Clinical trials: Cardiac Defects
Congenital Heart Disease
Study on Clinical Prognosis, Risk Factors and Genetic Basis of Congenital Heart Disease
The objective of this study is to investigate the effect of parental peri-natal environmental risk factors and genetic factors on the development of Congenital Heart Disease (CHD).
- Trial name
- SCPRFGBCHD (NCT01669057)
- Where
- China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Congenital Heart Disease
Endothelin Blockade in Patients With Single Ventricle Physiology
Recent studies have shown beneficial effects of sildenafil in patients with single ventricle congenital heart disease. The purpose of this study is to determine whether Bosentan, a drug with similar effects, will have similar…
- Trial name
- NCT00989911
- Testing
- Bosentan
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of California, Los Angeles
Congenital Heart Defects
Plasma Angiopoietin Levels in Children Following Cardiopulmonary Bypass
During cardiopulmonary bypass (CPB) after heart surgery, a child's blood is exposed to many foreign entities. These conditions trigger the body's inflammatory response which results in leaky capillaries, increased swelling and…
- Trial name
- NCT01489475
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Congenital Heart Defects, Inherited Cardiac Arrhythmias
Healthy Lifestyles for Children With Complex Heart Problems
Healthy Lifestyles for Children with Complex Heart Problems is a planning and resource development project. The goal of the project is to develop an implementation plan that would enable children with complex heart problems to…
- Conditions
- Congenital Heart Defects, Inherited Cardiac Arrhythmias, Cardiomyopathy
- Trial name
- ReACH (NCT01785498)
- Testing
- Supplementary resources
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Children's Hospital of Eastern Ontario
Heart Septal Defects, Ventricular, Double Outlet Right Ventricle, Noncommitted VSD
A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect
The purpose of this study is to investigate the security and validity of transesophageal echocardiography(TEE)-guided perventricular device closure(TPDC) through minithoracotomy in treatment of infundibular ventricular septal…
- Conditions
- Heart Septal Defects, Ventricular, Double Outlet Right Ventricle, Noncommitted VSD, Double Outlet Right Ventricle, Subaortic VSD, Double Outlet Right Ventricle, Subpulmonary VSD
- Trial name
- NCT02361008
- Testing
- TEE-guided perventricular device closure without CBP, Surgery repair with CBP
- Where
- China
- Volunteers
- 20,121,212 people
- Sponsor
- Bentong Yu
Heart Defects, Congenital, Hypertension, Pulmonary
Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery
This clinical trial will determine the safety and effectiveness of intravenous L-citrulline in children undergoing cardiopulmonary bypass during heart surgery.
- Trial name
- NCT00335244
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Pulmonary Arterial Hypertension, Congenital Heart Disease
Iloprost for the Treatment of Pulmonary Hypertension in Adults With Congenital Heart Disease
Pulmonary arterial hypertension (PAH), or high blood pressure in the lungs, is common in patients with congenital heart disease.
- Conditions
- Pulmonary Arterial Hypertension, Congenital Heart Disease, Eisenmenger's Syndrome
- Trial name
- NCT01319045
- Testing
- Iloprost
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of California, Los Angeles
Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure
Inhaled Iloprost as an Adjunct to Inhaled Nitric Oxide in Pediatric Critical Care Patients
The purpose of this study is to determine whether inhaled iloprost is safe and effective in pediatric patients with pulmonary hypertension who are sick in the intensive care unit.
- Conditions
- Pulmonary Hypertension, Neonatal Hypoxic Respiratory Failure, Persistent Pulmonary Hypertension of Newborn, Congenital Heart Defects
- Trial name
- NCT00981591
- Testing
- Iloprost
- Sponsor
- Seattle Children's Hospital
Congenital Heart Disease
Value of 6-minute Walk Test in Grown Ups With Congenital Heart Defects (GUCH)
The six-minute walk test is an established submaximal exercise test. Its role in examination of grown-up patients with congenital heart disease (GUCH) is not studied so far.
- Trial name
- NCT02193243
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Anemia
Iron Prophylaxis for Anemia in Infants With Cyanotic Congenital Heart Disease
Anemia is a common disorder in infants with one working chamber of the heart that pumps blood. Anemia is when the level of healthy blood cells becomes too low.
