Clinical trials: Cardiac Bypass Patients
Heart Valve Diseases
Cardiopulmonary Bypass Prime Solution in Patients Undergoing Heart Valve Surgery
In this randomized clinical trial, patients with undergoing open heart valve surgery will be enrolled into the study. Participants will be divided into two groups based on the priming solution type.
- Trial name
- NCT05223361
- Testing
- Six percent hydroxy ethyl starch 130/0.4, Ringer lactate
- Where
- Iran
- Volunteers
- 120 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Counterpulsation, Coronary Artery Bypass
Efficacy of External CounterPulsation for Postoperative Coronary Artery Bypass Grafting Patients
The aim of this study is to evaluate the effect of External CounterPulsation on postoperative heart function and vein graft failure rates of coronary artery bypass grafting patients.
- Trial name
- SEECABG (NCT03235323)
- Testing
- External Counterpulsation
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Mengya Liang
Heart Diseases, Heart Valve Diseases
Acute Kidney Injury After Cardiac Surgery
The study aims to identify the Following: - 1. incidence and mortality of cardiac Surgery associated -AKI based on the new consensus diagnostic systems of KDIGO (Kidney Disease Improving Global Outcomes). 2.
- Conditions
- Heart Diseases, Heart Valve Diseases, Heart Shock, Cardiac Disease
- Trial name
- NCT05079724
- Testing
- Cardiac Surgery
- Volunteers
- 200 people
- Sponsor
- Assiut University
Coronary Artery Disease
Association Between Intraoperative Pulse Pressure Variation and Postoperative Lactate Clearance in Cardiac Surgery
This study aims to evaluate the relationship between intraoperative pulse pressure variation (PPV) and postoperative lactate clearance in adult patients undergoing elective cardiac surgery.
- Trial name
- NCT07871188
- Testing
- No Study-Specific Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Elzem SEN
Coronary Artery Bypass, Delirium
Organ Protection for Coronary Artery Bypass Graft (CABG): Propofol Versus Desflurane
Background: Different anaesthetic agents have been shown to have different protective effects upon heart, brain and renal function under ischaemic conditions (oxygen starvation).
- Conditions
- Coronary Artery Bypass, Delirium, Dementia, Amnesia
- Trial name
- NCT00400790
- Testing
- propofol, desflurane
- Where
- Australia
- Volunteers
- 182 people
- Sponsor
- University of Melbourne
Postoperative Atrial Fibrillation, Strains
Predictive Value of Right Atrial Strain in Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
The incidence of postoperative atrial fibrillation (POAF) after cardiac surgery is around 30%. POAF increases the risk of developing permanent atrial fibrillation and raises the risk of cardiac decompensation, stroke, acute…
- Trial name
- ODFAPO (NCT06054360)
- Where
- France
- Volunteers
- 334 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Low Cardiac Output
Efficacy, Safety of Hypertonic Lactate Soln. as Fluid Resuscitation Compared With Ringer's Lactate in Post-CABG Pats
Prospective, randomized, open-label study to assess the efficacy and safety of hypertonic lactate solution, compared to Ringer's Lactate as fluid resuscitation to maintain hemodynamic stability in post-coronary artery bypass…
- Trial name
- NCT00529490
- Testing
- Hypertonic lactate, Ringer's lactate
- Where
- Indonesia
- Volunteers
- 230 people
- Sponsor
- Innogene Kalbiotech Pte. Ltd
Cardiac Surgery, Cardiopulmonary Bypass
Calcium Administration in Cardiac Surgery
Termination of cardiopulmonary bypass is a critical step in any cardiac surgical procedure and requires a thorough planning. Debate about rationale of calcium administration during weaning of cardiopulmonary bypass has been…
- Trial name
- ICARUS (NCT03772990)
- Testing
- Calcium Chloride, 0.9% Sodium Chloride
- Where
- 11 sites in Bahrain, Russia and 1 more
- Volunteers
- 820 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Coronary Artery Disease, Physical Activity
Preoperative Excercise Training for Patients Undergoing Coronary Artery Bypass Graft Surgery
Patients (pts) with stable coronary artery disease (CAD) requiring coronary artery bypass graft surgery (CABG) may be physically inactive during the waiting period to avoid further risks.
- Conditions
- Coronary Artery Disease, Physical Activity, Coronary Artery Bypass Graft Surgery
- Trial name
- NCT04111744
- Testing
- Preoperative Exercise Training, Optimal medical therapy
- Where
- Germany
- Volunteers
- 203 people
- Sponsor
- Kerckhoff Klinik
Myocardial Injury, Coronary Artery Disease
Perioperative Myocardial Injury in Patients Undergoing Coronary Artery Bypass Grafting: A Prospective Clinical Study
Perioperative myocardial injury (PMI) following coronary artery bypass grafting (CABG) is associated with postoperative morbidity, mortality, and long-term outcomes.
