Clinical trials: Cardiac Infection
Bacteremia, Endocarditis
An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures
Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens.
- Trial name
- NCT06422221
- Testing
- Clindamycin, Doxycycline
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- University of Santiago de Compostela
Sepsis, Septic Shock
The Role of Serotonin in Intensive Care Patients
Sepsis, cardiac arrest and multiple trauma are potentially life-threatening conditions and common reasons for intensive care unit (ICU) admission.
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest With Successful Resuscitation, Multiple Trauma
- Trial name
- SERO-22 (NCT05386199)
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Pneumonia, Lung Cancer
On Dose Efficiency of Modern CT-scanners in Chest Scans
CT scans of the chest / thorax are of great importance both in the initial diagnosis and in the follow-up of pulmonary or thoracic diseases.
- Conditions
- Pneumonia, Lung Cancer, Pulmonary Embolism, Pulmonary Disease
- Trial name
- NCT04996693
- Testing
- Imaging on Scanner with Spectral Imaging Capabilities, CT Scan using an Energy-Integrating Detector CT (128 slice MDCT), CT Scan using an Energy-Integrating Detector CT (20-slice MDCT)
- Where
- Germany
- Volunteers
- 958 people
- Sponsor
- University Hospital Augsburg
COVID-19, Myocarditis
Clinical Significance of Subclinical Myocardial Involvement in Recovered COVID-19 Patients Using Cardiovascular Magnetic Resonance
Introduction: Coronavirus disease 2019 (COVID-19) remains a major health issue resulting in >800,000 deaths as of 30th August 2020. A concerning discovery of COVID-19 is the involvement of the myocardium.
- Trial name
- R-COVID-CMR (NCT05184114)
- Testing
- Cardiac Magnetic Resonance, Blood Tests
- Where
- Hong Kong
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cardiovascular Risk, HIV Infections
Cardiovascular Risk Evaluation and Antiretrovirals in HIV
The purpose of the study is to determine the main factors contributing to predicted 10 year cardiovascular risk in an HIV infected cohort, and the role of anti-HIV drug use in altering this risk
- Trial name
- CREATE1 (NCT01015092)
- Where
- United Kingdom
- Volunteers
- 1,024 people
- Sponsor
- King's College London
Neonatal Sepsis, Markers
Tissue Doppler Echocardiographic Assessment of Cardiac Function in Neonatal Sepsis
1. To assess myocardial function in neonates with sepsis using tissue doppler echocardiography. 2. To assess sepsis induced cardiac dysfunction. 3.
- Trial name
- NCT07572916
- Testing
- cardiac troponin, and blood culture
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Infection Cardiac, Heart Failure
Tauropace to Prevent Cardiac Implantable Device Infections in Heart Failure Patients
The main purpose of the study is to evaluate the ability of the Tauropace to reduce major cardiac implantable electronic device (CIED) infections through 12-months post-procedure following CIED in heart failure participants.
- Conditions
- Infection Cardiac, Heart Failure, Cardiac Implantable Electronic Device Infections, High Risk
- Trial name
- TRICE-HF (NCT05103267)
- Testing
- Tauropace
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Federico II University
Pre-Term, Neonatal Infection
Non-invasive Measurement of Neonatal Central and Peripheral Hemodynamics
Non-invasively neonatal cardiac output can be measured by multiple methods, but the gold standard still remains conventional echocardiography. It is accurate, but needs a long training for new users to assess cardiac function.
- Trial name
- NInHeDyNeo (NCT04200807)
- Testing
- Ultrasound Cardiac Output Monitor (USCOM 1A)
- Where
- Lithuania
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Vilnius University
CABG
Effects of Acapella VS CHEST Physiotherapy in Post-Operative CABG Patients
Coronary artery bypass grafting (CABG) is a surgical procedure that is performed to improve blood flow to the heart by bypassing blocked or narrowed arteries.
- Trial name
- NCT06317363
- Testing
- Base Line + ACEPELLA, Base Line + Manual Chest Physiotherapy
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Tuberculosis
Digitally Facilitated, Integrated Community and Facility-Based Interventions: The HEART-TB Trial Protocol
Effective tuberculosis treatment outcome relies on adherence. However, many TB patients struggle to adequately adhere to their prescribed regimen due to various social, economic, personal, and healthcare system barriers.
