Clinical trials: Cardiac Infection
COVID-19
Arrhythmias in Patients With COVID-19
The study is a prospective clinical cohort study of consecutive patients hospitalized at all hospitals of greater Copenhagen with a laboratory confirmed diagnosis of COVID-19.
- Trial name
- ACOVID (NCT04395664)
- Testing
- C3+ Holter Monitor
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Herlev and Gentofte Hospital
Surgical Site Infection
24 Vs 48 Hours of Cefazolin or Cefuroxime as Prophylaxis
A randomized control trial studying the effect of prophylactic antibiotics to reduce surgical site infections following cardiac surgery in adults using 1st generation cephalosporin (Cefazolin) or 2nd generation cephalosporin…
- Trial name
- NCT04303390
- Testing
- Cefuroxime, Cefazolin, 24 hours
- Where
- Saudi Arabia
- Volunteers
- 568 people
- Sponsor
- Saud Al Babtain Cardiac Center
Cardiogenic Shock, Postresuscitation Disease
Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome.
- Conditions
- Cardiogenic Shock, Postresuscitation Disease, Septic Shock
- Trial name
- NCT05586282
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatic Heart Disease, Heart Failure
Dapagliflozin Effect on Rheumatic Mitral Stenosis
Rheumatic mitral stenosis remains a health problem in developing countries. Progressive fibrosis of the valves and myocardium is the main pathophysiology that plays an important role.
- Conditions
- Rheumatic Heart Disease, Heart Failure, Mitral Stenosis
- Trial name
- Dapa-Rhemis (NCT05618223)
- Testing
- Dapagliflozin
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Universitas Sebelas Maret
Chagas Disease, Heart Diseases
Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients With Chagas Disease
The study "Reveal Chagas: Clinical Evidence of the Implantable Cardiac Monitor in Patients with Chagas Disease" is a prospective, multicenter, randomized study that is being conducted at several centers in Latin America with…
- Trial name
- NCT01539161
- Testing
- Implantable Cardiac Monitor, Standard of Care
- Where
- 4 sites in Argentina, Colombia
- Volunteers
- 12 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Post-Op Complication
A Randomized Trial of Lenient Versus Strict Arm Instruction Post Cardiac Device Surgery
The purpose and objectives of this study is to investigate whether reducing the existing arm restrictions on patients who receive Cardiac Implantable Electronic Devices (CIED) will result in an improved patient experience post…
- Trial name
- LENIENT (NCT04915261)
- Testing
- Lenient Arm Restriction, Strict Arm Restriction
- Where
- Canada
- Volunteers
- 6,300 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Surgical Site Infection, Antibiotic Prophylaxis
The Role of Guideline-adherent Perioperative Antibiotic Administration and the Risk of Surgical Site Infections After Non-cardiac Surgery.
This study will seek to describe current practice of antibiotic prophylaxis to identify the effect of appropriate perioperative antimicrobial coverage - specifically regarding timing, dose adjustments, and redosing - on surgical…
- Trial name
- NCT03982810
- Testing
- Antibiotics
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Shortness of Breath, Acute Respiratory Failure
Enhanced FoCUS in Patients With Shortness of Breath
Retrospective observational study performed in a internal medicine ward of a French university hospital. Included patients were hospitalized for acute shortness of breath who have benefited from a eFOCUS which was defined as a…
- Trial name
- eFOCUS (NCT05403619)
- Testing
- Diagnostic test
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Nantes University Hospital
HIV Infections, Heart Disease
Use of Rosuvastatin in HIV-Infected Subjects to Modulate Cardiovascular Risks
The hypothesis of this study is that 96 weeks of Rosuvastatin will be safe and effective in decreasing cardiovascular risk and bone loss in the HIV+ population.
- Trial name
- NCT01218802
- Testing
- Rosuvastatin 10 mg. daily for 96 weeks
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- University Hospitals Cleveland Medical Center
Infectious Endocarditis
Characterization of Enterococcus Faecalis Endocarditis and Impact of Amoxicillin MIC Elevation on Patient Outcome
Infective endocarditis is a complex infection that can be life-threatening. These infections also cause anatomical lesions that can be severe.
- Trial name
- ENDO_ENTERO (NCT05530837)
- Where
- 2 sites in France
- Volunteers
- 281 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Cirrhosis, Liver, Cirrhotic Cardiomyopathy
Echocardiography-guided Cirrhosis and Liver Failure-Intensive Care Protocol Sepsis
Point-of-care echocardiography is used to guide septic shock resuscitation in patients with severe sepsis in the intensive care unit (ICU), but without systematic evidence for efficacy in critically patients with Cirrhosis and…
- Conditions
- Cirrhosis, Liver, Cirrhotic Cardiomyopathy, Septic Shock
- Trial name
- ECLIPSE-I (NCT07286643)
- Testing
- POCUS, Fixed Resuscitation Strategy based on Target MAP
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Community-acquired Pneumonia
MACCE in Hospitalized Patients With Community-acquired Pneumonia
Community-acquired pneumonia is the most common infection leading to hospitalization in intensive care units and the most common cause of death associated with infection disease.
- Trial name
- NCT01773863
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Roma La Sapienza
Hepatitis B
Study to Evaluate the Effect of Bepirovirsen on Cardiac Conduction as Assessed by 12-lead Electrocardiogram in Healthy Volunteers
This study will evaluate the effect of a single dose of bepirovirsen on the QT interval corrected by Fridericia's formula (QTcF) as compared to placebo.
- Trial name
- NCT06422767
- Testing
- Bepirovirsen
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Septic Shock, Sepsis
Sepsis in the ICU-II
Sepsis-induced cardiac dysfunction (SIMD) is a well-known phenomenon yet its diagnosis remains elusive with no accepted definition, or defining pathophysiological mechanism associated with this disease.
- Conditions
- Septic Shock, Sepsis, Cardiomyopathies, Organ Failure, Multiple
- Trial name
- NCT04695119
- Testing
- Exposure is septic shock (defined according to Sepsis-III) and standard treatment according to departmental protocols.
- Where
- 4 sites in France, Sweden
- Volunteers
- 379 people
- Sponsor
- Linkoeping University
Sarcopenia, Post-operative Infections
Phase Angle, Lean Body Mass Index and Tissue Edema and Immediate Outcome of Cardiac Surgery Patients
In general, malnutrition in surgical patients is associated with a higher risk of postoperative infections, decreased immune response, more cardiac complications, prolonged mechanical ventilation , and a higher rate of…
- Conditions
- Sarcopenia, Post-operative Infections, Sepsis
- Trial name
- NCT03644030
- Where
- Greece
- Volunteers
- 179 people
- Sponsor
- Aristotle University Of Thessaloniki
Necrotizing Fascitis, Cellulitis
Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions
The central venous-arterial carbon dioxide tension difference is used daily in intensive care to establish peripheral tissue hypoperfusion, mainly mediated by a low cardiac index.
- Conditions
- Necrotizing Fascitis, Cellulitis, Septic Shock
- Trial name
- SEPTICO2HBO (NCT07492030)
- Testing
- Echography
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Lille
Surgical Site Infection, Sternal Wound Infection
Sternal Wound and Aortic Graft (SWAG), an Observational Cohort Study.
The aim of this study is to systematically explore the perioperative presence of P acnes in all layers of sternal wound incision as well as contamination of graft material and prosthetic valves during primary operation.
- Trial name
- SWAG (NCT04592328)
- Testing
- Bacterial cultures taken during surgery.
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Region Örebro County
Streptococcus Group A
Rheumatic Heart Disease Prevalence in Leon, Nicaragua
A bacterium called Group A Steptoccoccus or "strep" is commonly found in the nose and throat of healthy adults and children and can cause a variety of illnesses.
- Trial name
- NCT00307112
- Where
- Nicaragua
- Volunteers
- 2,193 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Coronary Bypass Stenosis, Graft Infection
Endoscopic Harvesting in Coronary Artery Bypass Grafting.
This is a retrospective data collection looking at patients who received either an endoscopic vessel harvesting procedure versus the conventional open procedure.
- Trial name
- NCT04127461
- Testing
- Medtronic endoscope
- Volunteers
- 773 people
- Sponsor
- Dr. Gianluigi Bisleri
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
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