Clinical trials: Cardiac Infection
Myocardial Infarction, Influenza, Human
Study on the Effect of Influenza Vaccination After Heart Attack on Future Cardiovascular Prognosis
Background. For more than a century a causal link between influenza and cardiovascular disease has been suspected. It is conceivable that influenza may precipitate plaque rupture, increase cytokines with central roles in plaque…
- Conditions
- Myocardial Infarction, Influenza, Human, Influenza Vaccines, Heart Failure
- Trial name
- IAMI (NCT02831608)
- Testing
- Influenza vaccine
- Where
- 29 sites in Australia, Bangladesh and 6 more
- Volunteers
- 2,571 people
- Sponsor
- Ole Frobert, MD, PhD
Cardiovascular Disease
A Study Exploring the Effect of Adjuvanted RZV or RSVPreF3 Vaccines on Coronary Plaque Progression in Adults >=50 Years of Age at Risk for Cardiovascular Events
This study is designed to evaluate whether the adjuvanted recombinant zoster vaccine (RZV) or the adjuvanted respiratory syncytial virus PreFusion protein 3 (RSVPreF3) vaccine can attenuate the progression of coronary plaque in…
- Trial name
- NCT07712380
- Testing
- Adjuvanted RZV vaccine, Adjuvanted RSVPreF3 vaccine
- Volunteers
- 450 people
- Sponsor
- GlaxoSmithKline
Covid19, Dyspnea
Understanding Exertional Dyspnea and Exercise Intolerance in COVID-19
A novel corona virus emerged in 2019 causing Corona Virus Disease 2019 (covid-19). In one year more than 80 000 000 cases worldwide were documented.
- Trial name
- NCT04732663
- Testing
- No Intervention
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Infections, Heart Diseases
Effect of Synapse Medicine Decision Support on Inpatient Pharmacist Efficacy and Efficiency
Adverse drug events (ADE) are common and dangerous in the hospital and following discharge to the ambulatory setting. One cause of ADEs in both settings is medication regimen inappropriateness, including polypharmacy, drug-drug…
- Conditions
- Infections, Heart Diseases, Lung Diseases, Kidney Diseases
- Trial name
- NCT05459155
- Testing
- Synapse medicine platform
- Where
- United States
- Volunteers
- 1,485 people
- Sponsor
- Brigham and Women's Hospital
COVID-19, Chronic Heart Failure
Analysis of Health Status of Сomorbid Adult Patients With COVID-19 Hospitalised in Fourth Wave of SARS-CoV-2 Infection
Depersonalized multi-centered registry initiated to analyze dynamics of non-infectious diseases after SARS-CoV-2 infection in population of Eurasian adult patients.
- Conditions
- COVID-19, Chronic Heart Failure, Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- ACTIV4 (NCT05226416)
- Where
- Russia
- Volunteers
- 3,554 people
- Sponsor
- Eurasian Association of Therapists
Infective Endocarditis (IE)
Metabolic Profiling Among Patients Suspected of Infective Endocarditis - PPSIE Comparing Metabolomes of Bloodstream Infections Versus Infective Endocarditis
Most cases of Infective endocarditis (IE) are caused by Gram-positive bacteria, primarily Staphylococcus aureus, oral or intestinal streptococci, and enterococci (especially Enterococcus faecalis).
- Trial name
- PPSIE (NCT07917325)
- Testing
- Blood sample
- Where
- 3 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Angers
Intubation Complication, Intubation; Difficult or Failed
Prehospital Intubation of COVID-19 Patient With Personal Protective Equipment
The safety and efficacy of a laryngoscopy as a primary intubation tool in urgent endotracheal intubation of cardiac arrest patients with suspected/confirmed COVID-19 has not been well-described in the literature.
- Conditions
- Intubation Complication, Intubation; Difficult or Failed, Cardiac Arrest, Influenza
- Trial name
- NCT04365608
- Testing
- Direct laryngoscopy, Vie Scope laryngoscopy
- Where
- 2 sites in Poland
- Volunteers
- 90 people
- Sponsor
- Lazarski University
COVID, Sars-CoV2
Prospective Registry of Corona Virus Disease 2019 (Covid-19) Patients With Neuromuscular Involvement
Prospective registry for multimodal assessment of neuromuscular pathology associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, enrolling consecutive patients with corona virus disease 2019…
- Conditions
- COVID, Sars-CoV2, Corona Virus Infection, Myositis
- Trial name
- NCT04367350
- Testing
- laboratory biomarkers, muscle ultrasound
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital Tuebingen
Rheumatic Heart Disease
Comparison of Wire Assisted Percutaneous Balloon Mitral Valvulotomy With Standard Inoue Balloon Valvulotomy
The goal of this randomised study is comparison of wire assisted balloon mitral valvulotomy to standard Inoue balloon technique on patients with rheumatic mitral stenosis.