- Trial name
- NCT00459225
- Testing
- Iron (ferrous sulfate)
- Where
- United States
- Sponsor
- Emory University
Congenital Heart Disease
Congenital Heart Disease Research Registry
The Congenital Heart Disease Research Registry (CHDRR) is a program dedicated to understanding the etiology and improving the treatment of Congenital Heart Disease (CHD).
- Trial name
- CHDRR (NCT00757510)
- Where
- United States
- Volunteers
- 861 people
- Sponsor
- Emory University
Bundle-Branch Block, Heart Septal Defects, Ventricular
Right Bundle Branch Block After Surgical Closure of Ventricular Septal Defect
The most common congenital heart disease is the ventricular septal defect, and after surgical closure of a such defect, an arrythmia called the right bundle branch block, is very frequent.
- Trial name
- NCT01480908
- Testing
- Echocardiography at rest, Echocardiography during exercise, MRI at rest
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Congenital Heart Disease
Relationship of Brain Natriuretic Peptide (BNP) Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome
The purpose of this study is to assess brain natriuretic peptide levels to evaluate the relationship of those levels with the diagnosis of congenital cardiac disease, operation performed, post-operative course, and outcome.
- Trial name
- NCT00238810
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Healthcare of Atlanta
Congenital Disorders
Eisenmenger's Syndrome in Adults With CHD
Review the outcome of treatment with endothelin receptor antagonists (bosentan or sitaxsetan) alone or in combination with Sildenafil (a PDE-5 inhibitor) in adult patients with pulmonary hypertension due to congenital heart…
- Trial name
- NCT00266903
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Children's Healthcare of Atlanta
Cyanotic Congenital Heart Disease
Probiotics in Infants With Cyanotic Congenital Heart Disease
Infants with congenital heart disease have more frequent infections and exposures to antibiotics than healthy infants. It is unknown how congenital heart disease affects the development of bacterial colonization of the…
- Trial name
- NCT01018472
- Testing
- Bifidobacterium infantis
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, Davis
Congenital Heart Disease
Postoperative Troponin in Children With Congenital Heart Disease
The aim of the study is to evaluate the value of postoperative troponin in the prediction of mid term and long term mortality and morbidity in children with congenital heart disease undergoing cardiac surgery.
- Trial name
- NCT01616394
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Heart Defects, Congenital
Efficacy And Safety Of Clopidogrel In Neonates /Infants With Systemic To Pulmonary Artery Shunt Palliation
Contemporary management of cyanotic congenital heart disease includes three stages of surgery. Incidence of shunt thrombosis and death between the two first stages of palliation remains important.
- Trial name
- CLARINET (NCT00396877)
- Testing
- Clopidogrel (SR25990)
- Where
- 31 sites in United States, Argentina and 29 more
- Volunteers
- 906 people
- Sponsor
- Sanofi
Congenital Heart Defects, Growth Failure
Intestinal Function in Neonates With Complex Congenital Heart Disease
Postnatal intestinal function in cardiac infants. The overall goal of this proposal is to address a widespread health problem in the pediatric cardiac infant population - poor postnatal growth - through a collaborative effort…
- Trial name
- NCT01475357
- Testing
- Arm 1: NPO by mouth pre-operative, Arm 2: Fresh Breast Milk pre-operative
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Medical University of South Carolina
Congenital Heart Defects
Cardiac Resynchronization Therapy in Congenital Heart Defects
The objective of this multicentre prospective therapeutic study is to evaluate the effects of CRT on the right and left ventricular function of patients with CHD in the medium and long term.
- Trial name
- CARE-CHD (NCT00450684)
- Testing
- Implantation and testing of CRT
- Where
- 16 sites in Austria, Germany
- Volunteers
- 55 people
- Sponsor
- Competence Network for Congenital Heart Defects
Congenital Heart Disease
Effect of eHealth Encouragements to Intensive Exercise in Adolescents With Congenital Heart Disease
All over the world 0.8 % of all live children are born with a Congenital Heart Disease (CHD) due to genetic end environmental causes.
- Trial name
- PReVaiL (NCT01189981)
- Testing
- Lifestyle counseling, eHealth intervention
- Where
- Denmark
- Volunteers
- 158 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet