Clinical trials: Cardiac Flow
Coronary Artery Stenosis
Fractional Flow Reserve and Intravascular Ultrasound in Evaluating Intermediate Coronary Lesions
Recent studies have shown that optimal IVUS criteria defining the functional significance (FFR < 0.8) of intermediate coronary stenoses is different according to their locations of the coronary tree.
- Trial name
- NCT01414361
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
Myocardial Infarction, Multivessel Coronary Artery Disease
Comparison Between FFR Guided Revascularization Versus Conventional Strategy in Acute STEMI Patients With MVD.
The Compare-Acute trial is a prospective randomised trial in patients with multivessel disease, who are admitted into hospital with a ST-elevation Myocardial Infarction.
- Trial name
- CompareAcute (NCT01399736)
- Testing
- FFR-guided revascularisation strategy, randomised to guidelines group
- Where
- 26 sites in Czechia, Germany and 6 more
- Volunteers
- 885 people
- Sponsor
- Maasstad Hospital
Coronary Artery Disease, Dyslipidemia
The Impact of Tredaptive on Flow-Mediated Dilation in Cardiac Patients
Laropiprant (LRP; Merck \& Co., Inc, Whitehouse Station, NJ, USA) is a potent, once-daily, highly selective PGD2-receptor (DP1) antagonist.
- Trial name
- NCT01052311
- Testing
- Tredaptive (1 g extended release niacin+ 20 mg laropiprant), Tredaptive
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Sheba Medical Center
Esophagus Cancer, Stomach Cancer
Effects of S-1 and Capecitabine on Coronary Artery Blood Flow
Fluoropyrimidine chemotherapy agents , such as 5-fluorouracil and capecitabine, are occasionally associated with cardiac toxicity.
- Conditions
- Esophagus Cancer, Stomach Cancer, Small Bowel Cancer, Colon Cancer
- Trial name
- FluoHeart (NCT02216149)
- Testing
- S-1, Capecitabine, Oxaliplatin
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- Heikki Joensuu
Heart Failure With Normal Ejection Fraction
Flow Regulation by Opening the Septum in Patients With Heart Failure Trial
To investigate the safety and efficacy of a novel atrial flow regulator (AFR) device in patients with heart failure and preserved ejection fraction.
- Trial name
- FROST-HF (NCT03751748)
- Testing
- AFR implantation
- Where
- 3 sites in Canada
- Volunteers
- 230 people
- Sponsor
- Unity Health Toronto
Heart Failure
Data Collection During CT for Axial Flow VADs
At present, there is not accurate way to determine specific flow rates for axial flow ventricular assist devices (VADS). If a right heart cath is needed for these patients for clinical purposes, they will also undergo a cardiac…
- Trial name
- NCT00427739
- Testing
- Cardiac CT
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Subha Raman
Cardiac Surgery
Diagnostic Interest of Leukocyte Immunophenotyping Using Multiparameter 8-color Flow Cytometry in Heart Surgery
In septic patients, Septiflux1 study identified immature granulocytes which may have a diagnostic and prognostic interest. However, with these preliminary results it is not possible to make a difference between what is linked to…
- Trial name
- INFLUX (NCT02216019)
- Testing
- Whole blood
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Limoges
Heart Failure, Endothelium
Effect of Urocortins in Patients With Heart Failure
Despite modern advances in treatment, heart failure continues to carry a poor prognosis with high morbidity and mortality rates.
- Trial name
- NCT01599728
- Testing
- Urocortin 2, Urocortin 3 and Substance P
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
CABG Graft Integrity, CABG
The Relationship Between Blood Flow Readings During Surgery and How Well the Graft Stays Open and How Patients Recover Afterward in Coronary Artery Bypass Graft Surgery
The purpose of this study is to learn more about a tool called Transit-Time Flow Measurement (TTFM). TTFM uses sound waves during surgery to check how well blood is flowing through blood vessels.
- Conditions
- CABG Graft Integrity, CABG, Blood Flow, Transit-time Flow Measurement
- Trial name
- SMARTFLOW (NCT07485738)
- Testing
- Transit-Time Flow Measurement (TTFM)
- Where
- United States
- Volunteers
- 1,242 people
- Sponsor
- Weill Medical College of Cornell University
Heart Failure, Exercise Tolerance (Measured in Minutes)
High-Flow Nasal Cannula on Exercise Tolerance in Heart Failure Patients Undergoing Cardiac Rehabilitation
The goal of this clinical trial is to learn if a high-flow nasal cannula (HFNC) - a device that delivers warm, humidified air through a small tube placed in the nostrils - can improve exercise tolerance in adults with heart…
- Conditions
- Heart Failure, Exercise Tolerance (Measured in Minutes), Cardiac Rehabilitation
- Trial name
- NCT07613762
- Testing
- High-Flow Nasal Cannula (HFNC)
- Where
- Chile
- Volunteers
- 28 people
- Sponsor
- Universidad de Santiago de Chile
Coronary Artery Disease, In-stent Restenosis
CT-FFR-guided Strategy for In-stent Restenosis
This study will be a prospective, randomized clinical trial to compare standard practice guided by usual care testing to CT-FFR-guided management in patients with in-stent restenosis.
