Clinical trials: Cardiac Bypass Patients
Postoperative Cognitive Dysfunction
Identification of Factors Causing Postoperative Cognitive Dysfunction in Patients Undergoing Cardiac Surgery With CPB
The incidence of cognitive decline occurs in 53% of patients after cardiac surgery. Causes of POCD can be various: age, duration of cardiac bypass, medicaments and many others.
- Trial name
- NCT03641833
- Testing
- blood sample for brain biomarkers
- Where
- Lithuania
- Volunteers
- 130 people
- Sponsor
- Rasa Bukauskiene
Coronary Artery Disease
On Versus Off Pump Myocardial Revascularization Study
Compare completeness and modality of revascularization, operative and postoperative results and 1 year clinical outcomes in unselected high risk patients referred for primary coronary artery bypass surgery.
- Trial name
- On-Off (NCT01290952)
- Testing
- Off-pump bypass surgery, On-pump bypass surgery
- Where
- 8 sites in Italy, Switzerland
- Volunteers
- 411 people
- Sponsor
- Medtronic Italia
Coronary Arterial Disease (CAD), Coronary Artery Bypass
Minimally Invasive Coronary Artery Bypass Surgery in Patients With Multi Vessel Coronary Disease
The objective of this study is to evaluate the safety and feasibility of Minimally Invasive Coronary Artery Bypass surgery in selected patients ,with multi vessel coronary disease.
- Trial name
- MINICABG (NCT06794359)
- Testing
- Minimally Invasive Coronary Artery Bypass Grafting, Coronary artery bypass surgery
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Coronary Syndrome
Timing of Coronary Artery Bypass Surgery Among Patients With Acute Coronary Syndromes Initially on Ticagrelor
Ticagrelor, a more potent P2Y12 inhibitor, has been shown to reduce major adverse cardiac events (MACE) in acute coronary syndromes (ACS). It is increasingly used as a first line therapy in ACS.
- Trial name
- RAPID CABG (NCT02668562)
- Testing
- Early CABG (Day 2-3 after ticagrelor discontinuation), Delayed CABG (Day 5-7 after ticagrelor discontinuation)
- Where
- 2 sites in Canada
- Volunteers
- 143 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Coronary Disease, Aortic Valve Stenosis
Quantitative Measurement of Myocardial Perfusion by Cardiac CT in Patients
It is a common understanding that patients with coronary heart disease are suffering, among others, from reduced myocardial perfusion.
- Trial name
- CCT/MPERF (NCT02361996)
- Where
- 3 sites in Austria, Russia and 1 more
- Volunteers
- 690 people
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Heart Failure Patients, Cardiac Ischemia
Safety and Efficacy of Cardiac Shockwave Therapy in Patients Undergoing Coronary Artery Bypass Grafting
This randomised, controlled clinical trial aims to evaluate the safety and efficacy of Cardiac Shockwave Therapy (CAST-HF) in patients with ischaemic heart failure requiring surgical revascularization.
- Trial name
- CAST-HF (NCT03859466)
- Testing
- Shockwave Therapy
- Where
- Austria
- Volunteers
- 63 people
- Sponsor
- Medical University Innsbruck
Complication of Coronary Artery Bypass Graft, Peri-operative Hemorrhage or Hematoma
Platelet Reactivity in Patients on a Thienopyridine and Awaiting Coronary Artery Bypass Grafting
The primary objective of this exploratory cohort study is to describe levels of platelet reactivity in patients on a thienopyridine awaiting coronary artery bypass grafting (CABG).
- Conditions
- Complication of Coronary Artery Bypass Graft, Peri-operative Hemorrhage or Hematoma, Post Operative Bleeding
- Trial name
- Serial CABG (NCT01406483)
- Testing
- Platelet reactivity assessment
- Volunteers
- 75 people
- Sponsor
- Medstar Health Research Institute
Coronary Artery Disease, Anemia
Clinical and Chemical Outcomes Following Cardiac Surgery: The Post-Operative Effects of MUF
It is hypothesized that on-line modified ultrafiltration (MUFF) post-cardiopulmonary bypass will result in improved patient outcomes over the 12-hour post-operative period as compared to control and off-line MUFF.
- Trial name
- MUF (NCT01864395)
- Testing
- Centrifugation Method, Online MUF, Offline MUF
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Saskatchewan
Microcirculatory Alterations
The Sublingual Microcirculatory Alterations in Patients Undergoing Extracorporeal Flow Conditions
The aim of this study is to observe the perioperative course of sublingual microcirculatory alterations in patients undergoing coronary artery bypass grafting (CABG) using cold blood compared with cristalloid cardioplegia.
- Trial name
- NCT02144298
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Frisius Medisch Centrum
Coronary Artery Disease, Vascularization
Acceptance and Commitment Therapy for Patients Undergoing Coronary Artery Bypass Graft Surgery
Heart disease is the leading cause of death globally, accounting for 16% of the world's total deaths. The number of cases is expected to increase as our population ages. Heart disease also results in large economic burden.
