Clinical trials: Cardiac Defects
Heart Block After Surgery
Rhythm Disturbances After Ventricular Septal Defects
We would like to conduct a retrospective chart review examining the incidence of surgical heart block in children treated in the Cardiac Service Line at Children's Healthcare of Atlanta.
- Trial name
- NCT00208624
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Patent Ductus Arteriosus
HeartR™ PDA Occluder Post-Market Follow-Up Study
The HeartR™ PDA Occluder Post-Market Clinical Follow-up (PMCF) Study is a multi-center, retrospective, single-arm study sponsored by Lifetech Scientific (Shenzhen) Co., Ltd., aiming to evaluate the long-term safety and…
- Trial name
- NCT07646704
- Testing
- HeartR™ PDA Occluder
- Where
- Indonesia
- Volunteers
- 140 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Myocardial Injury, Cardiac Surgery
Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery
The study aimed to evaluate the combined effects of cyclosporine and remote ischemic preconditioning on MDA, calcium cytosol concentration, and mitochondrial edema in tetralogy Fallot patients undergoing corrective surgery.
- Trial name
- NCT05691764
- Testing
- Cyclosporin, remote ischemic preconditioning
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Indonesia
Atrial Fibrillation, Atrial Septal Defect
Utility of the Perclose ProGlide™ Suture-Mediated Closure Device After Cardiologic Procedures Via the Femoral Vein Approach (Eight-Clover)
The purpose of this study is to evaluate the clinical efficacy and safety of the Perclose ProStyle™ Suture-Mediated Closure Device in patients undergoing cardiologic procedures via a femoral vein approach using a sheath size of 8…
- Conditions
- Atrial Fibrillation, Atrial Septal Defect, Vascular Closure Device
- Trial name
- Eight-CLOVER (NCT07827287)
- Testing
- Perclose ProStyle™ Suture-Mediated Closure System, Conventional Hemostasis (Manual Compression or Figure-of-Eight Suture)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Heart Defects, Congenital, Breast Feeding
Study on the Construction and Application of Breastfeeding Behavior Intervention Program for Mothers of Infants With Congenital Heart Disease
This study is a randomized block trial designed to evaluate the effectiveness of a breastfeeding behavioural intervention program for mothers of infants with congenital heart disease (CHD).
- Trial name
- NCT05961540
- Testing
- Conventional care, Breastfeeding behavioural intervention for mothers of infants with CHD
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Children's Hospital of Fudan University
RASopathy, Costello Syndrome
Effect of RAS/MAPK Pathway Hyperactivation on Growth' and Bone' Profile of the RASopathies
Costello syndrome (CS) and cardio-facio cutaneous syndrome (CFCS) belongs to RASopathies, a group of multisystemic disorders caused by unregulated signalling through the RAS/MAPK pathway, an intracellular signalling pathway…
- Conditions
- RASopathy, Costello Syndrome, Noonan Syndrome, Cardio-Facio-Cutaneous Syndrome
- Trial name
- 3776 (NCT06331117)
- Testing
- Diagnostic test
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Patent Foramen Ovale (PFO), High Altitude Pulmonary Edema
The Cardiovascular Effects of Patent Foramen Ovale in Hypoxia
Before birth, the foramen ovale is a normal opening in the heart that allows blood to flow from the mother to the baby. After birth, this opening usually closes.
- Trial name
- NCT07742540
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Patients Who Underwent Surgery for Congenital Heart Disease
Influence of Tidal Volume During Mechanical Ventilation on Postoperative Clinical Outcome in Pediatric Patients Undergoing Congenital Heart Surgery
High tidal volume during mechanical ventilation has been reported to increase mortality in patients with acute lung injury or acute respiratory distress syndrome.
- Trial name
- NCT02081274
- Testing
- Surgery for congenital heart disease
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Congenital Heart Disease
The Co-Op @ HeartWorks
This protocol is a research study involving human subjects diagnosed with Congenital Heart Defects/Disease (CHD). The Co-Op @ HeartWorks is a cooperative between the research platform at HeartWorks and members of the CHD…
- Trial name
- NCT06469918
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- HeartWorks, Inc.