- Trial name
- NCT05611190
- Testing
- CT-FFR, Usual Care
- Volunteers
- 294 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Cardiac Arrest, Out-of-hospital Cardiac Arrest (OHCA)
Mean Arterial Pressure After Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest is a public health problem for which overall survival is below 10%. Post-cardiac arrest syndrome is the principal cause of death in intensive care units (ICU), due to refractory shock or brain…
- Trial name
- METAPHORE (NCT05486884)
- Testing
- Maintain MAP ≥ 90 mmHg, Maintain MAP ≥ 65 mmHg
- Where
- 31 sites in France
- Volunteers
- 1,380 people
- Sponsor
- Centre Hospitalier le Mans
Hypertension, Left Ventricular Diastolic Dysfunction
Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart
To investigate whether treatment with Nebivolol in subjects with high blood pressure and abnormal filling of left ventricle (LVDD) improves exercise time by improving Left Ventricular deformation and filling.
- Trial name
- NCT01961323
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Percutaneous Coronary Intervention, Coronary Physiology
QFR-based Virtual PCI Versus Angio-guided PCI
A significant portion of patients continue to experience both adverse events and symptoms after angiographically successful PCI.
- Trial name
- AQVA (NCT04664140)
- Testing
- QFR-based virtual PCI, angiography-based PCI
- Where
- 3 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University Hospital of Ferrara
Chest Pain, Coronary Artery Disease
Study of Value of Cardiac PET Scans With or Without CT Angiography and/or Measurement of Coronary Flow Reserve
How does PET myocardial perfusion imaging involving CT angiography and measurement of coronary flow reserve affect patient care.
- Trial name
- NCT00669968
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Kettering Health Network
Coronary Artery Disease, Acute Myocardial Infarction
Effects of Intracoronary Progenitor Cell Therapy on Coronary Flow Reserve After Acute MI
Coronary flow reserve is an important measure of the integrity of the coronary microcirculation. Moreover, impaired coronary flow reserve is a predictor of future cardiovascular events and poor prognosis in patients after acute…
- Trial name
- REPAIR-ACS (NCT00711542)
- Testing
- autologous bone marrow-derived progenitor cells
- Where
- 2 sites in Germany
- Volunteers
- 31 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Coronary Artery Disease
Stem Cell Mobilization to Treat Chest Pain and Shortness of Breath in Patients With Coronary Artery Disease
This two-part study will determine whether stem cells (primitive cells produced by the bone marrow that can develop into blood cells or other types of cells) can be pushed out into the bloodstream, relocate in the heart, and grow…
- Trial name
- NCT00043628
- Testing
- Stem Cell Mobilization
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease, Coronary Stenosis
QFR-Guided Virtual Stenting for Preprocedural Physiological Optimization of Percutaneous Coronary Intervention: A Randomized Controlled Trial
Coronary angiography-guided percutaneous coronary intervention (PCI) remains the standard treatment strategy for patients with coronary artery disease; however, suboptimal post-PCI physiological outcomes remain common and are…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Ischemic Heart Disease
- Trial name
- FAVOR-Virtual (NCT07635407)
- Testing
- Virtual Stenting-Guided PCI Optimization, Standard Angiography-Guided PCI
- Where
- China
- Volunteers
- 1,472 people
- Sponsor
- China National Center for Cardiovascular Diseases
Percutaneous Coronary Intervention, No-reflow Phenomen
The RESTORE-SIRIO Randomized Controlled Trial
Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion strategy for treating acute ST-segment elevation myocardial infarction (STEMI).
- Conditions
- Percutaneous Coronary Intervention, No-reflow Phenomen, Acute ST-segment Elevation Myocardial Infarction
- Trial name
- RESTORE-SIRIO (NCT02405130)
- Testing
- intracoronary epinephrine, no intracoronary epinephrine
- Where
- Germany
- Sponsor
- Heinrich-Heine University, Duesseldorf
Sickle Cell Disease
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart…
- Trial name
- NCT05583721
- Testing
- [13N]NH3, Lexiscan, Positron emission tomography
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
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