Clinical trials: Cardiac Flow
Coronary Vessels, Endothelins
Endothelin-Receptor Blockade in Coronary Heart Disease
Endothelin is a hormon that causes acute and chronic narrowing of heart vessels. The purpose of this study is to assess whether suppression of this activity by using two types of receptor antagonists can reduce this effect and…
- Conditions
- Coronary Vessels, Endothelins, Vascular Resistance
- Trial name
- NCT00427232
- Testing
- BQ-123 and BQ-788
- Where
- Austria
- Volunteers
- 26 people
- Sponsor
- Medical University of Vienna
Chest Wall Blocks
Serratus Anterior Plan Block (SAP) and Pectoralis (PECSI-II) Blocks on Left Internal Mammarian Artery (LIMA) Blood Flow
To investigate whether the anterior chest wall blocks performed before the surgery have an effect on the LIMA (left internal mammarian artery) blood flow in patients who will undergo coronary artery bypass surgery.
- Trial name
- NCT05907798
- Testing
- LIMA Blood flow
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Heart Failure
Study to Evaluate the Effects of AZD3427 in Patients With Heart Failure
The primary purpose of this mechanistic study is to evaluate the vasodilatory effects of AZD3427 in adult patients with heart failure and will be performed at approximately 2 study sites in the United Kingdom.
- Trial name
- NCT04890548
- Testing
- AZD3427
- Sponsor
- AstraZeneca
Aortic Stenosis, Severe
Exercise CMR in (p)LF-LG AS
Patient with paradoxical or conventional low-flow low-gradient aortic stenosis on echocardiographic assessment will undergo physiological exercise-stress CMR in addition to guideline recommended surveys prior to TAVR.
- Trial name
- NCT06129799
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Göttingen
Cardiovascular Abnormalities
Heartflow (AFFECTS)
The overall objective of the AFFECTS Study is to assess agreement between SPECT and FFRct in identifying vessel-specific, hemodynamically significant CAD in patients scheduled for invasive coronary angiography (ICA) based on…
- Trial name
- AFFECTS (NCT02973126)
- Testing
- FFRct and SPECT
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Baylor Research Institute
Microcirculatory Alterations
The Sublingual Microcirculatory Alterations in Patients Undergoing Extracorporeal Flow Conditions
The aim of this study is to observe the perioperative course of sublingual microcirculatory alterations in patients undergoing coronary artery bypass grafting (CABG) using cold blood compared with cristalloid cardioplegia.
- Trial name
- NCT02144298
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Frisius Medisch Centrum
Coronary Artery Disease (CAD), Stable Angina Pectoris
Identification of Lesion Characteristics in Coronary Plaques Using Multimodality Intravascular Imaging and Novel Photon-counting CT in Stable Angina
Coronary artery disease, caused by the furring up of the heart arteries by atherosclerosis, is a major cause of death in the UK.
- Conditions
- Coronary Artery Disease (CAD), Stable Angina Pectoris, Ischaemic Heart Disease (IHD)
- Trial name
- ILUMINA (NCT07864025)
- Testing
- observational study
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Queen Mary University of London
Aortic Valve Stenosis, Mitral Regurgitation
Coronary Physiology Peri-Transcatheter Left-sided Valvular Interventions
Prospective, single-arm, observational study with invasive coronary physiology measurements before and after transcatheter left-sided valvular intervention.
- Conditions
- Aortic Valve Stenosis, Mitral Regurgitation, Coronary Artery Disease, Fractional Flow Reserve
- Trial name
- POTUS (NCT05374733)
- Testing
- Coronary Physiology assessment
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Erasmus Medical Center
Coronary Stenosis
Pronostic Impact of Flow Fraction Reserve on Intermediate Stenoses
The intermediate coronary stenoses defined by a degree of stenosis from 40 to 70 % are frequent. The Flow Fraction Reserve (FFR), realized during coronarography, is an hemodynamic evaluation by the functional impact measuring the…
- Trial name
- NCT03588455
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Heart Failure
Effects of Increased CF-LVAD Pump Speed During Sustained Submaximal Exercise
This randomized trial has been designed to study if it is possible to enhance work capacity during submaximal efforts in heart failure patients supported with continuous-flow left ventricular assist devices (CF-LVAD).
- Trial name
- NCT02335684
- Testing
- CF-LVAD pump speed baseline., CF-LVAD pump speed increased.
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Disease
Prognostic Implications of Physiologic Investigation After Revascularization With Stent
Percutaneous coronary intervention (PCI) is a standard treatment strategy for coronary artery disease (CAD). With the presence of myocardial ischemia, PCI reduces the risks of death, myocardial infarction (MI) and…
- Trial name
- POST-PCI FLOW (NCT04684043)
- Testing
- Percutaneous coronary intervention
- Where
- South Korea
- Volunteers
- 5,100 people
- Sponsor
- Bon-Kwon Koo
Cardiomyopathies, Myocardial Injury
Cardiac Blood Flow Patterns Associated With Left Ventricular Myocardial Damage
Various factors affect the performance of the heart: The contractile properties of myocardial muscle cells are the fundamental devices for translating tension-generation and shortening of the cardiac muscle into…
- Conditions
- Cardiomyopathies, Myocardial Injury, Healthy
- Trial name
- CMR-LHD (NCT03253835)
- Testing
- Single Group Assignment
- Where
- Austria
- Volunteers
- 150 people
- Sponsor
- Medical University of Graz
Partial Anomalous Pulmonary Venous Connection
Percutaneous Treatment of Partial Anomalous Pulmonary Venous Drainage
Partial anomalous pulmonary venous drainage (PAPVD) occurs in around 1 in every 1000 people. Blood from part of the lung returns to the wrong side of the heart, causing the heart to stretch.
- Trial name
- NCT06048679
- Testing
- Endovascular pulmonary artery flow-limiting covered stent implantation
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Congestive Heart Failure (CHF)
Evaluation of Blood Flow Patterns in Lung Blood Vessels Using Ultrasound Technique in Patients With Congestive Heart Failure
Historically, transthoracic Doppler echocardiography has been unable to provide interpretable data of blood flow within the lung parenchyma because of air attenuation of Doppler signals.
- Trial name
- NCT01744210
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Echosense Ltd.
Coronary Artery Disease, Magnetic Resonance Angiography
Correlation Between Quantitative Analysis of Coronary MRA and FFR
This study aims to evaluate whether quantitative analysis of coronary MR angiogram would improve the detection of functionally-significant coronary artery stenosis.
- Conditions
- Coronary Artery Disease, Magnetic Resonance Angiography, Fractional Flow Reserve
- Trial name
- NCT03117218
- Testing
- Coronary MR angiography
- Where
- South Korea
- Volunteers
- 89 people
- Sponsor
- Seoul National University Bundang Hospital
Atherosclerosis and Blood Flow in Coronary Artery
Geometrical Influences on Atherosclerosis and Blood Flow
The study investigates the use of advanced imaging techniques and computational methods to identify high-risk plaques in coronary arteries.
- Trial name
- NCT07002697
- Where
- Bangladesh
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bangladesh University of Engineering and Technology
Coronary Artery Disease
Side Branch FFR After Provisional Stenting
The purpose of this study is to predict any changes in the side branch after stenting the main branch blood vessel using three dimensional intravascular images. (Frequency domain optical coherence tomography FD OCT).
- Trial name
- ORBID-FFR (NCT03115580)
- Testing
- Rotational atherectomy, Cutting Balloon Angioplasty
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Electrographic Flow Mapping Validation in Patients With Persistent Atrial Fibrillation (EVAL AF)
This is a prospective, observational, single center pilot trial to find out if a new computerized technology for analysis of the electrical activity recorded during atrial fibrillation can identify the electrical source of this…
- Trial name
- NCT05093868
- Testing
- Electrographic Flow Mapping
- Where
- United States
- Sponsor
- Corewell Health East
Cardiovascular Diseases, Chronic Heart Failure
FLOWS-HF : Feasibility of Lymphatic Offloading With Stenting in Heart Failure
The main objective is to evaluate the safety of lymphatic decompression in heart failure. The research hypothesis is that lymphatic decompression is safe and feasible in heart failure patients with recurrent congestion despite on…
- Trial name
- FLOW-HF (NCT06554912)
- Testing
- Lymphatic Decompression
- Sponsor
- University Hospital, Grenoble
Aortic Valve Stenosis
TranScatheter Aortic Valve RepLacement System US Feasibility Trial
A study to assess the safety and effectiveness of the Direct Flow Medical aortic valve system. This is for people with severe aortic stenosis who are not well enough to undergo a surgical repair.
- Trial name
- SALUS (NCT01932099)
- Testing
- Transcatheter aortic valve replacement
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Direct Flow Medical, Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.