Clinical trials: Cardiac Bypass Patients
Coronary Artery Disease, Postoperative Complications
Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The goal of this clinical trial is to learn whether two approaches to anesthesia and blood pressure management can improve care for adults having off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT07787364
- Testing
- Targeted Blood Pressure Management, Liberal Blood Pressure Management, Remimazolam
- Volunteers
- 416 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Nitroprusside, Thyroid Hormones
Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function
Whether use of SNP during cardiac surgery has any effect on thyroid function has not yet been investigated in humans. The aim of this study was to investigate the effects of SNP administration during the rewarming period of…
- Trial name
- NCT00636584
- Testing
- sodium nitroprusside
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Kavaklıdere Umut Hospital
Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
The Effect of Prophylactic Hemodialysis on the Morbidity and Mortality of the Patients With Chronic Kidney Disease Stages 3-4 Undergoing Coronary Artery Graft Bypass
Coronary artery disease is a major cause of death in patients with renal dysfunction Among patients who undergo coronary artery bypass grafting ,renal dysfunction is known To be a major predictor of in-hospital and remote…
- Conditions
- Chronic Kidney Disease stage3, Chronic Kidney Disease stage4, Coronary Artery Disease
- Trial name
- NCT01410617
- Testing
- hemodialysis
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Imam Khomeini Hospital
Multi Vessel Coronary Artery Disease
Dual Antiplatelet Therapy in Patients With Clopidogrel Resistance Following Off-Pump Coronary Artery Bypass
Ticagrelor, a direct-acting oral P2Y12-receptor antagonist, provides greater and more consistent platelet inhibition than clopidogrel.
- Trial name
- NCT05166538
- Testing
- Ticagrelor, Clopidogrel
- Where
- South Korea
- Volunteers
- 204 people
- Sponsor
- Yonsei University
Myocardial Reperfusion Injury, Hypoxia
Effects of Hypoxic-hyperoxic Preconditioning in Cardio-surgical Patients
Coronary artery bypass grafting (CABG) with cardiopulmonary bypass is a common surgical therapy for patients suffering from coronary artery diseases.
- Conditions
- Myocardial Reperfusion Injury, Hypoxia, Hyperoxia, Coronary Artery Disease
- Trial name
- NCT05354648
- Testing
- Hypoxic-hyperoxic preconditioning
- Volunteers
- 120 people
- Sponsor
- Alexander Averyanov
Cardiac Surgery for Bypass Grafting
Pilot Study to Establish a Repertoire of Megakaryocyte Markers, Quantifiable by Spectral Flow Cytometry, in Bone Marrow and Circulating in Patients Undergoing Cardiac Surgery for Bypass Grafting
Megakaryopoiesis, the mechanism of blood platelet production, is difficult to assess in clinical practice as it relies solely on microscopic description.
- Trial name
- EPIMéCA (NCT07026851)
- Testing
- Blood and bone marrow sampling
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Toulouse
Coronary Artery Bypass Graft, Hypokalemia
Comparison of Dexmedetomidine and Remifentanil Infusion During CABG
We are trying to investigate whether intraoperative dexmedetomidine infusion could decrease the incidence of intraoperative hypokalemia and arrhythmia, and myocardial injury in patients undergoing off-pump coronary artery bypass…
- Conditions
- Coronary Artery Bypass Graft, Hypokalemia, Cardiac Arrhythmia, Dexmedetomidine
- Trial name
- NCT01572454
- Testing
- Dexmedetomidine infusion, Remifentanil infusion
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Samsung Medical Center
Bleeding, Platelets
Autologous Cold-stored Apheresis Platelets
The Auto-PLTS Study is a single-centre trial performed at Toronto General Hospital (TGH) that uses a randomized, patient preference design.
- Conditions
- Bleeding, Platelets, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- Auto-PLTS (NCT07064954)
- Testing
- Autologous Cold-Stored Platelets, Allogeneic Room Temperature-Stored Platelets (Standard of Care)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Coronary Artery Disease, Cardiac Disease
Effects of Early Telerehabilitation in Coronary Artery Bypass Surgery Patients
The aim of this study was to investigate the effects of phase I and early phase II rehabilitation with telerehabilitation method and sleep hygiene training on physical capacity, cardiac functions, anxiety level, quality of life…
- Trial name
- NCT06240702
- Testing
- Telerehabilitation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Necmettin Erbakan University
Acute Coronary Syndrome
Effects and Plasma Concentration of Ticagrelor, After Crushed and Non-crushed Intake, After Acute Coronary Syndrome
The first aim of the study is to prove that after starting the therapy with crushed tablets, the platelet inhibition will be as expected after starting therapy with intact tablets. Gurbel et al.
- Trial name
- ticagrelor (NCT02341729)
- Testing
- ticagrelor
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Ghent
Cardiopulmonary Bypass
Validation of Near Infrared Spectroscopy (NIRS) During Heart-Lung Bypass in Children
Non-invasive assessment of blood flow to organs has long challenged clinicians. Recently, near infrared spectroscopy (NIRS) has been recognized as a methodology that may achieve this goal.
- Trial name
- NIRS (NCT00745394)
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Wounds, Infection
Autologous Platelet Gel in Wound Healing of Coronary Artery Bypass Grafting (CABG) Patients
This study will determine if autologous platelet gel (APG) on sternal incision and conduit sites will improve wound healing and decrease infection in coronary artery bypass grafting surgery patients.
- Trial name
- NCT00672672
- Testing
- autologous platelet gel
- Sponsor
- University of Nebraska
Coronary Artery Disease
Rehabilitation After Coronary Bypass Grafting. Comparison of Different Types of Rehabilitation Programs
The purpose of this study is to compare different types of rehabilitation after coronary bypass surgery. The investigators wish to compare rehabilitation in an institution for four weeks with a home based rehabilitation.
- Trial name
- NCT00363922
- Testing
- Rehabilitation in institution, Rehabilitation at home, Out-patient rehabilitation at the hospital
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Limb Edema, Surgical Site Infections
Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages
The study aimed to assess the efficacy of customized pressure-guided elastic bandages (CPG-EB) in preventing postoperative edema and complications in Coronary Artery Bypass Graft (CABG) patients.
- Conditions
- Limb Edema, Surgical Site Infections, Leg Swelling, Compression Bandages
- Trial name
- PEACCE (NCT06603961)
- Testing
- CPG-EB group
- Where
- 2 sites in Thailand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Cardiovascular Event, Coronary Artery Bypass Graft
Glycosylated Hemoglobin and Risk of Perioperative Major Cardiovascular Events in Diabetic Patients Undergoing Coronary Bypass Revascularization (HbA1c)
Glycosylated Hemoglobin (HbA1c) is considered as one of the best markers to assess the glycaemia treatment over a period of 3 to 4 months, and is considered as predictive marker for perioperative mortality and morbidity.
- Conditions
- Cardiovascular Event, Coronary Artery Bypass Graft, Diabetes Mellitus
- Trial name
- NCT03590223
- Testing
- Coronary Bypass Revascularization
- Where
- Switzerland
- Volunteers
- 589 people
- Sponsor
- University Hospital, Basel, Switzerland
Inflammatory Response, COVID-19
Pericardial Histopathology and COVID-19 Seropositivity
This prospective study aims to investigate the association between pericardial histopathologic inflammation grades (acute, chronic, or absent) and COVID-19 seropositivity in adult patients undergoing first-time isolated coronary…
- Conditions
- Inflammatory Response, COVID-19, Pericardial Disease
- Trial name
- NCT06952179
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Samsun University
Delirium
Delirium and EuroSCORE II in Cardiac Surgery
The goal of this observational study is to find out the association between EuroSCORE II of Delirium in patients undergoing cardiac surgery.
- Trial name
- NCT05218720
- Testing
- EuroSCORE II risk score and CAM-ICU (The Confusion Assessment Method for the Intensive Care Unit)
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University
Coronary Artery Disease
Tranexamic Acid in Clopidogrel Exposure to Decrease Hemorrhage and Transfusion
The use of platelet aggregation inhibitors, including aspirin and clopidogrel(CPDG), has become a standard management strategy for patients with acute coronary syndrome.
- Trial name
- TRACED (NCT01060163)
- Testing
- Tranexamic Acid, Saline
- Where
- 7 sites in China
- Volunteers
- 552 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Anemia, Renal Impairment
Blood Products in Cardiac Surgery
Blood transfusion is a common procedure essential for the treatment of patients undergoing cardiac surgery. Inappropriate transfusions, however, not only incur needless healthcare costs, but increase unnecessary risks due to…
- Conditions
- Anemia, Renal Impairment, Thrombocytopenia
- Trial name
- BiCS (NCT02068755)
- Volunteers
- 31,000 people
- Sponsor
- University of Turku
Patients Undergoing Cardiac Surgery Using Cardiopulmonary Bypass
FiO2 and Outcomes After Cardiac Surgery With Cardiopulmonary Bypass
Conventionally, a relatively high level of fraction of inspired oxygen (FiO2) has been used for secure a margin of safety in patients undergoing cardiac surgery using cardiopulmonary bypass (CPB).
- Trial name
- NCT03939832
- Testing
- Fraction of inspired oxygen level
- Where
- South Korea
- Sponsor
- Seoul National University Hospital