Clinical trials: Cardiac Infarct, open to volunteers
Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease
Temporary MCS With the iVAC 2L Transaortic Device in High-risk PCI
Patients with coronary artery disease and undergoing high-risk percutaneous coronary intervention (PCI) are at increased risk of hemodynamic instability and poor outcomes.
- Conditions
- Ischemic Cardiovascular Disease, Multivessel Coronary Artery Disease, Coronary Artery Disease, Cardiogenic Shock
- Trial name
- POTOK (NCT07149714)
- Testing
- iVAC 2L
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Cardiogenic Shock, ECMO
Inhaled Isoflurane for Sedation of Invasively Ventilated Patients With Cardiogenic Shock on Extracorporeal Membrane Oxygenation
Midazolam and propofol are the most used intravenous (IV) sedative agents, but their use is associated with well-known adverse effects such as accumulation, myotoxicity, tachyphylaxis, and unpredictable wake-up time.
- Trial name
- INSEPTION (NCT07099014)
- Testing
- Inahled Isoflurane, Propofol, midazolam
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction
Hong Kong Cardiogenic Shock Initiative
Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) is a severe condition with high mortality. Early revascularization and Impella device (Abiomed) support improve outcomes.
- Conditions
- Cardiogenic Shock Acute, STEMI - ST Elevation Myocardial Infarction, Cardiogenic Shock, Cardiogenic Shock Post Myocardial Infarction
- Trial name
- HK CSI (NCT07323238)
- Where
- Hong Kong
- Volunteers
- 320 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Erectile Disfunction, Coronary Artery Disease (CAD)
"Erectile Function After PCI in MI and Non-MI Patients"
The goal of this observational study is to assess changes in patients' erectile function after percutaneous coronary intervention (PCI) using a standard IIEF (International Index of Erectile Function) questionnaire at 1, 3, and 6…
- Conditions
- Erectile Disfunction, Coronary Artery Disease (CAD), Diabete Mellitus, Anxiety
- Trial name
- ERECT-PCI (NCT07444697)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Coronary Artery Disease, Myocardial Infarction
Foundation Model for Post-MI Cardiovascular Event Alert Using Huawei Watch
The goal of this randomized controlled trial is to evaluate whether a HUAWEI smartwatch integrated with a foundation model can enhance daily monitoring and management of AMI patients during outpatient cardiac rehabilitation after…
- Trial name
- NCT07395648
- Testing
- Smartwatch + AI assisted, Smartwatch only, Conventional care
- Volunteers
- 1,050 people
- Sponsor
- Tongji Hospital
MINOCA
Myocardial Infarction With Non-obstructive Coronary Arteries: Italian Study
Acute coronary syndromes have been extensively studied in recent decades, focusing mainly on myocardial infarctions with obstructive coronary artery disease and early revascularisation strategies.
- Trial name
- MINOCA-IT (NCT06511817)
- Testing
- No intervention will be performed
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
ST Elevation Myocardial Infarction
Efficacy and Safety of a Half-dose Bolus of r-SAK Prior to Primary PCI in ST-elevation Myocardial Infarction
As an effective treatment for acute ST-segment elevation myocardial infarction (STEMI), early reperfusion may reduce the infarct size and improve the prognosis of patients.
- Trial name
- OPTIMA-6 (NCT05410925)
- Testing
- Recombinant staphylokinase
- Where
- 61 sites in China
- Volunteers
- 2,260 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
STEMI - ST Elevation Myocardial Infarction
Century Clot-Guided Prophylactic Rivaroxaban for Post STEMI Complicating Left Ventricular Thrombus
To manage the ST-segment elevation myocardial infarction (STEMI) caused by plaque rupture, triggers platelet activation/aggregation and thrombin generation, requires dual (platelet and coagulation) pathway inhibition.
- Trial name
- NCT06013020
- Testing
- NOAC+DAPT, DAPT
- Where
- China
- Volunteers
- 374 people
- Sponsor
- Zunyi Medical College
Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI)
BRIDGE Trial: Embedding Consumer-grade mHealth Technologies Into Cardiac Rehabilitation
The purpose of the BRIDGE study is to learn whether supplementing traditional center-based cardiac rehabilitation (CBCR) with a mobile health technology intervention can help patients monitor their health, stay engaged in healthy…
- Conditions
- Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft Surgery (CABG), Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)
- Trial name
- BRIDGE (NCT07741396)
- Testing
- CBCR, BRIDGE mHealth intervention
- Volunteers
- 30 people
- Sponsor
- University of Illinois Chicago
Acute Coronary Syndromes (ACS)
Evaluation Through Innovative Examinations of Intestinal Dysbiosis Status in Patients Diagnosed With Cardiovascular Diseases and Evaluation of the Efficacy of Natural and Probiotic Extracts in the Non-pharmacological Approach to Improving Intestinal Dysbiosis Status.