Coarctation of the Aorta, Aortic Arch Obstruction
The Arch Watch Study: An Integrated Evaluation of Hemodynamics in Infants With Suspected Coarctation of the Aorta
Unrecognized coarctation of the aorta (CoA) is a life-threatening component of congenital heart disease (CHD) in which narrowing of the aorta causes obstructed blood flow to the lower half of the body; it can occur in isolation…
- Trial name
- NCT05880576
- Testing
- Monitoring using resonance Raman spectroscopy, pulse oximetry, blood pressure, and near-infrared spectroscopy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Congenital Heart Disease
Comparison Between Multislice CT and Echocardiography in Diagnosis of Pediatric Congenital Heart Disease
1. Assesment of pediatric CHD by Echocardiography and Multislice CT before operation and compare with surgical results. 2. Compare echocardiogram and 128-Multislice spiral computed tomography(MSCT) in the diagnosis of pediatric…
- Trial name
- CHD (NCT05546008)
- Testing
- Multislice CT
- Volunteers
- 150 people
- Sponsor
- Assiut University
Thoracic Aorta Dilatation, Marfan Syndrome
Thoracic Aortic Dilatation Syndromes
Aortic dilatation syndromes are comprised by a group of different syndromes, of which Marfan syndrome is the best described. Many of the aorta dilatation associated syndromes are heritable connective tissue disorders but some…
- Trial name
- NCT02111668
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- University of Aarhus
Hypoplastic Left Heart Syndrome
Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome
This study is intended to evaluate the safety and feasibility of intramyocardial injection of allogeneic mesenchymal cells during the Bi-Directional Cavopulmonary Anastomosis (BDCPA) surgery for hypoplastic left heart syndrome…
- Trial name
- ELPIS (NCT02398604)
- Testing
- Allo-hMSCs
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Longeveron Inc.
Transposition of the Great Arteries, Systemic Right Ventricle
Systemic Right Ventricle Long-term Outcome
Patients with the transposition of great arteries (TGA) who undergo atrial switch operation and congenitally corrected TGA (ccTGA) patients have the right ventricle as their systemic ventricle.
- Trial name
- SINCERE (NCT06258083)
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 542 people
- Sponsor
- University Medical Center Groningen
Congenital Heart Disease, Oral Aversion
Nasal vs. Oral Intubation for Neonates Requiring Cardiac Surgery
Often, infants struggle to feed orally after surgery for congenital heart disease and may require supplemental feeding interventions at discharge.
- Trial name
- NCT05378685
- Testing
- Endotracheal intubation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Virginia
Mitral Valve Insufficiency, Heart Septal Defects, Atrial
MitraClip® and Hemodynamic Effects of Relevant Iatrogenic Atrial Septum Defect Closure
Aim of this prospective trial is to assess the hemodynamic effects of a MitraClip procedure caused iatrogenic arterial septal defect (iASD) and the functional changes after interventional iASD closure in a randomized setting.
- Trial name
- NCT03024268
- Testing
- Figulla Flex Occluder (Occlutech)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Heart Center Leipzig - University Hospital
Congenital Heart Defect
Use of ROTEM® in Pediatric Cardiac Surgical Patients
Cardiac surgery requiring use of a heart-lung machine, also known as cardiopulmonary bypass (CPB) can induce abnormalities in blood coagulation (clotting) that lead to excessive blood loss during and after operation.
- Trial name
- PedsROTEM (NCT01212289)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Weill Medical College of Cornell University
DiGeorge Syndrome, Velocardiofacial Syndrome
Velocardiofacial (VCFS; 22q11.2; DiGeorge) Syndrome Study
Velocardiofacial syndrome, also known as 22q11.2 syndrome or DiGeorge syndrome, has been associated with many features such as a cleft palate, heart defects, and learning, speech and feeding problems.
- Conditions
- DiGeorge Syndrome, Velocardiofacial Syndrome, 22q11.2 Syndrome
- Trial name
- NCT00105274
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Congenital Heart Disease
Peri-conception Key Nutritional Factors and Congenital Heart Disease
The study is a nested case-control study and the purpose is to describe the status of key nutrients(eg.folic acid and vitamins) supplementation among pregnant women in Shanghai, to find out the association between the level of…
- Trial name
- PKNFCHD (NCT02737644)
- Testing
- observation
- Where
- China
- Volunteers
- 37,000 people
- Sponsor
- Children's Hospital of Fudan University
Congenital Heart Disease
Quality of Life and Neurodevelopment Assessment of Children With Congenital Heart Disease Aged 2 to 4 Years
Congenital heart diseases (CHD) are the firt cause of congenital malformations (8 for 1000 births). Since the 90's, great advances in prenatal diagnosis, pediatric cardiac surgery, intensive care, and cardiac catheterization have…
- Trial name
- QoLCHD (NCT04812210)
- Where
- France
- Volunteers
- 248 people
- Sponsor
- University Hospital, Montpellier
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