Post-operative Analgesia
Advantage of Tramadol in Local Analgesia Post-Sternotomy
Sternotomy, the reference approach for heart surgery, may induce profound and intense post-operative pain. One method of analgesia used is patient-controlled intravenous morphine.
- Trial name
- ATLAS (NCT02851394)
- Testing
- Levobupivacaine, tramadol
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Anesthesia, Hypotension
Prospective Trial of Alerting to Extended Hypotensive Exposures on Long-Term Outcome After Surgery
Patients undergoing anesthesia for non-cardiac surgery will be randomized to either having their anesthesia team alerted or kept blinded to extended periods of less than normal blood pressure with the goal of studying if…
- Trial name
- SLUScore™ (NCT02217969)
- Testing
- Electronic alert to SLUScore increase
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- St. Louis University
Renal Injury, Anesthesia
Cardiac and Renal Biomarkers in Arthroplasty Surgery
The investigators will compare the effect of spinal anesthesia to general anesthesia on the level of high sensitivity cardiac biomarkers in patients undergoing hip or knee arthroplasty.
- Conditions
- Renal Injury, Anesthesia, Myocardial Injury, Arthropathy of Knee
- Trial name
- NCT03940651
- Testing
- Spinal Anesthesia, General Anesthetics
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Washington University School of Medicine
Anesthesia
The Cardioprotective Effect of Intralipid in Decreasing the Ischemic Insults During Off-pump Coronary Artery Revascularization
the aim of the study is to assess the effect of intralipid as regard efficiency in decreasing myocardial ischemia , given during preconditioning in off pump coronary artery revascularization
- Trial name
- NCT04806425
- Testing
- Intralipid
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Ain Shams University
Anaesthesia
Dexmedetomidine-propofol-remifentanil Anaesthesia and Reactivity to Noxious Stimuli
Dexmedetomidine acts at central nervous system (specifically: at locus caeruleus), providing sedative and analgesic effects. It is widely used in intensive care.
- Trial name
- NCT01076790
- Testing
- Dexmedetomidine, Saline
- Where
- Finland
- Volunteers
- 44 people
- Sponsor
- Arvi Yli-Hankala
Cardiovascular Surgical Procedures, Pain, Postoperative
Fascial Plane Blocks and Quality of Recovery in Cardiac Surgery
In this randomized trial, the investigators will test the hypothesis that combining regional analgesia techniques-which have the potential to improve the quality of postoperative recovery following median sternotomy-with PIFB…
- Conditions
- Cardiovascular Surgical Procedures, Pain, Postoperative, Cardiovascular Diseases
- Trial name
- NCT07557108
- Testing
- Ultrasound-Guided Pectointercostal Fascial Plane Block, Ultrasound-Guided Rectus Sheath Block, Ultrasound-Guided Recto-Intercostal Fascial Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 123 people
- Sponsor
- Ordu University
Post Anesthesia Care Optimaization
Agreements Between Transcutaneous and Arterial Monitoring of Oxygen and Carbon Dioxide After Non-cardiac Surgery
The primary aim of the study is to describe the association between changes in TcO2 and TcCO2 and interventions such as blood transfusion, fluid therapy, respiratory support, use of vasopressors, analgesics, and adverse events…
- Trial name
- NCT04735380
- Testing
- TCM-5 Flex monitor connected to a Sensor 84 (Radiometer Medical Aps, Brønshøj, Denmark)
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Anesthesia, Postoperative Delirium
Postoperative Delirium and Its Biomarkers in Elderly Patients Undergoing Non-cardiac and Non-neurosurgery.
Postoperative delirium (POD) is a common complication in elderly patients and is associated with negative clinical outcomes, such as prolonged hospitalizations, cognitive impairment, and higher mortality rate.
- Trial name
- NCT05177159
- Testing
- The regional cerebral oxygen saturation (rSO2), The glial fibrillary acidic protein (GFAP), The brain-derived-neurotrophic factor (BDNF)
- Where
- China
- Volunteers
- 417 people
- Sponsor
- Beijing Tiantan Hospital
Postoperative Mortality, Anesthesia
The Study of Anesthesia-related Risk Factors for Postoperative Death in Elderly Non-cardiac Surgery Patients in China
At present, the elderly population in China has reached 241 million, and there are more than 20 million elderly surgical patients every year, accounting for about 25% of the surgical population.
- Conditions
- Postoperative Mortality, Anesthesia, Elderly Patients, Noncardiac Surgery
- Trial name
- NCT04389008
- Testing
- no interventions
- Where
- China
- Volunteers
- 300,000 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Cognitive Dysfunction
Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia
As the investigators know, postoperative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon, which affect patients' short-term and long-term outcome.
- Trial name
- NCT02931877
- Testing
- sevoflurane, propofol
- Where
- 3 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Xinqiao Hospital of Chongqing
Analgesics, Opioid, Anesthesia, General
Asleep Fiberoptic vs Direct Laryngoscopy Effect on Hemodynamic Stability Using Opioid Free Anesthesia Induction
The goal of this clinical trial is to compare heart rate between the fiberoptic and direct oral intubation using opioid free anesthesia induction.
- Conditions
- Analgesics, Opioid, Anesthesia, General, Heart Rate, Blood Pressure
- Trial name
- NCT06487988
- Testing
- direct conventional laryngoscopy, fiberoptic guided intubation
- Where
- Lebanon
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Intraoperative Hypotension
PPI Guided Strategies for Prevention and Treatment of Intraoperative Hypotension
Intraoperative hypotension is closely related to the poor prognosis of surgery. The study is focused on the effectiveness of maintaining normal peripheral perfusion index (PPI) on time-weighted average of hypotension during…
- Trial name
- NCT05792696
- Testing
- PPI guided strategies, Empirical strategies
- Where
- China
- Volunteers
- 54 people
- Sponsor
- zhiqiang zhou
Dental Anxiety
Modification of Blood Pressure Levels and Oxygen Saturation in Patients Undergoing Conscious Sedation
The objective is to compare the changes produced in cardiological and respiratory parameters in three groups of patients undergoing oral surgery.
- Trial name
- NCT03789942
- Testing
- Oral surgery
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Clinica Luis Ortiz
Arrhythmia
The Effect of General Anesthesia on the Risk for Arrhythmia
Polymorphic ventricular tachycardia, known as Torsades de Pointes (TdP), is a specific form of ventricular arrhythmia with a characteristic twist of the QRS complex around the isoelectric baseline.
- Trial name
- 10-02725 (NCT01174251)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of California, San Francisco
Regional Anesthesia
Comparison of Post-operative Analgesia in Pediatric Superficial TTMPB
When a patient is to undergo heart surgery with a sternotomy, a transthoracic block is performed. The thoracic block is an analgesic technique which consists of injecting anesthetic product into the nerves, in order to avoid…
- Trial name
- PEPOST (NCT05792345)
- Testing
- Transversus Thoracic Muscle Plane Block, Control
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Coronary Heart Disease
Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG
This study intends to compare the combination of general anesthesia (GA) and single-shot bilateral thoracic paravertebral block (TPVB) by ropivacaine in the patients undergoing off-pump coronary artery bypass surgery ( OPCAB)…
- Trial name
- NCT02727712
- Testing
- bilateral thoracic paravertebral block, Transesophageal Echocardiography（TEE）, Lung protection measure during the surgery（Dräger Primus）
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiangya Hospital of Central South University
Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use
Effects of Intrathecal Local Anesthetics on Left Ventricular Global Longitudinal Strain
The objective of this study is to assess the effects of intrathecal local anesthetics on left ventricular global longitudinal strain (LVGLS) using transthoracic echocardiography (TTE).
- Conditions
- Left Ventricular Dysfunction, Spinal Anesthetics Causing Adverse Effects in Therapeutic Use, Global Cardiac Wall Motion Dysfunction
- Trial name
- NCT05650008
- Testing
- Intrathecal local anesthesia
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Hip Fractures, Anesthesia
Fractional Spinal Anesthesia and Systemic Hemodynamics in Frail Elderly Hip Fracture Patients.
Aging and frailty make the elderly patients susceptible to hypotension following spinal anaesthesia. The systemic haemodynamic effects of spinal anaesthesia are not well known.
- Conditions
- Hip Fractures, Anesthesia, Hypotension Drug-Induced, Cardiac Output, Low
- Trial name
- NCT05101291
- Testing
- Bupivacain
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Sahlgrenska University Hospital