The prospective experimental study aims to take an instantaneous photograph of the subject at time T0 and after 24 hours of intestinal permeability and dysbiosis indices in patients with acute coronary syndromes (ACS) which…
- Trial name
- DISBIO (NCT07429227)
- Testing
- Tea tree (Melaleuca alternifolia), Cinnamon (Cynnamomum zeylanicum) bark, Clove carnation (Eugenia caryopyllus) flowers, Red thyme (Thymus vulgaris) plant
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Casa di Cura Dott. Pederzoli
STEMI, PCI
Intravascular Ultrasound guidaNce versuS angIoGrapHy Guidance in Patients With ST-segment Elevation Myocardial Infarction
STEMI represents the subtype of ACS with the worst prognosis, associated with high mortality and an elevated risk of complications. The use of IVI guidance holds the potential to reduce the incidence of MACE.
- Trial name
- INSIGHT-STEMI (NCT07616024)
- Testing
- Intravascular Ultrasound, Coronary angiography guidance
- Where
- China
- Volunteers
- 2,488 people
- Sponsor
- Shanghai Zhongshan Hospital
Myocardial Infarction
Innate Immune Cell Phenotypes and Early Fibrotic Repair in Acute Myocardial Infarction
To determine the relationship of the phenotypes of neutrophils and monocytes with early fibrotic repair after acute myocardial infarction.
- Trial name
- ICE-AMI (NCT07764588)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai 10th People's Hospital
Myocardial Infarction, Gender
Barts-MINOCA Registry
The last 15 years the introduction of primary angioplasty has radically improved outcomes for acute myocardial infarction (AMI).
- Conditions
- Myocardial Infarction, Gender, Coronary Microvascular Disease
- Trial name
- NCT04440761
- Testing
- Observation only
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- Queen Mary University of London
Cardiogenic Shock
The Clinical and Hemodynamic Course of Cardiogenic Shocks Hospitalized in Critical Care
Cardiogenic shock is a frequent reason for hospitalization in critical care units, with high mortality (50%). Several French registries have been created to improve knowledge of the prognostic factors of cardiogenic shock.
- Trial name
- HEMOCARD (NCT05752383)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Myocardial Infarction (AMI)
Stellate Ganglion Morphine Infiltration on Myocardial I/R Injury
The goal of this clinical trial is to investigate whether morphine modulates the functions of the stellate ganglion to reduce myocardial ischemia/reperfusion (I/R) injury in AMI patients.
- Trial name
- tSGM-AMI (NCT07023679)
- Testing
- Morphine
- Where
- 2 sites in China
- Volunteers
- 2,588 people
- Sponsor
- The Second Hospital of Anhui Medical University
Posttraumatic Stress Disorder, Myocardial Infarction
EMDR Treatment in PTSD Following Cardiac Events
Cardiac events can often result in debilitating and persistent psychological symptoms. A key question involves whether optimal treatment of cardiac-induced posttraumatic stress disorder (PTSD) reduces PTSD symptoms and thereby…
- Conditions
- Posttraumatic Stress Disorder, Myocardial Infarction, Eye Movement Desensitization and Reprocessing
- Trial name
- EMDR_PTSD_MI (NCT04672551)
- Testing
- EMDR Treatment
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
MINOCA, STEMI
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
The aim of this study is to evaluate microvascular dysfunction through OCTA in MINOCA patients. In order to better understand the condition, OCTA will also be performed in two matched patient groups: healthy controls and ACS…
- Conditions
- MINOCA, STEMI, Normal
- Trial name
- REVEAL (NCT07055152)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Pisa
STEMI, No-Reflow Phenomenon
Insulin Resistance and Its Association With no Reflow Phenomenon After Primary PCI in Type II Diabetic STEMI Patients.
To investigate the relationship between the TyG index, coronary lesion complexity assessed by the SYNTAX score, and the development of the no-reflow phenomenon in STEMI patients with T2DM.
- Conditions
- STEMI, No-Reflow Phenomenon, Diabetic Patient
- Trial name
- NCT07706335
- Testing
- PCI
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
MINOCA, Shortness of Breath
Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)
The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it. This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease…
- Conditions
- MINOCA, Shortness of Breath, Atherosclerotic Heart Disease of Native Coronary Artery
- Trial name
- NCT07182955
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
Diabetes Mellitus, Type 2, Cardiovascular Diseases
The Cardio-Metabolic Clinic
This study aims to investigate whether a Cardio-Metabolic Clinic can protect the cardiovascular health of patients with both diabetes and cardiovascular disease.
- Trial name
- ProtecT-2-D (NCT06203860)
- Testing
- Cardio-Metabolic Clinic
- Where
- Denmark
- Volunteers
- 1,600 people
- Sponsor
- Odense University Hospital