Clinical trials: Cardiac Imaging
Coronary Heart Disease
Exercise and Brain in Coronary Heart Disease
The Heart-Brain project is a randomized controlled trial designed to examine the effects of two different exercise programs of 12-week duration: 1) aerobic high intensity interval training (HIIT), and 2) aerobic HIIT plus…
- Trial name
- Heart-Brain (NCT06214624)
- Testing
- Two types of exercise interventions
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- Universidad de Granada
Patients Being Assessed With Nuclear Stress Testing of the Heart Using the Stress Agent Regadenoson, Lexiscan
Study With Aminophylline to Attenuate of the Side Effects of Regadenoson
The routine administration of 75 mg of intravenous aminophylline following regadenoson (Lexiscan®), a commonly used medication for nuclear stress testing of the heart, can reduce the gastrointestinal (diarrhea and stomach upset)…
- Trial name
- ASSUAGE (NCT01250496)
- Testing
- Aminophylline
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Rush University Medical Center
Thrombosis, Atherothrombosis
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer
To date, the investigators have successfully employed a radiotracer (18F-sodium fluoride) as a marker of necrotic inflammation in human atherosclerosis.
- Conditions
- Thrombosis, Atherothrombosis, Myocardial Infarction, STEMI
- Trial name
- iThrombus (NCT03943966)
- Testing
- 18F-GP1 PET CT
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- University of Edinburgh
Myocardial Infarction
Rapid Diagnosis of Myocardial Damage and Coronary Stenosis With Magnetic Resonance Imaging (MRI)
The hypothesis is that single-shot imaging of myocardial infarction is possible in atrial fibrillation using MRI late enhancement technique
- Trial name
- NCT00188123
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- University Hospital, Linkoeping
Arrhythmias, Cardiac
Clinically Indicated Magnetic Resonance Imaging in Patients With Cardiac Devices
Patients with implanted cardiac devices who meet appropriate entrance criteria undergo clinically indicated Magnetic Resonance (MR) Imaging Studies using an established safety protocol.
- Trial name
- NCT01130896
- Where
- United States
- Volunteers
- 1,509 people
- Sponsor
- Johns Hopkins University
Plaque
Adverse Plaque Characteristics in CCTA and TVC Imaging
The present study is intended to assess the vulnerability of plaques seen on CCTA by means of TVC Imaging System and to make comparisons between plaques with adverse plaque characteristics and ones without adverse plaque…
- Trial name
- CITRUS (NCT02350959)
- Testing
- Atorvastatin
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- National Health Insurance Service Ilsan Hospital
Heart Failure, Systolic
Mechanistic Clinical Trial of Advanced Imaging for CRT
This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.
- Trial name
- NCT03398369
- Testing
- CMR/CTA Guidance for CRT
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Virginia
Atrial Fibrillation
One More Magnetic Resonance Imaging
The objective of this study is to utilize delayed enhanced cardiac magnetic resonance imaging to assess the success of pulmonary vein isolation after cryoablation of paroxysmal atrial fibrillation.
- Trial name
- OMM (NCT02293070)
- Testing
- Delayed Enhanced Cardiac Magnetic Resonance Imaging, Cryoablation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Saint Luke's Health System
Fabry Disease
Study of the Relation Between Lipid Myocardial Overload Evaluated by Cardiac Magnetic Resonance Imaging (MRI), Alteration of Longitudinal Myocardial Deformations by Echocardiography, and Clinical Achievements (Functional, Biological and Electrical) in Fabry Disease, and Its Outcomes.
Anderson-Fabry disease is a genetic lysosomal storage disease, linked to chromosome X (gene GLA), responsible of enzyme synthesis deficit in α-galactosidase A with intracellular sphingolipids accumulation and multiorganic…
- Trial name
- FABRY-Image (NCT03123523)
- Testing
- Echocardiography at T0, Exercise test, Biological assays
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Heart Failure, Heart Failure, Systolic
Predicting Heart Failure Outcomes With Biomarkers and Imaging
This study aims to develop a better model to predict one-year risk of death in patients with heart failure. We will test whether combining information from routine blood tests (like NT-proBNP) and heart scans (measuring features…
- Conditions
- Heart Failure, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Failure With Reduced Ejection Fraction (HFrEF)
- Trial name
- BIOPHF (NCT07332520)
- Volunteers
- 4,000 people
- Sponsor
- Xinjiang Medical University
Cardiovascular Disease, Coronary Artery Disease
Mental Stress Ischemia: Biofeedback Study
The purpose of this study is to evaluate the blood flow to the heart during stress and assess changes in blood flow after psychological treatment in participants with coronary artery disease.
