Clinical trials: Cardiac Arrest, Sudden
Cardiac Arrest, Sudden Death
A Comparative Study Between a Pre-hospital and an In-hospital Circulatory Support Strategy (ECMO) in Refractory Cardiac Arrest (APACAR2)
Cardiac arrest (CA) affects approximately 40,000 people in France. It is still a major cause of death in a young population. Management of CA is defined by international recommendations, detailed by learned societies in each…
- Trial name
- APACAR2 (NCT02527031)
- Testing
- ECMO Insertion on pre hospital setting, In Hospital ECMO
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Arrest, Ventricular Fibrillation
The OSIRIS ECPR Trial
The OSIRIS trial is an investigator-initiated, multicenter, multinational, open-label, randomized controlled trial with a 2:1 concealed allocation of refractory out-of-hospital cardiac arrest (OHCA) patients to the extracorporeal…
- Conditions
- Cardiac Arrest, Ventricular Fibrillation, Out-Of-Hospital Cardiac Arrest, Sudden Cardiac Arrest
- Trial name
- OSIRIS (NCT06805344)
- Testing
- Extracorporeal cardiopulmonary resuscitation based approach, Conventional cardiopulmonary resuscitation
- Volunteers
- 686 people
- Sponsor
- General University Hospital, Prague
Cardiac Arrest, Fibrillation, Ventricular
Early Double Sequential Defibrillation in Out-of-hospital Cardiac Arrest
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation.
- Conditions
- Cardiac Arrest, Fibrillation, Ventricular, Sudden Cardiac Death, Sudden Cardiac Arrest
- Trial name
- DOUBLE-D (NCT06447805)
- Testing
- Double Sequential Defibrillation (DSD), Standard defibrillation
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Long QT Syndrome, Sudden Cardiac Death
Electromechanical Profiling of the Long-QT Syndrome (LQTS)
High-resolution, non-invasive electromechanical mapping in genotyped long-QT syndrome patients and healthy controls at baseline and during smart provocation.
- Conditions
- Long QT Syndrome, Sudden Cardiac Death, Ventricular Tachycardia
- Trial name
- EMLoQ (NCT04074122)
- Testing
- Adenosine and epinephrine, isoprenaline provocation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Inherited Cardiac Arrhythmias, Long QT Syndrome
Long Term Monitoring for Risk of Sudden Death
Risk prediction in in inherited heart rhythm conditions that may cause sudden cardiac arrest or death is difficult. Sometimes the risks may be low but the loss of life in an otherwise healthy young individual is catastrophic.
- Conditions
- Inherited Cardiac Arrhythmias, Long QT Syndrome, Arrhythmogenic Right Ventricular Cardiomyopathy, Brugada Syndrome
- Trial name
- NCT04124237
- Where
- Canada
- Volunteers
- 1,051 people
- Sponsor
- University of British Columbia
Sudden Cardiac Death
Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD)
The PROTECT-ICD trial is a physician-led, multi-centre randomised controlled trial targeting prevention of sudden cardiac death in patients who have poor cardiac function following a myocardial infarct (MI).
- Trial name
- PROTECT-ICD (NCT03588286)
- Testing
- Electrophysiology study (EPS), Standard Care, Cardiac Magnetic Resonance (CMR)
- Where
- 52 sites in United States, Australia and 13 more
- Volunteers
- 1,058 people
- Sponsor
- Western Sydney Local Health District
Ventricular Tachyarrhythmia, Sudden Cardiac Death
Domperidone and Risk of Serious Cardiac Events in Postpartum Women
The purpose of this study is to determine whether the use of domperidone is associated with an increased risk of serious cardiac events among postpartum women in the six months following delivery.
- Conditions
- Ventricular Tachyarrhythmia, Sudden Cardiac Death, Lactation, Breast Feeding
- Trial name
- NCT04024865
- Testing
- Domperidone, No domperidone
- Where
- Canada
- Volunteers
- 184,929 people
- Sponsor
- Canadian Network for Observational Drug Effect Studies, CNODES
Sudden Cardiac Death, Implantable Defibrillator
SCREENING FOR THE IMPLANTATION OF A SUBCUTANEOUS IMPLANTABLE AUTOMATIC DEFIBRILLATOR
S-ICD (subcutaneous implantable cardioverter-defibrillator) screening failure occurs in about 10% of cases. Predictors of screening failure are not yet well determined.
- Trial name
- SIS (NCT04101253)
- Testing
- new screening procedure with small variations in electrode positioning
- Where
- 16 sites in France
- Volunteers
- 480 people
- Sponsor
- Centre Hospitalier de PAU
Electrocardiography
Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney Disease
Patients with insulin-dependent diabetes mellitus (DM) and chronic kidney disease (CKD) exhibit an excessive risk for cardiac arrhythmias, in particular sudden cardiac death (SCD).
- Trial name
- HypoArrhyth (NCT02315300)
- Testing
- medilog® DARWIN FD12, Continuous Glucose Monitoring
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- RWTH Aachen University
PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM)
A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)
This Phase 1 dose escalation trial will assess the safety and preliminary efficacy of a single dose intravenous infusion of RP-A601 in high-risk adult patients with PKP2-ACM.
- Trial name
- NCT05885412
- Testing
- RP-A601
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Cardiac Arrest, Sudden
Impact of the Organization of the First Responders in the Remote Areas on Cardiac Arrest Victim Survival
Emergency medical services (EMS) provide emergency care not only in the urban but also in the remote areas which could be up to 40 minutes from the EMS station.
- Trial name
- NCT04485390
- Testing
- Basic life support witn use of an AED before EMS
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Maribor
Sudden Cardiac Death, Ventricular Tachycardia
Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias
The purpose of this research study is to examine the effect of cardiac sympathetic denervation (CSD) surgery on life threatening abnormal heart rhythms called ventricular tachycardia or ventricular fibrillation that can lead to…
- Conditions
- Sudden Cardiac Death, Ventricular Tachycardia, Ventricular Fibrillation, Cardiomyopathy
- Trial name
- PREVENT VT (NCT01013714)
- Testing
- Cardiac Sympathetic Denervation (CSD), Routine Care
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Death, Sudden, Cardiac
An Observational Study to Assess the Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Users of Proton Pump Inhibitors, and Users of Metoclopramide
The purpose of this observational study is to assess the risk of out-of-hospital Sudden Cardiac (heart) Death (SCD) associated with current use of domperidone compared to current use of a Proton Pump Inhibitor (PPI), current use…
- Trial name
- NCT01907633
- Testing
- No intervention
- Volunteers
- 15,000 people
- Sponsor
- Janssen Research & Development, LLC
Long QT Syndrome Type 3
Effect of Eleclazine on Shortening of the QT Interval, Safety, and Tolerability in Adults With Long QT Syndrome Type 3
The primary objective of this study is to evaluate the effect of oral eleclazine on mean daytime QTcF interval after 24 weeks of treatment with elecalzine in participants with long QT syndrome Type 3.
- Trial name
- NCT02300558
- Testing
- Eleclazine
- Where
- 12 sites in United States, Canada and 6 more
- Volunteers
- 41 people
- Sponsor
- Gilead Sciences
Dilated Cardiomyopathy, Primary Prevention of Sudden Cardiac Death
Electrophysiologic and Morphologic Assessment of the Substrate to Guide Implantation of Defibrillators in Dilated Cardiomyopathy
With the present study the investigators intend to identify the morphologic and electrophysiologic substrate markers of increased arrhythmic risk in patients with dilated cardiomyopathy undergoing implantation of a defibrillator…
- Conditions
- Dilated Cardiomyopathy, Primary Prevention of Sudden Cardiac Death, Implantable Cardioverter Defibrillator
- Trial name
- EMOSIDD (NCT01378572)
- Where
- 3 sites in United States, Italy
- Volunteers
- 200 people
- Sponsor
- Catholic University of the Sacred Heart
Tetralogy of Fallot, Ventricular Tachycardia
Electroanatomic Interactions Between Transcatheter Pulmonary Valve Prostheses and Anatomic Isthmuses in Repaired Tetralogy of Fallot
Individuals with repaired Tetralogy of Fallot (rTOF) remain at risk for sudden cardiac death from ventricular tachycardia (VT). Transcatheter pulmonary valve replacement (TPVR) indications continue to broaden, yet its capability…
- Conditions
- Tetralogy of Fallot, Ventricular Tachycardia, Sudden Cardiac Death
- Trial name
- NCT05236153
- Testing
- Electroanatomic substrate mapping
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Primary Prevention of Sudden Cardiac Arrest, Secondary Prevention of Sudden Cardiac Arrest
Longitudinal Surveillance Study of the 4-SITE Lead/Header System
Post-approval studies of implanted leads provide an opportunity to observe and assess patient outcomes and technology performance in a real-world setting.
- Trial name
- LSS of 4-SITE (NCT01596595)
- Where
- 111 sites in United States, Australia and 1 more
- Volunteers
- 1,820 people
- Sponsor
- Boston Scientific Corporation
Defibrillators, Implantable, Sudden Cardiac Death Due to Cardiac Arrhythmia
French COhoRte Extra-Vascular Implantable CardiovErter DefibrillatoR
Implantable cardioverter-defibrillators (ICDs) are widely recognized for their efficacy in reducing the risk of sudden cardiac death in high-risk patients.
- Trial name
- FOREVER (NCT06739239)
- Testing
- Extra-Vascular Implantable Cardioverter Defibrillator
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Paris Sudden Death Expertise Center
Long QT Syndrome, ADHD
Drug-induced Repolarization ECG Changes
Studies have shown that the risk of developing heart arrhythmias, is increased in patients receiving medication for Attention-deficit hyperactivity disorder (ADHD) and depression.
- Conditions
- Long QT Syndrome, ADHD, Depression, Death
- Trial name
- NCT03642405
- Testing
- Electrocardiogram examination, Echocardiography, Blood Samples
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Copenhagen University Hospital at Herlev
Sudden Cardiac Arrest
HeartStart FRx Defibrillator Event Registry
This post market clinical follow-up study is a multi-center, non-randomized, unblinded, observational registry of the performance of the FRx Automated external defibrillator (AED) used in conjunction with electrodes with or…
- Trial name
- NCT04250857
- Testing
- HeartStart FRX
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- Heartstream US LLC