- Trial name
- NCT07650487
- Testing
- High-Sensitivity Troponin, Cardiac MRI
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Hospital of Jilin University
Coronary Artery Bypass Graft Surgery, Pain
Effect of Using Walking Aid on Mobility
The goal of this clinical trial is to evaluate the effect of using walking aid during out-of-bed mobilization of patients who underwent open coronary artery bypass graft surgery on levels of pain and mobility.
- Conditions
- Coronary Artery Bypass Graft Surgery, Pain, Early Mobilization, Walking, Difficulty
- Trial name
- NCT05830682
- Testing
- using a walking aid
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Trakya University
Heart Failure, Arteriosclerosis of Coronary Artery Bypass Graft or Other Coronary Reperfusion
PAC-IC-SAOS Obstructive Sleep Apnea Syndrome and Ventricular Function
The aim of this clinical trial is to evaluate the effect of obstructive sleep apnea syndrome (OSAS) treatment in heart failure patients following coronary artery bypass graft (CABG) surgery or other coronary reperfusion.
- Conditions
- Heart Failure, Arteriosclerosis of Coronary Artery Bypass Graft or Other Coronary Reperfusion, Sleep Apnea, Obstructive
- Trial name
- PAC-IC-SAOS (NCT01900379)
- Testing
- CPAP treatment
- Where
- France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Grenoble
Myocardial Stunning
Safety and Efficacy of IV Diazoxide as an Additive to Hyperkalemic Cardioplegia in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
This study aims to confirm the safety and efficacy of diazoxide as an additive to hyperkalemic cardioplegia in patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- NCT04830982
- Testing
- IV Diazoxide
- Where
- United States
- Sponsor
- Johns Hopkins University
Postoperative Hemorrhage
Aprotinin US Special Access Protocol
This is a special access protocol that will allow physicians access to aprotinin during the temporary marketing suspension. The program will provide aprotinin for treatment of surgical patients undergoing coronary artery bypass…
- Trial name
- NCT00611845
- Testing
- Aprotinin (Trasylol, BAYA0128)
- Where
- 17 sites in United States
- Sponsor
- Bayer
Wounds, Infection
Autologous Platelet Gel in Wound Healing of Coronary Artery Bypass Grafting (CABG) Patients
This study will determine if autologous platelet gel (APG) on sternal incision and conduit sites will improve wound healing and decrease infection in coronary artery bypass grafting surgery patients.
- Trial name
- NCT00672672
- Testing
- autologous platelet gel
- Sponsor
- University of Nebraska
Cardiac Surgery
Efficacy and Safety of Sodium Heparin in Patients Submitted to Heart Surgery Using Bypass
The objective of this study is to verify, through a randomized, single-blind, multicentre, parallel and comparative study, the effectiveness of heparin sodium of porcine origin in patients undergoing heart surgery that require…
- Trial name
- NCT00905216
- Testing
- heparin sodium - Bergamo, heparin sodium - APP
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Azidus Brasil
Hypotension, Cardiopulmonary Bypass
Pharmacokinetics and Pharmacodynamics of MTR105 in Hypotensive Cardiac Surgery Patients
The purpose of this study is to evaluate the safety, pharmacokinetic and the pharmacodynamic effects of escalating doses of MTR105 while weaning from bypass in a hypotensive population of cardiac surgery patients.
- Trial name
- NCT00482287
- Testing
- MTR105
- Where
- United States
- Sponsor
- Meditor Pharmaceuticals Ltd.
Intensive Care Unit, Coronary Artery Bypass Grafting (CABG)
Intravenous Fish Oil Based Lipid Emulsion to Enhance Recovery in High-Risk Cardiac Surgery Patients
The MODIFY CSX study is a prospective, randomized, placebo-controlled trial conducted in heart centers in Germany and Italy. A total of 550 high-risk cardiac surgery patients will receive either 0.20 g fish oil/kg body weight…
- Conditions
- Intensive Care Unit, Coronary Artery Bypass Grafting (CABG), High Risk Patients, Cardiopulmonary Bypass
- Trial name
- MODIFY CSX (NCT06279793)
- Testing
- Fish Oil, Intravenous 0.9% Sodium Chloride
- Where
- 10 sites in Germany
- Volunteers
- 550 people
- Sponsor
- GCP-Service International West GmbH
Kidney Failure, Chronic, Coronary Artery Disease
Prophylactic Effect of Nifedipine on Further Decline in Renal Function in Patients Undergoing Open-Heart Surgery
To compare renal function (51Cr-EDTA clearance) 48 hours post open-heart surgery (coronary bypass or valve surgery) in patients with impaired renal function after randomization to either nifedipine infusion at start of surgery…
- Trial name
- NCT00244530
- Testing
- Nifedipine
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- University of Oslo School of Pharmacy
Congestive Heart Failure
Feasibility Study of BMAC Enhanced CABG
Patients undergoing CABG will have 60 mL of bone marrow drawn, concentrated in a SmartPRep2 centrifuge and have the concentrated nucleated cells injected into areas of ischemic myocardium
- Trial name
- NCT01074099
- Testing
- BMAC, CABG only
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Harvest Technologies