Clinical trials: Cardiac Autonomic Function
Syncope, Syncope, Vasovagal
Assessment of the Mechanism of Non-cardiac Syncope
Identifying the mechanism of non-cardiac syncope is the essential prerequisite for an effective personalized therapy. Aim of this multicentre, prospective, cross-sectional, observational study is to assess effectiveness and…
- Conditions
- Syncope, Syncope, Vasovagal, Orthostatic Hypotension, Syncope, Carotid Sinus
- Trial name
- 2STEPS (NCT05728255)
- Testing
- ABPM plys SCAFB
- Where
- 8 sites in France, Italy and 3 more
- Volunteers
- 330 people
- Sponsor
- Istituto Auxologico Italiano
Heart Failure, Systolic Dysfunction
A Pilot Study of Spinal Cord Stimulation in Heart Failure Patients With Depressed Left Ventricular Function
A randomized pilot study of spinal cord stimulation in patients with chronic heart failure aiming to show whether this therapy impacts central haemodynamic and autonomic regulations.
- Trial name
- RAPID-HELP (NCT02450110)
- Testing
- Spinal cord stimulation
- Where
- Russia
- Volunteers
- 3 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Takotsubo Cardiomyopathy
The Role of Sympathetic Tone Regarding the Anatomical and Functional Recovery of the Left Ventricle in TakoTsubo Syndrome
TakoTsubo Syndrome (TTS) constitutes an increasingly recognised, heterogenous clinical entity which is associated with considerable short-term mortality.
- Trial name
- SYMPATAK (NCT04695587)
- Testing
- 123 MIBG scintigraphy testing, MSNA, ABPM
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Hippocration General Hospital
Oxidative Stress, Inflammatory Stress
Melatonin Treatment and Inflammation, Oxidative Stress and Autonomic Function in Connection With Surgery
The purpose of this study is to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.
- Conditions
- Oxidative Stress, Inflammatory Stress, Myocardial Ischaemia
- Trial name
- NCT00311259
- Testing
- Melatonin (drug), Laktose
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Caffeine, Exercise
7-Day Caffeine and Upper-Body Power in Active Women
This study investigated the effects of a 7-day caffeine supplementation on heart rate variability, cognitive performance, and upper-body anaerobic power in active women.
- Conditions
- Caffeine, Exercise, Physical Fitness
- Trial name
- NCT07771556
- Testing
- Caffeine
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Birjand University of Medical Sciences
Improvement of Functional Capacity., Improvement of Quality of Life.
Effect of a Program of Deep Inspiration Combined to Expiratory Positive Airway Pressure in Asthmatic
The purpose of this study is to determine the effects of a deep inspiration combined to expiratory positive airway pressure protocol on respiratory function, quality of life, exercise tolerance and heart rate variability in…
- Conditions
- Improvement of Functional Capacity., Improvement of Quality of Life., Improvement of Cardiovascular Autonomic Control.
- Trial name
- NCT01643421
- Testing
- Deep inspiration and positive expiratory airway pressure
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Federal University of Health Science of Porto Alegre
End Stage Renal Disease, Chronic Kidney Disease
Risk Stratification in End Stage Renal Disease (ESRD) - ISAR Study
The purpose of this study is to evaluate the use of non-invasive markers of the autonomic function and micro- and macrocirculation to predict mortality and cardiovascular end points in end-stage renal disease patients.
- Conditions
- End Stage Renal Disease, Chronic Kidney Disease, Cardiovascular Event, Sudden Cardiac Death
- Trial name
- ISAR (NCT01152892)
- Where
- 17 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Technical University of Munich
Heart Failure, Depression
Vascular Effects of Sertraline in Heart Failure
To determine the effects of chronic sertraline treatment on brachial artery flow-mediated dilation in patients with chronic heart failure and depression
- Trial name
- NCT00585455
- Testing
- sertraline
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Yale University
Fatigue; Muscle, Heart, Fatigue, Mental
Effects of Oral Nicotine and Caffeine Pouches on Anaerobic Performance, Autonomic Function, Cognition, and Behavior
The goal of this randomized placebo controlled crossover trial is to determine effects of oral nicotine and caffeine pouches on anaerobic performance, autonomic function, cognition, and behavior in adult non-obese adult male…
- Trial name
- NCT06529055
- Testing
- Oral Pouch - Nicotine, Oral Pouch - Caffeine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern Mississippi
Autonomic Nervous System
Combining Motor Imagery With Action Observation Does Not Lead to a Greater Autonomic Response Than Motor Imagery Alone During Simple and Functional Movements: a Randomized Controlled Trial.
