Clinical trials: Cardiac Flow
Heart Failure, Right Ventricular Dysfunction
Mitigating Post-Op RV Dysfunction After LVAD Implantation
This project evaluates right ventricle (RV) protective strategies after left ventricular assist device (LVAD) implantation.
- Conditions
- Heart Failure, Right Ventricular Dysfunction, Right Ventricular Failure
- Trial name
- NCT05758194
- Testing
- Standardized RV Management, Usual Care RV Management
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
HIV-1-infection, Coronary Microvascular Dysfunction
Improving Coronary Vascular Health in Women
Women with HIV have an increased risk of having a myocardial infarction (heart attack) as compared to women without HIV. One of the mechanisms underlying the increased risk of myocardial infarction among women with HIV may…
- Conditions
- HIV-1-infection, Coronary Microvascular Dysfunction, Metabolic Disease
- Trial name
- INFORM_2 (NCT06843902)
- Testing
- Health Education, Subspecialty clinic referral
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Heart Failure
ExplorATory Study oF the EdWards Transcatheter Atrial Shunt System (AlT FloW Germany)
The Exploratory Study of the Edwards Transcatheter Atrial Shunt System is a multi-center, prospective, exploratory study to evaluate initial clinical safety, device functionality, and effectiveness of the Edwards Transcatheter…
- Trial name
- AlT-FloW (NCT04965623)
- Testing
- Atrial Shunt
- Sponsor
- Edwards Lifesciences
Cardiovascular Disease
Cerebrovascular Outcomes in Ischemic Heart Disease
This project will examine the association between (cardio)vascular disease, blood supply to the brain, and cerebrovascular endothelial activation.
- Trial name
- IHD (NCT02715661)
- Testing
- exercise
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
No-Reflow Phenomenon, Coronary Artery Disease
A Study to Evaluate the Impact of Pre-procedural Intracoronary Nicorandil Injection to PREVENT reductioN Of decREased TIMI FLOW in Patients Who Undergoing Percutaneous Coronary Intervention for the Coronary Artery Disease
The aim of this study was to determine the effect of intra-coronary administration of nicorandil on the prevention of lowering of coronary blood flow for high-risk plaque lesions defined as the high value of lipid core burden…
- Conditions
- No-Reflow Phenomenon, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- NCT05427786
- Testing
- Nicorandil
- Where
- South Korea
- Volunteers
- 458 people
- Sponsor
- Korea University Anam Hospital
Coronary Artery Disease
Impact of Coronary Artery Stenting on Quantitative Myocardial Blood Flow and Health Status
We propose to perform PET MPI studies in patients before and after stenting to evaluate changes (or lack thereof) in MBFR and how that is associated with changes (or lack thereof) in symptoms, functional status and quality of…
- Trial name
- NCT04475094
- Testing
- Rubidium-82, Seattle Angina Questionnaire-7, Rose Dyspnea Scale
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Cardiovascular Imaging Technologies
Coronary Artery Disease
Diagnostic Accuracy of Quantitative Flow Ratio
The aim of this study was to investigate the accuracy of quantitative flow ratio (QFR) for predicting fractional flow reserve (FFR) ≤0.80 in an independent core laboratory.
- Trial name
- NCT06305572
- Testing
- QFR
- Where
- South Korea
- Volunteers
- 280 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
One-Dimensional Mathematical Model-Based Automated Assessment of Fractional Flow Reserve
This study evaluates the diagnostic efficiency of an automated method of noninvasive assessment of the fractional reserve of coronary blood flow.
- Trial name
- NCT03797118
- Testing
- FFR
- Where
- Russia
- Volunteers
- 31 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Mechanical Circulatory Support
BRAIN-HEART Ultrasound Study Normative Values for Transcranial Doppler Based Cerebral Blood Flow Assessment
There is a dire need to establish normative values for transcranial Doppler(TCD) derived cerebral blood flow parameters for each type of Mechanical circulatory support (MCS) device and explore the relationship between the MCS…
- Trial name
- MCS (NCT05924503)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Wake Forest University Health Sciences
Coronary Artery Disease
Evaluation of Health Economics for Noninvasive Coronary Fractional Flow Reserve Measurement Technology
To determine whether, in a Chinese population of patients presenting to Wuhan Asia Heart Hospital, Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography (CT-FFR) as a default test is noninferior in terms…
- Trial name
- NCT05593120
- Testing
- CT-FFR, Routine care
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shenzhen Raysight Intelligent Medical Technology Co., Ltd.
Coronary Artery Disease
Myocardial Flow Reserve and 99mTc-DTPA Cardiac Dynamic SPECT
New CZT-based SPECT cameras are potentially capable of dynamic 3-D acquisition. Preliminary results suggested that dynamic acquisitions could allow the assessment of myocardial flow reserve using 99mTc-labelled perfusion tracers.
- Trial name
- Flow-Heart (NCT02844686)
- Testing
- Cardiac SPECT
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Heart Failure
Blood Flow Restriction Combined With Aerobic or Resistance Exercise in Heart Failure
The aim of this study is to compare the clinical effects of aerobic and resistance exercise modalities combined with blood flow restriction in patients with stable heart failure, and to determine the most effective, feasible, and…
- Trial name
- NCT07627737
- Testing
- Aerobic Exercise Plus Blood Flow Restriction Resistance Training, Resistance Training Plus Blood Flow Restriction Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Biruni University
Myocardial Ischemia
Effect of Timi3 Ultrasound on Myocardial Blow Flow in the Hibernating Myocardium
The purpose of this study is to evaluate whether the use application of low frequency ultrasound, administered by the Timi3 ultrasound device, increases myocardial blood flow to the heart, in subjects with reduced myocardial…
- Trial name
- NCT00655070
- Testing
- Timi3 Transthoracic ultrasound
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of California, San Francisco
Infarction, Myocardial Infarction
Which Platelet Function Test Best Reflects the In Vivo Plasma Concentrations of Ticagrelor and Its Active Metabolite?
Ticagrelor is a direct-acting, reversible platelet P2Y12 receptor inhibitor recommended by the recent European Society of Cardiology guidelines in patients with acute coronary syndromes (ACS) (class of recommendation I, level of…
- Conditions
- Infarction, Myocardial Infarction, Cardiovascular Diseases, Heart Diseases
- Trial name
- HARMONIC (NCT02690454)
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Blood Flow Restriction Exercise, Aging
Acute Autonomic Responses During and After BFR Training
The goal of this clinical trial is to compare how the body's nervous system responds to two different types of leg exercise in young and older adults.
- Trial name
- HOLD TIGHT (NCT07722403)
- Testing
- High-Intensity Resistance Training (HIRT), Low-Intensity Resistance Training with Blood Flow Restriction (LIRT-BFR)
- Where
- Portugal
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Bifurcating Coronary Artery Lesions, Main Branch Stent Implantation
Mechanism and Predictor of Side Branch Jailing
Coronary artery bifurcation lesion is still one of the most challenging lesion subsets in the field of non-surgical treatment for a stenotic coronary artery.
- Conditions
- Bifurcating Coronary Artery Lesions, Main Branch Stent Implantation, Side Branch Jailing
- Trial name
- PRESSURE (NCT00553670)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Angiography-derived FFR GPS in Predicting Post-PCI Physiological and Clinical Outcomes
To investigate the feasibility of physiological map generated from angiography-derived fractional flow reserve (FFR) (angio-FFR) pullback and its value in predicting physiological and clinical outcomes after stenting.
- Trial name
- Angio-GPS (NCT05496023)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 329 people
- Sponsor
- Shanghai Zhongshan Hospital
Chest Pain, Stable Angina
In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes?
A randomised controlled trial to compare two strategies for the investigation of coronary artery disease at the time of angiography.
- Conditions
- Chest Pain, Stable Angina, Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome
- Trial name
- RIPCORD 2 (NCT02892903)
- Testing
- Routine Measurement of FFR
- Where
- 17 sites in United Kingdom
- Volunteers
- 1,100 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Heart Failure
Inspiratory Muscle Training for People With Heart Failure
Heart failure is frequently associated with inspiratory muscle weakness, which contributes to dyspnea, reduced exercise capacity, impaired quality of life, and adverse cardiovascular outcomes.
- Trial name
- NCT07672041
- Testing
- Inspiratory muscle training with Tapered Resistive Load, Inspiratory muscle training with threshold load, Concurrent Exercise Training
- Where
- Chile
- Volunteers
- 108 people
- Sponsor
- Universidad Nacional Andres Bello
Coronary Artery Disease
F-18 Rhodamine 6G PET Imaging for Myocardial Blood Flow
Use of novel radio-pharmaceutical Rhodamine 6G to determine myocardial blood flow
- Trial name
- NCT04528758
- Testing
- Rhodamine 6G
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
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