- Trial name
- ACT for CABG (NCT06207318)
- Testing
- Acceptance and commitment therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Iowa
Congenital Heart Disease
Study of Possible Brain Hormone Problems After Open Heart Surgery in Infants
The goal of this study is to evaluate specific hormone levels in children undergoing heart surgery in order to identify patterns associated with any unstable vital signs.
- Trial name
- NCT00850720
- Testing
- Blood draws
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Coronary Artery Disease, Sleep Quality
Effect of Eye Mask Use on Sleep Quality and Delirium After CABG Surgery
Coronary artery bypass graft (CABG) surgery is an effective treatment for coronary artery disease; however, sleep disturbances and delirium are common during the postoperative period and may adversely affect recovery.
- Conditions
- Coronary Artery Disease, Sleep Quality, Postoperative Delirium (POD)
- Trial name
- EYE-CABG (NCT07768020)
- Testing
- Eye Mask
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Munzur University
Delirium - Postoperative, BDNF
The Relationship Between Delirium and BDNF in Coronary Artery Bypass Graft Surgery
This study is aimed at finding a correlation between postoperative delirium occurrence, severity and duration after cardiac surgery and the level of brain-derived neurotrophic factor (BDNF) in plasma as a marker of brain injury…
- Conditions
- Delirium - Postoperative, BDNF, CABG
- Trial name
- NCT06967779
- Where
- Poland
- Volunteers
- 107 people
- Sponsor
- Pomeranian Medical University Szczecin
Coronary Artery Disease, Coronary Arteriosclerosis
Combination Stem Cell (MESENDO) Therapy for Utilization and Rescue of Infarcted Myocardium
The purpose of this research study is to determine if the transplant of a combination of stem cells, obtained from the bone marrow of the same patient, is effective for utilization and rescue of infarcted myocardium.
- Conditions
- Coronary Artery Disease, Coronary Arteriosclerosis, Coronary Atherosclerosis, Coronary Disease
- Trial name
- NCT00548613
- Testing
- MESENDO
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- TCA Cellular Therapy
Lung Injury, Postoperative Complications
Ventilation During Cardiopulmonary Bypass
Postoperative pulmonary dysfunction (PPD) is a widely reported complication of cardiopulmonary bypass (CPB) although there is improvement in perioperative management, that leads to increased morbidity and mortality in cardiac…
- Conditions
- Lung Injury, Postoperative Complications, Pulmonary Collapse
- Trial name
- NCT04962542
- Testing
- ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Acute Coronary Syndrome
Platelet Reactivity After CABG
Patients who have a heart attack are regularly treated with either clopidogrel or ticagrelor. In a large clinical trial, treatment with ticagrelor before coronary bypass surgery (CABG) was associated with a lower risk of death…
- Trial name
- NCT01793597
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Vermont
Coronary Artery Disease, Postoperative Complications
Intraoperative Targeted Versus Liberal Blood Pressure Management in Patients Undergoing Off-pump Coronary Artery Bypass Grafting
The goal of this clinical trial is to learn whether two approaches to anesthesia and blood pressure management can improve care for adults having off-pump coronary artery bypass grafting (OPCAB).
- Trial name
- NCT07787364
- Testing
- Targeted Blood Pressure Management, Liberal Blood Pressure Management, Remimazolam
- Volunteers
- 416 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Analgesia
Dexmedetomidine for Pain Reduction in CABG
The purpose of this study is to determine whether adjuvant intravenous dexmedetomidine infusion starting after induction of general anesthesia can provide superior pain management (decrease pain scores) and decrease opioid…
- Trial name
- NCT05534230
- Testing
- Dexmedetomidine Injectable Solution, Saline
- Volunteers
- 100 people
- Sponsor
- Wayne State University
Diabetes Mellitus, Type 2, Coronary Artery Disease
POST-CABGDM: Empagliflozin in Perioperative CABG
Introduction: Diabetes Mellitus (DM) is a condition known to be associated with coronary artery disease (CAD) and its role as promoter of atherosclerosis is well stablished.
- Conditions
- Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury
- Trial name
- POST-CABGDM (NCT04523064)
- Testing
- Empagliflozin 25 MG
- Where
- Brazil
- Volunteers
- 155 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Kidney Injury, Heart Valve Diseases
Correlation of Brain and Thenar Muscle Oximetry During Cardiac Surgery With Parameters of Acute Kidney Injury
Identification of risk factors of acute kidney injury (AKI). It is hypothesized that there might be a correlation between brain oximetry, tissue saturation of thenar muscle and marker of AKI in blood - neutrophil…
- Trial name
- NCT02979275
- Testing
- Open heart surgery on cardiopulmonary bypass.
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk