Clinical trials: Cardiac Infection
Cardiac Arrhythmia
New Onset Cardiac Arrhythmias in Septic Patients in Critical Care Setting, Predictors and Outcomes.
New Onset Cardiac Arrhythmias in Septic Patients in Critical Care Setting, Predictors and Outcomes
- Trial name
- NCT06351956
- Volunteers
- 72 people
- Sponsor
- Assiut University
Pacemaker Complication, Infections
Impact of Partial Capsule Decortication on Device-related Infection in Patients Receiving Cardiac Implantable Electronic Device Replacement
Increasing number of cardiac implantable electronic devices (CIEDs) have been implanted in the worldwide every year, which is accompanied by the growing number of CIED-related infection, especially in patients with CIED…
- Trial name
- STERILE (NCT05390216)
- Testing
- Partial capsule decortication
- Where
- China
- Volunteers
- 1,016 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Tuberculous Pericarditis
A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis
Human immunodeficiency virus (HIV) infection puts people at risk of opportunistic infections, such as tuberculosis. In Africa, the HIV epidemic has resulted in an increase in the number of cases of tuberculosis affecting various…
- Trial name
- IMPI (NCT00810849)
- Testing
- Prednisolone, Mycobacterium w immunotherapy
- Where
- South Africa
- Volunteers
- 1,400 people
- Sponsor
- University of Cape Town
Driveline Heart-assisted Device Related Infection
Driveline Silicone Skin Interface Registry
The purpose of this observational registry is to determine the freedom from driveline (DL) infection events in subjects implanted with a HeartMate II LVAD in whom only the silicone portion of the DL is externalized resulting in a…
- Trial name
- SSI (NCT01577433)
- Where
- 15 sites in United States
- Volunteers
- 400 people
- Sponsor
- Abbott Medical Devices
Heart Diseases, Myocardial Diseases
Chagas Disease as an Undiagnosed Type of Cardiomyopathy in the United States
A detailed review was made of data pertinent to the occurrence of chronic Chagas disease in the United States.
- Conditions
- Heart Diseases, Myocardial Diseases, Chagas Disease
- Trial name
- NCT00005455
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Congenital Heart Diseases, Aortic Valve Disorder
Pre-operative Prophylaxis With Vancomycin and Cefazolin in Pediatric Cardiovascular Surgery Patients
The investigators hope to learn 1) if the addition of prophylaxis with vancomycin will decrease the rate of cefazolin non-susceptible surgical site infections (SSI), in high risk population 2) to develop better understanding of…
- Trial name
- NCT01619982
- Testing
- Cefazolin 25 mg/kg body weight and Vancomycin hydrochloride, Cefazolin 30 mg/kg body weight
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stanford University
Sepsis With Hemodynamic Instability
Correlation of Aortic Versus Pulmonary ITV in Response to Vascular Filling
This is a multicenter study conducted in the emergency department of the Nantes University Hospital and the Confluent Private Hospital, over a period of 5 months, based on hemodynamic ultrasound.
- Trial name
- CIAOP (NCT04899323)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Nantes University Hospital
Infection, Heart Failure
Prediction of Patient Deterioration Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05045742
- Testing
- Traditional vital sign alarms versus the BioVitals Index vs the National Early Warning Score 2
- Where
- 2 sites in United States
- Volunteers
- 526 people
- Sponsor
- Brigham and Women's Hospital
Sternal Wound Infection
Topical Vancomycin Over Sternal Edge in Cardiac Surgery
This is a single-blind 1:1 randomized controlled trial based on the hypothesis that topical application of vancomycin paste over sternum edge is safe and can reduce sternal wound infection after elective cardiac surgery.
- Trial name
- NCT04500275
- Testing
- Vancomycin Hydrochloride, Normal Saline
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- National Cheng-Kung University Hospital
Rheumatic Heart Disease, Valvular Disease
Role of Statins In Slowing Rheumatic Heart Disease (RHD) Progression
The goal of this study is to address specific implementation questions necessary and sufficient to ensure the feasibility of the larger randomized trial examining the efficacy of statin medications in slowing rheumatic heart…
- Trial name
- NCT04575857
- Testing
- Atorvastatin
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- University of Washington
Cardiogenic Shock, Septic Shock
Levosimendan Versus Dobutamine in Shock Patients
The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock).
- Trial name
- NCT00093301
- Testing
- Levosimendan, Dobutamine
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Wentworth Area Health Services
Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy
The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the…
- Conditions
- Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant
- Trial name
- ALLELE (NCT03394365)
- Testing
- tabelecleucel
- Where
- 71 sites in United States, Australia and 7 more
- Volunteers
- 115 people
- Sponsor
- Pierre Fabre Medicament
Infection
Salvage of Infected Cardiovascular Implantable Electronic Devices (CIED) by Localized High-dose Antibiotics
Following previous positive experience with regulated CITA-RNPT of infected CIEDs, we suggest increasing the number of recruited patients and that CITA-RNPT can be administered prophylactically to patients prior to replacement of…
- Trial name
- NCT01770067
- Testing
- CITA-RNPT, Extraction of infected CIED
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hillel Yaffe Medical Center
Acute Coronary Syndrome, Helicobacter Pylori Infection
The Effect of Dual Eradication Therapy vs PPI on Gastrointestinal Bleeding in ACS Patients
Patients with acute coronary syndrome (ACS) after Percutaneous Coronary Intervention (PCI) require routine treatment with dual antiplatelet (DAPT) treatment, but with the high risk of bleeding, gastrointestinal bleeding is the…
- Trial name
- NCT04728516
- Testing
- Vonoprazan-based dual eradication therapy for two weeks, amoxicillin, Pantoprazole
- Where
- 42 sites in China
- Volunteers
- 2,600 people
- Sponsor
- Qilu Hospital of Shandong University
Transplant
Cell Mediated Immunity and the Prediction of CMV Infection In Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut, and the liver.
- Trial name
- NCT00436384
- Testing
- Monitoring-blood samples drawn for CMV testing
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Cytomegalovirus Infections, Heart Transplantation
Quantiferon CMV to Identify Treatment Need for Asymptomatic CMV Infection After Solid Organ Transplant (QUANTIFOT)
Context Cytomegalovirus (CMV) infection is a frequent and potentially severe event in solid organ transplant (SOT) recipients. Most of available treatment display adverse effects that limit their use.
- Conditions
- Cytomegalovirus Infections, Heart Transplantation, Kidney Transplantation, Lung Transplantation
- Trial name
- QUANTIFOT (NCT06341543)
- Testing
- Quantiferon CMV (assay that determine the presence of CMV-specific T lymphocytes)., Communication of the result of the QF-CMV to the clinician in charge
- Where
- France
- Volunteers
- 288 people
- Sponsor
- University Hospital, Grenoble
HIV Infections, Sexually Transmitted Diseases
Reducing HIV Risk Among Adolescents: Evaluating HEART for Teens
This study evaluates an educational web-based intervention designed to increase adolescent boys' and girls' motivation and skills to engage in safer sexual behavior (HEART: Health Education and Relationship Training).
- Trial name
- NCT03453515
- Testing
- HEART, Growing Minds
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- North Carolina State University
HIV Infections, Coronary Disease
HIV-HEART Aging Study
The HIV/HEART Aging study (HIVH) is an ongoing, prospective, multicentre trial that was conducted to assess the incidence, the prevalence and the clinical course of cardiovascular diseases (CVD) in HIV-infected patients.
- Conditions
- HIV Infections, Coronary Disease, Myocardial Infarction, HIV Encephalopathy
- Trial name
- HIVH (NCT04330287)
- Where
- 5 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Essen
Infective Endocarditis (IE)
From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective Endocarditis
Enterococci are pathobionts of the human intestinal microbiota: they colonize the gastrointestinal tract as well as the skin, urine, wounds, bile, the oral cavity and endodontic canal, and medical devices (urinary catheters…
- Trial name
- BAC-ENDO (NCT07313865)
- Testing
- Microbiological sampling (swab collection)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
HIV/AIDS, Cardiovascular Risk Factors
Healing Our Hearts Minds and Bodies: CVD Reduction in Persons With HIV
"Healing our Minds and Bodies" (HHMB) uses a a hybrid type II effectiveness/implementation study design to increase both patient and organizational readiness to address trauma and CVD risk among African American and Latino…
- Conditions
- HIV/AIDS, Cardiovascular Risk Factors, Trauma, Psychological
- Trial name
- HHMB (NCT04025463)
- Testing
- HHMB
- Where
- 2 sites in United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
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