- Trial name
- HEART-TB (NCT07440160)
- Testing
- HEART-TB
- Where
- Ethiopia
- Volunteers
- 278 people
- Sponsor
- Arba Minch University
Non-infectious Uveitis
Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis
This extension study will assess the safety and efficacy of AIN457 versus placebo for maintaining uveitis suppression when reducing systemic immunosuppression
- Trial name
- ENDURE (NCT01090310)
- Testing
- AIN457
- Where
- 35 sites in United States, Brazil and 6 more
- Volunteers
- 86 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure, Covid19
Impact of COVID-19 on the Benefit of Cardiac Rehabilitation
The COVID-19 attack is polymorphic with otorhinolaryngological, pneumological, cardiac, digestive, neurological, muscular attacks with a higher mortality in subjects with comorbidity [> 70 years old, cardiovascular history in…
- Trial name
- REACARDIOCOVID (NCT04513964)
- Sponsor
- Fondation Hôpital Saint-Joseph
Cardiac Surgery in Adult Patient
Randomized Trial of 2% Chlorhexidine-70% Isopropanol vs 5% Povidone Iodine-69% Ethanol for Skin Antisepsis in Reducing Surgical-site Infection After Cardiac Surgery
Despite completion of more than 9 million procedures each year in France, the best antiseptic solution to be used for preparing the skin to reduce risk of surgical site infection (SSI) remains unknown.
- Trial name
- CLEAN2 (NCT03560193)
- Testing
- 2%Chlorhexidine-70%Isopropanol, 5%Povidone Iodine- 69%Ethanol
- Where
- 8 sites in France
- Volunteers
- 3,316 people
- Sponsor
- Poitiers University Hospital
HIV, Cardiovascular Disease
Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology
Background: Antiretroviral therapy has increased the lifespan of people with human immunodeficiency virus (HIV), but recent research suggests that people with HIV also have an increased risk of developing cardiovascular disease.
- Trial name
- NCT01089114
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Heart Failure, Gut Microbiome
Enhanced Nutritional Optimization in LVAD Trial
The goal of this clinical trial is to assess whether a peri-operative intervention with nutritional immune modulating intervention (Ensure Surgery Immunonutrition shake) has beneficial effects on the complex interplay between gut…
- Conditions
- Heart Failure, Gut Microbiome, Nutritional Deficiency
- Trial name
- ENOL (NCT05655910)
- Testing
- Ensure Surgery Immunonutrition shake
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Cardiac Surgery, Infection, Postoperative Wound
Management Practices and the Risk of Infection Following Cardiac Surgery
The purpose of the study is to determine the best ways to prevent infections after heart surgery. Participation in the study will last at most 3 months after heart surgery.
- Conditions
- Cardiac Surgery, Infection, Postoperative Wound, Postoperative Wound Infection, Infections, Nosocomial
- Trial name
- NCT01089712
- Where
- 10 sites in United States, Canada
- Volunteers
- 5,158 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Covid19 Pneumonia, Chronic Thromboembolic Pulmonary Hypertension
COVID-19 Pneumonia: Pulmonary Physiology, Health-related Quality of Life and Benefit of a Rehabilitation Program
The pathophysiological processes involved in COVID-19 pneumonia are not fully understood. Specific alterations of the airways, lung parenchyma and pulmonary vascular tree could explain a severe ventilation/perfusion heterogeneity…
- Conditions
- Covid19 Pneumonia, Chronic Thromboembolic Pulmonary Hypertension, Myopathy, Restrictive Lung Disease
- Trial name
- COVISQAR (NCT04881214)
- Testing
- Pulmonary rehabilitation
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Geneva
Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
The study investigators are interested in learning more about how drugs, that are given to children by their health care provider, act in the bodies of children and young adults in hopes to find the most safe and effective dose…
- Conditions
- Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension, Urinary Tract Infections in Children, Hypertension
- Trial name
- POPS or POP02 (NCT04278404)
- Testing
- The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Sepsis Newborn
Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Congenital Heart Disease
The use of neutrophil lymphocyte ratio is useful for the detection of infection status in newborns after surgery
- Trial name
- NCT03923543
- Testing
- Neutrophil to lymphosit ratio
- Volunteers
- 60 people
- Sponsor
- Firat Ergin
Acute Coronary Syndrome, Heart Failure
Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP)
The aim of this study is to evaluate the effect of offering intrahospital influenza vaccination as an adjunct to active counseling during the index hospitalization to adult patients hospitalized for acute coronary syndrome (ACS)…
- Conditions
- Acute Coronary Syndrome, Heart Failure, Influenza, Human, Cardiovascular Diseases
- Trial name
- VACC-UP (NCT07721649)
- Testing
- Intrahospital seasonal influenza vaccination offer, Standardized active influenza vaccination counseling, Standard of care discharge recommendation for ambulatory vaccination
- Where
- 2 sites in Germany
- Volunteers
- 482 people
- Sponsor
- Stephan Baldus
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