Clinical trials: Cardiac Bypass Patients
Coronary Artery Disease, Stable Angina
The Effect Of Ticagrelor On Saphenous Vein Graft Patency In Patients Undergoing Coronary Artery Bypass Grafting Surgery
In the POPular CABG study we investigate if the addition of ticagrelor, a drug that inhibits blood platelets from clotting, to treatment with aspirin will reduce the rate of saphenous vein graft occlusion as assessed with…
- Conditions
- Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- POPular CABG (NCT02352402)
- Testing
- Ticagrelor
- Where
- 6 sites in Netherlands
- Volunteers
- 487 people
- Sponsor
- J.M. ten Berg
Intraocular Pressure, Anesthesia
Intraocular Pressure in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass
The aim of the study to compare the effects of sevoflurane-based anesthesia and propofol-based total intravenous anesthesia on intraocular pressure (IOP) during coronary artery bypass graft surgery (CABG) with cardiopulmonary…
- Trial name
- NCT06494969
- Testing
- Intraocular pressure measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Antalya Training and Research Hospital
Cardiac Surgery and Cardiopulmonary Bypass
High-Dose N-Acetylcysteine in Cardiac Surgery
At least 14% of patients develop kidney failure after cardiac surgery. Although this kidney failure can usually be treated effectively, a longer stay in intensive care is often required.
- Trial name
- NCT00332631
- Testing
- N-acetylcysteine
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Austin Health
Coronary Artery Disease, Coronary Arteriosclerosis
Combination Stem Cell (MESENDO) Therapy for Utilization and Rescue of Infarcted Myocardium
The purpose of this research study is to determine if the transplant of a combination of stem cells, obtained from the bone marrow of the same patient, is effective for utilization and rescue of infarcted myocardium.
- Conditions
- Coronary Artery Disease, Coronary Arteriosclerosis, Coronary Atherosclerosis, Coronary Disease
- Trial name
- NCT00548613
- Testing
- MESENDO
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- TCA Cellular Therapy
Coronary Artery Disease, Stable Angina
Study Comparing Ticagrelor With Aspirin for Prevention of Vascular Events in Patients Undergoing CABG
The primary objective of this study ist to test the hypothesis that ticagrelor is superior to Aspirin (ASA) fort he prevention of major cardio- and cerebrovascular events (MACCE) in patients undergoing artery bypass operation.
- Conditions
- Coronary Artery Disease, Stable Angina, Acute Coronary Syndrome
- Trial name
- TiCAB (NCT01755520)
- Testing
- Ticagrelor, Aspirin
- Where
- 29 sites in Austria, Germany and 1 more
- Volunteers
- 1,893 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Valvular Heart Disease, Aortic Arch Aneurysm
The Effects of Intermittent Hypoxic-hyperoxic Preconditioning for Patients Undergoing Cardiopulmonary Bypass.
The aim of the study is to evaluate the effects of intermittent hypoxic-hyperoxic training (IHHT) to protect myocardium against perioperative myocardial injury during cardiac surgery using cardiopulmonary bypass.
- Conditions
- Valvular Heart Disease, Aortic Arch Aneurysm, Surgery
- Trial name
- NCT04833283
- Testing
- ReOxy Cardio device, intermittent hypoxic-hyperoxic training ( IHHT), ReOxy Cardio device
- Where
- Russia
- Volunteers
- 115 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Complications Due to Coronary Artery Bypass Graft, Coronary Artery Disease
Neurological Complications Comparing Endoscopically vs. Open Harvest of the Radial Artery
Coronary artery bypass grafting (CABG) using the radial artery (RA) has since the nineties gone through a revival. The initially reported worse outcome in RA graft patients compared to patients grafted with the saphenous vein…
- Conditions
- Complications Due to Coronary Artery Bypass Graft, Coronary Artery Disease, Myocardial Ischemia, Coronary Disease
- Trial name
- NEO (NCT01848886)
- Testing
- Endoscopic radial artery harvest, Open radial artery harvest, Mammarioradial graft (Y-graft)
- Where
- Denmark
- Volunteers
- 301 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiac Surgical Patients (CABG,Mammary Coronary Bypass Surgery,Plastic and Replacement of Valves, Atrial Septal Defect,Ventricular Septal Defect)
Evaluation of the Effectiveness and Safety of Vibro-acoustic Pulmonary Therapy (VAPT) in Complex Therapy for Acute Respiratory Failure of Mixed Type I-II Stages in Comparison With Percussion Massage in Cardiac Surgical Patients in the Early Postoperative Period
The goal of this observational study is to evaluate the effectiveness and safety of vibro-acoustic pulmonary therapy (VAPT) in complex therapy for the acute respiratory failure of mixed type I-II stages in comparison with…
- Trial name
- NCT06320483
- Testing
- Vibroacoustic device BARK VibroLUNG
- Where
- 5 sites in Kazakhstan
- Volunteers
- 310 people
- Sponsor
- Bark Technology LLP
Coronary Artery Disease, Acute Coronary Syndromes
CRAGS (Coronary aRtery diseAse in younG adultS)
Young patients requiring myocardial revascularization are generally considered at low operative risk, but data on their immediate and late outcome are scarce.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndromes, Young Patient, Percutaneous Coronary Intervention
- Trial name
- CRAGS (NCT01838746)
- Where
- 9 sites in Finland, Iceland and 2 more
- Volunteers
- 2,000 people
- Sponsor
- University of Turku
Coronary Artery Disease
Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass (PRIMO-CABG II)
During a heart bypass procedure, a substance called "complement" is activated by the body. This "complement activation" causes an inflammatory response that can lead to side affects such as chest pain, heart attacks, stroke…
- Trial name
- NCT00088179
- Testing
- pexelizumab in conjunction with CABG
- Where
- 188 sites in United States, France and 2 more
- Volunteers
- 4,000 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Fluid Volume Disorder
Effects of Hypertonic Saline-HES Solution on Extracellular Water in Cardiac Surgery Patients
The aim of the study is to describe the effects of hypertonic saline/hydroxyethylstarch solution in comparison to saline solution for 25 + 25 patients undergoing coronary bypass grafting surgery (CABG) using CPB.
- Trial name
- NCT01348659
- Testing
- 7.2% NaCl/hydroxyethylstarch, NaCl 0.9%
- Where
- Finland
- Volunteers
- 48 people
- Sponsor
- Kati Järvelä
Hypotension, Cardiopulmonary Bypass
Pharmacokinetics and Pharmacodynamics of MTR105 in Hypotensive Cardiac Surgery Patients
The purpose of this study is to evaluate the safety, pharmacokinetic and the pharmacodynamic effects of escalating doses of MTR105 while weaning from bypass in a hypotensive population of cardiac surgery patients.
- Trial name
- NCT00482287
- Testing
- MTR105
- Where
- United States
- Sponsor
- Meditor Pharmaceuticals Ltd.
Patient Care Team, Coronary Artery Disease
Developing an Intervention to Improve the Non-Technical Skills of the Cardiac Surgical Teams
Teams of several medical professionals conduct high-risk cardiac surgical procedures. These professionals work in complex, stressful operating room environments requiring effective communication and teamwork skills.
- Conditions
- Patient Care Team, Coronary Artery Disease, Coronary Artery Bypass, Surgery
- Trial name
- NCT06257511
- Testing
- Simulation-Based Mastery Learning of the Non-technical skills
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Diabetes, Coronary Artery Bypass Grafting
Vein-Coronary Atherosclerosis And Rosiglitazone After Bypass Surgery: The VICTORY Trial
HYPOTHESES Rosiglitazone in diabetic patients with previous coronary bypass surgery may prevent or slow the progression of atherosclerosis in SVGs and native coronary arteries.
- Trial name
- VICTORY (NCT00169832)
- Where
- 9 sites in Canada, Spain
- Volunteers
- 193 people
- Sponsor
- Laval University
Genetic Polymorphism, Coronary Artery Disease
Association Study of Gene Polymorphisms With Cardiac Performance
The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.
- Conditions
- Genetic Polymorphism, Coronary Artery Disease, Hemodynamics
- Trial name
- NCT00730899
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital, Essen
Heart Failure, Acute Coronary Syndrome
Platform Therapeutic Education in Heart Failure and Coronary Disease
A first therapeutic education is given before patient's discharge at the hospital, then a dedicated nurse follows patients through the phone,regularly according to patients' needs, continues to give advise on risk factors…
- Conditions
- Heart Failure, Acute Coronary Syndrome, Coronary Bypass Graft Stenosis of Native Artery Graft
- Trial name
- METISCARDIO (NCT01869452)
- Testing
- therapeutic education
- Where
- 4 sites in France
- Volunteers
- 555 people
- Sponsor
- Resicard
Surgical Blood Loss
Patient Blood Management in Cardiac Surgery
Preoperative anemia is associated with an important increase in transfusions of red blood cells (RBC) compared to a non-anemic patient in cardiac and non cardiac surgery.
- Trial name
- PBMc (NCT04040023)
- Testing
- Iron and vitamin Deficiencies Correction Program, PBMi: Training program to improve transfusion practices
- Where
- France
- Volunteers
- 900 people
- Sponsor
- Clinique Pasteur
Patients on Clopidogrel, Platelets Transfusion
Frequency of Platelets Transfusion & Post-Operative Bleeding Risk in Patients on Clopidogrel Undergoing CABG
The goal of this retrospective cohort study Is to Primarily be platelet transfusion frequency and postoperative bleeding risk, analysis using descriptive and inferential statistics in all eligible patients admitted to the cardiac…
- Trial name
- NCT07600060
- Where
- Pakistan
- Volunteers
- 227 people
- Sponsor
- Aga Khan University
Coronary Artery Bypass
Short-Stay Intensive Care for Coronary Artery Bypass Patients
Objective: To evaluate the safety and cost-effectiveness of Short Stay Intensive Care (SSIC) treatment for low-risk coronary artery bypass patients Design: Randomized clinical equivalence trial Setting: University Hospital…
- Trial name
- NCT00707044
- Testing
- Control group (usual care), Short-Stay Intensive Care treatment (SSIC)
- Where
- Netherlands
- Volunteers
- 597 people
- Sponsor
- Maastricht University Medical Center
Heart Valve Disease, Coronary Artery Disease
RiaSTAP vs. Conventional Transfusion in Patients Having Heart Valve Surgery
Heart surgery involving valve replacement often involves the use of the heart-lung machine for over 90 minutes, and bleeding tendency is frequently seen.
- Trial name
- RiaCT (NCT01283321)
- Testing
- Human fibrinogen concentrate, apheresis platelets
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Emory University