Clinical trials: Cardiac Flow
Acute Myocardial Infarction, Diabetes Mellitus
Coronary Flow Reserve and Glucometabolic State
Diabetes mellitus is a major risk factor for the development of ischemic heart disease, and patients with diabetes mellitus have a worse outcome following an acute myocardial infarction than non-diabetic patients.
- Conditions
- Acute Myocardial Infarction, Diabetes Mellitus, Prediabetes
- Trial name
- NCT00845468
- Where
- Denmark
- Volunteers
- 190 people
- Sponsor
- Medicinsk Forsknings Afdeling
Ischemic Stroke
Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke
This study investigates if there are hemodynamic alterations in acute stroke that predispose patients to impaired perfusion and regulation of cerebral blood flow.
- Trial name
- NCT02056821
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Henry Ford Health System
Heart Disease, Neurocognitive Decline
Continuous Cellsaver and Neurocognitive Decline Post Cardiac Surgery
Patients having cardiac surgery to correct their heart disease may suffer a decline in mental and neurologic abilities. Passage of small particles of fat, tissue waste and air bubbles to the brain while on the heart-lung machine…
- Trial name
- NCT00296985
- Testing
- Fresenius Cellsaver
- Where
- Canada
- Volunteers
- 312 people
- Sponsor
- University Health Network, Toronto
Atherosclerosis
Hemodynamic Change of Coronary Atherosclerotic Plaque After Evolocumab Treatment
Compelling evidences indicate that lipid-lowering therapy can reduce the high-risk plaque feathers and improve the coronary flow reserve.
- Trial name
- NCT04416425
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zibo Central Hospital
Coronary Artery Disease
Computed Tomography Coronary Angiography (CTCA) and Coronary Flow in Stenosis Analysis
The investigators' rationale was to evaluate whether a 64-slice CT scanner allows accurate measurement of computed tomographic changes in coronary artery flow profiles and whether CT flow measurements are suitable for classifying…
- Trial name
- NCT00921440
- Volunteers
- 50 people
- Sponsor
- University of Cologne
Coronary Angiography
"Normal Coronary Artery" With Slow Flow Improved by Adenosine Injection, Dipyridamole Treatment and Clinical Follow-up
The investigators will investigate patients undergoing coronary angiography with normal coronary but slow blood flow that was normalized after adenosine injection into the coronary artery.
- Trial name
- NCT00960817
- Testing
- Statin, aspirin, Dipyridamole
- Where
- Israel
- Sponsor
- Hillel Yaffe Medical Center
Cardiac Surgery
Consistency of Carotid Doppler Blood Flow and Thermodilution Technique
Currently, the gold standard method to estimate CO is the thermodilution technique, pulmonary artery catheter (PAC) and PiCCO system included, however, the invasiveness and complexity of the thermodilution technique have limited…
- Trial name
- NCT05944146
- Testing
- passive leg raising, Dobutamine
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai Zhongshan Hospital
Hypotension Symptomatic, Ischemic Heart Disease
A Validation Study of Nitroglycerin Induced Acute Drop of Pd/Pa (NTG-Pd/Pa) in Clinical Practice
Hyperemia with adenosine was an elemental process in FFR examination. Adenosine injection will induce some discomfort, and increase cost expenditure.
- Trial name
- NCT04700397
- Testing
- Nitroglycerine
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Normal Healthy Volunteers Without Chronic Medical Conditions, Coronary Artery Disease
3D PET Myocardial Blood Flow and Rb82 Infusion Profiles
The investigators seek to test bolus infusions (50ml/min) vs. slow infusions (20 ml/min) of Rb-82 on metrics of coronary blood flow assessed on a modern 3D PET/CT.
- Conditions
- Normal Healthy Volunteers Without Chronic Medical Conditions, Coronary Artery Disease, Cardiac Risk Factors, Myocardial Infarction
- Trial name
- NCT05286593
- Testing
- Slow Infusion of Rubidium-82
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Fluid Responsiveness, Passive Leg Raising
Fluid Responsiveness With Passive Leg Raising in Patients Undergoing Coronary Artery Bypass Surgery
The aim of this study is to investigate the reliability of corrected carotid flow time (ccFT) and the percentage change in peak flow velocity (ΔVpeak), as non-invasive methods for assessing fluid responsiveness using the passive…
- Conditions
- Fluid Responsiveness, Passive Leg Raising, Corrected Carotid Flow Time
- Trial name
- NCT07245485
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara City Hospital Bilkent
Coronary Artery Insufficiency
FROST 4: Study of the Optimal Spreading of a Coronary Stent Guided With Pressure Into the Coronary Arteries
Hypothesis : it is known that the stent must be well opened out in order to avoid restenosis into the stent. Intra coronary pressure would allow the stent to be well deployed and so the restenose into the stent should diminish.
- Trial name
- NCT00242892
- Testing
- Intra coronary measures of pressure
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Severe Cardiac Insufficiency
Determination of Risk Factors of Ventricular Arrhythmias (VAs) After Implantation of Continuous Flow Left Ventricular Assist Device With Continuous Flow Left Ventricular Assist Device (CF-LVAD)
Determination of risk factors of ventricular arrhythmias (VAs) after implantation of continuous flow left ventricular assist device in order to characterize which patient requires ICD implantation in primary prevention.
- Trial name
- ASSIST-ICD (NCT02873169)
- Testing
- Implantable cardioverter-defibrillator
- Where
- 20 sites in France
- Volunteers
- 681 people
- Sponsor
- Rennes University Hospital
Healthy
Trial to Assess the Effects of Different Trans-fatty Acids on Endothelial Function in Humans
The aim of the study is to compare a diet rich in trans fatty acids (TFA) from ruminant sources with a diet rich in TFA from hydrogenated vegetable oils (PHVO) in regard to their effects on cardiovascular risk markers…
- Trial name
- NCT00933322
- Testing
- diet enriched with industrial trans fatty acids, diet enriched with ruminant trans fatty acids, diet without any trans fatty acids
- Where
- Switzerland
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Disease
Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease
This is a prospective pilot study to evaluate the safety, tolerability and technical feasibility of utilizing carbon dioxide for assessing coronary blood flow in subjects with coronary artery disease.
- Trial name
- NIMO-CAD (NCT06253884)
- Testing
- RespirAct
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Coronary Microvascular Dysfunction
A Plant-Based Diet in the Treatment of Coronary Microvascular Dysfunction
This study will evaluate whether a fully provided, unrefined, polyphenol-rich plant-based diet can improve blood vessel function in adults with coronary microvascular dysfunction (CMD), a condition that causes reduced blood flow…
- Trial name
- NCT07821372
- Testing
- Polyphenol-Rich Plant-Based Diet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Single Ventricle Defect
Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction
This study seeks to determine cerebral blood flow changes in single ventricle patients during staged surgical reconstruction as compared with normal children.
- Trial name
- CBF (NCT02135081)
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Children's Hospital of Philadelphia
Anesthesia, Cardiac Disease
High Flow Nasal Oxygen During Sedation
The primary objective of this study is to test the hypothesis that using high flow nasal oxygen improves ventilation during cardiac implantable electronic device procedures performed with conscious sedation.
- Trial name
- NCT03858257
- Testing
- High flow nasal oxygen, Standard oxygenation
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- University Health Network, Toronto
Heart Failure, Diastolic, Diastolic Heart Failure
Myocardial Perfusion, Oxidative Metabolism, and Fibrosis in HFpEF
Unlike heart failure with reduced ejection fraction (HFrEF) where several medicines and devices have been demonstrated to reduce mortality, no such therapies have been identified in HFpEF.
- Conditions
- Heart Failure, Diastolic, Diastolic Heart Failure, Hypertension
- Trial name
- HFpEF-PRoF (NCT02589977)
- Testing
- regadenoson
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Marvin W. Kronenberg, M.D.
Coronary Artery Disease
Measurements to Assess Severity of Epicardial Stenoses
Newly developed diagnostic parameters have potential to differentiate between epicardial disease and microvascular dysfunction with the help of anatomical details and physiological endpoints and can be used in present clinical…
- Trial name
- MASES (NCT00760630)
- Testing
- FFR/CFR and IVUS
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Atrial Septal Defect
The Effect of the Hole in the Cardiac Septum Developed by the MitraClip Procedure on the Blood Flow Mechanics
Patients received a MitraClip procedure because of a leakiness of their mitral valves. During this procedure the atrioventricular valves were stuck together permanently via a clip which leads to a reduction of leakiness.
- Trial name
- MitraClipASD (NCT02453451)
- Testing
- 2D-/3D-TTE, 3D-TEE, Walking Test
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- RWTH Aachen University
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