- Trial name
- MIBS (NCT02657382)
- Testing
- Heart Rate Variability (HRV) Biofeedback (BF), Mental Stress Protocol
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Chronic Coronary Syndrome
Multimodality Imaging and Functional Lesion Assessment in Intermediate Coronary Stenosis in Chronic Coronary Syndrome
The aim of this prospective, investigator-initiated study is to evaluate the diagnostic accuracy and correlations between functional indices (fractional flow reserve, FFR) and morphometric indices: luminal and qualitative…
- Trial name
- MultiInter-CCS (NCT06261866)
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Acute Ischemic Stroke, Transient Ischemic Attack
Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
The goal of this observational study is to to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; to evaluate the influence of lesion location on autonomic dysfunction; to…
- Trial name
- ARIADNE (NCT06740942)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Amyloidogenic Transthyretin (ATTR) Amyloidosis, Cardiac Amyloidosis
PET Imaging Study Using Evuzamitide to Detect Cardiac Amyloidosis in Patients With Inconclusive Nuclear Scans and Elevated TAD1 Levels
The goal of this study is to learn whether PET-CT imaging using evuzamitide can help diagnose transthyretin cardiac amyloidosis (ATTR-CA) in patients whose standard nuclear imaging results are unclear but who have elevated TAD1…
- Trial name
- TRACE (NCT07538518)
- Testing
- Evuzamitide
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Lorena Saelices
Vascular Calcification* / Diagnostic Imaging, Atherectomies, Coronary
Calcium Reduction by Orbital Atherectomy in Western Europe
In calcified lesions, optimal stent placement and expansion may prove to be challenging. Lesion preparation is necessary to facilitate optimal stenting in calcified lesions, for which orbital atherectomy can used.
- Conditions
- Vascular Calcification* / Diagnostic Imaging, Atherectomies, Coronary, Tomography, Optical Coherence, Coronary Intervention, Percutaneous
- Trial name
- CROWN (NCT06035783)
- Testing
- Orbital Atherectomy
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Erasmus Medical Center
Cardiac Diseases
Comparison of Nexfin Pulse Contour Analysis and Cardiac Magnetic Resonance Imaging for the Measurement of Cardiac Output
A growing interest in monitoring cardiac output (CO) non-invasively has emerged, however its determination has been difficult using the standard approaches.
- Trial name
- NCT01639313
- Where
- Germany
- Volunteers
- 39 people
- Sponsor
- Universitätsmedizin Mannheim
COVID-19 Infection
Cardiac and Thoracic Imaging in Pediatric Patients With Evidence of Systemic Inflammation COVID19 Linked
To perform comprehensive cardiac and thoracic non invasive imaging assessment by MRI and/or CT scan including cardiac functional evaluation and myocardial tissue characterization of COVID_19 related disease in pediatric patients…
- Trial name
- CARDOVID (NCT04455347)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Imagine Institute
Cardiac Imaging Techniques
Safety and Efficacy of EchoNavigator System Release II During Structural Heart Interventions
The purpose of this study is to collect data regarding the safety and efficacy of EchoNavigator System Release II during structural heart interventions in the clinical practice.
- Trial name
- EchoNav (NCT02608008)
- Testing
- Data analysis
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Myocardial Ischemia
Multi-modality Imaging of Ischemia With 18F-FDG PET and CTA
Coronary artery disease results in narrowing of the blood vessels supplying oxygenated blood to the heart muscle. Diagnosis in patients with symptoms of chest pain is now quickly done with CT coronary angiography.
- Trial name
- NCT01520025
- Testing
- PET MPI imaging with 18F-Fluorodeoxyglucose
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation, Atrial Flutter
Comparison of Intracardiac Echocardiography and Transesophageal Echocardiography
The presence of intracardiac thrombi and their propensity for systemic embolism is a major concern in patients with atrial fibrillation (AF) and atrial flutter (AFL) undergoing cardioversion and ablation procedures.
- Trial name
- ICE-TEE (NCT02213666)
- Testing
- Intracardiac Imaging
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Elad Anter