- Trial name
- CROSSVal (NCT06150274)
- Testing
- Percutaneous Balloon Mitral Valvulotomy
- Where
- Ethiopia
- Volunteers
- 20 people
- Sponsor
- Helse Stavanger HF
Patients Undergoing Routine Health Care, Heart Diseases
The 1200 Patients Project: Studying the Implementation of Clinical Pharmacogenomic Testing
The purpose of this study is to collect DNA samples from patients undergoing routine care at the University of Chicago. These samples will be tested for differences in genes that may suggest greater risk of side effects or chance…
- Conditions
- Patients Undergoing Routine Health Care, Heart Diseases, Inflammatory Bowel Diseases, Autoimmune Disease
- Trial name
- NCT01280825
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Mitral Annulus Calcification, Rheumatic Heart Disease
Treating Severe Mitral Valve Annular or Valvular Calcification Using Shockwave Balloon SMARTWAVE
Mitral stenosis (MS) is a heavily symptomatic valvular heart disease. Common causes of MS included chronic rheumatic heart disease (CRHD) and mitral annular calcification (MAC).
- Trial name
- SMARTMAC (NCT06952374)
- Testing
- SmartWave Lithotripsy balloon
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Myocardial Infarction, Acute Coronary Syndrome
Acute Coronary Syndrome in Patients With COVID-19
The aim of this study was to find a clinical or laboratory parameter, that would help in distinguishing between COVID-19 patients with myocardial infarction (MI), who have an infarct-related artery (IRA) and therefore, require…
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, COVID-19, Myocardium; Injury
- Trial name
- ACS-COVID (NCT05732597)
- Testing
- Coronary angiography
- Where
- Bulgaria
- Volunteers
- 26 people
- Sponsor
- Bulgarian Cardiac Institute
Preterm, Patent Ductus Arteriosus
NeoDoppler: New Ultrasound Technology for Continuous Monitoring of Cerebral Circulation Pilot
Non-invasive tools for monitoring of course of disease are important and necessary in the treatment of pre-term/premature infants and sick neonates.
- Conditions
- Preterm, Patent Ductus Arteriosus, Sepsis, Asphyxia
- Trial name
- CE-NeoDoppler (NCT06646250)
- Testing
- NeoDoppler - CE certified
- Where
- Norway
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Cardiac Arrest, Emergencies
Intravascular Access of COVID-19 Patient Under Personal Protective Equipment
The current COVID-19 pandemic, this is especially since the transmission of SARS-CoV-2 is thought to occur mainly through respiratory droplets generated by coughing and sneezing, by direct contact with contaminated surfaces and…
- Trial name
- NCT04366297
- Testing
- Intravenous access, Intraosseous access
- Where
- Poland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Lazarski University
Autoimmune Diseases, Cardiovascular Disorders
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions
This multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions.
- Conditions
- Autoimmune Diseases, Cardiovascular Disorders, Diabetes Complications, Integumentary Disease
- Trial name
- NCT04684602
- Testing
- PrimePro™/ PrimeMSK™
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Thomas Advanced Medical LLC
Limb Edema, Surgical Site Infections
Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages
The study aimed to assess the efficacy of customized pressure-guided elastic bandages (CPG-EB) in preventing postoperative edema and complications in Coronary Artery Bypass Graft (CABG) patients.
- Conditions
- Limb Edema, Surgical Site Infections, Leg Swelling, Compression Bandages
- Trial name
- PEACCE (NCT06603961)
- Testing
- CPG-EB group
- Where
- 2 sites in Thailand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Sepsis, Need of Cardiac Surgery
International Registry on the Use of the CytoSorb Adsorber
Registry on the use of the CytoSorb® adsorber in ICU patients.
- Trial name
- CytoSorb (NCT02312024)
- Testing
- Use of CytoSorb adsorber
- Where
- 19 sites in Austria, Germany and 1 more
- Volunteers
- 1,434 people
- Sponsor
- Jena University Hospital
Cardiac Implantable Electronic Device Infection
Taurolidine Containing Antimicrobial CIED Wash to Prevent Infection
From January 1st 2020, any CIED procedure conducted with adjunct TauroPace™ CIED and pocket irrigation is enrolled in a consecutive manner and followed up in one centre. Follow-up is prospectively.
- Trial name
- NCT05576194
- Testing
- TauroPace, Hydrogen Peroxide, Taurolidine
- Where
- Germany
- Volunteers
- 1,417 people
- Sponsor
- Prof. Dr. Hendrik Bonnemeier
Endocarditis, Bacterial
Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis.
The aim of this study is to determine the safety and efficacy of daptomycin when used as an adjuvant agent to standard care in the treatment of proven native valve Enterococcal endocarditis.
- Trial name
- NCT00401960
- Testing
- Daptomycin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Weill Medical College of Cornell University
Rheumatic Heart Disease, Pregnancy
Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease
The hemodynamic parameters of 31 pregnant women with rheumatic valve disease, undergoing restorative dentistry under local anesthesia with 2% solution of lidocaine, divided in two groups, with (Group LE) and without 1:100,000…
- Conditions
- Rheumatic Heart Disease, Pregnancy, Dental Caries
- Trial name
- NCT00482573
- Testing
- Dental local anesthesia
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
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