Clinical trials: Cardiac Autonomic Neuropathy
Diabetic Autonomic Neuropathy Type 2, Perioperative Complication
Effect of Diabetes Mellitus on Cardiac Autonomic Function in Surgical Patients Undergoing General Anesthesia
Because autonomic neuropathy affects the constriction of thermoregulatory blood vessels, it is more difficult for diabetic patients to maintain their own body temperature in cold environments than normal people, and therefore it…
- Conditions
- Diabetic Autonomic Neuropathy Type 2, Perioperative Complication, Temperature Change, Body
- Trial name
- NCT06432270
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Diabetes Mellitus
Effects of Physical Training on Heart Rate Variability and Exercise Capacity in Diabetes With Autonomic Neuropathy
This study aimed to investigate effects of physical training on exercise capacity and changes of heart rate variability (HRV) at rest, during exercise, and post-exercise in the patient with diabetes with autonomic neuropathy…
- Trial name
- NCT00904761
- Testing
- exercise training
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Complex Regional Pain Syndrome, Carpal Tunnel Syndrome
Examination of the Pathophysiologic Mechanisms of CRPS by Using QST, CPM, RIC, and Heart Rate Variability QST
This study aims for a better understanding of the pathophysiological mechanisms of the complex regional pain syndrome (CRPS). This will be done by testing the quantitative sensory testing, the remote ischemic conditioning, the…
- Conditions
- Complex Regional Pain Syndrome, Carpal Tunnel Syndrome, Neuralgia
- Trial name
- NCT02261012
- Where
- Germany
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Tuberous Sclerosis Complex (TSC), Lymphangioleiomyomatosis (LAM)
Efficacy and Safety of RAD001 in Patients Aged 18 and Over With Angiomyolipoma Associated With Either Tuberous Sclerosis Complex (TSC) or Sporadic Lymphangioleiomyomatosis (LAM)
This study will evaluate the safety and efficacy of RAD001 in treating patients with Angiomyolipoma associated with Tuberous Sclerosis Complex or Sporadic Lymphangioleiomyomatosis.
- Trial name
- EXIST-2 (NCT00790400)
- Testing
- Everolimus (RAD001)
- Where
- 25 sites in United States, Canada and 9 more
- Volunteers
- 118 people
- Sponsor
- Novartis Pharmaceuticals
Autonomic Nervous System Disease, Amyloid Neuropathies
Autonomic Evaluation of Patients With Hereditary Amyloidotic Cardiomyopathy: Hereditary Amyloidotic Heart Disease
Transthyretin amyloidosis exhibits a variety of possible phenotypes, the hereditary neurological form being the most commonly found and studied (familial amyloidotic polyneuropathy or FAP), which can present from oligosymptomatic…
- Trial name
- NCT05087953
- Testing
- Head-Up Tilt table test, Heart Rate Variability
- Where
- 3 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Type 2 Diabetes, Diabetes With Diabetic Autonomic Neuropathy (Diagnosis)
The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy
Diabetic cardiac autonomic neuropathy (DCAN) is a common chronic complication that reduces survival in patients with diabetes. Epidemiological surveys have shown that the prevalence of DCAN is 25-75% in people with type 2…
- Trial name
- NCT06461377
- Testing
- Glucagon-like peptide-1 receptor agonist：Semaglutide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cardiac Autonomic Neuropathy, Diabete Type 1
Evaluation of Cardiac Autonomic Neuropathy in Children and Adolescents With Type 1 Diabetes Mellitus
study is to evaluate the prevalence of cardiac autonomic neuropathy in children with Type 1 DM and correlation with duration of DM and glycemic control.
- Conditions
- Cardiac Autonomic Neuropathy, Diabete Type 1, Pediatrics
- Trial name
- NCT07613372
- Testing
- Holter
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Marwa Abouelela Abd Elsalam
Syncope, Vasovagal
Cardiac Autonomic Dysfunction in Diabetics Patients With Syncope
Study hypothesis: cardiac autonomic dysfunction may affect vaso vagal syncope recurrences in type 2 patients with diabetes vs. patients without diabetes.
- Trial name
- NCT03717207
- Testing
- ecg Holter,, cardiac scintigraphy
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- University of Campania Luigi Vanvitelli
Parkinson's Disease, Autonomic Neuropathy
Effects of Feet Mechanical Stimulation on Cardiovascular Autonomic Profile and Inflammation in Parkinson's Disease
In the present study, investigators test the hypothesis that a controlled mechanical pressure applied on specific sites of both fore-feet (ES) can reduce the inflammatory state and arterial blood pressure in patients with…
- Conditions
- Parkinson's Disease, Autonomic Neuropathy, Inflammation, Hypertension
- Trial name
- parkgo-1 (NCT02608424)
- Testing
- Foot Mechanical Stimulation (Gondola®, CE marking n° 0476)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Clinico Humanitas
Chronic Kidney Disease, Cardiovascular Morbidity
Chemoreflex Sensitivity in Chronic Kidney Disease
Cardiovascular morbidity and mortality are markedly increased in chronic kidney disease (CKD) and may be explained in part by sympathetic hyperactivity.
- Trial name
- NCT00794872
- Testing
- blood sampling
- Where
- Germany
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Coronary Artery Disease, Cardiac Autonomic Neuropathy
IMPACT OF CARDIAC AUTONOMIC NEUROPATHY ON QT AND QTC INTERVAL
This prospective observational cohort study evaluated the effect of cardiac autonomic neuropathy (CAN) on perioperative ventricular repolarization, specifically QT and corrected QT (QTc) intervals, in patients undergoing elective…
- Conditions
- Coronary Artery Disease, Cardiac Autonomic Neuropathy, QT Interval Prolongation
- Trial name
- QT interval (NCT07684768)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Haseki Training and Research Hospital
Autonomic Neuropathy
A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes
This study will examine if one of the following methods: pupillometry, spectral analysis of heart rate variability and metaiodobenzylguanidine scintigraphy, is more capable to detect early diabetic autonomic neuropathy in…
- Trial name
- NCT01822431
- Testing
- metaiodobenzylguanidine scintigraphy
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- AHEPA University Hospital
Systemic Lupus Erythematosus, Autonomic Dysfunction
Vagus Nerve Stimulation for Systemic Lupus Erythematous
This trial uses a double blinded, randomized 1:1 (active:sham) placebo controlled, parallel group design, investigating the effects of transcutaneous vagus nerve stimulation (tVNS) in patients with systemic lupus erythematosus…
- Conditions
- Systemic Lupus Erythematosus, Autonomic Dysfunction, Autonomic Neuropathy, Fatigue
- Trial name
- SLE-VNS (NCT05315739)
- Testing
- Non-invasive transcutaneous vagus nerve stimulation (tVNS)
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 1 Diabetes Mellitus
To Evaluate if Wide Blood Sugar Fluctuations Lead to Injury of Heart Function and Heart Nerves
This proposal will test if, in patients with type 1 diabetes, wide blood glucose fluctuations lead to the injury to heart nerves , called cardiac autonomic neuropathy (CAN), and to impaired heart contractile (pumping) function…
- Trial name
- NCT01170832
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetes Complications
Pyridostigmine and Its Effects on Autonomic Modulation in Diabetic Patients
The purpose of the study is to determine if pyridostigmine bromide improves heart rate variability of type 2 diabetes mellitus subjects with cardiovascular autonomic neuropathy.
- Trial name
- NCT00953914
- Testing
- Pyridostigmine
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Primary Familial Dilated Cardiomyopathy
Exploratory Study of Danicamtiv in Patients With Primary Dilated Cardiomyopathy (DCM) Due to Genetic Variants or Other Causalities
The purpose of this Phase 2a study is to establish safety and preliminary efficacy of treatment with danicamtiv in patients with primary dilated cardiomyopathy (DCM) due to MYH7 or TTN variants or other causalities.
- Trial name
- NCT04572893
- Testing
- danicamtiv
- Where
- 19 sites in United States, Germany and 2 more
- Volunteers
- 41 people
- Sponsor
- Bristol-Myers Squibb