The main objective of this study was to compare the activation of the Sympathetic Nervous System in a program that combined Motor Imagery with Action Observation, in contrast to an isolated Motor Imagery program on the one hand…
- Trial name
- NCT03232879
- Testing
- Motor Imagery, Action Observation
- Where
- Spain
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Atrioventricular Block
Pacemaker Implantation Versus Cardioneuroablation for Functional Atrioventricular Block
The TELE-SPACER study is a multicenter, noncommercial, physician-initiated, proof-of-concept, prospective, randomized, controlled, unblinded clinical trial and registry designed to compare two methods of treatment of patients…
- Trial name
- TELE-SPACER (NCT05774262)
- Testing
- Pacemaker implantation, Cardioneuroablation (CNA)
- Where
- 2 sites in Poland
- Volunteers
- 300 people
- Sponsor
- American Heart of Poland
Fibromyalgia Syndrome
Unilateral and Bilateral taVNS in Fibromyalgia
This randomized controlled trial aimed to compare the effects of unilateral (left-sided) and bilateral transcutaneous auricular vagus nerve stimulation (taVNS) combined with a home exercise program on clinical outcomes, autonomic…
- Trial name
- taVNS-FMS (NCT07577102)
- Testing
- taVNS, Home Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul Gelisim University
Attention-deficit/Hyperactivity Disorder, Autonomic Nervous System Imbalance
Brain Tissue Integrity and Autonomic Function Alterations in Childhood OSA and ADHD, and After Adenotonsillectomy.
Obstructive sleep apnea (OSA) and attention-deficit/hyperactivity disorder (ADHD) are two common, severe disorders in children. Unfortunately, pediatric OSA is closely associated with ADHD, and both diseases can cause cognitive…
- Conditions
- Attention-deficit/Hyperactivity Disorder, Autonomic Nervous System Imbalance, Obstructive Sleep Apnea of Child
- Trial name
- NCT04732572
- Testing
- Sleep and healthy lifestyle education, Other supportive care, Adenotonsillectomy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Heart Rate Variability, Biofeedback, Nicotine Dependence, Nicotine Withdrawal, Anxiety, Depression, Insomnia
Effects of HRV Biofeedback on Autonomic Function and Nicotine Withdrawal Symptoms and Dependence in Smoking Cessation Adults
This study is a randomized controlled trial. It is estimated that 80 quitters will be recruited, and they will be randomly included in the experimental group and 40 in the control group.
- Trial name
- NCT04679636
- Testing
- heart rate variability biofeedback
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Defense Medical Center, Taiwan
Obesity, Pre-hypertension
The Effects of Stretching Training on Arterial Function and Autonomic Control
Hypertension is a major risk factor for cardiovascular disease. Hypertension and abdominal obesity are associated with dysfunction of the main mechanisms of cardiovascular regulation, the autonomic nervous system and the vascular…
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT01741766
- Testing
- Stretching Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Acute Ischaemic Stroke, Autonomic Dysfunction
Effects of Heart Rate Variability Biofeedback in Patients With Acute Ischemic Stroke
This explorative prospective study aims to assess the effects of heart rate variability biofeedback (HRV biofeedback) in patients with acute ischaemic stroke.
- Trial name
- Strokeback01 (NCT03865225)
- Testing
- Biofeedback
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Technische Universität Dresden
Recurrent Pregnancy Loss Without Current Pregnancy, Anxiety Disorder
Altered Interhemispheric DLPFC Coordination and Cardiac Hyperreactivity During Multisensory Aversive Challenge in Recurrent Pregnancy Loss With Comorbid Anxiety
This exploratory clinical study, NEURO-CARD-2, will use simultaneous functional near-infrared spectroscopy (fNIRS) and electrocardiography (ECG) to investigate interhemispheric dysfunction in the dorsolateral prefrontal cortex…
- Trial name
- NCT07045818
- Testing
- Multisensory aversive emotional challenge task
- Where
- 4 sites in China
- Volunteers
- 70 people
- Sponsor
- Shenyang Medical College
Stress
Time, Touch, Attention and the Autonomic Nervous System
The purpose of this study is to describe the onset, duration and dose-response of interpersonal mindful compassion on respiratory rate and heart rate variability in healthy adults in order to prepare for research evaluating the…
- Trial name
- NCT01428674
- Testing
- Interpersonal Mindful Compassion with Touch, Reading while extending loving kindness
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Chronic Migraine, Headache
Comprehensive Approach to Lifestyle Modification in Chronic Migraine
Migraine is a highly prevalent neurological disorder and one of the leading causes of disability worldwide, substantially affecting quality of life and individuals during their most productive years.
- Trial name
- CALM-Migraine (NCT07802860)
- Testing
- Comprehensive Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Spinal Cord Injuries, Cardiovascular Abnormalities
The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
The aims of this proposal are to: 1) investigate whether individuals with spinal cord injury (SCI) demonstrate cardiac autonomic, cerebrovascular, and cognitive dysfunctions compared to non-injured age- and sex-matched controls…
- Conditions
- Spinal Cord Injuries, Cardiovascular Abnormalities, Cerebrovascular Disease; Sequelae, Cognitive Impairment
- Trial name
- NCT05542238
- Testing
- One bout of moderate-intensity sub-maximal aerobic exercise
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo