Clinical trials: Cardiac Bypass Patients
Coronary Artery Bypass, Cardiac Rehabilitation
Effects of Diaphragm Release Technique on Sleep Quality and Respiratory Function in Coronary Artery Bypass Graft Patients
This study aims to investigate the effects of diaphragm relaxation technique on sleep quality and respiratory functions in patients who have undergone coronary artery bypass graft (CABG) surgery.
- Trial name
- NCT07470034
- Testing
- Intervention Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Sanko University
Coronary Artery Disease
FiO2 and Outcomes After OPCAB (the CARROT Trial)
Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery including off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT03945565
- Testing
- Fraction of inspired oxygen level
- Where
- South Korea
- Volunteers
- 414 people
- Sponsor
- Seoul National University Hospital
Congenital Heart Disease, Congenital Heart Defect
Nitric Oxide Effect on Brain and Kidney in Pediatric Patients Undergoing Cardiopulmonary Bypass
The goals of this study are: 1. To evaluate the neuroprotective effect of nitric oxide by measuring glial fibrillary acid protein (GFAP) before and after surgery.
- Conditions
- Congenital Heart Disease, Congenital Heart Defect, Congenital Heart Malformations
- Trial name
- NCT05101746
- Testing
- Nitric Oxide (NO) 20 part per million (ppm), Standard of care cardiopulmonary bypass
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University Medical Center
Prevention & Control
Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease
The primary objectives of this study are: To determine whether rivaroxaban 2.5 mg twice daily (bid) + aspirin 100 mg once daily (od) compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction…
- Trial name
- COMPASS (NCT01776424)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Aspirin, Pantoprazole
- Where
- 565 sites in United States, Argentina and 31 more
- Volunteers
- 27,395 people
- Sponsor
- Bayer
Right Ventricular Function, Prone Position
Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine
Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay.
- Conditions
- Right Ventricular Function, Prone Position, Atelectasis, Atelectases, Postoperative Pulmonary
- Trial name
- BAROLO (NCT07632027)
- Testing
- Prone position
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Sahlgrenska University Hospital
Surgery, Coronary Artery Disease
Role of Sugammadex as Reversal Agent in Patients Extubated Immediately After Isolated Coronary Artery Bypass Grafting Surgery
The purpose of this study is to examine whether the use of Sugammadex will reduce time from reversal to extubation and improve other post extubation outcomes in Coronary artery bypass grafting patients.
- Trial name
- NCT03939923
- Testing
- Rocuronium, Neostigmine, Glycopyrrolate
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- West Virginia University
Coronary Artery Disease, Coronary Artery Disease (CAD)
Surgical Versus Percutaneous Revascularization in Patients With Reduced Left Ventricular Function (STICH 3.0-NL)
This randomized multicenter trial compares coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) in 358 patients with ischemic left ventricular dysfunction and multivessel coronary disease.
- Conditions
- Coronary Artery Disease, Coronary Artery Disease (CAD), Multivessel Coronary Artery Disease, CABG
- Trial name
- STICH 3*0-NL (NCT07269366)
- Testing
- CABG, PCI
- Where
- Netherlands
- Volunteers
- 358 people
- Sponsor
- University Medical Center Groningen
Chronic Coronary Syndrome, Coronary Artery Bypass Graft CABG
Antiplatelet Strategy for CCS Patients Undergoing CABG
To evaluate the long-term outcomes of different antiplatelet strategies, including DAPT, aspirin monotherapy, and clopidogrel monotherapy, in CCS patients undergoing CABG.
- Trial name
- CABG_DAPT_SAPT (NCT06881901)
- Volunteers
- 29,898 people
- Sponsor
- Samsung Medical Center
Cardiac Surgery, Cardiopulmonary Bypass
Voluven® in Paediatric Patients
This study will compare the clinical efficacy and safety of Voluven® and Human Albumin during elective open-heart surgery in pediatric patients.
- Trial name
- NCT00860405
- Testing
- HES 130/0.4 (6%) in sodium chloride (Voluven®, solution for infusion), Human serum albumin (HSA 50g/L), Human serum albumin (HSA 50g/L)
- Where
- 2 sites in Austria, Belgium
- Volunteers
- 61 people
- Sponsor
- Fresenius Kabi
Delirium
The Effects of Anaesthetic Agents on Postoperative Delirium
The purpose of this study is to prove the correlation between the post-operative delirium (POD) and anesthetic agents. The investigators hypothesized that intravenous anaesthetics would show the lower incidence of POD, compared…
- Trial name
- NCT02374177
- Volunteers
- 292 people
- Sponsor
- Konkuk University Medical Center
Cardiovascular, Coronary Artery Bypass
A Single-centre Study Comparing a Non-invasive Lactate Sensor to Standard Invasive Measurements in Patients Undergoing Coronary Artery Bypass Surgery.
The main goal of this study is to see how well a non-invasive lactate sensor measures lactate levels compared to standard blood tests.
- Conditions
- Cardiovascular, Coronary Artery Bypass, Valve Replacement
- Trial name
- CONTINUUM L (NCT06597253)
- Testing
- Lactate sensor
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Queen Mary University of London
Stem Cell Transplantation, Ventricular Dysfunction, Left
Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS)
Heart attacks are a leading cause of death in both men and women in the United States. When a person has a heart attack, blood is unable to reach a certain area of the heart, and if the blood supply is not re-established quickly…
- Trial name
- PROMETHEUS (NCT00587990)
- Testing
- Lower dose mesenchymal stem cell (MSC) injection, Higher dose MSC injection
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Joshua M Hare
Coronary Artery Disease, Atherosclerosis
Nitrite Effects on Cardiac Muscle in CABG
The purpose of this study is to test whether sodium nitrite affects the expression of cellular proteins important for metabolic and vascular function in vascular offcuts and cardiac biopsies taken from patients undergoing…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Vascular Diseases, Cardiac Disease
- Trial name
- NCT04001283
- Testing
- Sodium Nitrite, 0.9% Sodium-chloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of East Anglia
Cardiovascular Diseases
Effects of Lower Limb Resistance Band Exercises in Phase 1 Cardiac Rehabilitation
This study will be randomized controlled trial with non-probability purposive sampling. Study conducted among post CABG patients. Sample size will be 56, 28 in each group.
- Trial name
- NCT06319651
- Testing
- Lower Limb Resistance Band Exercises, Routine Phase 1 cardiac rehabilitation
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Riphah International University
Adult Patients Undergoing Cardiac Surgery, High Bleeding Risks
Transfusion Reduction in High-Bleeding-Risk Cardiac Surgery With Desmopressin
Rationale Bleeding after cardiac surgery is a complication that might result in increased morbidity, mortality, and cost of cardiac surgery by 1.76 (confidence interval (CI), 1.64-1.90) times and a median increase in costs by…
- Conditions
- Adult Patients Undergoing Cardiac Surgery, High Bleeding Risks, Planned Elective Cardiac Surgery Using CPB
- Trial name
- REDES-BLEED (NCT07012837)
- Testing
- Desmopresin
- Where
- Saudi Arabia
- Volunteers
- 112 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Cardiac Surgery, Coronary Artery Bypass
An Trial of Two Dosing Regimens of AP214 for the Prevention of Kidney Injury in Patients Undergoing Cardiac Surgery
This study investigates the effect of two dose-levels of AP214 on the prevention of (acute) kidney injury after cardiac surgery.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass, Aortic Aneurysm, Valve Surgery
- Trial name
- NCT01256372
- Testing
- AP214
- Where
- Denmark
- Volunteers
- 77 people
- Sponsor
- Action Pharma A/S
Cerebral Oxygen Saturation
The Effects of Demographic and Clinical Data of Patients on Cerebral Oxygen Monitoring Values
The aim of this study is to examine the effects of patients' clinical and demographic datas on cerebral oxygen saturation values. Brain oxygenation is measured using near infrared spectroscopy (NIRS).
- Trial name
- NCT07228546
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Tuna Şahin
Coronary Artery Disease, Coronary Artery Bypass
Glycemic Control Using Mobile-based Intervention in Patients With Diabetes Undergoing Coronary Artery Bypass to Promote Self-management
The study is a two-arm parallel, randomized clinical trial. The purpose of the study is to evaluate the effectiveness and feasibility of using high-quality medication reminder smartphone application as a tool for secondary…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass, Diabetes Mellitus
- Trial name
- GUIDEME (NCT04192409)
- Testing
- Smartphone Application
- Where
- China
- Volunteers
- 1,038 people
- Sponsor
- China National Center for Cardiovascular Diseases
Reperfusion Injury
Cardiac REperfusion With Intralipid® at Reperfusion
This study will evaluate the benefit of Intralipid® or placebo administered prior to reperfusion to limit ischemia reperfusion injury as measured by the geometric mean difference of the release of troponin I over 72 hours after…
- Trial name
- CREW-I (NCT02807727)
- Testing
- Intralipid 20%, Modified Ringers Lactate
- Where
- South Africa
- Volunteers
- 30 people
- Sponsor
- Nkanyiso Hadebe
Coronary Artery Bypass Graft Surgery, Cardiac Valve Surgery
Preparation of Patients for Cardiac Surgery
This was a prospective randomised trial of metabolic therapy including antioxidants and cellular energisers to determine whether this therapy could improve the results of cardiac surgery.
- Trial name
- MPM (NCT00906646)
- Testing
- Metabolic therapy
- Where
- Australia
- Volunteers
- 117 people
- Sponsor
- Bayside Health